AU2001288019A1 - Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues - Google Patents

Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues

Info

Publication number: AU2001288019A1
Authority: AU; Australia
Prior art keywords: modifying; cells; nucleic acid; acid constructs; methods utilizing
Prior art date: 2000-10-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU2001288019A

Other languages

English (en)

Inventor

Yair Feld

Meira Frank

Lior Gepstein

Shimon Marom

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Technion Research and Development Foundation Ltd

Original Assignee

Technion Research and Development Foundation Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-20

Filing date

2001-09-05

Publication date

2002-04-29

2001-09-05 Application filed by Technion Research and Development Foundation Ltd filed Critical Technion Research and Development Foundation Ltd

2002-04-29 Publication of AU2001288019A1 publication Critical patent/AU2001288019A1/en

Status Abandoned legal-status Critical Current

Links

150000007523 nucleic acids Chemical class 0.000 title 1
102000039446 nucleic acids Human genes 0.000 title 1
108020004707 nucleic acids Proteins 0.000 title 1
102000004310 Ion Channels Human genes 0.000 abstract 1
208000026062 Tissue disease Diseases 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0657—Cardiomyocytes; Heart cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1323—Adult fibroblasts
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1329—Cardiomyocytes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/99—Coculture with; Conditioned medium produced by genetically modified cells

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Cell Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Cardiology (AREA)
Analytical Chemistry (AREA)
Physics & Mathematics (AREA)
Rheumatology (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Medicinal Chemistry (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AU2001288019A 2000-10-20 2001-09-05 Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues Abandoned AU2001288019A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US09/691,889		2000-10-20
US09/691,889 US7294333B1 (en)	2000-10-20	2000-10-20	Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues
PCT/IL2001/000833 WO2002033111A2 (fr)	2000-10-20	2001-09-05	Constructions d'acide nucleique et cellules, et leurs methodes d'utilisation pour modifier la fonction electrophysiologique de tissus excitables

Publications (1)

Publication Number	Publication Date
AU2001288019A1 true AU2001288019A1 (en)	2002-04-29

Family

ID=24778375

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU2001288019A Abandoned AU2001288019A1 (en)	2000-10-20	2001-09-05	Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues

Country Status (7)

Country	Link
US (2)	US7294333B1 (fr)
EP (3)	EP1326879B1 (fr)
AT (1)	ATE403664T1 (fr)
AU (1)	AU2001288019A1 (fr)
CA (1)	CA2426460A1 (fr)
DE (1)	DE60135237D1 (fr)
WO (1)	WO2002033111A2 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2421584C (fr) *	2000-09-06	2013-12-31	Johns Hopkins University	Therapie genique pour les arythmies cardiaques
US7491385B2 (en)	2001-09-05	2009-02-17	Genegrafts Ltd.	Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues
AU2002359371A1 (en)	2001-11-08	2003-05-19	The Regents Of The University Of California	Methods and compositions for correction of cardiac conduction disturbances
JP2006508073A (ja)	2002-10-02	2006-03-09	ザ・ジョンズ・ホプキンス・ユニバーシティー	限局的カルシウムチャネル調節方法
US20050002914A1 (en) *	2003-01-15	2005-01-06	Rosen Michael R.	Mesenchymal stem cells as a vehicle for ion channel transfer in syncytial structures
US8013133B2 (en) *	2003-04-25	2011-09-06	Medtronic, Inc.	Genetic modification of targeted regions of the cardiac conduction system
US20040214182A1 (en) *	2003-04-25	2004-10-28	Vinod Sharma	Genetic modification of targeted regions of the cardiac conduction system
US20070021375A1 (en)	2003-04-25	2007-01-25	Vinod Sharma	Genetic modification of targeted regions of the cardiac conduction system
WO2005092033A2 (fr) *	2004-03-22	2005-10-06	The Johns Hopkins University	Prevention d'arythmies associees a la transplantation cellulaire
US7993906B2 (en) *	2004-05-28	2011-08-09	The Board Of Trustees Of The Leland Stanford Junior University	Closed-loop electrical stimulation system for cell cultures
US8565898B2 (en) *	2005-04-28	2013-10-22	Medtronic, Inc.	Rate control during AF using cellular intervention to modulate AV node
EP2289397A3 (fr)	2006-01-19	2011-04-06	The General Hospital Corporation	Procédés et systèmes pour visualiser de manière optique des organes intracavitaires épithéliaux lors d'un balayage au faisceau
EP2306141A1 (fr)	2006-02-24	2011-04-06	The General Hospital Corporation	Procédés et systèmes destinés à réaliser une tomographie par cohérence optique dans le domaine de Fourier avec résolution angulaire
US8838213B2 (en)	2006-10-19	2014-09-16	The General Hospital Corporation	Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample, and effecting such portion(s)
WO2008078325A2 (fr) *	2006-12-27	2008-07-03	Genegrafts Ltd.	Méthode de traitement de la schizophrénie
US9150832B2 (en) *	2007-05-08	2015-10-06	Cardiac Pacemakers, Inc.	Cell training for local field stimulation
US20080280341A1 (en) *	2007-05-08	2008-11-13	Kenknight Bruce	System And Method For Local Field Stimulation
US8311620B2 (en) *	2007-08-22	2012-11-13	Cardiac Pacemakers, Inc.	Methods and apparatus to treat and prevent atrial tachyarrhythmias
US20110144028A1 (en) *	2009-12-11	2011-06-16	Vinod Sharma	Modulating cellular electrophysiology
US8639323B2 (en)	2010-11-01	2014-01-28	Medtronic, Inc.	System and apparatus to monitor biopacemaker maturation

