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AU2001228665A1 - Toll-like receptor - Google Patents

Toll-like receptor

Info

Publication number
AU2001228665A1
AU2001228665A1 AU2001228665A AU2866501A AU2001228665A1 AU 2001228665 A1 AU2001228665 A1 AU 2001228665A1 AU 2001228665 A AU2001228665 A AU 2001228665A AU 2866501 A AU2866501 A AU 2866501A AU 2001228665 A1 AU2001228665 A1 AU 2001228665A1
Authority
AU
Australia
Prior art keywords
toll
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001228665A
Other languages
English (en)
Inventor
Alan Peter Lewis
Keith Paul Ray
Original Assignee
Glaxosmithkline
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline filed Critical Glaxosmithkline
Publication of AU2001228665A1 publication Critical patent/AU2001228665A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2001228665A 2000-01-25 2001-01-25 Toll-like receptor Abandoned AU2001228665A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0001704.6A GB0001704D0 (en) 2000-01-25 2000-01-25 Protein
GB0001704 2000-01-25
PCT/GB2001/000299 WO2001055386A1 (fr) 2000-01-25 2001-01-25 Recepteur de type toll

Publications (1)

Publication Number Publication Date
AU2001228665A1 true AU2001228665A1 (en) 2001-08-07

Family

ID=9884315

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001228665A Abandoned AU2001228665A1 (en) 2000-01-25 2001-01-25 Toll-like receptor

Country Status (5)

Country Link
US (1) US20030022302A1 (fr)
EP (1) EP1250436A1 (fr)
AU (1) AU2001228665A1 (fr)
GB (1) GB0001704D0 (fr)
WO (1) WO2001055386A1 (fr)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030032090A1 (en) 1997-05-07 2003-02-13 Schering Corporation, A New Jersey Corporation Human receptor proteins; related reagents and methods
US6303321B1 (en) 1999-02-11 2001-10-16 North Shore-Long Island Jewish Research Institute Methods for diagnosing sepsis
US20030083244A1 (en) * 2000-04-26 2003-05-01 Vernet Corine A.M. Novel proteins and nucleic acids encoding same
EP1714980A1 (fr) * 2000-05-25 2006-10-25 Schering Corporation Protéines réceptrices humaines, réactifs et méthodes associés
JP2002034565A (ja) * 2000-07-19 2002-02-05 Japan Science & Technology Corp 細菌ｄｎａを特異的に認識する受容体タンパク質
US6943240B2 (en) 2000-09-15 2005-09-13 Coley Pharmaceuticals Gmbh Nucleic acids for high throughput screening of CpG-based immuno-agonist/antagonist
US6677347B2 (en) * 2000-12-08 2004-01-13 3M Innovative Properties Company Sulfonamido ether substituted imidazoquinolines
JP2008531580A (ja) * 2000-12-08 2008-08-14 スリーエム イノベイティブ プロパティズ カンパニー 免疫応答修飾因子の標的化送達のための組成物および方法
US7220723B2 (en) 2001-05-15 2007-05-22 The Feinstein Institute For Medical Research Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents
US7304034B2 (en) 2001-05-15 2007-12-04 The Feinstein Institute For Medical Research Use of HMGB fragments as anti-inflammatory agents
AU2002360243A1 (en) * 2001-07-26 2003-05-06 Tanox, Inc. Agents that activate or inhibit toll-like receptor 9
US7709451B2 (en) * 2001-09-07 2010-05-04 Trustees Of Boston University Method and composition for treating immune complex associated disorders
CN1633598A (zh) * 2001-10-05 2005-06-29 科勒制药股份公司 Toll样受体3信号传导的激动剂和拮抗剂
EP1302206A1 (fr) * 2001-10-11 2003-04-16 Universitair Medisch Centrum Utrecht Procédés et moyens pour l'utilisation du récépteur toll-like adventitiel
AU2002362138A1 (en) 2001-12-11 2003-06-23 Eva Lorenz Toll-like receptor 4 mutations
PT1478327E (pt) * 2002-02-22 2015-08-04 Meda Ab Método de redução e tratamento de imunossupressão induzida por uvb
AU2003255969A1 (en) * 2002-07-17 2004-02-02 Coley Pharmaceutical Gmbh Use of cpg nucleic acids in prion-disease
ES2306752T3 (es) * 2002-07-24 2008-11-16 Centre National De La Recherche Scientifique (Cnrs) Metodo para indentificar compuestos biologicamente activos con propiedades antiasmaticas y/o antialergicas.
JP4860923B2 (ja) 2002-08-15 2012-01-25 スリーエム イノベイティブ プロパティズ カンパニー 免疫刺激性組成物、および免疫応答の刺激方法
WO2004026888A2 (fr) * 2002-09-19 2004-04-01 Coley Pharmaceutical Gmbh Recepteur tlr9 derive de diverses especes mammaliennes
AU2003287316A1 (en) * 2002-12-11 2004-06-30 3M Innovative Properties Company Assays relating to toll-like receptor activity
EP2572715A1 (fr) 2002-12-30 2013-03-27 3M Innovative Properties Company Combinaisons immunostimulantes
WO2004070344A2 (fr) * 2003-02-04 2004-08-19 Bayer Healthcare Ag Procedes destines a l'identification et la validation de reactifs qui modulent l'activite de tlr9 et des procedes et compositions pour la prediction, le diagnostic, le pronostic, la prevention et le traitement de maladies liees a tlr9
JP2006517974A (ja) * 2003-02-13 2006-08-03 スリーエム イノベイティブ プロパティズ カンパニー Ｉｒｍ化合物およびトル様受容体８に関する方法および組成物
WO2004075865A2 (fr) * 2003-02-27 2004-09-10 3M Innovative Properties Company Modulation selective d'une activite biologique induite par le recepteur tlr
US8110582B2 (en) * 2003-03-04 2012-02-07 3M Innovative Properties Company Prophylactic treatment of UV-induced epidermal neoplasia
CA2518445A1 (fr) * 2003-03-13 2004-09-23 3M Innovative Properties Company Procede d'elimination d'un tatouage
WO2004080293A2 (fr) * 2003-03-13 2004-09-23 3M Innovative Properties Company Methodes de diagnostic de lesions de la peau
ATE556711T1 (de) * 2003-03-13 2012-05-15 3M Innovative Properties Co Verfahren zur verbesserung der hautqualität
WO2004087049A2 (fr) * 2003-03-25 2004-10-14 3M Innovative Properties Company Activation selective d'activites cellulaires realisee par l'intermediaire d'un recepteur toll commun
EP1631687A2 (fr) * 2003-04-22 2006-03-08 Coley Pharmaceutical GmbH Procedes et produits pour identifier et evaluer des ligands des tlr
US7696169B2 (en) 2003-06-06 2010-04-13 The Feinstein Institute For Medical Research Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents
US20050013812A1 (en) * 2003-07-14 2005-01-20 Dow Steven W. Vaccines using pattern recognition receptor-ligand:lipid complexes
AU2004264330A1 (en) * 2003-08-05 2005-02-24 3M Innovative Properties Company Infection prophylaxis using immune response modifier compounds
JP2007502293A (ja) * 2003-08-12 2007-02-08 スリーエム イノベイティブ プロパティズ カンパニー ヒドロキシルアミン置換イミダゾ含有化合物
CA2551075A1 (fr) * 2003-08-25 2005-03-03 3M Innovative Properties Company Combinaisons et traitements immunostimulatoires
PH12006500401A1 (en) * 2003-08-27 2005-03-10 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted imidazoquinolines
EP1660026A4 (fr) * 2003-09-05 2008-07-16 3M Innovative Properties Co Traitement pour le lymphome a cellules b cd5+
EP1668035A2 (fr) 2003-09-11 2006-06-14 Critical Therapeutics, Inc. Anticorps monoclonaux diriges contre hmgb1
EP1664342A4 (fr) * 2003-09-17 2007-12-26 3M Innovative Properties Co Modulation selective de l'expression de genes tlr
US7544697B2 (en) * 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
US8871782B2 (en) * 2003-10-03 2014-10-28 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
US20090075980A1 (en) * 2003-10-03 2009-03-19 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and Analogs Thereof
WO2005039504A2 (fr) * 2003-10-24 2005-05-06 Eisai Co., Ltd. Composes et methodes permettant de traiter les maladies et etats pathologiques lies au recepteur 2 de type toll
AU2004285575A1 (en) * 2003-10-31 2005-05-12 3M Innovative Properties Company Neutrophil activation by immune response modifier compounds
CA2545774A1 (fr) 2003-11-14 2005-06-02 3M Innovative Properties Company Composes d'un anneau d'imidazo substitues par oxime
CA2545825A1 (fr) * 2003-11-14 2005-06-02 3M Innovative Properties Company Composes d'un anneau d'imidazo substitue par hydroxylamine
KR101130928B1 (ko) * 2003-11-25 2012-04-12 쓰리엠 이노베이티브 프로퍼티즈 컴파니 치환된 이미다조 고리 시스템 및 방법
US20050226878A1 (en) * 2003-12-02 2005-10-13 3M Innovative Properties Company Therapeutic combinations and methods including IRM compounds
JP2007513165A (ja) * 2003-12-02 2007-05-24 スリーエム イノベイティブ プロパティズ カンパニー Ｉｒｍ化合物を含む併用薬および治療方法
WO2005066170A1 (fr) * 2003-12-29 2005-07-21 3M Innovative Properties Company Imidazoquinolines a substitution arylalcenyle et arylalkynyle
JP2007517055A (ja) * 2003-12-30 2007-06-28 スリーエム イノベイティブ プロパティズ カンパニー 免疫応答の増強
WO2005066169A2 (fr) * 2003-12-30 2005-07-21 3M Innovative Properties Company Sulfonamides d'imidazoquinolinyle, d'imidazopyridinyle et d'imidazonaphtyridinyle
AU2005228150A1 (en) * 2004-03-24 2005-10-13 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
BRPI0510430A (pt) * 2004-04-28 2007-10-30 3M Innovative Properties Co composições e métodos para vacinação mucosal
US20050244410A1 (en) * 2004-04-29 2005-11-03 Ashlyn Bassiri Toll-like receptor 9 effector agents and uses thereof
US20050267145A1 (en) * 2004-05-28 2005-12-01 Merrill Bryon A Treatment for lung cancer
US8017779B2 (en) * 2004-06-15 2011-09-13 3M Innovative Properties Company Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
WO2006065280A2 (fr) * 2004-06-18 2006-06-22 3M Innovative Properties Company Composes a noyau imidazo a substitutif d'isoxazole, de dihydroisoxazole et d'oxadiazole
US20070259881A1 (en) * 2004-06-18 2007-11-08 Dellaria Joseph F Jr Substituted Imidazo Ring Systems and Methods
