NO20071937L - Fremgangsmater og mellomprodukter for fremstilling av cysteinproteaseinhibitorer - Google Patents
Fremgangsmater og mellomprodukter for fremstilling av cysteinproteaseinhibitorerInfo
- Publication number
- NO20071937L NO20071937L NO20071937A NO20071937A NO20071937L NO 20071937 L NO20071937 L NO 20071937L NO 20071937 A NO20071937 A NO 20071937A NO 20071937 A NO20071937 A NO 20071937A NO 20071937 L NO20071937 L NO 20071937L
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- protease inhibitors
- intermediates
- methods
- cysteine protease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
- C07C321/12—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms
- C07C321/16—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
- C07D213/34—Sulfur atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyridine Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61080604P | 2004-09-17 | 2004-09-17 | |
| PCT/US2005/033051 WO2006034004A2 (fr) | 2004-09-17 | 2005-09-16 | Procedes et produits intermediaires permettant de preparer des inhibiteurs de la cysteine protease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20071937L true NO20071937L (no) | 2007-06-15 |
Family
ID=35899659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20071937A NO20071937L (no) | 2004-09-17 | 2007-04-16 | Fremgangsmater og mellomprodukter for fremstilling av cysteinproteaseinhibitorer |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7737300B2 (fr) |
| EP (1) | EP1799645A2 (fr) |
| JP (1) | JP2008513472A (fr) |
| KR (1) | KR20070061877A (fr) |
| CN (1) | CN101068783A (fr) |
| AU (1) | AU2005287046A1 (fr) |
| BR (1) | BRPI0515470A (fr) |
| CA (1) | CA2580065A1 (fr) |
| CR (1) | CR8993A (fr) |
| EC (1) | ECSP077321A (fr) |
| IL (1) | IL181792A0 (fr) |
| MX (1) | MX2007003118A (fr) |
| NO (1) | NO20071937L (fr) |
| WO (1) | WO2006034004A2 (fr) |
| ZA (1) | ZA200703102B (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004274471A1 (en) | 2003-09-18 | 2005-03-31 | Virobay, Inc. | Haloalkyl containing compounds as cysteine protease inhibitors |
| JP5154944B2 (ja) | 2004-12-02 | 2013-02-27 | ビロベイ，インコーポレイティド | システインプロテアーゼインヒビターとしてのスルホンアミド含有化合物 |
| KR101447897B1 (ko) | 2005-03-21 | 2014-10-07 | 비로베이, 인코포레이티드 | 시스테인 단백질분해효소 억제제로서의 알파 케토아미드화합물 |
| CA2602112A1 (fr) | 2005-03-22 | 2006-09-28 | Celera Genomics | Composes contenant du sulfonyle en tant qu'inhibiteurs de cysteine proteases |
| WO2008028301A1 (fr) * | 2006-09-08 | 2008-03-13 | Merck Frosst Canada Ltd. | Promédicaments d'inhibiteurs de la cathepsine s |
| US20100048717A1 (en) * | 2006-09-25 | 2010-02-25 | MERCK FROSST CANADA LTD, Merk & Co., Inc. | Cathepsin b inhibitors |
| MX2009003563A (es) | 2006-10-04 | 2009-04-15 | Virobay Inc | Compuestos que contienen di-fluoro como inhibidores de proteasa de cisteina. |
| US7893112B2 (en) | 2006-10-04 | 2011-02-22 | Virobay, Inc. | Di-fluoro containing compounds as cysteine protease inhibitors |
| WO2008070994A1 (fr) | 2006-12-14 | 2008-06-19 | Nps Pharmaceuticals, Inc. | Utilisation de dérivés de la d-sérine pour le traitement de troubles de l'anxiété |
