NO20081376L - Kjemisk modifiserte, korte, interfererende nukleinsyremolekyler som medierer RNA-interferens - Google Patents
Kjemisk modifiserte, korte, interfererende nukleinsyremolekyler som medierer RNA-interferensInfo
- Publication number
- NO20081376L NO20081376L NO20081376A NO20081376A NO20081376L NO 20081376 L NO20081376 L NO 20081376L NO 20081376 A NO20081376 A NO 20081376A NO 20081376 A NO20081376 A NO 20081376A NO 20081376 L NO20081376 L NO 20081376L
- Authority
- NO
- Norway
- Prior art keywords
- nucleic acid
- acid molecules
- rna
- gene expression
- small nucleic
- Prior art date
Links
- 108020004707 nucleic acids Proteins 0.000 title abstract 6
- 150000007523 nucleic acids Chemical class 0.000 title abstract 6
- 102000039446 nucleic acids Human genes 0.000 title abstract 6
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 title abstract 3
- 230000009368 gene silencing by RNA Effects 0.000 title abstract 3
- 230000002452 interceptive effect Effects 0.000 title abstract 2
- 230000014509 gene expression Effects 0.000 abstract 5
- 239000004055 small Interfering RNA Substances 0.000 abstract 5
- 108020004459 Small interfering RNA Proteins 0.000 abstract 4
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 239000003112 inhibitor Substances 0.000 abstract 3
- 108091070501 miRNA Proteins 0.000 abstract 3
- 239000002679 microRNA Substances 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 230000006870 function Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 244000089409 Erythrina poeppigiana Species 0.000 abstract 1
- 235000009776 Rathbunia alamosensis Nutrition 0.000 abstract 1
- 108091027967 Small hairpin RNA Proteins 0.000 abstract 1
- 230000033077 cellular process Effects 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 238000012423 maintenance Methods 0.000 abstract 1
- 239000002105 nanoparticle Substances 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 230000009711 regulatory function Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Sammendrag Foreliggende oppfinnelse gjelder forbindelser, preparater og fremgangsmåter for undersøkelse, diagnose og behandling av trekk, sykdommer og tilstander som responderer på modulering av genekspresjon og/eller genaktivitet. Foreliggende oppfinnelse er også rettet mot forbindelser, preparater og fremgangsmåter forbundet med trekk, sykdommer og tilstander som responderer på modulering av ekspresjonen og/eller aktiviteten av gener som deltar i genekspresjons-reaksjonsveier eller andre cellulære prosesser som fomiidler vedlikeholdelse eller utvikling av slike trekk, sykdommer og tilstander. Nærmere bestemt gjelder oppfinnelsen dobbelttrådede nukleinsyremolekyler, innbefattet små nukle insyremolekyler, for eksempel korte interfererende nukleinsyremolekyler (siNA), korte interfererende RNA-molekyler (siRNA), dobbelttrådede RNA-molekyler (dsRNA), mikro- RNA-molekyler (miRNA) og korte håmåls-RNA- molekyler (shRNA) som kan formidle RNAinterferens (RNAi) mot genekspresjon, innbefattet blandinger av slike små nukleinsyremolekyler og lipidnanopartikkel (LNP)-utforniinger av slike små nukleinsyremolekyler. Foreliggende oppfinnelse gjelder også små nukleinsyremolekyler, for eksempel siNA, siRNA og andre, som kan inhibere funksjonen av endogene RNA-molekyler, for eksempel endogent mikro-RNA (miRNA) (for eksempel miRNAinhibitorer) eller endogene, korte interfererende RNA (siRNA) (for eksempel siRNA-inhibitorer) eller som kan inhibere funksjonen av RISC (for eksempel RISCinhibitorer) for modulering av genekspresjon ved å interferere med den regulatoriske funksjonen av slike.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/205,646 US20080161256A1 (en) | 2001-05-18 | 2005-08-17 | RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA) |
| US11/234,730 US20070270579A1 (en) | 2001-05-18 | 2005-09-23 | RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA) |
| US73702405P | 2005-11-15 | 2005-11-15 | |
| US11/299,254 US20060217331A1 (en) | 2001-05-18 | 2005-12-08 | Chemically modified double stranded nucleic acid molecules that mediate RNA interference |
| PCT/US2006/032168 WO2007022369A2 (en) | 2005-08-17 | 2006-08-17 | Chemically modified short interfering nucleic acid molecules that mediate rna interference |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20081376L true NO20081376L (no) | 2008-05-16 |
Family
ID=40328218
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20081376A NO20081376L (no) | 2005-08-17 | 2008-03-14 | Kjemisk modifiserte, korte, interfererende nukleinsyremolekyler som medierer RNA-interferens |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JP2009504190A (no) |
| BR (1) | BRPI0614407A2 (no) |
| IL (1) | IL189540A0 (no) |
| MX (1) | MX2008002369A (no) |
| NO (1) | NO20081376L (no) |
| NZ (1) | NZ565712A (no) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101597375B1 (ko) | 2007-12-21 | 2016-02-24 | 디티에스 엘엘씨 | 오디오 신호의 인지된 음량을 조절하기 위한 시스템 |
| JP5730508B2 (ja) * | 2009-07-10 | 2015-06-10 | アンジェスＭｇ株式会社 | 炎症性腸疾患の治療又は予防剤 |
| US8538042B2 (en) | 2009-08-11 | 2013-09-17 | Dts Llc | System for increasing perceived loudness of speakers |
| US9312829B2 (en) | 2012-04-12 | 2016-04-12 | Dts Llc | System for adjusting loudness of audio signals in real time |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050233996A1 (en) * | 2002-02-20 | 2005-10-20 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hairless (HR) gene expression using short interfering nucleic acid (siNA) |
| EP1432724A4 (en) * | 2002-02-20 | 2006-02-01 | Sirna Therapeutics Inc | INTERFERENCE MEDIATION INHIBITION OF GENE RNA FROM MAP KINASE |
-
2006
- 2006-08-17 JP JP2008527139A patent/JP2009504190A/ja active Pending
- 2006-08-17 NZ NZ565712A patent/NZ565712A/en not_active IP Right Cessation
- 2006-08-17 BR BRPI0614407-1A patent/BRPI0614407A2/pt not_active IP Right Cessation
- 2006-08-17 MX MX2008002369A patent/MX2008002369A/es active IP Right Grant
-
2008
- 2008-02-14 IL IL189540A patent/IL189540A0/en unknown
- 2008-03-14 NO NO20081376A patent/NO20081376L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ565712A (en) | 2011-09-30 |
| IL189540A0 (en) | 2008-08-07 |
| BRPI0614407A2 (pt) | 2009-08-18 |
| JP2009504190A (ja) | 2009-02-05 |
| MX2008002369A (es) | 2008-03-18 |
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