US7897609B2 (en) * 2004-06-18 2011-03-01 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
US8026366B2 (en) * 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
EP1786450A4 (fr) * 2004-08-27 2009-11-11 3M Innovative Properties Co Compositions immunostimulatrices contre le vih
US20090270443A1 (en) * 2004-09-02 2009-10-29 Doris Stoermer 1-amino imidazo-containing compounds and methods
EP1819364A4 (fr) * 2004-12-08 2010-12-29 3M Innovative Properties Co Compositions, combinaisons immunomodulatrices et procedes associes
JP4961556B2 (ja) * 2004-12-09 2012-06-27 国立大学法人大阪大学 ヘモゾイン誘導による自然免疫を利用したマラリア感染症の検出・測定、マラリア感染症の予防又は治療薬のスクリーニング、及び該自然免疫誘導の調節
JP5543068B2 (ja) * 2004-12-30 2014-07-09 スリーエム イノベイティブ プロパティズ カンパニー キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
US8034938B2 (en) 2004-12-30 2011-10-11 3M Innovative Properties Company Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds
US20090068224A1 (en) * 2005-01-31 2009-03-12 Vaxinnate Corporation Method to identify polypeptide toll-like receptor (tlr) ligands
US20090028889A1 (en) * 2005-01-31 2009-01-29 Vaxinnate Corporation Novel Polypeptide Ligands For Toll-Like Receptor 2 (TLR2)
JP2008530022A (ja) * 2005-02-04 2008-08-07 コーリー ファーマシューティカル グループ，インコーポレイテッド 免疫反応調節物質を含む水性ゲル処方物
US7968563B2 (en) 2005-02-11 2011-06-28 3M Innovative Properties Company Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
US7700728B2 (en) * 2005-03-24 2010-04-20 Schering Corporation Use of chimeric receptors in a screening assay for identifying agonists and antagonists of cell receptors
JP2008535832A (ja) 2005-04-01 2008-09-04 コーリー ファーマシューティカル グループ，インコーポレイテッド ピラゾロピリジン−１，４−ジアミン、およびそのアナログ
CA2602590A1 (fr) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. Composes cycliques 1-pyrazolo[3,4-c] substitues comme modulateurs de la biosynthese de cytokine destines au traitement d'infections virales et de maladies neoplastiques
CN101371141A (zh) 2006-01-10 2009-02-18 高露洁-棕榄公司 调节细胞表面受体预防或减少炎症的方法
WO2008008432A2 (fr) * 2006-07-12 2008-01-17 Coley Pharmaceutical Group, Inc. Composés à cycle [1,2] imidazo [4,5-c] fusionné chiral substitué et procédés correspondants
US8066981B2 (en) * 2006-11-14 2011-11-29 The Texas A & M University System Compositions and methods related to toll-like receptor-3
EP2094726B1 (fr) * 2006-11-15 2016-06-08 The Texas A & M University System Compositions et procédés associés au récepteur-3 de type toll
EP2328911A4 (fr) 2008-09-22 2012-03-14 Cedars Sinai Medical Center Md-2 humaine sous sa forme courte utilisée comme régulateur négatif de la signalisation par le récepteur de type toll-4
US9512196B2 (en) 2008-09-22 2016-12-06 Cedars-Sinai Medical Center Short-form human MD-2 as a negative regulator of toll-like receptor 4 signaling
AR076041A1 (es) 2009-04-01 2011-05-11 Colgate Palmolive Co Biomarcadores de proteina para el diagnostico de enfermedades de tejido blando y como objetivos terapeuticos para intervenciones de cuidado oral
AU2009344336B2 (en) 2009-04-01 2013-07-18 Colgate-Palmolive Company Menthol-derivative compounds and use thereof as oral and systemic active agents
TWI405565B (zh) 2009-04-01 2013-08-21 Colgate Palmolive Co 口腔用組成物之抗－骨質流失及抗－牙周附連喪失之功效
RU2526912C2 (ru) 2009-04-01 2014-08-27 Колгейт-Палмолив Компани Композиции карбонатных соединений, препятствующих образованию биопленки, для использования при уходе за полостью рта

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0980429B1 (fr) * 1997-05-07 2006-12-13 Schering Corporation Recepteur proteique humain du type toll, reactifs connexes et techniques afferentes

Also Published As

Publication number Publication date
WO2001055386A1 (fr) 2001-08-02
GB0001704D0 (en) 2000-03-15
US20030022302A1 (en) 2003-01-30
EP1250436A1 (fr) 2002-10-23

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