| WO2008119176A1 (fr) | 2007-04-02 | 2008-10-09 | Merck Frosst Canada Ltd. | Procédé d'amidation pour la préparation d'inhibiteurs de la cathepsine k |
| KR101286323B1 (ko) | 2008-10-17 | 2013-07-15 | 제논 파마슈티칼스 인크. | 스피로-옥스인돌 화합물 및 치료제로서의 그의 용도 |
| WO2010148488A1 (fr) * | 2009-06-22 | 2010-12-29 | Merck Frosst Canada Ltd. | Inhibiteurs de la cathepsine cystéine protéase pour traiter des maladies variées |
| US8324417B2 (en) | 2009-08-19 | 2012-12-04 | Virobay, Inc. | Process for the preparation of (S)-2-amino-5-cyclopropyl-4,4-difluoropentanoic acid and alkyl esters and acid salts thereof |
| WO2012119941A1 (fr) | 2011-03-04 | 2012-09-13 | Prozymex A/S | Composés de peptidylnitrile à titre d'inhibiteurs de peptidases |
| US20120329837A1 (en) * | 2011-06-17 | 2012-12-27 | Virobay, Inc. | Cathepsin inhibitors for treating microglia-mediated neuron loss in the central nervous system |
| CN106478564B (zh) * | 2015-08-29 | 2021-11-12 | 广东东阳光药业有限公司 | 组织蛋白酶k抑制剂及其用途 |
| WO2017036357A1 (fr) * | 2015-08-29 | 2017-03-09 | 广东东阳光药业有限公司 | Inhibiteur de cathepsine k et son application |
| US20220193048A1 (en) | 2019-04-05 | 2022-06-23 | Universite De Bretagne Occidentale | Protease-activated receptor-2 inhibitors for the treatment of sensory neuropathy induced by a marine neurotoxic poisoning |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK6572000A3 (en) * | 1997-11-05 | 2000-10-09 | Novartis Ag | Dipeptide nitriles, process for the preparation thereof, their use as medicaments and pharmaceutical composition comprising them |
| GB9723407D0 (en) * | 1997-11-05 | 1998-01-07 | Ciba Geigy Ag | Organic compounds |
| EP1155010A1 (fr) * | 1999-02-20 | 2001-11-21 | AstraZeneca AB | Derives acetamido acetonitriles en tant qu'inhibiteurs de la cathepsine l et/ou s |
| US6936606B2 (en) * | 2001-10-02 | 2005-08-30 | Boehringer Ingelheim Pharmaceuticals, Inc. | Cyanoamido-containing heterocyclic compounds useful as reversible inhibitors of cysteine proteases |
| DK1482924T3 (da) * | 2002-03-05 | 2008-09-29 | Merck Frosst Canada Ltd | Cathepsin-cystein-protease-inhibotorer |
| JP4076955B2 (ja) * | 2002-03-11 | 2008-04-16 | 花王株式会社 | 化粧料 |
-
2005
- 2005-09-16 BR BRPI0515470-7A patent/BRPI0515470A/pt not_active Application Discontinuation
- 2005-09-16 CN CNA2005800389964A patent/CN101068783A/zh active Pending
- 2005-09-16 WO PCT/US2005/033051 patent/WO2006034004A2/fr active Application Filing
- 2005-09-16 EP EP05796693A patent/EP1799645A2/fr not_active Withdrawn
- 2005-09-16 CA CA002580065A patent/CA2580065A1/fr not_active Abandoned
- 2005-09-16 US US11/662,933 patent/US7737300B2/en active Active
- 2005-09-16 JP JP2007532479A patent/JP2008513472A/ja active Pending
- 2005-09-16 AU AU2005287046A patent/AU2005287046A1/en not_active Abandoned
- 2005-09-16 MX MX2007003118A patent/MX2007003118A/es not_active Application Discontinuation
- 2005-09-16 KR KR1020077008584A patent/KR20070061877A/ko not_active Withdrawn
-
2007
- 2007-03-08 IL IL181792A patent/IL181792A0/en unknown
