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AU2001234779A1 - Structure identification methods using mass measurements - Google Patents

Structure identification methods using mass measurements

Info

Publication number
AU2001234779A1
AU2001234779A1 AU2001234779A AU3477901A AU2001234779A1 AU 2001234779 A1 AU2001234779 A1 AU 2001234779A1 AU 2001234779 A AU2001234779 A AU 2001234779A AU 3477901 A AU3477901 A AU 3477901A AU 2001234779 A1 AU2001234779 A1 AU 2001234779A1
Authority
AU
Australia
Prior art keywords
identification methods
structure identification
mass measurements
measurements
mass
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001234779A
Inventor
Olga L. Issakova
Nikolai F Sepetov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanoscale Combinatorial Synthesis Inc
Original Assignee
NANOSCALE COMBINATORIAL SYNTHE
Nanoscale Combinatorial Synthesis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NANOSCALE COMBINATORIAL SYNTHE, Nanoscale Combinatorial Synthesis Inc filed Critical NANOSCALE COMBINATORIAL SYNTHE
Publication of AU2001234779A1 publication Critical patent/AU2001234779A1/en
Abandoned legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00581—Mass
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    • B01J2219/00583—Features relative to the processes being carried out
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    • B01J2219/00583—Features relative to the processes being carried out
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00592—Split-and-pool, mix-and-divide processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00695—Synthesis control routines, e.g. using computer programs
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00752—Alloys
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
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    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
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    • C40B40/04—Libraries containing only organic compounds
    • C40B40/14—Libraries containing macromolecular compounds and not covered by groups C40B40/06 - C40B40/12
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/18—Libraries containing only inorganic compounds or inorganic materials
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2001234779A 2000-02-03 2001-02-02 Structure identification methods using mass measurements Abandoned AU2001234779A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US18011200P 2000-02-03 2000-02-03
US18011500P 2000-02-03 2000-02-03
US18011100P 2000-02-03 2000-02-03
US60180111 2000-02-03
US60180112 2000-02-03
US60180115 2000-02-03
US18893700P 2000-03-10 2000-03-10
US60188937 2000-03-10
PCT/US2001/003487 WO2001057523A1 (en) 2000-02-03 2001-02-02 Structure identification methods using mass measurements

Publications (1)

Publication Number Publication Date
AU2001234779A1 true AU2001234779A1 (en) 2001-08-14

Family

ID=27497387

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2001234779A Abandoned AU2001234779A1 (en) 2000-02-03 2001-02-02 Structure identification methods using mass measurements
AU2001233321A Abandoned AU2001233321A1 (en) 2000-02-03 2001-02-02 Nonredundant split/pool synthesis of combinatorial libraries

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2001233321A Abandoned AU2001233321A1 (en) 2000-02-03 2001-02-02 Nonredundant split/pool synthesis of combinatorial libraries

Country Status (5)

Country Link
US (2) US6625546B2 (en)
EP (2) EP1252126A4 (en)
AU (2) AU2001234779A1 (en)
CA (2) CA2396755A1 (en)
WO (2) WO2001057523A1 (en)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6937330B2 (en) 1999-04-23 2005-08-30 Ppd Biomarker Discovery Sciences, Llc Disposable optical cuvette cartridge with low fluorescence material
JP3866446B2 (en) * 1999-05-07 2007-01-10 株式会社東芝 Automatic analyzer
US6687395B1 (en) * 1999-07-21 2004-02-03 Surromed, Inc. System for microvolume laser scanning cytometry
DE10028875A1 (en) * 2000-06-10 2001-12-20 Hte Gmbh Automatic formation and iterative optimization of substance library, employs integrated process embracing manufacture, performance testing, and test result analysis
US7313541B2 (en) 2000-11-03 2007-12-25 Jpmorgan Chase Bank, N.A. System and method for estimating conduit liquidity requirements in asset backed commercial paper
US6787761B2 (en) * 2000-11-27 2004-09-07 Surromed, Inc. Median filter for liquid chromatography-mass spectrometry data
US20020095260A1 (en) * 2000-11-28 2002-07-18 Surromed, Inc. Methods for efficiently mining broad data sets for biological markers
US20030087334A1 (en) * 2001-04-02 2003-05-08 Libraria, Inc. Method of flexibly generating diverse reaction chemistries
US7006928B2 (en) * 2001-06-13 2006-02-28 Rpd Tool Ag Device and method for determining the stability of substances and formulations
US7727713B2 (en) 2001-06-20 2010-06-01 Nuevolution A/S Templated molecules and methods for using such molecules
US6873915B2 (en) * 2001-08-24 2005-03-29 Surromed, Inc. Peak selection in multidimensional data
US20030055587A1 (en) * 2001-09-17 2003-03-20 Symyx Technologies, Inc. Rapid throughput surface topographical analysis
US20030078739A1 (en) * 2001-10-05 2003-04-24 Surromed, Inc. Feature list extraction from data sets such as spectra
US20030139907A1 (en) * 2002-01-24 2003-07-24 Mccarthy Robert J System, Method, and Product for Nanoscale Modeling, Analysis, Simulation, and Synthesis (NMASS)
EP1487978B1 (en) 2002-03-15 2008-11-19 Nuevolution A/S An improved method for synthesising templated molecules
WO2003095978A2 (en) * 2002-05-09 2003-11-20 Surromed, Inc. Methods for time-alignment of liquid chromatography-mass spectrometry data
EP1539980B1 (en) 2002-08-01 2016-02-17 Nuevolution A/S Library of complexes comprising small non-peptide molecules and double-stranded oligonucleotides identifying the molecules
AU2003266932B2 (en) 2002-09-27 2009-04-09 Mpm-Holding Aps Spatially encoded polymer matrix
WO2004039825A2 (en) 2002-10-30 2004-05-13 Nuevolution A/S Method for the synthesis of a bifunctional complex
WO2004056994A2 (en) 2002-12-19 2004-07-08 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US20040136873A1 (en) * 2003-01-09 2004-07-15 Argonaut Technologies, Inc. Modular reactor system
WO2004074429A2 (en) 2003-02-21 2004-09-02 Nuevolution A/S Method for producing second-generation library
US20040176915A1 (en) * 2003-03-06 2004-09-09 Antony Williams Apparatus and method for encoding chemical structure information
US20100022414A1 (en) 2008-07-18 2010-01-28 Raindance Technologies, Inc. Droplet Libraries
GB0307428D0 (en) * 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
ATE447626T1 (en) 2003-09-18 2009-11-15 Nuevolution As METHOD FOR OBTAINING STRUCTURAL INFORMATION FROM ENCODED MOLECULES AND FOR SELECTING COMPOUNDS
EP1718962B1 (en) * 2004-02-13 2016-04-13 Waters Technologies Corporation System and method for tracking and quantitating chemical entities
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US7248360B2 (en) * 2004-04-02 2007-07-24 Ppd Biomarker Discovery Sciences, Llc Polychronic laser scanning system and method of use
GB0416496D0 (en) * 2004-07-23 2004-08-25 Council Of The Central Lab Of Imaging device
WO2006018277A1 (en) * 2004-08-17 2006-02-23 Universität Bern Method for rational combinatorial synthesis
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US8180579B2 (en) * 2005-03-25 2012-05-15 Lawrence Livermore National Security, Llc Real time gamma-ray signature identifier
US9574189B2 (en) 2005-12-01 2017-02-21 Nuevolution A/S Enzymatic encoding methods for efficient synthesis of large libraries
US20100137163A1 (en) 2006-01-11 2010-06-03 Link Darren R Microfluidic Devices and Methods of Use in The Formation and Control of Nanoreactors
US8280794B1 (en) * 2006-02-03 2012-10-02 Jpmorgan Chase Bank, National Association Price earnings derivative financial product
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
ATE540750T1 (en) 2006-05-11 2012-01-15 Raindance Technologies Inc MICROFLUIDIC DEVICE AND METHOD
US7403592B1 (en) * 2006-05-31 2008-07-22 The United States Of America As Represented By The Department Of Energy Digital lock-in detection of site-specific magnetism in magnetic materials
EP3536396B1 (en) 2006-08-07 2022-03-30 The President and Fellows of Harvard College Fluorocarbon emulsion stabilizing surfactants
WO2008097559A2 (en) 2007-02-06 2008-08-14 Brandeis University Manipulation of fluids and reactions in microfluidic systems
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
EP3415235A1 (en) 2009-03-23 2018-12-19 Raindance Technologies Inc. Manipulation of microfluidic droplets
US9023767B2 (en) * 2009-05-07 2015-05-05 Memorial Sloan-Kettering Cancer Center γ-Secretase substrates and methods of use
US8476587B2 (en) * 2009-05-13 2013-07-02 Micromass Uk Limited Ion source with surface coating
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
EP2517025B1 (en) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Methods for reducing the exchange of molecules between droplets
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
CA2789425C (en) 2010-02-12 2020-04-28 Raindance Technologies, Inc. Digital analyte analysis with polymerase error correction
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
DK2558577T3 (en) 2010-04-16 2019-04-01 Nuevolution As Bi-functional complexes and methods for the preparation and use of such complexes
US20130075331A1 (en) * 2010-06-10 2013-03-28 Ramila Hishantha Peiris Method for fluorescence-based fouling forecasting and optimization in membrane filtration operations
WO2012033831A2 (en) 2010-09-07 2012-03-15 Memorial Sloan-Kettering Cancer Center Methods and compositions for gamma-secretase assay
EP2622103B2 (en) 2010-09-30 2022-11-16 Bio-Rad Laboratories, Inc. Sandwich assays in droplets
US8386533B2 (en) * 2010-11-30 2013-02-26 Oracle International Corporation Records management of database tables
US10144950B2 (en) 2011-01-31 2018-12-04 Roche Sequencing Solutions, Inc. Methods of identifying multiple epitopes in cells
WO2012109600A2 (en) 2011-02-11 2012-08-16 Raindance Technologies, Inc. Methods for forming mixed droplets
EP2675819B1 (en) 2011-02-18 2020-04-08 Bio-Rad Laboratories, Inc. Compositions and methods for molecular labeling
EP2714970B1 (en) 2011-06-02 2017-04-19 Raindance Technologies, Inc. Enzyme quantification
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
US9977876B2 (en) 2012-02-24 2018-05-22 Perkinelmer Informatics, Inc. Systems, methods, and apparatus for drawing chemical structures using touch and gestures
EP4450644A3 (en) 2012-08-08 2025-01-08 F. Hoffmann-La Roche AG Increasing dynamic range for identifying multiple epitopes in cells
US9535583B2 (en) * 2012-12-13 2017-01-03 Perkinelmer Informatics, Inc. Draw-ahead feature for chemical structure drawing applications
US8854361B1 (en) 2013-03-13 2014-10-07 Cambridgesoft Corporation Visually augmenting a graphical rendering of a chemical structure representation or biological sequence representation with multi-dimensional information
US9751294B2 (en) 2013-05-09 2017-09-05 Perkinelmer Informatics, Inc. Systems and methods for translating three dimensional graphic molecular models to computer aided design format
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
EP3090063B1 (en) 2013-12-31 2019-11-06 Bio-Rad Laboratories, Inc. Method for detection of latent retrovirus
US20180320241A1 (en) * 2014-12-19 2018-11-08 Roche Sequencing Solutions, Inc. Methods for identifying multiple epitopes in selected sub-populations of cells
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
US10274440B2 (en) 2016-06-22 2019-04-30 International Business Machines Corporation Method to facilitate investigation of chemical constituents in chemical analysis data
CA3055172C (en) 2017-03-03 2022-03-01 Perkinelmer Informatics, Inc. Systems and methods for searching and indexing documents comprising chemical information
GB201800299D0 (en) * 2018-01-09 2018-02-21 Univ Court Univ Of Glasgow Digital reactioware
WO2022268932A1 (en) 2021-06-24 2022-12-29 Thermo Fisher Scientific Geneart Gmbh Systems and methods for single cell analysis

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59137854A (en) * 1983-01-28 1984-08-08 Jeol Ltd Inverse search for mass spectrum library
US4631211A (en) 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5541061A (en) * 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries
US5418918A (en) * 1993-09-10 1995-05-23 Compaq Computer Corp. Scanning initial CD-ROM sectors for a boot record and executing said boot record to load and execute floppy disk image corresponding to the existing floppy drive
US6017693A (en) 1994-03-14 2000-01-25 University Of Washington Identification of nucleotides, amino acids, or carbohydrates by mass spectrometry
US5463564A (en) * 1994-09-16 1995-10-31 3-Dimensional Pharmaceuticals, Inc. System and method of automatically generating chemical compounds with desired properties
US5688696A (en) * 1994-12-12 1997-11-18 Selectide Corporation Combinatorial libraries having a predetermined frequency of each species of test compound
GB9517661D0 (en) * 1995-08-30 1995-11-01 Smithkline Beecham Plc Novel compounds
GB2308917B (en) 1996-01-05 2000-04-12 Maxent Solutions Ltd Reducing interferences in elemental mass spectrometers
GB9603945D0 (en) * 1996-02-24 1996-04-24 Univ Dundee A microreactor
AU2537397A (en) * 1996-03-22 1997-10-10 Ontogen Corporation Methods for spatially-dispersed positionally-encoded combinatorial library synthesis
CZ217698A3 (en) 1996-04-08 1998-12-16 Glaxo Group Limited Reaction process monitoring
US6207370B1 (en) 1997-09-02 2001-03-27 Sequenom, Inc. Diagnostics based on mass spectrometric detection of translated target polypeptides
EP0918296A1 (en) * 1997-11-04 1999-05-26 Cerep Method of virtual retrieval of analogs of lead compounds by constituting potential libraries
US6207861B1 (en) * 1998-01-05 2001-03-27 Neogenesis, Inc. Method for producing and screening mass coded combinatorial libraries for drug discovery and target validation
US6541211B1 (en) * 1998-05-20 2003-04-01 Selectide Corporation Apparatus and method for synthesizing combinational libraries
US6147344A (en) 1998-10-15 2000-11-14 Neogenesis, Inc Method for identifying compounds in a chemical mixture

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