NO20070334L - 4,6-disubstituerte pyrimidiner og deres anvendelse som proteinkinaseinhibitorer - Google Patents
4,6-disubstituerte pyrimidiner og deres anvendelse som proteinkinaseinhibitorerInfo
- Publication number
- NO20070334L NO20070334L NO20070334A NO20070334A NO20070334L NO 20070334 L NO20070334 L NO 20070334L NO 20070334 A NO20070334 A NO 20070334A NO 20070334 A NO20070334 A NO 20070334A NO 20070334 L NO20070334 L NO 20070334L
- Authority
- NO
- Norway
- Prior art keywords
- protein kinase
- kinase inhibitors
- disubstituted pyrimidines
- pyrimidines
- disubstituted
- Prior art date
Links
- -1 4,6-disubstituted pyrimidines Chemical class 0.000 title 1
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title 1
- 239000003909 protein kinase inhibitor Substances 0.000 title 1
- 108091008611 Protein Kinase B Proteins 0.000 abstract 2
- 102000001708 Protein Isoforms Human genes 0.000 abstract 1
- 108010029485 Protein Isoforms Proteins 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 102000005765 Proto-Oncogene Proteins c-akt Human genes 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04103011 | 2004-06-28 | ||
| EP05102355 | 2005-03-23 | ||
| PCT/EP2005/053019 WO2006000589A1 (fr) | 2004-06-28 | 2005-06-28 | Pyrimidines 4,6-disubstituees et leur utilisation comme inhibiteurs des proteines kinases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20070334L true NO20070334L (no) | 2007-03-28 |
Family
ID=34973043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20070334A NO20070334L (no) | 2004-06-28 | 2007-01-18 | 4,6-disubstituerte pyrimidiner og deres anvendelse som proteinkinaseinhibitorer |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7879853B2 (fr) |
| EP (1) | EP1763526B1 (fr) |
| JP (1) | JP5065017B2 (fr) |
| KR (1) | KR20070027723A (fr) |
| CN (1) | CN1972934A (fr) |
| AT (1) | ATE434614T1 (fr) |
| AU (1) | AU2005256659A1 (fr) |
| BR (1) | BRPI0512547A (fr) |
| CA (1) | CA2570552A1 (fr) |
| DE (1) | DE602005015110D1 (fr) |
| ES (1) | ES2328601T3 (fr) |
| IL (1) | IL179883A0 (fr) |
| MX (1) | MXPA06014747A (fr) |
| NO (1) | NO20070334L (fr) |
| WO (1) | WO2006000589A1 (fr) |
| ZA (1) | ZA200609637B (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6907921B2 (en) | 1998-06-18 | 2005-06-21 | 3M Innovative Properties Company | Microchanneled active fluid heat exchanger |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| WO2008006032A1 (fr) | 2006-07-06 | 2008-01-10 | Array Biopharma Inc. | Cyclopenta [d] pyrimidines utiles en tant qu'inhibiteurs de la protéine kinase akt |
| SG158147A1 (en) | 2006-10-09 | 2010-01-29 | Takeda Pharmaceutical | Kinase inhibitors |
| US20090012434A1 (en) * | 2007-07-03 | 2009-01-08 | Anderson Robert S | Apparatus, method, and system to treat a volume of skin |
| CA2702674C (fr) * | 2007-10-19 | 2016-05-03 | Avila Therapeutics, Inc. | Composes heteroaryles et leurs utilisations |
| PL2694073T3 (pl) | 2011-04-01 | 2019-06-28 | Genentech, Inc. | Kombinacje inhibitorów AKT i MEK do leczenia nowotworu |
| ES2620644T3 (es) | 2011-04-01 | 2017-06-29 | Genentech, Inc. | Combinaciones de compuestos inhibidores de AKT y agentes quimioterapéuticos, y métodos de uso |
| WO2013063401A1 (fr) * | 2011-10-28 | 2013-05-02 | Celgene Avilomics Research, Inc. | Méthodes de traitement d'une maladie ou d'une affection associée à la tyrosine-kinase btk (bruton's tyrosine kinase) |
| AU2012321091B2 (en) * | 2011-10-28 | 2016-05-12 | Celgene Avilomics Research, Inc. | Methods of treating a Bruton's Tyrosine Kinase disease or disorder |
| AU2013243506A1 (en) * | 2012-04-04 | 2014-10-09 | Amgen Inc. | Heterocyclic compounds and their uses |
| JP2016509012A (ja) | 2013-02-08 | 2016-03-24 | セルジーン アビロミクス リサーチ， インコーポレイテッド | Ｅｒｋ阻害剤およびそれらの使用 |
| WO2015013579A1 (fr) | 2013-07-26 | 2015-01-29 | Update Pharma Inc. | Compositions permettant d'améliorer l'avantage thérapeutique du bisantrène |
| US9492471B2 (en) | 2013-08-27 | 2016-11-15 | Celgene Avilomics Research, Inc. | Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase |
| CN103601675B (zh) * | 2013-10-08 | 2015-10-28 | 南京复兴生物科技有限公司 | 一种5-氨甲基烟酸的制备方法 |
| CN103483250B (zh) * | 2013-10-08 | 2015-07-22 | 南京复兴生物科技有限公司 | 一种5-氨甲基烟酸的制备方法 |
| ES2741785T3 (es) | 2014-08-13 | 2020-02-12 | Celgene Car Llc | Formas y composiciones de un inhibidor de ERK |
