NO20081101L - Regioselektiv metode for fremstilling av benzimidazol-tiofener - Google Patents
Regioselektiv metode for fremstilling av benzimidazol-tiofenerInfo
- Publication number
- NO20081101L NO20081101L NO20081101A NO20081101A NO20081101L NO 20081101 L NO20081101 L NO 20081101L NO 20081101 A NO20081101 A NO 20081101A NO 20081101 A NO20081101 A NO 20081101A NO 20081101 L NO20081101 L NO 20081101L
- Authority
- NO
- Norway
- Prior art keywords
- thiophenes
- benzimidazole
- preparation
- regioselective method
- regioselective
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D333/40—Thiophene-2-carboxylic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71430105P | 2005-09-06 | 2005-09-06 | |
| PCT/US2006/033793 WO2007030366A1 (fr) | 2005-09-06 | 2006-08-28 | Procede regioselectif de preparation de benzimidazole thiophenes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20081101L true NO20081101L (no) | 2008-04-04 |
Family
ID=37605702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20081101A NO20081101L (no) | 2005-09-06 | 2008-03-03 | Regioselektiv metode for fremstilling av benzimidazol-tiofener |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20080249301A1 (fr) |
| EP (1) | EP1924572B1 (fr) |
| JP (1) | JP2009507022A (fr) |
| KR (1) | KR20080045266A (fr) |
| CN (1) | CN101304986A (fr) |
| AT (1) | ATE453634T1 (fr) |
| AU (1) | AU2006287771A1 (fr) |
| BR (1) | BRPI0615705A2 (fr) |
| CA (1) | CA2621073A1 (fr) |
| DE (1) | DE602006011482D1 (fr) |
| EA (1) | EA200800549A1 (fr) |
| ES (1) | ES2338590T3 (fr) |
| IL (1) | IL189769A0 (fr) |
| MA (1) | MA29781B1 (fr) |
| MX (1) | MX2008003172A (fr) |
| NO (1) | NO20081101L (fr) |
| WO (1) | WO2007030366A1 (fr) |
| ZA (1) | ZA200801950B (fr) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602006012694D1 (de) * | 2005-09-06 | 2010-04-15 | Glaxosmithkline Llc | Benzimidazolthiophenverbindungen als plk-modulatoren |
| DE602006011192D1 (de) * | 2005-09-06 | 2010-01-28 | Smithkline Beecham Corp | Benzimidazolthiophenverbindungen als plk-inhibitoren |
| CA2637335A1 (fr) * | 2006-01-23 | 2007-08-02 | Vertex Pharmaceuticals Incorporated | Thiophene-carboxamides utiles en tant qu'inhibiteurs de proteines kinases |
| US7829590B2 (en) | 2006-04-13 | 2010-11-09 | Guy Brenchley | Thiophene-carboxamides useful as inhibitors of protein kinases |
| US8853244B2 (en) | 2006-05-23 | 2014-10-07 | Vertex Pharmaceuticals Incorporated | Thiophene-carboxamides useful as inhibitors of protein kinases |
| JP2009538305A (ja) | 2006-05-23 | 2009-11-05 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼのインヒビターとして有用なチオフェンカルボキサミド |
| US7615643B2 (en) | 2006-06-02 | 2009-11-10 | Smithkline Beecham Corporation | Benzimidazole thiophene compounds |
| EP2170871A2 (fr) * | 2007-06-26 | 2010-04-07 | GlaxoSmithKline LLC | Procédés de préparation de thiophènes de benzimidazole |
| EP2100894A1 (fr) | 2008-03-12 | 2009-09-16 | 4Sc Ag | Pyridopyrimidinones utilisés comme inhibiteurs de la kinase de type Plk1 (polo-like kinase) |
| MX2012011821A (es) * | 2010-04-12 | 2012-11-30 | Supernus Pharmaceuticals Inc | Metodos para producir sales de viloxazina y polimorfos novedosos de las mismas. |
| EP2588107A1 (fr) | 2010-07-01 | 2013-05-08 | Takeda Pharmaceutical Company Limited | Combinaison d'un inhibiteur de cmet et d'un anticorps dirigé contre hgf et/ou cmet |
| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| EP2565186A1 (fr) | 2011-09-02 | 2013-03-06 | Hybrigenics S.A. | Inhibiteurs sélectifs et réversibles de la protéase 7 spécifique de l'ubiquitine |
| KR20150000900A (ko) | 2012-04-10 | 2015-01-05 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | 신규한 1-치환된 인다졸 유도체 |
| HUE042374T2 (hu) | 2012-06-13 | 2019-06-28 | Incyte Holdings Corp | Szubsztituált triciklusos vegyületek mint FGFR inhibitorok |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| CN105263931B (zh) | 2013-04-19 | 2019-01-25 | 因赛特公司 | 作为fgfr抑制剂的双环杂环 |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| US9708318B2 (en) | 2015-02-20 | 2017-07-18 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| WO2019126731A1 (fr) | 2017-12-22 | 2019-06-27 | Petra Pharma Corporation | Dérivés d'aminopyridine utilisés en tant qu'inhibiteurs de la phosphatidylinositol phosphate kinase |
