NO20031911L - Inhalation solution formulation with a tiotropium salt - Google Patents
Inhalation solution formulation with a tiotropium saltInfo
- Publication number
- NO20031911L NO20031911L NO20031911A NO20031911A NO20031911L NO 20031911 L NO20031911 L NO 20031911L NO 20031911 A NO20031911 A NO 20031911A NO 20031911 A NO20031911 A NO 20031911A NO 20031911 L NO20031911 L NO 20031911L
- Authority
- NO
- Norway
- Prior art keywords
- solution formulation
- inhalation solution
- tiotropium salt
- propellant
- water
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 238000009472 formulation Methods 0.000 title abstract 3
- 229940041682 inhalant solution Drugs 0.000 title 1
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical class O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- LERNTVKEWCAPOY-VOGVJGKGSA-N C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 Chemical compound C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 LERNTVKEWCAPOY-VOGVJGKGSA-N 0.000 abstract 1
- 239000000443 aerosol Substances 0.000 abstract 1
- 229960000257 tiotropium bromide Drugs 0.000 abstract 1
- MQLXPRBEAHBZTK-SEINRUQRSA-M tiotropium bromide hydrate Chemical compound O.[Br-].C[N+]1(C)[C@H]2C[C@@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 MQLXPRBEAHBZTK-SEINRUQRSA-M 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Otolaryngology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Foreliggende oppfinnelse angår en drivmiddelfri inhalerbar formulering av tiotropiumbromid eller tiotropiumbromidmonohydrat oppløst i vann eller i en blanding av vann og etanol og drivmiddelfrie, inhalerbare aerosol-formuleringer resulterende derfra.The present invention relates to a propellant-free inhalable formulation of tiotropium bromide or tiotropium bromide monohydrate dissolved in water or in a mixture of water and ethanol and propellant-free, inhalable aerosol formulations resulting therefrom.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10054036 | 2000-10-31 | ||
| PCT/EP2001/012292 WO2002036104A2 (en) | 2000-10-31 | 2001-10-24 | Inhalative solution formulation containing a tiotropium salt |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20031911L true NO20031911L (en) | 2003-04-29 |
| NO20031911D0 NO20031911D0 (en) | 2003-04-29 |
| NO332519B1 NO332519B1 (en) | 2012-10-08 |
Family
ID=7661723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20031911A NO332519B1 (en) | 2000-10-31 | 2003-04-29 | Inhalation solution formulation with a tiotropium salt, process for the preparation thereof and such formulations for the treatment of disease |
Country Status (39)
| Country | Link |
|---|---|
| EP (2) | EP1837021A3 (en) |
| JP (1) | JP4344135B2 (en) |
| KR (1) | KR100853107B1 (en) |
| CN (2) | CN100396285C (en) |
| AR (1) | AR038764A1 (en) |
| AT (1) | ATE373473T1 (en) |
| AU (2) | AU2173802A (en) |
| BG (1) | BG66315B1 (en) |
| BR (1) | BRPI0115076B8 (en) |
| CA (1) | CA2426074C (en) |
| CY (1) | CY1107825T1 (en) |
| CZ (1) | CZ300794B6 (en) |
| DE (2) | DE50113037D1 (en) |
| DK (1) | DK1333819T3 (en) |
| EA (1) | EA007604B1 (en) |
| EC (1) | ECSP034541A (en) |
| EE (1) | EE05314B1 (en) |
| ES (1) | ES2294045T3 (en) |
| HK (1) | HK1060524A1 (en) |
| HR (1) | HRP20030338B1 (en) |
| HU (1) | HU229411B1 (en) |
| IL (2) | IL155538A0 (en) |
| ME (1) | ME00244B (en) |
| MX (1) | MXPA03003742A (en) |
| MY (1) | MY138940A (en) |
| NO (1) | NO332519B1 (en) |
| NZ (1) | NZ526023A (en) |
| PE (1) | PE20030092A1 (en) |
| PL (1) | PL203316B1 (en) |
| PT (1) | PT1333819E (en) |
| RS (1) | RS50859B (en) |
| SA (1) | SA01220482B1 (en) |
| SI (1) | SI1333819T1 (en) |
| SK (1) | SK286027B6 (en) |
| TW (1) | TWI293885B (en) |
| UA (1) | UA78690C2 (en) |
| UY (1) | UY26989A1 (en) |
| WO (1) | WO2002036104A2 (en) |
| ZA (1) | ZA200302922B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10216036A1 (en) * | 2002-04-11 | 2003-10-23 | Boehringer Ingelheim Pharma | Aerosol formulation for inhalation containing a tiotropium salt |
| CN1292748C (en) * | 2003-03-05 | 2007-01-03 | 南昌弘益科技有限公司 | Timepidium bromide inhalant powders and their preparing process |
| SI1682541T1 (en) * | 2003-11-03 | 2010-06-30 | Boehringer Ingelheim Int | Method for producing tiotropium salts |
| EP1682543B1 (en) * | 2003-11-03 | 2010-08-18 | Boehringer Ingelheim International Gmbh | Methods for the production of novel tiotropium salts |
| DK1881980T3 (en) | 2005-05-02 | 2012-10-01 | Boehringer Ingelheim Int | New crystalline forms of tiotropium bromide |
| EP2044967A1 (en) * | 2007-10-01 | 2009-04-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Atomiser |
| CN104306361A (en) * | 2014-09-24 | 2015-01-28 | 万特制药(海南)有限公司 | Tiotropium bromide-containing inhalable solution |
| CN111374963A (en) * | 2018-12-31 | 2020-07-07 | 天津药业研究院有限公司 | Tiotropium solution for inhalation |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3931041C2 (en) * | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Esters of thienyl carboxylic acids with amino alcohols, their quaternization products, processes for their preparation and medicaments containing them |
| SG45171A1 (en) * | 1990-03-21 | 1998-01-16 | Boehringer Ingelheim Int | Atomising devices and methods |
| DE19536902A1 (en) * | 1995-10-04 | 1997-04-10 | Boehringer Ingelheim Int | Miniature fluid pressure generating device |
| DE19653969A1 (en) * | 1996-12-20 | 1998-06-25 | Boehringer Ingelheim Kg | New aqueous pharmaceutical preparation for the production of propellant-free aerosols |
| DE19847968A1 (en) * | 1998-10-17 | 2000-04-20 | Boehringer Ingelheim Pharma | Separate storage of an active material and a solvent comprises a closure cap and a container, with a chamber attached to the unit. |
-
2001
- 2001-10-24 AT AT01992567T patent/ATE373473T1/en active
- 2001-10-24 ES ES01992567T patent/ES2294045T3/en not_active Expired - Lifetime
- 2001-10-24 JP JP2002538916A patent/JP4344135B2/en not_active Expired - Lifetime
- 2001-10-24 SK SK527-2003A patent/SK286027B6/en not_active IP Right Cessation
- 2001-10-24 WO PCT/EP2001/012292 patent/WO2002036104A2/en active IP Right Grant
- 2001-10-24 HU HU0301378A patent/HU229411B1/en unknown
- 2001-10-24 BR BRPI0115076A patent/BRPI0115076B8/en not_active IP Right Cessation
- 2001-10-24 CN CNB018183158A patent/CN100396285C/en not_active Expired - Lifetime
- 2001-10-24 EA EA200300482A patent/EA007604B1/en not_active IP Right Cessation
- 2001-10-24 DE DE50113037T patent/DE50113037D1/en not_active Expired - Lifetime
- 2001-10-24 AU AU2173802A patent/AU2173802A/en active Pending
- 2001-10-24 PL PL360405A patent/PL203316B1/en unknown
- 2001-10-24 UA UA2003054959A patent/UA78690C2/en unknown
- 2001-10-24 AU AU2002221738A patent/AU2002221738B2/en not_active Expired
- 2001-10-24 EE EEP200300203A patent/EE05314B1/en unknown
- 2001-10-24 EP EP07111499A patent/EP1837021A3/en not_active Withdrawn
- 2001-10-24 ME MEP-2008-404A patent/ME00244B/en unknown
- 2001-10-24 MX MXPA03003742A patent/MXPA03003742A/en active IP Right Grant
- 2001-10-24 CA CA002426074A patent/CA2426074C/en not_active Expired - Fee Related
- 2001-10-24 SI SI200130774T patent/SI1333819T1/en unknown
- 2001-10-24 CZ CZ20031486A patent/CZ300794B6/en unknown
- 2001-10-24 RS YUP-330/03A patent/RS50859B/en unknown
- 2001-10-24 KR KR1020037006013A patent/KR100853107B1/en not_active Expired - Lifetime
- 2001-10-24 DE DE10152521A patent/DE10152521A1/en not_active Withdrawn
- 2001-10-24 DK DK01992567T patent/DK1333819T3/en active
- 2001-10-24 CN CNA2008100985489A patent/CN101292964A/en active Pending
- 2001-10-24 EP EP01992567A patent/EP1333819B1/en not_active Expired - Lifetime
- 2001-10-24 IL IL15553801A patent/IL155538A0/en active IP Right Grant
- 2001-10-24 PT PT01992567T patent/PT1333819E/en unknown
- 2001-10-24 NZ NZ526023A patent/NZ526023A/en not_active IP Right Cessation
- 2001-10-28 SA SA01220482A patent/SA01220482B1/en unknown
- 2001-10-29 TW TW090126764A patent/TWI293885B/en active
- 2001-10-29 MY MYPI20015000A patent/MY138940A/en unknown
- 2001-10-29 UY UY26989A patent/UY26989A1/en not_active Application Discontinuation
- 2001-10-31 PE PE2001001086A patent/PE20030092A1/en not_active Application Discontinuation
- 2001-10-31 AR ARP010105087A patent/AR038764A1/en not_active Ceased/Invalidation/Refusal/Rejection/Nullification
-
2003
- 2003-04-07 EC EC2003004541A patent/ECSP034541A/en unknown
- 2003-04-14 ZA ZA200302922A patent/ZA200302922B/en unknown
- 2003-04-16 BG BG107727A patent/BG66315B1/en active Active
- 2003-04-21 IL IL155538A patent/IL155538A/en unknown
- 2003-04-28 HR HR20030338A patent/HRP20030338B1/en not_active IP Right Cessation
- 2003-04-29 NO NO20031911A patent/NO332519B1/en not_active IP Right Cessation
-
2004
- 2004-05-20 HK HK04103586A patent/HK1060524A1/en not_active IP Right Cessation
-
2007
- 2007-12-07 CY CY20071101562T patent/CY1107825T1/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |