CA2361046A1 - Procede permettant d'attenuer les desagrements lies aux bouffees de chaleur et compositions a cet effet - Google Patents
Procede permettant d'attenuer les desagrements lies aux bouffees de chaleur et compositions a cet effet Download PDFInfo
- Publication number
- CA2361046A1 CA2361046A1 CA002361046A CA2361046A CA2361046A1 CA 2361046 A1 CA2361046 A1 CA 2361046A1 CA 002361046 A CA002361046 A CA 002361046A CA 2361046 A CA2361046 A CA 2361046A CA 2361046 A1 CA2361046 A1 CA 2361046A1
- Authority
- CA
- Canada
- Prior art keywords
- cooling
- group
- cooling agent
- menthyl
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 208000033830 Hot Flashes Diseases 0.000 title claims abstract description 60
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- 238000001816 cooling Methods 0.000 claims abstract description 87
- 239000002826 coolant Substances 0.000 claims description 53
- ZBJCYZPANVLBRK-UHFFFAOYSA-N Menthone 1,2-glyceryl ketal Chemical compound CC(C)C1CCC(C)CC11OC(CO)CO1 ZBJCYZPANVLBRK-UHFFFAOYSA-N 0.000 claims description 13
- 125000004432 carbon atom Chemical group C* 0.000 claims description 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 12
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- UJNOLBSYLSYIBM-WISYIIOYSA-N [(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexyl] (2r)-2-hydroxypropanoate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)[C@@H](C)O UJNOLBSYLSYIBM-WISYIIOYSA-N 0.000 claims description 9
- 229940041616 menthol Drugs 0.000 claims description 9
- VUNOFAIHSALQQH-UHFFFAOYSA-N Ethyl menthane carboxamide Chemical compound CCNC(=O)C1CC(C)CCC1C(C)C VUNOFAIHSALQQH-UHFFFAOYSA-N 0.000 claims description 7
- RWAXQWRDVUOOGG-UHFFFAOYSA-N N,2,3-Trimethyl-2-(1-methylethyl)butanamide Chemical compound CNC(=O)C(C)(C(C)C)C(C)C RWAXQWRDVUOOGG-UHFFFAOYSA-N 0.000 claims description 6
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- RZLHKMZWJJBZTP-UHFFFAOYSA-N (1-methyl-4-propan-2-ylcyclohexyl) hydrogen carbonate Chemical class CC(C)C1CCC(C)(OC(O)=O)CC1 RZLHKMZWJJBZTP-UHFFFAOYSA-N 0.000 claims description 5
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- BLILOGGUTRWFNI-UHFFFAOYSA-N Monomenthyl succinate Chemical class CC(C)C1CCC(C)CC1OC(=O)CCC(O)=O BLILOGGUTRWFNI-UHFFFAOYSA-N 0.000 description 3
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- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 2
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- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
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- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- RCEFMOGVOYEGJN-UHFFFAOYSA-N 3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-1,4-dihydropyrimidin-2-one Chemical compound OC1=CC=CC=C1N1C(=O)NC(C=2C=C(C=CC=2)[N+]([O-])=O)=CC1 RCEFMOGVOYEGJN-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
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- 241000124008 Mammalia Species 0.000 description 1
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- 206010027940 Mood altered Diseases 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
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- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/24—Thermal properties
- A61K2800/244—Endothermic; Cooling; Cooling sensation
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- Health & Medical Sciences (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Reproductive Health (AREA)
- Medicinal Preparation (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne un procédé permettant d'atténuer les désagréments tels que la sensation de chaleur intense dont souffre une femme à l'occasion de bouffées de chaleur. L'invention concerne également des compositions pouvant s'utiliser pour la mise en pratique de ce procédé. L'invention concerne plus particulièrement l'application locale de compositions comportant des composés rafraîchissants, et ce, afin d'atténuer les désagréments dont souffre une femme pendant une bouffée de chaleur.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24328999A | 1999-02-02 | 1999-02-02 | |
US09/243,289 | 1999-02-02 | ||
PCT/US2000/002638 WO2000045815A1 (fr) | 1999-02-02 | 2000-02-02 | Procede permettant d'attenuer les desagrements lies aux bouffees de chaleur et compositions a cet effet |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2361046A1 true CA2361046A1 (fr) | 2000-08-10 |
Family
ID=22918145
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002361046A Abandoned CA2361046A1 (fr) | 1999-02-02 | 2000-02-02 | Procede permettant d'attenuer les desagrements lies aux bouffees de chaleur et compositions a cet effet |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1171120A4 (fr) |
JP (1) | JP2002536069A (fr) |
AU (1) | AU2751000A (fr) |
CA (1) | CA2361046A1 (fr) |
WO (1) | WO2000045815A1 (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2483090C (fr) * | 2002-05-02 | 2011-01-25 | Cragmont Pharmaceuticals, Llc | Utilisation de compositions therapeutiques a base de 1,2,3,6-tetrahydropyrimidine-2-one |
US7632531B2 (en) | 2003-04-11 | 2009-12-15 | International Flavors & Fragnances Inc. | Alkyldienamides exhibiting taste and sensory effect in flavor compositions |
US7361376B2 (en) | 2003-04-11 | 2008-04-22 | International Flavors & Fragrances Inc. | Alkyldienamides exhibiting taste and sensory effect in flavor compositions |
JP4018032B2 (ja) * | 2003-06-17 | 2007-12-05 | 高砂香料工業株式会社 | 毛髪及び身体洗浄剤組成物 |
US6884906B2 (en) | 2003-07-01 | 2005-04-26 | International Flavors & Fragrances Inc. | Menthyl half acid ester derivatives, processes for preparing same, and uses thereof for their cooling/refreshing effect in consumable materials |
US7141686B2 (en) | 2003-07-10 | 2006-11-28 | International Flavors & Fragrances Inc. | E2, E4, Z8-undecatrienoic acid and ester and carboxamide derivatives thereof, organoleptic uses thereof and processes for preparing same |
US8007839B2 (en) | 2003-10-03 | 2011-08-30 | International Flavors & Fragrances | Conjugated dienamides, methods of production thereof, compositions containing same and uses thereof |
US7329767B2 (en) | 2003-10-03 | 2008-02-12 | International Flavors & Fragrances Inc. | Conjugated dienamides, methods of production thereof, compositions containing same and uses thereof |
US7541055B2 (en) | 2004-09-10 | 2009-06-02 | International Flavors & Fragrances Inc. | Saturated and unsaturated N-alkamides exhibiting taste and flavor enhancement effect in flavor compositions |
US7427421B2 (en) | 2004-09-10 | 2008-09-23 | International Flavors & Fragrances Inc. | Saturated and unsaturated N-alkamides exhibiting taste and flavor enhancement effect in flavor compositions |
DE102004048987B3 (de) * | 2004-10-04 | 2005-12-15 | Coty Deutschland Gmbh | Kühlende kosmetische Zusammensetzung und deren Verwendung |
DK1833443T3 (da) * | 2005-01-04 | 2012-01-23 | Teikoku Pharma Usa Inc | Kølende topisk plastersammensætning |
US12290640B2 (en) | 2006-04-20 | 2025-05-06 | University of Pittsburgh—of the Commonwealth System of Higher Education | Noninvasive, regional brain thermal stimulation for inducing relaxation |
US11684510B2 (en) | 2006-04-20 | 2023-06-27 | University of Pittsburgh—of the Commonwealth System of Higher Education | Noninvasive, regional brain thermal stimuli for the treatment of neurological disorders |
US8425583B2 (en) | 2006-04-20 | 2013-04-23 | University of Pittsburgh—of the Commonwealth System of Higher Education | Methods, devices and systems for treating insomnia by inducing frontal cerebral hypothermia |
US9480633B2 (en) * | 2011-04-28 | 2016-11-01 | Kimberly-Clark Worldwide, Inc. | Temperature management composition |
RU2638793C2 (ru) | 2012-06-08 | 2017-12-15 | Те Огайо Стейт Юниверсити | Способ лечения ожоговых и рубцовых повреждений с применением токотриенольных композиций |
AU2014204112B2 (en) | 2013-01-02 | 2018-05-24 | Ebb Therapeutics, Inc. | Systems for enhancing sleep |
WO2016123241A1 (fr) * | 2015-01-27 | 2016-08-04 | Cerêve, Inc. | Procédé et appareils de modulation du sommeil par l'activation chimique des thermorécepteurs |
CN115297852A (zh) * | 2020-04-10 | 2022-11-04 | 宝洁公司 | 用于处理潮热的组合物和方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4193936A (en) * | 1971-02-04 | 1980-03-18 | Wilkinson Sword Limited | N-substituted paramenthane carboxamides |
GB1421743A (en) * | 1972-04-18 | 1976-01-21 | Wilkinson Sword Ltd | Ingestible topical and other compositions |
GB1436329A (en) * | 1972-08-07 | 1976-05-19 | Unilever Ltd | Esters of menthol and a heterocyclic carboxylic acid and their use in cosmetic preparations |
DE4110973A1 (de) * | 1991-04-05 | 1992-10-08 | Haarmann & Reimer Gmbh | Mittel mit physiologischem kuehleffekt und fuer diese mittel geeignete wirksame verbindungen |
DE69314025T2 (de) * | 1992-05-18 | 1998-04-16 | Procter & Gamble | Zusammensetzungen mit kühleffekt |
GB2273299A (en) * | 1992-12-08 | 1994-06-15 | Nelly Kamel Rizk | Mixture that produces cooling |
-
2000
- 2000-02-02 EP EP00905910A patent/EP1171120A4/fr not_active Withdrawn
- 2000-02-02 AU AU27510/00A patent/AU2751000A/en not_active Abandoned
- 2000-02-02 WO PCT/US2000/002638 patent/WO2000045815A1/fr not_active Application Discontinuation
- 2000-02-02 CA CA002361046A patent/CA2361046A1/fr not_active Abandoned
- 2000-02-02 JP JP2000596935A patent/JP2002536069A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP1171120A4 (fr) | 2004-11-17 |
AU2751000A (en) | 2000-08-25 |
JP2002536069A (ja) | 2002-10-29 |
WO2000045815A1 (fr) | 2000-08-10 |
EP1171120A1 (fr) | 2002-01-16 |
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