| ES2991427T3 (es) | 2018-05-04 | 2024-12-03 | Incyte Corp | Formas sólidas de un inhibidor de FGFR y procedimientos para preparar las mismas |
| MA52493A (fr) | 2018-05-04 | 2021-03-10 | Incyte Corp | Sels d'un inhibiteur de fgfr |
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| CN109988098A (zh) * | 2019-05-23 | 2019-07-09 | 常州工程职业技术学院 | 一种(r)-n-叔丁氧羰基-3-羟甲基哌啶的合成方法 |
| TW202112767A (zh) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物 |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| US12122767B2 (en) | 2019-10-01 | 2024-10-22 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| US11607416B2 (en) | 2019-10-14 | 2023-03-21 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021076728A1 (fr) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr |
| US11407750B2 (en) | 2019-12-04 | 2022-08-09 | Incyte Corporation | Derivatives of an FGFR inhibitor |
| JP2023505258A (ja) | 2019-12-04 | 2023-02-08 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤としての三環式複素環 |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| TW202304459A (zh) | 2021-04-12 | 2023-02-01 | 美商英塞特公司 | 包含ｆｇｆｒ抑制劑及ｎｅｃｔｉｎ－４靶向劑之組合療法 |
| AR126102A1 (es) | 2021-06-09 | 2023-09-13 | Incyte Corp | Heterociclos tricíclicos como inhibidores de fgfr |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5990146A (en) * | 1997-08-20 | 1999-11-23 | Warner-Lambert Company | Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation |
| US6162804A (en) * | 1997-09-26 | 2000-12-19 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| GB0005642D0 (en) * | 2000-03-10 | 2000-05-03 | Astrazeneca Uk Ltd | Chemical compounds |
| EP1451173A4 (fr) * | 2001-11-01 | 2005-10-26 | Icagen Inc | Piperidines |
| NZ538134A (en) * | 2002-08-08 | 2006-03-31 | Smithkline Beecham Corp | Thiophene compounds |
| US7491737B2 (en) * | 2002-10-30 | 2009-02-17 | Merck & Co., Inc. | Heterarylpiperidine modulators of chemokine receptor activity |
| EP1685128A1 (fr) * | 2003-10-16 | 2006-08-02 | Smithkline Beecham Corporation | Procede de preparation de thiophenes de benzimidazole |
-
2006
- 2006-08-28 DE DE602006011482T patent/DE602006011482D1/de active Active
- 2006-08-28 WO PCT/US2006/033793 patent/WO2007030366A1/fr active Application Filing
- 2006-08-28 KR KR1020087008167A patent/KR20080045266A/ko not_active Withdrawn
- 2006-08-28 EP EP06813938A patent/EP1924572B1/fr active Active
- 2006-08-28 EA EA200800549A patent/EA200800549A1/ru unknown
- 2006-08-28 CA CA002621073A patent/CA2621073A1/fr not_active Abandoned
- 2006-08-28 MX MX2008003172A patent/MX2008003172A/es not_active Application Discontinuation
- 2006-08-28 AT AT06813938T patent/ATE453634T1/de not_active IP Right Cessation
- 2006-08-28 JP JP2008529214A patent/JP2009507022A/ja not_active Ceased
- 2006-08-28 US US12/065,655 patent/US20080249301A1/en not_active Abandoned
- 2006-08-28 AU AU2006287771A patent/AU2006287771A1/en not_active Abandoned
- 2006-08-28 BR BRPI0615705A patent/BRPI0615705A2/pt not_active IP Right Cessation
- 2006-08-28 ES ES06813938T patent/ES2338590T3/es active Active
- 2006-08-28 CN CNA2006800413629A patent/CN101304986A/zh active Pending
-
2008
- 2008-02-26 IL IL189769A patent/IL189769A0/en unknown
- 2008-02-29 ZA ZA200801950A patent/ZA200801950B/xx unknown
- 2008-03-03 NO NO20081101A patent/NO20081101L/no not_active Application Discontinuation
- 2008-03-17 MA MA30750A patent/MA29781B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200801950B (en) | 2009-09-30 |
| BRPI0615705A2 (pt) | 2016-08-23 |
| MX2008003172A (es) | 2008-03-18 |
| IL189769A0 (en) | 2008-08-07 |
| EP1924572B1 (fr) | 2009-12-30 |
| WO2007030366A1 (fr) | 2007-03-15 |
| EA200800549A1 (ru) | 2008-08-29 |
| ES2338590T3 (es) | 2010-05-10 |
| EP1924572A1 (fr) | 2008-05-28 |
| AU2006287771A1 (en) | 2007-03-15 |
| US20080249301A1 (en) | 2008-10-09 |
| CN101304986A (zh) | 2008-11-12 |
| DE602006011482D1 (de) | 2010-02-11 |
| MA29781B1 (fr) | 2008-09-01 |
| KR20080045266A (ko) | 2008-05-22 |
| CA2621073A1 (fr) | 2007-03-15 |
| ATE453634T1 (de) | 2010-01-15 |
| JP2009507022A (ja) | 2009-02-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |