NO20081124L - Anti-CD 3 antistoff-formuleringer - Google Patents
Anti-CD 3 antistoff-formuleringerInfo
- Publication number
- NO20081124L NO20081124L NO20081124A NO20081124A NO20081124L NO 20081124 L NO20081124 L NO 20081124L NO 20081124 A NO20081124 A NO 20081124A NO 20081124 A NO20081124 A NO 20081124A NO 20081124 L NO20081124 L NO 20081124L
- Authority
- NO
- Norway
- Prior art keywords
- antibody formulations
- formulations
- doses
- antibodies
- diagnostic
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71631105P | 2005-09-12 | 2005-09-12 | |
| PCT/US2006/035615 WO2007033230A2 (fr) | 2005-09-12 | 2006-09-12 | Formulations d'anticorps anti-cd3 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20081124L true NO20081124L (no) | 2008-05-22 |
Family
ID=37865544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20081124A NO20081124L (no) | 2005-09-12 | 2008-03-04 | Anti-CD 3 antistoff-formuleringer |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20070065437A1 (fr) |
| EP (2) | EP1933868A2 (fr) |
| JP (1) | JP2009507838A (fr) |
| KR (1) | KR20080042905A (fr) |
| CN (1) | CN101309703A (fr) |
| AR (1) | AR057807A1 (fr) |
| AU (1) | AU2006291005A1 (fr) |
| BR (1) | BRPI0615745A2 (fr) |
| CA (1) | CA2625815A1 (fr) |
| EA (1) | EA014025B1 (fr) |
| IL (1) | IL189876A0 (fr) |
| NO (1) | NO20081124L (fr) |
| SG (1) | SG174779A1 (fr) |
| UA (1) | UA92505C2 (fr) |
| WO (1) | WO2007033230A2 (fr) |
| ZA (1) | ZA200802051B (fr) |
Families Citing this family (101)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS52492B (en) * | 2007-04-03 | 2013-02-28 | Amgen Research (Munich) Gmbh | MOLECULES WHICH INTERSPECIALLY SPECIFICALLY BISPECIFICALLY Bind |
| EP4059964A1 (fr) * | 2007-04-03 | 2022-09-21 | Amgen Research (Munich) GmbH | Domaine de liaison inter-especes |
| KR101626988B1 (ko) * | 2007-04-03 | 2016-06-02 | 암젠 리서치 (뮌헨) 게엠베하 | 종간 특이적 이중특이적인 결합제들 |
| JP2010524851A (ja) * | 2007-04-03 | 2010-07-22 | マイクロメット アーゲー | 種間特異的結合ドメイン |
| WO2009005673A1 (fr) * | 2007-06-28 | 2009-01-08 | Schering Corporation | Anti-igf1r |
| WO2009009406A1 (fr) * | 2007-07-06 | 2009-01-15 | Smithkline Beecham Corporation | Formulations d'anticorps |
| US20110091447A1 (en) * | 2008-03-13 | 2011-04-21 | The Hospital For Sick Children | Lymphocyte control of obesity and insulin resistance |
| SI2356153T1 (sl) | 2008-10-01 | 2016-07-29 | Amgen Research (Munich) Gmbh | Bispecifično enoverižno protitelo, specifično za križane vrste |
| AU2009299794B2 (en) | 2008-10-01 | 2015-08-13 | Amgen Research (Munich) Gmbh | Cross-species-specific single domain bispecific single chain antibody |
| KR101942694B1 (ko) * | 2008-10-01 | 2019-01-25 | 암젠 리서치 (뮌헨) 게엠베하 | 종간 특이적 ＰＳＣＡｘＣＤ３, ＣＤ19ｘＣＤ3, ｃ-ＭＥＴｘＣＤ3, 엔도시알린ｘＣＤ3, ＥｐＣＡＭｘＣＤ3, ＩＧＦ-1ＲｘＣＤ3 또는 ＦＡＰαｘＣＤ3 이중특이적 단일쇄 항체 |
| WO2010132872A1 (fr) * | 2009-05-15 | 2010-11-18 | Novimmune S.A | Polythérapies et méthodes utilisant des agents de modulation anti-cd3 et des antagonistes anti-tnf |
| JP2013508392A (ja) * | 2009-10-20 | 2013-03-07 | グラクソ グループ リミテッド | 自己免疫疾患における抗ｃｄ３抗体の投薬 |
| CN105521491B (zh) * | 2010-03-01 | 2020-03-24 | 西托戴恩有限公司 | 浓缩蛋白制剂及其用途 |
| TWI653333B (zh) | 2010-04-01 | 2019-03-11 | 安進研究（慕尼黑）有限責任公司 | 跨物種專一性之ＰＳＭＡｘＣＤ３雙專一性單鏈抗體 |
| MX349057B (es) * | 2010-11-30 | 2017-07-07 | Chugai Pharmaceutical Co Ltd | Agente terapeutico que induce citotoxicidad. |
| US20120189621A1 (en) | 2011-01-21 | 2012-07-26 | Yann Dean | Combination Therapies and Methods Using Anti-CD3 Modulating Agents and Anti-IL-6 Antagonists |
| US8974782B2 (en) * | 2011-02-07 | 2015-03-10 | Glaxo Group Limited | Treatment of stroke comprising anti-MAG antibodies |
| JP2014515598A (ja) | 2011-03-10 | 2014-07-03 | エイチシーオー アンティボディ， インク． | 二重特異性三鎖抗体様分子 |
| MY173899A (en) | 2011-05-21 | 2020-02-26 | Macrogenics Inc | Cd3-binding molecules capable of binding to human and non-human cd3 |
| WO2013073968A2 (fr) * | 2011-09-12 | 2013-05-23 | Industrial Research Limited | Agents de modulation de la signalisation cellulaire |
| US10851178B2 (en) | 2011-10-10 | 2020-12-01 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| TWI679212B (zh) | 2011-11-15 | 2019-12-11 | 美商安進股份有限公司 | 針對ｂｃｍａ之e3以及ｃｄ３的結合分子 |
| UA115789C2 (uk) | 2012-09-05 | 2017-12-26 | Трейкон Фармасутікалз, Інк. | Композиція антитіла до cd105 та її застосування |
| DK2900694T3 (en) | 2012-09-27 | 2018-11-19 | Merus Nv | BISPECIFIC IGG ANTIBODIES AS T-CELL ACTIVATORS |
| US9605084B2 (en) | 2013-03-15 | 2017-03-28 | Xencor, Inc. | Heterodimeric proteins |
| US9701759B2 (en) | 2013-01-14 | 2017-07-11 | Xencor, Inc. | Heterodimeric proteins |
| US10131710B2 (en) | 2013-01-14 | 2018-11-20 | Xencor, Inc. | Optimized antibody variable regions |
| US10487155B2 (en) | 2013-01-14 | 2019-11-26 | Xencor, Inc. | Heterodimeric proteins |
| DK2943511T3 (da) | 2013-01-14 | 2019-10-21 | Xencor Inc | Nye heterodimeriske proteiner |
| US11053316B2 (en) | 2013-01-14 | 2021-07-06 | Xencor, Inc. | Optimized antibody variable regions |
| JP6594855B2 (ja) * | 2013-03-15 | 2019-10-23 | ゼンコア インコーポレイテッド | ヘテロ二量体タンパク質 |
| WO2014141152A2 (fr) * | 2013-03-15 | 2014-09-18 | Glaxosmithkline Intellectual Property (No.2) Limited | Formulations d'anticorps à faibles concentrations |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| AU2014232416B2 (en) | 2013-03-15 | 2017-09-28 | Xencor, Inc. | Modulation of T Cells with Bispecific Antibodies and FC Fusions |
| US10106624B2 (en) | 2013-03-15 | 2018-10-23 | Xencor, Inc. | Heterodimeric proteins |
| KR20160007604A (ko) * | 2013-05-10 | 2016-01-20 | 누맙 아게 | 이중특이성 작제물 및 다양한 질병의 치료에서의 이의 용도 |
| CN113150164A (zh) | 2013-07-25 | 2021-07-23 | 西托姆克斯治疗公司 | 多特异性抗体、多特异性可活化抗体及其使用方法 |
| KR20230022270A (ko) | 2014-03-28 | 2023-02-14 | 젠코어 인코포레이티드 | Cd38 및 cd3에 결합하는 이중특이적 항체 |
| EP3164417A1 (fr) | 2014-07-01 | 2017-05-10 | Pfizer Inc. | Diabodies hétérodimères bispécifiques et leurs utilisations |
| BR112017001579A2 (pt) | 2014-07-25 | 2017-11-21 | Cytomx Therapeutics Inc | anticorpos anti-cd3, anticorpos anti-cd3 ativáveis, anticorpos anti-cd3 multiespecíficos, anticorpos anti-cd3 ativáveis multiespecíficos e métodos de uso dos mesmos |
| CA2966905A1 (fr) | 2014-11-12 | 2016-05-19 | Tracon Pharmaceuticals, Inc. | Anticorps anti-endogline et leurs utilisations |
| MX2017006918A (es) | 2014-11-26 | 2018-01-25 | Xencor Inc | Anticuerpos heterodimericos que se unen a cd3 y cd38. |
| US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
| HUE055115T2 (hu) | 2014-11-26 | 2021-10-28 | Xencor Inc | CD3-at és CD20-at kötõ heterodimer antitestek |
| EP3237449A2 (fr) | 2014-12-22 | 2017-11-01 | Xencor, Inc. | Anticorps trispécifiques |
| LT3115376T (lt) | 2015-07-10 | 2018-11-12 | Merus N.V. | Antikūnai, kurie jungiasi su žmogaus cd3 |
| IL307276B1 (en) | 2015-08-28 | 2025-04-01 | Amunix Operating Inc | Chimeric polypeptide composition and methods for its preparation and use |
| US10227410B2 (en) | 2015-12-07 | 2019-03-12 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and PSMA |
| PL3468586T3 (pl) | 2016-06-14 | 2025-01-07 | Xencor, Inc. | Przeciwciała inhibitora bispecyficznego punktu kontrolnego |
| IL299221A (en) | 2016-06-21 | 2023-02-01 | Teneobio Inc | CD3 binding antibodies |
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| ES2986900T3 (es) * | 2016-08-29 | 2024-11-13 | Tiziana Life Sciences Plc | Formulaciones de anticuerpos anti-cd3 |
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| RU2020124623A (ru) | 2017-12-27 | 2022-01-27 | Тенеобио, Инк. | Антитела, специфичные к гетеродимеру cd3-дельта/эпсилон |
| CN112469477A (zh) | 2018-04-04 | 2021-03-09 | Xencor股份有限公司 | 与成纤维细胞活化蛋白结合的异源二聚体抗体 |
| CN112437777A (zh) | 2018-04-18 | 2021-03-02 | Xencor股份有限公司 | 包含IL-15/IL-15RA Fc融合蛋白和TIM-3抗原结合结构域的靶向TIM-3的异源二聚体融合蛋白 |
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| MX2021003765A (es) | 2018-10-03 | 2021-07-15 | Xencor Inc | Proteínas il-12 de fusión a fc heterodimérico. |
| EP3864045A2 (fr) | 2018-10-11 | 2021-08-18 | Inhibrx, Inc. | Anticorps à domaine unique dll3 et compositions thérapeutiques |
| TW202028246A (zh) | 2018-10-11 | 2020-08-01 | 美商英伊布里克斯公司 | B7h3單域抗體及其治療性組合物 |
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-
2006
- 2006-09-12 EP EP06790218A patent/EP1933868A2/fr not_active Withdrawn
- 2006-09-12 US US11/520,312 patent/US20070065437A1/en not_active Abandoned
- 2006-09-12 CA CA002625815A patent/CA2625815A1/fr not_active Abandoned
- 2006-09-12 US US11/991,811 patent/US20100209437A1/en not_active Abandoned
- 2006-09-12 SG SG2011064219A patent/SG174779A1/en unknown
- 2006-09-12 CN CNA2006800334114A patent/CN101309703A/zh active Pending
- 2006-09-12 WO PCT/US2006/035615 patent/WO2007033230A2/fr active Application Filing
- 2006-09-12 EP EP10184453A patent/EP2354162A1/fr not_active Withdrawn
- 2006-09-12 EA EA200800812A patent/EA014025B1/ru not_active IP Right Cessation
- 2006-09-12 KR KR1020087007421A patent/KR20080042905A/ko not_active Ceased
- 2006-09-12 UA UAA200803005A patent/UA92505C2/ru unknown
- 2006-09-12 AR ARP060103968A patent/AR057807A1/es unknown
- 2006-09-12 AU AU2006291005A patent/AU2006291005A1/en not_active Abandoned
- 2006-09-12 BR BRPI0615745-9A patent/BRPI0615745A2/pt not_active Application Discontinuation
- 2006-09-12 JP JP2008530034A patent/JP2009507838A/ja active Pending
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2008
- 2008-03-02 IL IL189876A patent/IL189876A0/en unknown
- 2008-03-04 ZA ZA200802051A patent/ZA200802051B/xx unknown
- 2008-03-04 NO NO20081124A patent/NO20081124L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| SG174779A1 (en) | 2011-10-28 |
| UA92505C2 (ru) | 2010-11-10 |
| KR20080042905A (ko) | 2008-05-15 |
| US20100209437A1 (en) | 2010-08-19 |
| AU2006291005A1 (en) | 2007-03-22 |
| BRPI0615745A2 (pt) | 2011-05-24 |
| CA2625815A1 (fr) | 2007-03-22 |
| AR057807A1 (es) | 2007-12-19 |
| IL189876A0 (en) | 2008-11-03 |
| EP2354162A1 (fr) | 2011-08-10 |
| US20070065437A1 (en) | 2007-03-22 |
| EA014025B1 (ru) | 2010-08-30 |
| EP1933868A2 (fr) | 2008-06-25 |
| WO2007033230A3 (fr) | 2007-09-13 |
| ZA200802051B (en) | 2008-12-31 |
| CN101309703A (zh) | 2008-11-19 |
| JP2009507838A (ja) | 2009-02-26 |
| WO2007033230A2 (fr) | 2007-03-22 |
| EA200800812A1 (ru) | 2008-08-29 |
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