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CA2006008A1 - Methode pour obtenir des oligonucleotides synthetiques qui se lient specifiquement a des sites cibles sur des molecules d'adn double brin, en formant un triplex colineaire; methode d'utilisation de ces oligonucleotides synthetiques - Google Patents

Methode pour obtenir des oligonucleotides synthetiques qui se lient specifiquement a des sites cibles sur des molecules d'adn double brin, en formant un triplex colineaire; methode d'utilisation de ces oligonucleotides synthetiques

Info

Publication number
CA2006008A1
CA2006008A1 CA2006008A CA2006008A CA2006008A1 CA 2006008 A1 CA2006008 A1 CA 2006008A1 CA 2006008 A CA2006008 A CA 2006008A CA 2006008 A CA2006008 A CA 2006008A CA 2006008 A1 CA2006008 A1 CA 2006008A1
Authority
CA
Canada
Prior art keywords
synthetic oligonucleotides
dna
bind
duplex
duplex dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2006008A
Other languages
English (en)
Other versions
CA2006008C (fr
Inventor
Donald J. Kessler
Michael E. Hogan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2006008A1 publication Critical patent/CA2006008A1/fr
Application granted granted Critical
Publication of CA2006008C publication Critical patent/CA2006008C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
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    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
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CA002006008A 1988-12-20 1989-12-19 Methode pour obtenir des oligonucleotides synthetiques qui se lient specifiquement a des sites cibles sur des molecules d'adn double brin, en formant un triplex colineaire; methode d'utilisation de ces oligonucleotides synthetiques Expired - Fee Related CA2006008C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28735988A 1988-12-20 1988-12-20
US287,359 1988-12-20

Publications (2)

Publication Number Publication Date
CA2006008A1 true CA2006008A1 (fr) 1990-06-20
CA2006008C CA2006008C (fr) 2000-02-15

Family

ID=23102554

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002006008A Expired - Fee Related CA2006008C (fr) 1988-12-20 1989-12-19 Methode pour obtenir des oligonucleotides synthetiques qui se lient specifiquement a des sites cibles sur des molecules d'adn double brin, en formant un triplex colineaire; methode d'utilisation de ces oligonucleotides synthetiques

Country Status (10)

Country Link
EP (2) EP0449972A4 (fr)
JP (1) JPH04502407A (fr)
AT (1) ATE118818T1 (fr)
AU (1) AU640910B2 (fr)
CA (1) CA2006008C (fr)
DE (1) DE68921315T2 (fr)
DK (1) DK120091D0 (fr)
ES (1) ES2069598T3 (fr)
PT (1) PT92640B (fr)
WO (1) WO1990006934A1 (fr)

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DK120091A (da) 1991-06-20
PT92640B (pt) 1995-09-12
EP0375408B1 (fr) 1995-02-22
JPH04502407A (ja) 1992-05-07
ES2069598T3 (es) 1995-05-16
AU4838490A (en) 1990-07-10
DE68921315T2 (de) 1995-08-03
EP0449972A1 (fr) 1991-10-09
DK120091D0 (da) 1991-06-20
EP0375408A1 (fr) 1990-06-27
EP0449972A4 (en) 1992-03-18
PT92640A (pt) 1990-06-29
AU640910B2 (en) 1993-09-09
WO1990006934A1 (fr) 1990-06-28
ATE118818T1 (de) 1995-03-15
DE68921315D1 (de) 1995-03-30
CA2006008C (fr) 2000-02-15

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