NO20063676L - Indolderivater og anvendelse derav som kinaseinhibitorer i spesielle IKK2 inhibitorer - Google Patents

Indolderivater og anvendelse derav som kinaseinhibitorer i spesielle IKK2 inhibitorer

Info

Publication number: NO20063676L
Authority: NO; Norway
Prior art keywords: inhibitors; indole derivatives; kinase inhibitors; particular ikk2; kinase
Prior art date: 2004-01-15

Application number

NO20063676A

Other languages

English (en)

Norwegian (no)

Inventor

Paul Bamborough

Lan Robert Baldwin

John Andrew Christopher

Jeffrey K Kerns

Timothy Longstaff

David Drysdale Miller

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-01-15

Filing date

2006-08-15

Publication date

2006-10-13

2006-08-15 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

2006-10-13 Publication of NO20063676L publication Critical patent/NO20063676L/no

Links

102100021854 Inhibitor of nuclear factor kappa-B kinase subunit beta Human genes 0.000 title abstract 2
101710205525 Inhibitor of nuclear factor kappa-B kinase subunit beta Proteins 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title abstract 2
229940054051 antipsychotic indole derivative Drugs 0.000 title 1
150000002475 indoles Chemical class 0.000 title 1
229940043355 kinase inhibitor Drugs 0.000 title 1
239000003757 phosphotransferase inhibitor Substances 0.000 title 1
230000000694 effects Effects 0.000 abstract 2
VFHUJFBEFDVZPJ-UHFFFAOYSA-N 1h-indole-2-carboxamide Chemical class C1=CC=C2NC(C(=O)N)=CC2=C1 VFHUJFBEFDVZPJ-UHFFFAOYSA-N 0.000 abstract 1
108091000080 Phosphotransferase Proteins 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000002757 inflammatory effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
102000020233 phosphotransferase Human genes 0.000 abstract 1
230000017423 tissue regeneration Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- C—CHEMISTRY; METALLURGY
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- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Neurosurgery (AREA)
Dermatology (AREA)
Neurology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Virology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Endocrinology (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)

NO20063676A 2004-01-15 2006-08-15 Indolderivater og anvendelse derav som kinaseinhibitorer i spesielle IKK2 inhibitorer NO20063676L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0400895.9A GB0400895D0 (en)	2004-01-15	2004-01-15	Chemical compounds
PCT/GB2005/000085 WO2005067923A1 (fr)	2004-01-15	2005-01-13	Derives d'indole et utilisation de ceux-ci comme inhibiteurs de kinase, notamment des inhibiteurs de ikk2

Publications (1)

Publication Number	Publication Date
NO20063676L true NO20063676L (no)	2006-10-13

Family

ID=31726240

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20063676A NO20063676L (no)	2004-01-15	2006-08-15	Indolderivater og anvendelse derav som kinaseinhibitorer i spesielle IKK2 inhibitorer

Country Status (24)

Country	Link
US (1)	US20080269200A1 (fr)
EP (1)	EP1703905B1 (fr)
JP (2)	JP4975447B2 (fr)
KR (1)	KR20070026357A (fr)
CN (1)	CN1933830A (fr)
AT (1)	ATE413877T1 (fr)
AU (1)	AU2005205090A1 (fr)
BR (1)	BRPI0506802A (fr)
CA (1)	CA2552953A1 (fr)
DE (1)	DE602005010970D1 (fr)
DK (1)	DK1703905T3 (fr)
ES (1)	ES2317184T3 (fr)
GB (1)	GB0400895D0 (fr)
HK (1)	HK1098047A1 (fr)
HR (1)	HRP20090071T3 (fr)
IL (1)	IL176739A0 (fr)
MA (1)	MA28279A1 (fr)
NO (1)	NO20063676L (fr)
PL (1)	PL1703905T3 (fr)
PT (1)	PT1703905E (fr)
RU (1)	RU2006129492A (fr)
SI (1)	SI1703905T1 (fr)
WO (1)	WO2005067923A1 (fr)
ZA (1)	ZA200604855B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
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AR050253A1 (es) *	2004-06-24	2006-10-11	Smithkline Beecham Corp	Compuesto derivado de indazol carboxamida, composicion que lo comprende y su uso para la preparacion de un medicamento
PE20060748A1 (es) *	2004-09-21	2006-10-01	Smithkline Beecham Corp	Derivados de indolcarboxamida como inhibidores de quinasa ikk2
US8063071B2 (en)	2007-10-31	2011-11-22	GlaxoSmithKline, LLC	Chemical compounds
AR055343A1 (es) *	2005-06-30	2007-08-22	Smithkline Beecham Corp	Derivados de indolcarboxamida inhibidores de quinasas ikk2
WO2007114848A2 (fr) *	2005-10-25	2007-10-11	Smithkline Beecham Corporation	Composés chimiques
JP2009516702A (ja) *	2005-11-18	2009-04-23	スミスクライン・ビーチャム・コーポレイション	化合物
US20080293802A1 (en) *	2005-12-16	2008-11-27	Smithline Beecham Corporation	Chemical Compounds
JP5070067B2 (ja) *	2007-01-15	2012-11-07	参天製薬株式会社	ＩκＢキナーゼβ阻害活性を有する新規インドール誘導体
PE20081889A1 (es) *	2007-03-23	2009-03-05	Smithkline Beecham Corp	Indol carboxamidas como inhibidores de ikk2
NZ587165A (en) *	2008-02-04	2012-03-30	Mercury Therapeutics Inc	Ampk modulators
EP2253618A1 (fr) *	2008-02-27	2010-11-24	Takeda Pharmaceutical Company Limited	Composé contenant un cycle aromatique à 6 chaînons
WO2010007972A1 (fr) *	2008-07-14	2010-01-21	参天製薬株式会社	Nouveau dérivé d'indole comportant un groupe carbamoyle, un groupe uréido et un groupe oxy substitué
JP2010229128A (ja) *	2009-03-05	2010-10-14	Sumitomo Chemical Co Ltd	ハロゲン置換テレフタル酸ジアミド化合物、その製造方法及び該化合物を用いたハロゲン置換ベンゼンジメタノールの製造方法
WO2010102968A1 (fr)	2009-03-10	2010-09-16	Glaxo Group Limited	Dérivés d'indole comme inhibiteurs de ikk2
WO2012075080A1 (fr) *	2010-12-01	2012-06-07	Glaxosmithkline Llc	Indoles
WO2014036268A2 (fr) *	2012-08-29	2014-03-06	Mount Sinai School Of Medicine	Dérivés d'indole en tant qu'activateurs de la protéine sumo
FR3001219A1 (fr) *	2013-01-22	2014-07-25	Centre Nat Rech Scient	Inhibiteurs de kinases
JP6424173B2 (ja)	2013-02-04	2018-11-14	ヤンセンファーマシューティカエヌ．ベー．	Ｆｌａｐ調節因子
TWI644899B (zh)	2013-02-04	2018-12-21	健生藥品公司	Ｆｌａｐ調節劑
MX355943B (es) *	2013-06-26	2018-05-07	Abbvie Inc	Carboxamidas primarias como inhibidores de btk.
EP3233835B1 (fr) *	2014-12-18	2019-01-23	F.Hoffmann-La Roche Ag	Composés sulfonamide de benzazépine
US20170158702A1 (en) *	2015-12-02	2017-06-08	Kyras Therapeutics, Inc.	Multivalent ras binding compounds
WO2018013430A2 (fr)	2016-07-12	2018-01-18	Arisan Therapeutics Inc.	Composés hétérocycliques pour le traitement d'une infection à arenavirus
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2004
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2005
- 2005-01-13 JP JP2006548393A patent/JP4975447B2/ja not_active Expired - Fee Related
- 2005-01-13 PT PT05701855T patent/PT1703905E/pt unknown
- 2005-01-13 CA CA002552953A patent/CA2552953A1/fr not_active Abandoned
- 2005-01-13 DK DK05701855T patent/DK1703905T3/da active
- 2005-01-13 PL PL05701855T patent/PL1703905T3/pl unknown
- 2005-01-13 SI SI200530567T patent/SI1703905T1/sl unknown
- 2005-01-13 RU RU2006129492/04A patent/RU2006129492A/ru not_active Application Discontinuation
- 2005-01-13 CN CNA2005800083624A patent/CN1933830A/zh active Pending
- 2005-01-13 KR KR1020067014178A patent/KR20070026357A/ko not_active Withdrawn
- 2005-01-13 AT AT05701855T patent/ATE413877T1/de not_active IP Right Cessation
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- 2005-01-13 WO PCT/GB2005/000085 patent/WO2005067923A1/fr active Application Filing
- 2005-01-13 AU AU2005205090A patent/AU2005205090A1/en not_active Abandoned
2006
- 2006-06-13 ZA ZA200604855A patent/ZA200604855B/xx unknown
- 2006-07-03 MA MA29154A patent/MA28279A1/fr unknown
- 2006-07-06 IL IL176739A patent/IL176739A0/en unknown
- 2006-08-15 NO NO20063676A patent/NO20063676L/no not_active Application Discontinuation
2007
- 2007-03-16 HK HK07102877.7A patent/HK1098047A1/xx not_active IP Right Cessation
2009
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Also Published As

Publication number	Publication date
KR20070026357A (ko)	2007-03-08
JP2012025761A (ja)	2012-02-09
HK1098047A1 (en)	2007-07-13
CA2552953A1 (fr)	2005-07-28
IL176739A0 (en)	2006-10-31
ATE413877T1 (de)	2008-11-15
JP4975447B2 (ja)	2012-07-11
RU2006129492A (ru)	2008-02-27
US20080269200A1 (en)	2008-10-30
EP1703905B1 (fr)	2008-11-12
CN1933830A (zh)	2007-03-21
ZA200604855B (en)	2007-11-28
WO2005067923A1 (fr)	2005-07-28
DK1703905T3 (da)	2009-02-16
PL1703905T3 (pl)	2009-04-30
MA28279A1 (fr)	2006-11-01
JP2007517848A (ja)	2007-07-05
BRPI0506802A (pt)	2007-05-29
ES2317184T3 (es)	2009-04-16
PT1703905E (pt)	2009-02-04
SI1703905T1 (sl)	2009-04-30
AU2005205090A1 (en)	2005-07-28
DE602005010970D1 (de)	2008-12-24
GB0400895D0 (en)	2004-02-18
HRP20090071T3 (en)	2009-04-30
EP1703905A1 (fr)	2006-09-27

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