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5683912A (en)	1994-07-21	1997-11-04	The Salk Institute For Biological Studies	Cloning and expression of a novel acetylcholine-gated ion channel receptor subunit
US5602301A (en) *	1993-11-16	1997-02-11	Indiana University Foundation	Non-human mammal having a graft and methods of delivering protein to myocardial tissue
US5837220A (en)	1995-09-19	1998-11-17	Merck & Co., Inc.	Method for analyzing the immunosuppressant activity of ion channel blockers using the mini-pig
US5955259A (en)	1996-12-19	1999-09-21	Brandeis University	Method for assessing modulation of potassium ion channel activity
US6110459A (en)	1997-05-28	2000-08-29	Mickle; Donald A. G.	Transplants for myocardial scars and methods and cellular preparations
US6099832A (en)	1997-05-28	2000-08-08	Genzyme Corporation	Transplants for myocardial scars
US5986081A (en)	1997-10-22	1999-11-16	Wisconsin Alumni Research Foundation	Polynucleotides encoding herg-3
US6913925B1 (en) *	1998-08-12	2005-07-05	Signal Pharmaceuticals Llc	Human mesencephalon cell lines and methods of use therefor
WO2000018903A2 (fr) *	1998-09-29	2000-04-06	The Johns Hopkins University	Suppression genetique inductible de l'excitabilite cellulaire
WO2000043039A1 (fr) *	1999-01-22	2000-07-27	Matthew John During	Traitement de troubles psychologiques a base de vaccin
AU778566B2 (en)	1999-04-15	2004-12-09	University Of Utah Research Foundation	MinK-related genes, formation of potassium channels and association with cardiac arrhythmia
CA2421584C (fr) *	2000-09-06	2013-12-31	Johns Hopkins University	Therapie genique pour les arythmies cardiaques
CA2445578C (fr)	2001-04-27	2012-08-28	Johns Hopkins University	Stimulateur cardiaque biologique comprenant une dominante negative de kir2.1aaa

2000
- 2000-10-20 US US09/691,889 patent/US7294333B1/en not_active Expired - Fee Related
2001
- 2001-09-05 CA CA002426460A patent/CA2426460A1/fr not_active Abandoned
- 2001-09-05 AT AT01967651T patent/ATE403664T1/de not_active IP Right Cessation
- 2001-09-05 EP EP01967651A patent/EP1326879B1/fr not_active Expired - Lifetime
- 2001-09-05 WO PCT/IL2001/000833 patent/WO2002033111A2/fr active IP Right Grant
- 2001-09-05 US US10/399,715 patent/US20040029148A1/en not_active Abandoned
- 2001-09-05 DE DE60135237T patent/DE60135237D1/de not_active Expired - Lifetime
- 2001-09-05 EP EP10181137.0A patent/EP2385056B1/fr not_active Expired - Lifetime
- 2001-09-05 EP EP08160306A patent/EP2166017A1/fr not_active Withdrawn
- 2001-09-05 AU AU2001288019A patent/AU2001288019A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1326879A2 (fr)	2003-07-16
DE60135237D1 (de)	2008-09-18
US20040029148A1 (en)	2004-02-12
CA2426460A1 (fr)	2002-04-25
EP1326879B1 (fr)	2008-08-06
WO2002033111A2 (fr)	2002-04-25
ATE403664T1 (de)	2008-08-15
EP2385056B1 (fr)	2015-06-10
EP2166017A1 (fr)	2010-03-24
EP1326879A4 (fr)	2004-09-22
WO2002033111A3 (fr)	2002-12-19
US7294333B1 (en)	2007-11-13
EP2385056A3 (fr)	2012-02-01
EP2385056A2 (fr)	2011-11-09

Publication	Publication Date	Title
AU2001288019A1 (en)	2002-04-29	Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues
TW428026B (en)	2001-04-01	Bifunctional protein, preparation and use
WO2000005367A3 (fr)	2000-05-04	Proteines humaines a domaines hydrophobes et adn codant pour ces proteines
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WO2002029086A3 (fr)	2002-10-03	Sequences d'acide nucleique differentiellement exprimees dans un tissu cancereux
AU5408300A (en)	2001-01-22	Snail, new tumoral progression marker and target protein of new antitumoral compounds
WO2001064738A3 (fr)	2002-09-06	Sequences d"acides amines derivees des proteines humaines reagissant avec l"heparine facilitant le transfert de substances d"interet a l"interieur des cellules et/ou des noyaux cellulaires
PL341703A1 (en)	2001-04-23	Laccase containing composition for oxidatingly dyeing creatine fibre and dyeing method employing such composition
WO2001068828A3 (fr)	2002-06-13	Compositions et methodes destinees a l'expression regulee d'une proteine dans l'intestin
WO2000013015A8 (fr)	2000-05-11	Modulation de proteines kinase a lignee multiple
EP1304123A3 (fr)	2003-11-19	Procédés servant a moduler la croissance d'artères collatérales ou d'autres artères depuis des branchements artériolaires préexistants
AU6028898A (en)	1998-08-25	Methods for cultivating cells and propagating viruses
AU3354499A (en)	1999-10-11	Human mekk proteins, corresponding nucleic acid molecules, and uses therefor
AU2002364302A1 (en)	2003-07-15	Bag3 nucleotide and protein sequences to be used in research, diagnostics and therapy for cell death-involving diseases
AU5026600A (en)	2000-12-05	Methods of regulating the condition of mammalian keratinous tissue
AU2001238064A1 (en)	2001-08-20	18477, a human protein kinase and uses therefor
WO2000017346A3 (fr)	2000-08-03	Molecules hybridantes en epingle a cheveux servant a moduler l'expression genique
EP1368029A4 (fr)	2006-02-15	Procede et composition de rajeunissement des cellules, des tissus, des organes, des cheveux et des ongles
WO1994016085A3 (fr)	1994-12-22	Proteines hybrides presentant des activites de reticulation et de liaison tissulaire
AU4974299A (en)	2000-02-21	Methods and constructs for protein expression
WO2002014536A3 (fr)	2003-01-30	Procedes permettant de moduler des proteines kinase a lignee multiple et de cribler des composes les modulant
WO2001030966A3 (fr)	2001-10-18	Molecule de recombinaison modifiee regulant les fonctions effectrices humorales et cellulaires du systeme immunitaire
WO2000077179A3 (fr)	2001-02-22	Materiaux poly(adp-ribose) polymerase 2 humains et procedes
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