| CN113509471B (zh) * | 2021-07-19 | 2023-06-13 | 中国药科大学 | Akt2抑制剂在制备治疗阿霉素引发心肌损伤药物中的应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW321649B (fr) * | 1994-11-12 | 1997-12-01 | Zeneca Ltd | |
| ZA986732B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| CZ20001709A3 (cs) | 1997-11-11 | 2001-12-12 | Pfizer Products Inc. | Deriváty thienopyrimidu a thienopyridinu, farmaceutické kompozice a způsoby léčení na jejich bázi |
| GB9924092D0 (en) | 1999-10-13 | 1999-12-15 | Zeneca Ltd | Pyrimidine derivatives |
| ES2335265T3 (es) | 1999-12-28 | 2010-03-24 | Pharmacopeia, Inc. | Inhibidores de citoquina, especialmente de tnf-alfa. |
| US20020065270A1 (en) * | 1999-12-28 | 2002-05-30 | Moriarty Kevin Joseph | N-heterocyclic inhibitors of TNF-alpha expression |
| CN1468225A (zh) | 2000-08-08 | 2004-01-14 | ����-������ҩƷ��˾ | 4-嘧啶胺衍生物、药用组合物和相关方法 |
| AR035967A1 (es) | 2001-05-18 | 2004-07-28 | Altana Pharma Ag | Un compuesto de piridilmetilaminopirimidina, un medicamento que lo comprende y el uso del mismo |
| CN100491371C (zh) | 2001-11-01 | 2009-05-27 | 詹森药业有限公司 | 用作糖原合酶激酶3β抑制剂(GSK3抑制剂)的杂芳胺化合物 |
| PL368917A1 (en) | 2001-11-01 | 2005-04-04 | Janssen Pharmaceutica N.V. | Amide derivatives as glycogen synthase kinase 3-beta inhibitors |
| US20030187026A1 (en) * | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
| JP4508645B2 (ja) | 2002-01-04 | 2010-07-21 | ザ ロックフェラー ユニバーシティー | アミロイド−βペプチド関連疾患の予防および治療用の組成物および方法 |
| DK2316831T3 (da) | 2002-11-21 | 2013-06-10 | Novartis Ag | 2-(Morpholin-4-yl)pyrimidiner som phosphotidylinositol (PI)-3-kinaseinhibitorer samt deres anvendelse ved behandling af cancer |
| US8084457B2 (en) * | 2003-09-15 | 2011-12-27 | Lead Discovery Center Gmbh | Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases |
| US20080242681A1 (en) | 2004-01-22 | 2008-10-02 | Altana Pharma Ag | N-4-(6-(Hetero)Aryl-Pyrimidin-4-Ylaminophenyl)-Benzenesulfonamides as Kinase Inhibitors |
| EP1901747A2 (fr) * | 2005-05-25 | 2008-03-26 | Ingenium Pharmaceuticals AG | Inhibiteurs du cdk bases sur des pyrimidines destines au traitement de la douleur |
-
2005
- 2005-06-28 CA CA002570552A patent/CA2570552A1/fr not_active Abandoned
- 2005-06-28 WO PCT/EP2005/053019 patent/WO2006000589A1/fr active Application Filing
- 2005-06-28 CN CNA2005800205458A patent/CN1972934A/zh active Pending
- 2005-06-28 MX MXPA06014747A patent/MXPA06014747A/es not_active Application Discontinuation
- 2005-06-28 EP EP05769611A patent/EP1763526B1/fr not_active Expired - Lifetime
- 2005-06-28 AT AT05769611T patent/ATE434614T1/de not_active IP Right Cessation
- 2005-06-28 JP JP2007517306A patent/JP5065017B2/ja not_active Expired - Fee Related
- 2005-06-28 BR BRPI0512547-2A patent/BRPI0512547A/pt not_active IP Right Cessation
- 2005-06-28 US US11/630,352 patent/US7879853B2/en not_active Expired - Fee Related
- 2005-06-28 AU AU2005256659A patent/AU2005256659A1/en not_active Abandoned
- 2005-06-28 KR KR1020077001451A patent/KR20070027723A/ko not_active Withdrawn
- 2005-06-28 DE DE602005015110T patent/DE602005015110D1/de not_active Expired - Lifetime
- 2005-06-28 ES ES05769611T patent/ES2328601T3/es not_active Expired - Lifetime
-
2006
- 2006-11-20 ZA ZA200609637A patent/ZA200609637B/xx unknown
- 2006-12-06 IL IL179883A patent/IL179883A0/en unknown
-
2007
- 2007-01-18 NO NO20070334A patent/NO20070334L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE602005015110D1 (de) | 2009-08-06 |
| JP2008504251A (ja) | 2008-02-14 |
| US20070208034A1 (en) | 2007-09-06 |
| US7879853B2 (en) | 2011-02-01 |
| EP1763526A1 (fr) | 2007-03-21 |
| WO2006000589A1 (fr) | 2006-01-05 |
| ES2328601T3 (es) | 2009-11-16 |
| ZA200609637B (en) | 2008-08-27 |
| JP5065017B2 (ja) | 2012-10-31 |
| CN1972934A (zh) | 2007-05-30 |
| ATE434614T1 (de) | 2009-07-15 |
| AU2005256659A1 (en) | 2006-01-05 |
| MXPA06014747A (es) | 2007-02-16 |
| BRPI0512547A (pt) | 2008-03-25 |
| EP1763526B1 (fr) | 2009-06-24 |
| CA2570552A1 (fr) | 2006-01-05 |
| WO2006000589A8 (fr) | 2006-11-16 |
| KR20070027723A (ko) | 2007-03-09 |
| IL179883A0 (en) | 2007-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CREP | Change of representative |
Representative=s name: PLOUGMANN & VINGTOFT, POSTBOKS 1003 SENTRUM, 0104 |
|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |