+

NO20065957L - Metastinderivater og anvendelse derav - Google Patents

Metastinderivater og anvendelse derav

Info

Publication number
NO20065957L
NO20065957L NO20065957A NO20065957A NO20065957L NO 20065957 L NO20065957 L NO 20065957L NO 20065957 A NO20065957 A NO 20065957A NO 20065957 A NO20065957 A NO 20065957A NO 20065957 L NO20065957 L NO 20065957L
Authority
NO
Norway
Prior art keywords
metastine
derivatives
secretion
cancer
activity
Prior art date
Application number
NO20065957A
Other languages
English (en)
Norwegian (no)
Inventor
Chieko Kitada
Taiji Asami
Naoki Nishizawa
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34971534&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20065957(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of NO20065957L publication Critical patent/NO20065957L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Biophysics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
NO20065957A 2004-06-25 2006-12-21 Metastinderivater og anvendelse derav NO20065957L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2004187671 2004-06-25
JP2004363311 2004-12-15
PCT/JP2005/012021 WO2006001499A2 (fr) 2004-06-25 2005-06-23 Derives de metastine et leur utilisation

Publications (1)

Publication Number Publication Date
NO20065957L true NO20065957L (no) 2007-01-25

Family

ID=34971534

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20065957A NO20065957L (no) 2004-06-25 2006-12-21 Metastinderivater og anvendelse derav

Country Status (20)

Country Link
US (2) US7625869B2 (fr)
EP (2) EP2113513B1 (fr)
JP (3) JP4346650B2 (fr)
CN (2) CN101845091A (fr)
AR (1) AR049938A1 (fr)
AU (1) AU2005257484A1 (fr)
BR (1) BRPI0512397A (fr)
CA (1) CA2571420A1 (fr)
CL (1) CL2008003730A1 (fr)
CR (1) CR8828A (fr)
IL (1) IL179640A0 (fr)
MA (1) MA28903B1 (fr)
MX (1) MXPA06014206A (fr)
NO (1) NO20065957L (fr)
NZ (1) NZ552029A (fr)
PE (2) PE20091567A1 (fr)
RU (1) RU2006145886A (fr)
SG (1) SG153865A1 (fr)
TW (1) TW200607816A (fr)
WO (1) WO2006001499A2 (fr)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE385193T1 (de) 2002-03-20 2008-02-15 Mannkind Corp Inhalationsgerät
KR20050090420A (ko) 2002-12-26 2005-09-13 다케다 야쿠힌 고교 가부시키가이샤 메타스틴 유도체 및 이의 용도
WO2004080479A1 (fr) 2003-03-12 2004-09-23 Takeda Pharmaceutical Company Limited Agents ameliorant la fonction gonadique
NZ550119A (en) 2004-04-08 2009-10-30 Biomatrica Inc Method for storing biological material in a dissolvable matrix
AU2005257484A1 (en) 2004-06-25 2006-01-05 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
AU2005277208B2 (en) 2004-08-20 2011-11-24 Mannkind Corporation Catalysis of diketopiperazine synthesis
ES2540886T3 (es) 2004-08-23 2015-07-14 Mannkind Corporation Sales de dicetopiperazina para la administración de fármacos
EP2656836B1 (fr) 2005-09-14 2017-07-26 MannKind Corporation Procédé de formulation de médicament sur la base de l'augmentation de l'affinité des surfaces de microparticules cristallines pour des agents actifs
AR058584A1 (es) * 2005-12-22 2008-02-13 Takeda Pharmaceutical Derivados de metastina y uso de los mismos
US8404643B2 (en) * 2005-12-22 2013-03-26 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
US20090093615A1 (en) * 2005-12-22 2009-04-09 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
US8039431B2 (en) 2006-02-22 2011-10-18 Mannkind Corporation Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
WO2007125619A1 (fr) * 2006-04-26 2007-11-08 Kyoto University Nouveau compose ayant une activite agoniste de gpr54
ITMI20061607A1 (it) 2006-08-09 2008-02-10 Maria Vincenza Carriero Peptidi con attivita farmacologica
JO3048B1 (ar) * 2006-10-25 2016-09-05 Takeda Pharmaceuticals Co مشتقات متاستين واستخدامها
CN101528772B (zh) * 2006-10-25 2013-03-13 武田药品工业株式会社 Metastin衍生物及其用途
JPWO2009131191A1 (ja) * 2008-04-24 2011-08-25 武田薬品工業株式会社 メタスチン誘導体およびその用途
WO2009139298A1 (fr) * 2008-04-30 2009-11-19 国立大学法人京都大学 Dérivé de metastine et son utilisation
EP2567723B1 (fr) 2008-06-13 2021-01-20 MannKind Corporation Inhalateur de poudre sèche et système d'administration de médicament
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
RU2470681C2 (ru) 2008-06-20 2012-12-27 Маннкайнд Корпорейшн Интерактивное устройство и способ профилирования усилий при ингаляции в реальном масштабе времени
PL2314609T3 (pl) * 2008-07-30 2017-07-31 Takeda Pharmaceutical Company Limited Pochodne metastyny i ich zastosowanie
MA32935B1 (fr) * 2008-12-29 2012-01-02 Takeda Pharmaceutical Agent prophylactique/therapeutique pour le cancer
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US8716228B2 (en) 2009-05-27 2014-05-06 Yeda Research And Development Co. Ltd. GPR54 agonists or antagonists for treatment of diseases presenting behavioral abnormalities
AR079657A1 (es) 2009-12-22 2012-02-08 Takeda Pharmaceutical Formulacion de liberacion sostenida
BR112012033060A2 (pt) 2010-06-21 2018-02-27 Mannkind Corp métodos de sistema de liberação de fármaco em pó seco
US9376709B2 (en) 2010-07-26 2016-06-28 Biomatrica, Inc. Compositions for stabilizing DNA and RNA in blood and other biological samples during shipping and storage at ambient temperatures
CA2806734A1 (fr) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions de stabilisation d'adn, d'arn, de proteines salivaires et d'autres echantillons biologiques lors du transport et du stockage a temperatures ambiantes
SG10201606220QA (en) 2011-04-01 2016-09-29 Mannkind Corp Blister package for pharmaceutical cartridges
WO2012174472A1 (fr) 2011-06-17 2012-12-20 Mannkind Corporation Microparticules de dicétopipérazine de capacité élevée
WO2013017631A1 (fr) 2011-08-04 2013-02-07 Msd Oss B.V. Conjugué kisspeptide-pentasaccharide
CN103945859A (zh) * 2011-10-24 2014-07-23 曼金德公司 用于治疗疼痛的方法和组合物
EP2825548A4 (fr) 2012-03-14 2016-02-24 Yeda Res & Dev Peptides de kisspeptine modifiés et leurs utilisations
SG11201500218VA (en) 2012-07-12 2015-03-30 Mannkind Corp Dry powder drug delivery systems and methods
US9725703B2 (en) 2012-12-20 2017-08-08 Biomatrica, Inc. Formulations and methods for stabilizing PCR reagents
WO2014119753A1 (fr) * 2013-01-31 2014-08-07 学校法人 東京薬科大学 Peptide inhibiteur de la myostatine
CN105451716A (zh) 2013-07-18 2016-03-30 曼金德公司 热稳定性干粉药物组合物和方法
WO2015112703A1 (fr) * 2014-01-22 2015-07-30 The Johns Hopkins University Compositions et méthodes de traitement du diabète
WO2015148905A1 (fr) 2014-03-28 2015-10-01 Mannkind Corporation Utilisation d'insuline à action ultrarapide
JP6661554B2 (ja) 2014-06-10 2020-03-11 バイオマトリカ，インク． 周囲温度における血小板の安定化
WO2017100212A1 (fr) 2015-12-08 2017-06-15 Biomatrica, Inc. Réduction de vitesse de sédimentation des érythrocytes
IL311335A (en) 2016-09-30 2024-05-01 Sumitomo Pharma Switzerland Gmbh Methods for treating female infertility
JP7215755B2 (ja) 2017-07-05 2023-01-31 エックスディーシーエクスプローラー （シャンハイ） カンパニー リミテッド ペプチド類化合物、その使用及びそれを含む組成物
CN108752233B (zh) * 2018-07-18 2020-10-16 河北师范大学 小分子凝胶因子、凝胶材料及制备方法和应用
CN115515937A (zh) * 2020-05-08 2022-12-23 范因斯坦医学研究院 用于合成肽模拟物的二聚体

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1524747A (en) * 1976-05-11 1978-09-13 Ici Ltd Polypeptide
FR2488253A1 (fr) * 1980-08-08 1982-02-12 Roques Bernard Nouveaux peptides et leur application en therapeutique
IL74827A (en) * 1984-05-21 1989-06-30 Salk Inst For Biological Studi Peptides active as gnrh antagonists and pharmaceutical compositions containing them
MX9100717A (es) * 1990-08-24 1992-04-01 Syntex Inc Antagonistas de la bradiquinina
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
EP0876349B1 (fr) 1995-10-19 2002-09-11 Takeda Chemical Industries, Ltd. Derives de la quinoleine en tant qu'antagonistes du gn-rh
JPH09169735A (ja) 1995-10-19 1997-06-30 Takeda Chem Ind Ltd キノリン誘導体、その製造法および用途
WO1997040071A1 (fr) 1996-04-19 1997-10-30 Novo Nordisk A/S Composes capables de liberer une hormone de croissance
WO1998039448A2 (fr) 1997-03-07 1998-09-11 Human Genome Sciences, Inc. 186 nouvelles proteines secretees
JP4486187B2 (ja) 1998-10-27 2010-06-23 武田薬品工業株式会社 新規ｇ蛋白質共役型レセプター蛋白質、そのｄｎａおよびそのリガンド
US6528054B1 (en) 1998-12-28 2003-03-04 Corixa Corporation Compositions and methods for the therapy and diagnosis of breast cancer
JP3822822B2 (ja) 1999-06-28 2006-09-20 ビーエーエスエフ アクチェンゲゼルシャフト 腫瘍の成長を予防する方法
US6638906B1 (en) 1999-12-13 2003-10-28 Nobex Corporation Amphiphilic polymers and polypeptide conjugates comprising same
CN1411509A (zh) 1999-12-17 2003-04-16 武田药品工业株式会社 Kiss－1肽的制造方法
JP2001231581A (ja) * 1999-12-17 2001-08-28 Takeda Chem Ind Ltd ＫｉＳＳ−１ペプチドの製造法
CZ20023567A3 (cs) 2000-03-29 2003-11-12 Corixa Corporation Sloučeniny a způsoby pro terapii a diagnostiku karcinomu plic
CA2404257A1 (fr) 2000-03-30 2001-10-11 Takeda Chemical Industries, Ltd. Nouvelle proteine, adn codant pour celle-ci, et son procede de production
US7834141B1 (en) 2000-03-31 2010-11-16 Theresa Siler-Khodr Non-mammalian GnRH analogs and uses thereof in tumor cell growth regulation and cancer therapy
RU2311920C2 (ru) 2000-09-20 2007-12-10 Корикса Корпорейшн Композиции и способы для лечения и диагностики рака легких
JP2003026601A (ja) 2000-11-29 2003-01-29 Takeda Chem Ind Ltd 医薬組成物およびその製造法
JP2002320496A (ja) 2001-02-26 2002-11-05 Takeda Chem Ind Ltd 新規マウス型ＫｉＳＳ−１レセプタータンパク質およびそのＤＮＡ
WO2002085399A1 (fr) 2001-04-20 2002-10-31 Takeda Chemical Industries, Ltd. Preparations contenant un peptide
US20040185525A1 (en) * 2001-05-17 2004-09-23 Osamu Nishimura Process for producing peptide
WO2003027149A1 (fr) 2001-09-19 2003-04-03 Takeda Chemical Industries, Ltd. Anticorps et utilisation de ce dernier
US20050176091A1 (en) * 2002-01-11 2005-08-11 Takao Yamada Process for producing kiss-1 peptide
JP2003300906A (ja) 2002-04-12 2003-10-21 Daiichi Fine Chemical Co Ltd がん転移抑制因子の安定化
CA2501556A1 (fr) * 2002-10-09 2004-04-29 Kyowa Hakko Kogyo Co., Ltd. Remede destine a un cancer hormono-dependant
AU2003301569A1 (en) 2002-10-25 2004-05-13 Paradigm Therapeutics Limited Gpr54 knock-out mammals and screening methods using them
KR20050090420A (ko) * 2002-12-26 2005-09-13 다케다 야쿠힌 고교 가부시키가이샤 메타스틴 유도체 및 이의 용도
JP4804714B2 (ja) 2002-12-26 2011-11-02 武田薬品工業株式会社 メタスチン誘導体およびその用途
US6800611B2 (en) * 2003-01-06 2004-10-05 Takeda Chemical Industries, Ltd. Metastin derivatives and their use
KR100595364B1 (ko) 2003-02-20 2006-07-03 재단법인 목암생명공학연구소 Ｌｋ8 단백질을 유효성분으로 포함하는 항암제
WO2004080479A1 (fr) 2003-03-12 2004-09-23 Takeda Pharmaceutical Company Limited Agents ameliorant la fonction gonadique
EP1464652A1 (fr) 2003-04-02 2004-10-06 Institut National De La Sante Et De La Recherche Medicale (Inserm) Agoniste et antagoniste du récepteur GPR54 utiles pour le traitement des maladies associées à la gonadotrophine
US20050002935A1 (en) 2003-04-17 2005-01-06 Vincent Ling Use of B7-H3 as an immunoregulatory agent
US20050026224A1 (en) 2003-04-28 2005-02-03 Follettie Maximillian T. Methods and compositions for modulating G-protein coupled receptor 54
WO2004101747A2 (fr) 2003-05-07 2004-11-25 The General Hospital Corporation Identification et utilisation de gpr54 et de ses ligands pour les troubles de la reproduction et la contraception
ATE399763T1 (de) 2003-05-30 2008-07-15 Prozymex As Proteasehemmer
RU2333221C2 (ru) 2003-11-03 2008-09-10 Бейцзин Санбио Байотек Ко., Лтд. Рекомбинантный белок, обладающий противораковым действием, кодирующий его ген и его применение
BRPI0318594B8 (pt) 2003-11-03 2021-05-25 Beijing Sunbio Biotech Co Ltd proteína recombinante que possui um efeito anticâncer, seu gene de codificação, seu uso, medicamento para tratar cânceres, vetor de expressão e microrganismo transgênico
WO2005095973A2 (fr) 2004-03-25 2005-10-13 Bayer Healthcare Ag Methodes diagnostiques et therapeutiques pour des maladies associees au recepteur 54 couple a la proteine g (gpr54)
CA2562676A1 (fr) 2004-04-23 2005-12-15 Applied Research Systems Ars Holding N.V. Utilisation de ligands gpcr54 pour le traitement de l'infertilite
AU2005257484A1 (en) 2004-06-25 2006-01-05 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
WO2007084211A2 (fr) 2005-11-11 2007-07-26 The General Hospital Corporation Utilisation de ligands du gpr54 pour le traitement de troubles de la reproduction, de troubles proliferatifs et pour la contraception
AR058584A1 (es) * 2005-12-22 2008-02-13 Takeda Pharmaceutical Derivados de metastina y uso de los mismos
US20090099334A1 (en) * 2005-12-22 2009-04-16 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
US8404643B2 (en) * 2005-12-22 2013-03-26 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
US20090093615A1 (en) * 2005-12-22 2009-04-09 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
MX2008012055A (es) 2006-03-20 2008-10-02 Merck & Co Inc Agonistas del receptor de neuromedina u y usos de los mismos.
AU2007231553B2 (en) * 2006-03-28 2012-10-25 Molecular Discovery Systems Agent for the treatment of hormone-dependent disorders and uses thereof
JO3048B1 (ar) * 2006-10-25 2016-09-05 Takeda Pharmaceuticals Co مشتقات متاستين واستخدامها
JPWO2009044918A1 (ja) * 2007-10-05 2011-02-17 武田薬品工業株式会社 ニューロメジンｕ誘導体
JPWO2009131191A1 (ja) 2008-04-24 2011-08-25 武田薬品工業株式会社 メタスチン誘導体およびその用途
WO2010033224A1 (fr) 2008-09-19 2010-03-25 Nektar Therapeutics Conjugués de polymère de peptides kiss1

Also Published As

Publication number Publication date
AU2005257484A1 (en) 2006-01-05
BRPI0512397A (pt) 2008-03-04
EP2113513A3 (fr) 2010-11-03
TW200607816A (en) 2006-03-01
NZ552029A (en) 2009-01-31
CR8828A (es) 2007-07-19
JP2008506632A (ja) 2008-03-06
CN101845091A (zh) 2010-09-29
EP1758932A2 (fr) 2007-03-07
EP2113513B1 (fr) 2016-05-18
US8778871B2 (en) 2014-07-15
JP2009024028A (ja) 2009-02-05
IL179640A0 (en) 2007-05-15
JP2009227687A (ja) 2009-10-08
CL2008003730A1 (es) 2009-05-04
US7625869B2 (en) 2009-12-01
JP4654284B2 (ja) 2011-03-16
CN101863971A (zh) 2010-10-20
WO2006001499A2 (fr) 2006-01-05
EP2113513A2 (fr) 2009-11-04
PE20091567A1 (es) 2009-11-03
US20090298765A1 (en) 2009-12-03
JP4346650B2 (ja) 2009-10-21
SG153865A1 (en) 2009-07-29
CA2571420A1 (fr) 2006-01-05
WO2006001499A3 (fr) 2006-03-02
MA28903B1 (fr) 2007-10-01
RU2006145886A (ru) 2008-06-27
AR049938A1 (es) 2006-09-13
MXPA06014206A (es) 2007-02-14
US20080312155A1 (en) 2008-12-18
PE20060371A1 (es) 2006-06-15

Similar Documents

Publication Publication Date Title
NO20065957L (no) Metastinderivater og anvendelse derav
EA200870446A1 (ru) Пиридон сульфонамиды и пиридон сульфамиды в качестве ингибиторов мек
DK3911648T3 (da) 6'-[[(1s,3s)-3-[[5-(difluormethoxy)-2-pyrimidinyl]amino]cyclopentyl]amino][1(2h),3'-bipyridin]-2-on som pcsk9-hæmmer og fremgangsmåder til anvendelse deraf
DK1751302T3 (da) Analytsensorer og fremgangsmåder til fremstilling og anvendelse heraf
EA200801291A1 (ru) Карбониламинопирролопиразолы в качестве эффективных ингибиторов киназ
DK2089369T3 (da) 2,4-pyrimidindiaminderivater som hæmmere af JAK-kinaser til behandling af autoimmune sygdomme
NO20082595L (no) Metastinderivater og deres anvendelse derav
WO2009143024A3 (fr) Composés et procédés de modulation des kinases, et indications associées
EA200700333A1 (ru) Терапевтические применения ингибиторов rtp801
MX2009006267A (es) Derivados de dihidropiridina de utilidad como inhibidores de la proteina quinasa.
ATE543907T1 (de) Stresstolerante baumwollpflanzen
NO20043259L (no) Bindingsproteiner som biosensorer
MXPA06011327A (es) Azaindoles utiles como inhibidores de jak y otras proteinas cinasas.
UA95244C2 (ru) Соединения и способ модулирования активности киназ, и показания для их применения
NO20062876L (no) Sammensetninger til kombinert radio- og kjemoterapi, og fremgangsmater
EP1584923A3 (fr) Stabilisation de biomolecules dans des échantillons
TN2009000140A1 (en) Metastin derivatives and use thereof
TW200745047A (en) Heterocyclic compounds
MX2008001538A (es) Aril piridinas y metodos para su uso.
EA200800357A1 (ru) Новые фармацевтические соединения
MX2014001157A (es) Agonistas de proteína-tirosina-fosfatasa-1 que contiene homología src-2 y métodos de tratamiento que usan los mismos.
EA200800253A1 (ru) Бессывороточная культуральная среда для получения рекомбинантных гонадотропинов
EA200700702A1 (ru) Аналоги локсапина и способы их применения
EA202092487A1 (ru) Ферменты кинурениназы человека и их применение
NO20081713L (no) Pyrimidinderivater og deres anvendelse som KCNQ-kaliumkanalapnere

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application
点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载