- 2007-03-15 EC EC2007007321A patent/ECSP077321A/es unknown
- 2007-03-15 CR CR8993A patent/CR8993A/es unknown
- 2007-04-16 ZA ZA200703102A patent/ZA200703102B/xx unknown
- 2007-04-16 NO NO20071937A patent/NO20071937L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1799645A2 (fr) | 2007-06-27 |
| IL181792A0 (en) | 2007-07-04 |
| JP2008513472A (ja) | 2008-05-01 |
| WO2006034004A2 (fr) | 2006-03-30 |
| ZA200703102B (en) | 2009-09-30 |
| BRPI0515470A (pt) | 2008-07-22 |
| ECSP077321A (es) | 2007-04-26 |
| MX2007003118A (es) | 2007-05-24 |
| US20080114175A1 (en) | 2008-05-15 |
| CR8993A (es) | 2007-10-04 |
| CN101068783A (zh) | 2007-11-07 |
| KR20070061877A (ko) | 2007-06-14 |
| WO2006034004A3 (fr) | 2006-11-23 |
| AU2005287046A1 (en) | 2006-03-30 |
| CA2580065A1 (fr) | 2006-03-30 |
| US7737300B2 (en) | 2010-06-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20071937L (no) | Fremgangsmater og mellomprodukter for fremstilling av cysteinproteaseinhibitorer | |
| EA200970050A1 (ru) | Ингибиторы пролилгидроксилаз | |
| EA200601795A1 (ru) | Синтез эфиров бороновой кислоты и кислотных соединений | |
| TW200716525A (en) | Process for preparation of sulfamide derivatives | |
| CY1114916T1 (el) | Μεθοδοι | |
| EA200970680A1 (ru) | N-замещенные производные глицина: ингибиторы гидроксилаз | |
| ECSP095220A (es) | Derivados de n-fenil-2-pirimidin-amina | |
| NO20071604L (no) | Loxapinanaloger og fremgangsmater for anvendelse derav. | |
| TNSN06138A1 (fr) | Inhibitors of the mutant form of kit | |
| HRP20080554A2 (en) | Process for preparation of hiv protease inhibitors | |
| TW200603823A (en) | Novel use of peptide compounds for treating essential tremor and other tremor syndromes | |
| DK1668001T3 (da) | Substituerede heteroarylbenzofuransyrer | |
| NO20065297L (no) | Anvendelse av GPCR54 ligander til behandling av infertilitet | |
| NO20082749L (no) | Fremgangsmate for fremstilling av ferri-succinylkasein | |
| DK1499213T3 (da) | Tandrengöringsanordning | |
| EA200601358A1 (ru) | Новые ингибиторы химазы | |
| NO20060535L (no) | Aztreonam-L-lysin og fremgangsmater for fremstilling av dette | |
| DE602005012097D1 (de) | Adjuvante zusammensetzung und anwendungsverfahren dafür | |
| EA200500201A1 (ru) | Новый способ синтеза (7-метокси-1-нафтил)ацетонитрила и его применение при синтезе агомелатина | |
| EA200700400A1 (ru) | Производные n-(1h-индолил)-1н-индол-2-карбоксамидов, их получение и их применение в терапии | |
| NO20080661L (no) | Nye cystein-protease-inhibitorer og deres terapeutiske anvendelser | |
| EA200800411A1 (ru) | Новая кристаллическая форма периндоприлэрбумина | |
| NO20072431L (no) | Fremgangsmate og intermediater for fremstilling av N-(1-benzohydryl-azetidin-3-yl-)-N-fenyl-metylsulfonamid-derivater | |
| EA200500204A1 (ru) | Новый способ синтеза (7-метокси-1-нафтил)ацетонитрила и его применение при синтезе агомелатина | |
| CY1112457T1 (el) | Χρωμανο- και θειοxρωμανο-3-υλο-1,3-διυδρο-ιμιδαζολια ως αναστολεις της ντοπαμινο-β-υδροξυλασης, και μεθοδοι παρασκευης αυτων |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |