+

AU2002218167A1 - N-phenyl-2-pyrimidine-amine derivatives - Google Patents

N-phenyl-2-pyrimidine-amine derivatives

Info

Publication number
AU2002218167A1
AU2002218167A1 AU2002218167A AU1816702A AU2002218167A1 AU 2002218167 A1 AU2002218167 A1 AU 2002218167A1 AU 2002218167 A AU2002218167 A AU 2002218167A AU 1816702 A AU1816702 A AU 1816702A AU 2002218167 A1 AU2002218167 A1 AU 2002218167A1
Authority
AU
Australia
Prior art keywords
pyrimidine
phenyl
amine derivatives
preparation
medicaments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002218167A
Inventor
Werner Breitenstein
Hans Michael Buerger
Giorgio Caravatti
Margaret Amelia Cudd
Paul William Manley
Juerg Zimmermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9899367&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2002218167(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Publication of AU2002218167A1 publication Critical patent/AU2002218167A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Liquid Crystal Substances (AREA)

Abstract

The invention relates to N-phenyl-2-pyrimidine-amine derivatives of formula I wherein the substituents are defined as indicated in the description, to processes for the preparation thereof, to medicaments comprising those compounds, and to the use thereof in the preparation of pharmaceutical compositions for the therapeutic treatment of warm-blooded animals, including humans.
AU2002218167A 2000-09-13 2001-09-11 N-phenyl-2-pyrimidine-amine derivatives Abandoned AU2002218167A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0022438 2000-09-13
GBGB0022438.6A GB0022438D0 (en) 2000-09-13 2000-09-13 Organic Compounds
PCT/EP2001/010503 WO2002022597A1 (en) 2000-09-13 2001-09-11 N-phenyl-2-pyrimidine-amine derivatives

Publications (1)

Publication Number Publication Date
AU2002218167A1 true AU2002218167A1 (en) 2002-03-26

Family

ID=9899367

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002218167A Abandoned AU2002218167A1 (en) 2000-09-13 2001-09-11 N-phenyl-2-pyrimidine-amine derivatives

Country Status (14)

Country Link
US (3) US7081532B2 (en)
EP (1) EP1322634B1 (en)
JP (1) JP2004509111A (en)
CN (2) CN100406452C (en)
AT (1) ATE452129T1 (en)
AU (1) AU2002218167A1 (en)
BR (1) BR0113838A (en)
CA (2) CA2687476A1 (en)
DE (1) DE60140814D1 (en)
ES (1) ES2336891T3 (en)
GB (1) GB0022438D0 (en)
HK (1) HK1057752A1 (en)
PT (1) PT1322634E (en)
WO (1) WO2002022597A1 (en)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0022438D0 (en) * 2000-09-13 2000-11-01 Novartis Ag Organic Compounds
WO2003000186A2 (en) 2001-06-21 2003-01-03 Ariad Pharmaceuticals, Inc. Novel phenylamino-pyrimidines and uses thereof
GB0201508D0 (en) * 2002-01-23 2002-03-13 Novartis Ag Organic compounds
AU2003246100A1 (en) 2002-06-28 2004-01-19 Nippon Shinyaku Co., Ltd. Amide derivative
US7585866B2 (en) * 2002-07-31 2009-09-08 Critical Outcome Technologies, Inc. Protein tyrosine kinase inhibitors
CA2439440A1 (en) 2002-09-05 2004-03-05 Emory University Treatment of tuberous sclerosis associated neoplasms
GB0222514D0 (en) * 2002-09-27 2002-11-06 Novartis Ag Organic compounds
US7629347B2 (en) * 2002-10-09 2009-12-08 Critical Outcome Technologies, Inc. Protein tyrosine kinase inhibitors
AU2003232650A1 (en) * 2003-05-06 2004-11-26 Il Yang Pharm Co., Ltd. N-phenyl-2-pyrimidine-amine derivatives and process for the preparation thereof
WO2004108699A1 (en) * 2003-06-06 2004-12-16 Natco Pharma Limited Process for the preparation of the anti-cancer drug imatinib and its analogues
EP1635835B1 (en) * 2003-06-13 2010-01-06 Novartis AG 2-aminopyrimidine derivatives as raf kinase inhibitors
WO2005063720A1 (en) * 2003-12-25 2005-07-14 Nippon Shinyaku Co., Ltd. Amide derivative and medicine
CA2551529C (en) * 2003-12-25 2011-02-01 Nippon Shinyaku Co., Ltd. Amide derivative and medicine
AR047530A1 (en) 2004-02-04 2006-01-25 Novartis Ag FORMS OF SALT OF 4- (4-METHYLIPIPERAZIN-1-ILMETIL) -N- (4-METHYL-3- (4-PIRIDIN-3-IL) PIRIMIDIN-2-ILAMINO) PHENYL) -BENZAMIDA
WO2006017353A2 (en) * 2004-07-13 2006-02-16 GOVERNMENT OF THE UNITED STATES, as represented byTHE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Treatment of viral infections
CN101068805B (en) 2004-09-09 2013-04-03 纳科法尔马有限公司 Novel phenylaminopyrimidine derivatives as inhibitors of BCR-ABL kinase
US7939541B2 (en) * 2004-09-09 2011-05-10 Natco Pharma Limited Intermediates and a process employing the intermediates for the preparation of (3-trifluoromethylsulfonyl)-N-[4-methyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phenyl]-benzamide
US8735415B2 (en) 2004-09-09 2014-05-27 Natco Pharma Limited Acid addition salts of (3,5-Bis trifluoromethyl)-N-[4-methyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phenyl]-benzamide
CN1972917B (en) * 2004-12-31 2010-08-25 孙飘扬 Aminopyrimidine compounds and their salts, process for preparation and pharmaceutical use thereof
CN1939910A (en) * 2004-12-31 2007-04-04 孙飘扬 Amino-metadiazine compound and its salt, its preparation and pharmaceutical use
US20080214445A1 (en) * 2005-06-23 2008-09-04 Sebastien Bihorel Method of Treating a Solid Tumor Disease Comprising Administering a Combination Comprising Imatinib and an Inhibitor of an Efflux Pump Active at the Blood Brain Barrier or Demethyl Imatinib
KR100674813B1 (en) * 2005-08-05 2007-01-29 일양약품주식회사 N-phenyl-2-pyrimidine-amine derivatives and preparation method thereof
KR101415426B1 (en) * 2005-09-27 2014-07-04 아이알엠 엘엘씨 Diarylamine-containing compounds and compositions, and uses thereof as modulators of C-KIT receptors
US8067421B2 (en) * 2006-04-27 2011-11-29 Sicor Inc. Polymorphic forms of imatinib mesylate and processes for preparation of novel crystalline forms as well as amorphous and form α
US7977348B2 (en) * 2006-04-27 2011-07-12 Sicor Inc. Polymorphic forms of imatinib mesylate and processes for preparation of novel crystalline forms as well as amorphous and form α
UA93548C2 (en) 2006-05-05 2011-02-25 Айерем Елелсі Compounds and compositions as hedgehog pathway modulators
US20090324718A1 (en) * 2006-09-01 2009-12-31 Ilan Zalit Imatinib compositions
CA2662677C (en) * 2006-09-05 2016-05-31 Emory University Kinase inhibitors for preventing or treating pathogen infection and method of use thereof
