CA2012175A1 - Traitement photochimique des vaisseaux sanguins - Google Patents

Traitement photochimique des vaisseaux sanguins

Info

Publication number: CA2012175A1
Authority: CA; Canada
Prior art keywords: blood vessel; photoreactive compound; blood; compound; photoreactive
Prior art date: 1989-03-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002012175A

Other languages

English (en)

Inventor

Michael W. Berns

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University of California San Diego UCSD

Original Assignee

University of California San Diego UCSD

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-31

Filing date

1990-03-14

Publication date

1990-09-30

1990-03-14 Application filed by University of California San Diego UCSD filed Critical University of California San Diego UCSD

1990-09-30 Publication of CA2012175A1 publication Critical patent/CA2012175A1/fr

Status Abandoned legal-status Critical Current

Links

210000004204 blood vessel Anatomy 0.000 title claims abstract description 74
238000011282 treatment Methods 0.000 title abstract description 8
150000001875 compounds Chemical class 0.000 claims abstract description 57
238000000034 method Methods 0.000 claims abstract description 41
230000006378 damage Effects 0.000 claims abstract description 21
210000004369 blood Anatomy 0.000 claims abstract description 6
239000008280 blood Substances 0.000 claims abstract description 6
230000004913 activation Effects 0.000 claims abstract 3
206010073306 Exposure to radiation Diseases 0.000 claims abstract 2
230000003902 lesion Effects 0.000 claims description 17
229940109328 photofrin Drugs 0.000 claims description 14
230000002500 effect on skin Effects 0.000 claims description 11
230000005855 radiation Effects 0.000 claims description 8
230000017531 blood circulation Effects 0.000 claims description 6
UJKPHYRXOLRVJJ-MLSVHJFASA-N CC(O)C1=C(C)/C2=C/C3=N/C(=C\C4=C(CCC(O)=O)C(C)=C(N4)/C=C4\N=C(\C=C\1/N\2)C(C)=C4C(C)O)/C(CCC(O)=O)=C3C Chemical class CC(O)C1=C(C)/C2=C/C3=N/C(=C\C4=C(CCC(O)=O)C(C)=C(N4)/C=C4\N=C(\C=C\1/N\2)C(C)=C4C(C)O)/C(CCC(O)=O)=C3C UJKPHYRXOLRVJJ-MLSVHJFASA-N 0.000 claims description 5
208000006787 Port-Wine Stain Diseases 0.000 claims description 4
-1 hematoporphyrin compound Chemical class 0.000 claims description 3
230000001225 therapeutic effect Effects 0.000 claims description 3
208000009056 telangiectasis Diseases 0.000 claims description 2
241000124008 Mammalia Species 0.000 claims 3
229960003569 hematoporphyrin Drugs 0.000 claims 3
230000003213 activating effect Effects 0.000 claims 1
238000009825 accumulation Methods 0.000 abstract description 3
210000001519 tissue Anatomy 0.000 description 26
239000000975 dye Substances 0.000 description 13
206010033546 Pallor Diseases 0.000 description 12
210000003491 skin Anatomy 0.000 description 12
241000287828 Gallus gallus Species 0.000 description 10
235000013330 chicken meat Nutrition 0.000 description 10
210000001520 comb Anatomy 0.000 description 10
206010028980 Neoplasm Diseases 0.000 description 9
238000002428 photodynamic therapy Methods 0.000 description 9
238000002347 injection Methods 0.000 description 7
239000007924 injection Substances 0.000 description 7
230000002159 abnormal effect Effects 0.000 description 6
230000003211 malignant effect Effects 0.000 description 6
208000027418 Wounds and injury Diseases 0.000 description 5
230000037396 body weight Effects 0.000 description 5
210000004207 dermis Anatomy 0.000 description 5
208000014674 injury Diseases 0.000 description 5
201000011510 cancer Diseases 0.000 description 4
239000003937 drug carrier Substances 0.000 description 4
230000000694 effects Effects 0.000 description 4
230000002085 persistent effect Effects 0.000 description 4
241001465754 Metazoa Species 0.000 description 3
210000002615 epidermis Anatomy 0.000 description 3
210000003743 erythrocyte Anatomy 0.000 description 3
239000000243 solution Substances 0.000 description 3
230000000712 assembly Effects 0.000 description 2
238000000429 assembly Methods 0.000 description 2
230000005540 biological transmission Effects 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
239000002537 cosmetic Substances 0.000 description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
208000035475 disorder Diseases 0.000 description 2
238000010253 intravenous injection Methods 0.000 description 2
239000013307 optical fiber Substances 0.000 description 2
150000004032 porphyrins Chemical class 0.000 description 2
BBNQQADTFFCFGB-UHFFFAOYSA-N purpurin Chemical compound C1=CC=C2C(=O)C3=C(O)C(O)=CC(O)=C3C(=O)C2=C1 BBNQQADTFFCFGB-UHFFFAOYSA-N 0.000 description 2
238000004626 scanning electron microscopy Methods 0.000 description 2
230000035939 shock Effects 0.000 description 2
230000008961 swelling Effects 0.000 description 2
238000002560 therapeutic procedure Methods 0.000 description 2
210000005166 vasculature Anatomy 0.000 description 2
206010002091 Anaesthesia Diseases 0.000 description 1
LLQPHQFNMLZJMP-UHFFFAOYSA-N Fentrazamide Chemical compound N1=NN(C=2C(=CC=CC=2)Cl)C(=O)N1C(=O)N(CC)C1CCCCC1 LLQPHQFNMLZJMP-UHFFFAOYSA-N 0.000 description 1
206010070834 Sensitisation Diseases 0.000 description 1
208000026062 Tissue disease Diseases 0.000 description 1
238000002679 ablation Methods 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
230000006978 adaptation Effects 0.000 description 1
230000037005 anaesthesia Effects 0.000 description 1
210000004027 cell Anatomy 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
150000004035 chlorins Chemical class 0.000 description 1
230000001427 coherent effect Effects 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
239000012895 dilution Substances 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000003814 drug Substances 0.000 description 1
238000001493 electron microscopy Methods 0.000 description 1
210000002889 endothelial cell Anatomy 0.000 description 1
210000003238 esophagus Anatomy 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
210000001508 eye Anatomy 0.000 description 1
210000003780 hair follicle Anatomy 0.000 description 1
230000035876 healing Effects 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
230000002962 histologic effect Effects 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
230000001678 irradiating effect Effects 0.000 description 1
229910052743 krypton Inorganic materials 0.000 description 1
DNNSSWSSYDEUBZ-UHFFFAOYSA-N krypton atom Chemical compound [Kr] DNNSSWSSYDEUBZ-UHFFFAOYSA-N 0.000 description 1
238000013532 laser treatment Methods 0.000 description 1
210000004072 lung Anatomy 0.000 description 1
KDXZREBVGAGZHS-UHFFFAOYSA-M methohexital sodium Chemical compound [Na+].CCC#CC(C)C1(CC=C)C(=O)N=C([O-])N(C)C1=O KDXZREBVGAGZHS-UHFFFAOYSA-M 0.000 description 1
238000001000 micrograph Methods 0.000 description 1
238000000386 microscopy Methods 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
210000003739 neck Anatomy 0.000 description 1
210000001640 nerve ending Anatomy 0.000 description 1
230000002186 photoactivation Effects 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
150000004033 porphyrin derivatives Chemical class 0.000 description 1
230000000644 propagated effect Effects 0.000 description 1
210000001732 sebaceous gland Anatomy 0.000 description 1
230000008313 sensitization Effects 0.000 description 1
206010040882 skin lesion Diseases 0.000 description 1
231100000444 skin lesion Toxicity 0.000 description 1
210000000106 sweat gland Anatomy 0.000 description 1
230000003685 thermal hair damage Effects 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
210000003932 urinary bladder Anatomy 0.000 description 1
230000002792 vascular Effects 0.000 description 1
230000006496 vascular abnormality Effects 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/067—Radiation therapy using light using laser light

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Life Sciences & Earth Sciences (AREA)
Pathology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Radiology & Medical Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Optics & Photonics (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Radiation-Therapy Devices (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA002012175A 1989-03-31 1990-03-14 Traitement photochimique des vaisseaux sanguins Abandoned CA2012175A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US33201589A	1989-03-31	1989-03-31
US332,015		1989-03-31

Publications (1)

Publication Number	Publication Date
CA2012175A1 true CA2012175A1 (fr)	1990-09-30

Family

ID=23296348

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002012175A Abandoned CA2012175A1 (fr)	1989-03-31	1990-03-14	Traitement photochimique des vaisseaux sanguins

Country Status (3)

Country	Link
AU (1)	AU5413490A (fr)
CA (1)	CA2012175A1 (fr)
WO (1)	WO1990011797A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5705518A (en) *	1992-11-20	1998-01-06	University Of British Columbia	Method of activating photosensitive agents
WO2006112379A1 (fr) *	2005-04-14	2006-10-26	Takafumi Ohshiro	Medicament pour le traitement ou le diagnostic d’une lesion vasculaire dans la peau ou le tissu mou sous-cutane provoquee par une irradiation

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5817089A (en) *	1991-10-29	1998-10-06	Thermolase Corporation	Skin treatment process using laser
US5752949A (en) *	1991-10-29	1998-05-19	Thermolase Corporation	Hair removal method
US5423803A (en) *	1991-10-29	1995-06-13	Thermotrex Corporation	Skin surface peeling process using laser
US5752948A (en) *	1991-10-29	1998-05-19	Thermolase Corporation	Hair removal method
US5425728A (en) *	1991-10-29	1995-06-20	Tankovich; Nicolai I.	Hair removal device and method
EG20471A (en)	1993-07-12	1999-05-31	Thermotrex Corp	Hair removal device and method
CA2131750C (fr) *	1994-07-26	2000-11-21	Nikolai I. Tankovich	Methode d'epilation
US6317616B1 (en) *	1999-09-15	2001-11-13	Neil David Glossop	Method and system to facilitate image guided surgery
US20070299431A1 (en)	2006-05-02	2007-12-27	Green Medical, Inc.	Systems and methods for treating superficial venous malformations like spider veins
US7465312B2 (en)	2006-05-02	2008-12-16	Green Medical, Inc.	Systems and methods for treating superficial venous malformations like spider veins

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3323365C2 (de) *	1982-09-04	1994-10-20	Gsf Forschungszentrum Umwelt	Verfahren und Vorrichtung zur Ausleuchtung von Hohlräumen
US4773899A (en) *	1982-11-23	1988-09-27	The Beth Israel Hospital Association	Method of treatment of artherosclerosis and balloon catheter the same
US4622953A (en) *	1983-01-13	1986-11-18	Gordon Robert T	Process for the treatment of atherosclerotic lesions
US4622952A (en) *	1983-01-13	1986-11-18	Gordon Robert T	Cancer treatment method
US4541438A (en) *	1983-06-02	1985-09-17	The Johns Hopkins University	Localization of cancerous tissue by monitoring infrared fluorescence emitted by intravenously injected porphyrin tumor-specific markers excited by long wavelength light
US4610241A (en) *	1984-07-03	1986-09-09	Gordon Robert T	Atherosclerosis treatment method
US4815447A (en) *	1985-03-19	1989-03-28	Mills Randell L	Mossbauer cancer therapy

1990
- 1990-03-14 CA CA002012175A patent/CA2012175A1/fr not_active Abandoned
- 1990-03-27 WO PCT/US1990/001647 patent/WO1990011797A1/fr unknown
- 1990-03-27 AU AU54134/90A patent/AU5413490A/en not_active Abandoned

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5705518A (en) *	1992-11-20	1998-01-06	University Of British Columbia	Method of activating photosensitive agents
US5770619A (en) *	1992-11-20	1998-06-23	University Of British Columbia	Method of activating photosensitive agents
EP0947222A2 (fr)	1992-11-20	1999-10-06	The University Of British Columbia	Procédé d'activation d'agents photosensibles
WO2006112379A1 (fr) *	2005-04-14	2006-10-26	Takafumi Ohshiro	Medicament pour le traitement ou le diagnostic d’une lesion vasculaire dans la peau ou le tissu mou sous-cutane provoquee par une irradiation

Also Published As

Publication number	Publication date
AU5413490A (en)	1990-11-05
WO1990011797A1 (fr)	1990-10-18

Legal Events

Date	Code	Title	Description
1992-09-15	FZDE	Dead

Publication	Publication Date	Title
EP0947222B1 (fr)	2006-04-12	Procédé d'activation d'agents photosensibles
US9227082B2 (en)	2016-01-05	Method and apparatus for acne treatment using low intensity light therapy
US6240925B1 (en)	2001-06-05	Photothermal vascular targeting with bioreductive agents
US6887260B1 (en)	2005-05-03	Method and apparatus for acne treatment
US8651112B2 (en)	2014-02-18	Process for treatment of psoriasis
Orenstein et al.	1990	Photochemotherapy of hypervascular dermal lesions: a possible alternative to photothermal therapy?
US20080221648A1 (en)	2008-09-11	Combined photocoagulation and photodynamic therapy
Xiao-xi et al.	1997	Treatment of capillary vascular malformation (port-wine stains) with photochemotherapy
AU5460799A (en)	2000-02-28	Treatment of pigmented tissues using optical energy
CA2012175A1 (fr)	1990-09-30	Traitement photochimique des vaisseaux sanguins
US4886831A (en)	1989-12-12	Medical uses for phycocyanin
US5163898A (en)	1992-11-17	Medical treatment of tumors with phycocyanin
Kliman et al.	1994	Retinal and choroidal vessel closure using phthalocyanine photodynamic therapy
RU2146159C1 (ru)	2000-03-10	Способ фотодинамической терапии злокачественных новообразований
Horsman et al.	1989	Vascular effects of photodynamic therapy in an intraocular retinoblastoma-like tumour
Leach et al.	1993	Normal brain tissue response to photodynamic therapy using aluminum phthalocyanine tetrasulfonate in the rat
Ohshiro et al.	2009	Histological responses of cutaneous vascular lesions following photodynamic therapy with talaporfin sodium: a chicken comb model
Nelson	1993	Photodynamic therapy of port wine stain: preliminary clinical studies
Hsiang et al.	1994	Selective treatment of atherosclerosis using photodynamic therapy in the Yucatan miniswine: preliminary results
Nelson et al.	1990	Photodynamic therapy of hypervascular cutaneous tissues in animal models using porphyrin or phthalocyanine activated by red light
Lewis et al.	1989	Photochemical thrombosis of retinal and choroidal vessels using rose bengal
Clark	1988	Investigational Applications
NELSON et al.	1990	PHOTODYNAMIC THERAPY OF HYPERVASCULAR CUTANEOUS TISSUES IN ANIMAL-MODELS
HK1025059B (en)	2006-10-27	Method of activating photosensitive agents