WO2008051597A1 (en) * 2006-10-26 2008-05-02 Sicor Inc. Process for the preparation of imatinib
EP2009008A1 (en) 2006-10-26 2008-12-31 Sicor, Inc. Imatinib base, and imatinib mesylate and processes for preparation thereof
US8138191B2 (en) 2007-01-11 2012-03-20 Critical Outcome Technologies Inc. Inhibitor compounds and cancer treatment methods
WO2008083491A1 (en) 2007-01-11 2008-07-17 Critical Outcome Technologies Inc. Compounds and method for treatment of cancer
AU2008247668B2 (en) * 2007-05-04 2013-01-10 Irm Llc Pyrimidine derivatives and compositions as c-kit and PDGFR kinase inhibitors
WO2008150481A2 (en) * 2007-05-29 2008-12-11 Sicor Inc. Processes for the preparation of crystalline form beta of imatinib mesylate
WO2008151183A1 (en) 2007-06-04 2008-12-11 Avila Therapeutics, Inc. Heterocyclic compounds and uses thereof
CN101784530A (en) * 2007-08-22 2010-07-21 Irm责任有限公司 5- (4- (haloalkoxy) phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors
CN101784539A (en) 2007-08-22 2010-07-21 Irm责任有限公司 2-heteroarylamino-pyrimidine derivatives as kinase inhibitors
US8414918B2 (en) * 2007-09-25 2013-04-09 Teva Pharmaceutical Industries Ltd. Stable imatinib compositions
US8466151B2 (en) * 2007-12-26 2013-06-18 Critical Outcome Technologies, Inc. Compounds and method for treatment of cancer
CA2713288A1 (en) * 2008-02-11 2009-08-20 The Government Of The United States Of America As Represented By The Sec Retary Of Department Of Health And Human Services Compounds with mdr1-inverse activity
CN102007124B (en) 2008-02-15 2014-06-18 里格尔制药公司 Pyrimidine-2-amine compounds and their use as inhibitors of jak kinases
KR101860057B1 (en) 2008-05-21 2018-05-21 어리어드 파마슈티칼스, 인코포레이티드 Phosphorous derivatives as kinase inhibitors
US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
US20110195975A1 (en) * 2008-06-27 2011-08-11 Clapp Wade D Materials and methods for suppressing and/or treating neurofibroma and related tumors
CN101417995B (en) * 2008-11-21 2012-06-06 陈依军 Phenoxy pyrimidine derivates and preparation method and use thereof
RU2011140238A (en) 2009-04-15 2013-05-20 Астразенека Аб Imidazole-substituted pyrimidines useful in the treatment of diseases associated with kinase-3 glycogen synthase, such as Alzheimer's disease
US8816077B2 (en) 2009-04-17 2014-08-26 Nektar Therapeutics Oligomer-protein tyrosine kinase inhibitor conjugates
WO2010120386A1 (en) 2009-04-17 2010-10-21 Nektar Therapeutics Oligomer-protein tyrosine kinase inhibitor conjugates
CA2794952C (en) 2010-04-01 2018-05-15 Critical Outcome Technologies Inc. Compounds and method for treatment of hiv
CN102212057B (en) * 2011-04-13 2013-11-27 合肥工业大学 A kind of carboxylic acid non-steroidal anti-inflammatory drug derivative and its preparation method and application
CA2832504C (en) 2011-05-04 2019-10-01 Ariad Pharmaceuticals, Inc. Compounds for inhibiting cell proliferation in egfr-driven cancers
CN102796110B (en) * 2011-05-23 2016-03-30 复旦大学 Aniline pyrimidine compound and its production and use
AU2013204563B2 (en) 2012-05-05 2016-05-19 Takeda Pharmaceutical Company Limited Compounds for inhibiting cell proliferation in EGFR-driven cancers
CN103044394A (en) * 2012-12-20 2013-04-17 北京理工大学 Phenyl aminopyrimidine derivant and preparation method and application thereof
CN103058935B (en) * 2013-01-15 2015-05-06 四川大学 Pyrimidine compound as well as preparation method and use for same
US9611283B1 (en) 2013-04-10 2017-04-04 Ariad Pharmaceuticals, Inc. Methods for inhibiting cell proliferation in ALK-driven cancers
CN105859683B (en) * 2016-04-11 2018-09-28 连云港恒运药业有限公司 The high-purity technical preparation process of Imatinib
CN107805240A (en) * 2016-09-08 2018-03-16 中国科学院合肥物质科学研究院 A kind of new PDGFR kinase inhibitors and application thereof
CN107652266A (en) * 2017-10-27 2018-02-02 上海应用技术大学 One kind targeting EGFR-TK micromolecular inhibitor and its application
US20220048893A1 (en) * 2019-03-05 2022-02-17 Hongyi & Associates Llc Compounds for Treating Neurodegenerative Diseases and Cancers
CN110078708B (en) * 2019-05-08 2020-12-11 东南大学 Smo/Bcr-Abl dual-targeted inhibitor and its synthesis method and application

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521184A (en) * 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
TW225528B (en) * 1992-04-03 1994-06-21 Ciba Geigy Ag
GB9914258D0 (en) 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
GB0022438D0 (en) * 2000-09-13 2000-11-01 Novartis Ag Organic Compounds

Also Published As

Publication number Publication date
CN1525967A (en) 2004-09-01
US20070265292A1 (en) 2007-11-15
US7329661B2 (en) 2008-02-12
BR0113838A (en) 2003-06-03
ATE452129T1 (en) 2010-01-15
CA2416274C (en) 2011-01-04
HK1057752A1 (en) 2004-04-16
CN1872850A (en) 2006-12-06
US20040102453A1 (en) 2004-05-27
US7081532B2 (en) 2006-07-25
US7312216B2 (en) 2007-12-25
WO2002022597A1 (en) 2002-03-21
EP1322634A1 (en) 2003-07-02
JP2004509111A (en) 2004-03-25
CA2416274A1 (en) 2002-03-21
PT1322634E (en) 2010-02-22
CA2687476A1 (en) 2002-03-21
ES2336891T3 (en) 2010-04-19
CN100406452C (en) 2008-07-30
US20060223818A1 (en) 2006-10-05
GB0022438D0 (en) 2000-11-01
EP1322634B1 (en) 2009-12-16
DE60140814D1 (en) 2010-01-28

Similar Documents

Publication Publication Date Title
AU2002218167A1 (en) N-phenyl-2-pyrimidine-amine derivatives
WO2003053368A3 (en) Chalcone derivatives and their use to treat diseases
MY139302A (en) Novel heterocyclic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof
HK1065483A1 (en) 4-amino-6-phenyl-pyrrolo[2,3-d]pyrimidine derivatives
MY139303A (en) Novel aromatic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof
MY137039A (en) Thiophene glycoside derivatives, processes for the preparation, medicaments comprising these compounds, and the use thereof
WO2004060882A8 (en) Cb 1/cb 2 receptor ligands and their use in the treatment of pain
ES2187300A1 (en) Sulphonamide derivatives, the preparation thereof and the application of same as medicaments
MXPA04000577A (en) Dolastatin 10 derivatives.
TW200510392A (en) Chemical compounds
TNSN04203A1 (en) Benzoxazinone-derived compounds, their preparation and use as medicaments
TW200505452A (en) Chemical compounds
DE60001586D1 (en) DIPHENYL-PIPERIDINE DERIVATIVES
UA86776C2 (en) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
TW200504029A (en) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
UA83832C2 (en) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
AU2001266019A1 (en) 2-amino-3-hydroxy-4-tert-leucyl-amino-5-phenyl-pentanoic acid amide derivatives
TW200504051A (en) Novel acridine derivatives and their use as medicaments
MY139613A (en) Novel piperazinyl-pyrazinone derivatives for the treatment of 5-ht2a receptor-related disorders
PE20030236A1 (en) DERIVATIVES OF BENZIMIDAZOLE 1-ARIL-2-N, S- OR O-SUBSTITUTES, OBTAINING DRUGS AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES
WO2004108094A3 (en) Sulfonamide-substituted chalcone derivatives and their use to treat diseases
DE60309926D1 (en) STEROID COMPOUNDS WITH ANTI-TUMORAL EFFECT
AU2003298203A1 (en) Medicaments containing substituted 2,5-diaminomethyl-1h-pyrroles
MXPA05003633A (en) 2" oxo-voruscharin and derivatives thereof.
UA81617C2 (en) Chalcone derivatives and their use
点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载