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NO20030302L - Nye heteroarylderivater og deres anvendelse som medikamenter - Google Patents

Nye heteroarylderivater og deres anvendelse som medikamenter

Info

Publication number
NO20030302L
NO20030302L NO20030302A NO20030302A NO20030302L NO 20030302 L NO20030302 L NO 20030302L NO 20030302 A NO20030302 A NO 20030302A NO 20030302 A NO20030302 A NO 20030302A NO 20030302 L NO20030302 L NO 20030302L
Authority
NO
Norway
Prior art keywords
drugs
heteroaryl derivatives
new heteroaryl
new
derivatives
Prior art date
Application number
NO20030302A
Other languages
English (en)
Norwegian (no)
Other versions
NO20030302D0 (no
Inventor
Peter Emig
Eckhard Guenther
Juergen Schmidt
Bernhard Kutscher
Bernd Nickel
Anita Storch
Original Assignee
Zentaris Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris Ag filed Critical Zentaris Ag
Publication of NO20030302D0 publication Critical patent/NO20030302D0/no
Publication of NO20030302L publication Critical patent/NO20030302L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
NO20030302A 2000-07-21 2003-01-20 Nye heteroarylderivater og deres anvendelse som medikamenter NO20030302L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10035908A DE10035908A1 (de) 2000-07-21 2000-07-21 Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
PCT/EP2001/008262 WO2002008190A2 (fr) 2000-07-21 2001-07-18 Nouveaux derives d'heteroaryle et leur utilisation en tant que medicaments

Publications (2)

Publication Number Publication Date
NO20030302D0 NO20030302D0 (no) 2003-01-20
NO20030302L true NO20030302L (no) 2003-02-07

Family

ID=7649970

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20030302A NO20030302L (no) 2000-07-21 2003-01-20 Nye heteroarylderivater og deres anvendelse som medikamenter

Country Status (21)

Country Link
US (1) US6638935B2 (fr)
EP (1) EP1305289A2 (fr)
JP (1) JP2004516243A (fr)
KR (1) KR20030015894A (fr)
CN (1) CN1447796A (fr)
AR (1) AR032467A1 (fr)
AU (2) AU2001281989B2 (fr)
BG (1) BG107506A (fr)
BR (1) BR0112711A (fr)
CA (1) CA2353353A1 (fr)
DE (1) DE10035908A1 (fr)
HU (1) HUP0300743A2 (fr)
IL (1) IL153931A0 (fr)
MX (1) MXPA03000596A (fr)
NO (1) NO20030302L (fr)
NZ (1) NZ524156A (fr)
PL (1) PL361354A1 (fr)
RU (1) RU2003105238A (fr)
SK (1) SK1942003A3 (fr)
WO (1) WO2002008190A2 (fr)
ZA (1) ZA200300545B (fr)

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CA2512243A1 (fr) * 2003-01-28 2004-09-16 Aventis Pharma S.A. Produits n-aryl-heteroaromatiques, compositions les contenant et utilisation
AR044586A1 (es) * 2003-06-04 2005-09-21 Aventis Pharma Sa Productos aril - heteroaromaticos, composiciones que los contienen y su utilizacion
FR2855825B1 (fr) * 2003-06-04 2008-08-22 Aventis Pharma Sa Produits aryl-heteroaromatiques, compositions les contenant et utilisation
US7592466B2 (en) 2003-10-09 2009-09-22 Abbott Laboratories Ureas having antiangiogenic activity
FR2871157A1 (fr) * 2004-06-04 2005-12-09 Aventis Pharma Sa Produits biaryl aromatiques, compositions les contenant et utilisation
EP1645556A1 (fr) * 2004-10-07 2006-04-12 Boehringer Ingelheim International GmbH Derives d'arylpiperazine-benzoylamide utiles comme agents pharmaceutiques
CA2677096A1 (fr) 2007-01-31 2008-08-07 Vertex Pharmaceuticals Incorporated Inhibiteurs de kinase
WO2008106128A2 (fr) * 2007-02-26 2008-09-04 Vitae Pharmaceuticals, Inc. Inhibiteurs d'urée et de carbamate de 11b-hydroxystéroïde déshydrogénase 1 cycliques
CL2008002199A1 (es) * 2007-07-26 2009-10-23 Vitae Pharmaceuticals Inc Compuestos derivados de 1,3-oxazin-2-ona; composicion farmaceutica que comprende a dichos compuestos; y uso para tratar una enfermedad asociada con la actividad de la 11beta-hidroxiesteroide deshidrogenasa tipo 1 (11beta-hsd1) tales como dislipidemia, hiperlipidemia, hipertension, obesidad y enfermedad cardiovascular, entre otras.
ES2389992T3 (es) 2007-11-02 2012-11-05 Vertex Pharmaceuticals Incorporated Derivados de [1H-pirazolo[3,4-b]piridin-4-il]-fenilo o -piridin-2-ilo como proteína cinasa c-theta
AR069207A1 (es) * 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
CA2708303A1 (fr) 2007-12-11 2009-06-18 Vitae Pharmaceuticals, Inc. Inhibiteurs cycliques d'uree de la 11.beta.-hydroxysteroide dehydrogenase 1
TW200934490A (en) * 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
EP2252601B1 (fr) 2008-01-24 2012-12-19 Vitae Pharmaceuticals, Inc. Carbazate cyclique et inhibiteurs du type semi-carbazide de la 11 -hydroxystéroïde déshydrogénase 1
EP2252598A2 (fr) * 2008-02-11 2010-11-24 Vitae Pharmaceuticals, Inc. Inhibiteurs 1,3-oxazepan-2-one et 1,3-diazepan-2-one de la 11 -hydroxystéroïde déshydrogénase (type1)
CA2715290A1 (fr) * 2008-02-15 2009-08-20 Vitae Pharmaceuticals, Inc. Inhibiteurs de la 11 beta-hydroxysteroide dehydrogenase 1
WO2009117109A1 (fr) * 2008-03-18 2009-09-24 Vitae Pharmaceuticals, Inc. Inhibiteurs de la 11-bêta-hydroxystéroïde déshydrogénase de type 1
EP2291371B1 (fr) 2008-05-01 2015-06-10 Vitae Pharmaceuticals, Inc. Inhibiteurs cycliques de la 11-bêta-hydroxystéroïde déhydrogénase 1
US8592410B2 (en) 2008-05-01 2013-11-26 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11BETA-hydroxysteroid dehydrogenase 1
AR071609A1 (es) 2008-05-01 2010-06-30 Vitae Pharmaceuticals Inc Inhibidores ciclicos de 11(beta) -hidroxiesteroide deshidrogenasa 1
JP5451752B2 (ja) * 2008-05-01 2014-03-26 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
US8569337B2 (en) 2008-07-23 2013-10-29 Vertex Pharmaceuticals Incorporated Tri-cyclic pyrazolopyridine kinase inhibitors
NZ590784A (en) 2008-07-23 2012-12-21 Vertex Pharma Pyrazolopyridine kinase inhibitors
CA2731498A1 (fr) 2008-07-23 2010-01-28 Vertex Pharmaceuticals Incorporated Inhibiteurs de pyrazolopyridine kinase tricylique
WO2010127237A2 (fr) * 2009-04-30 2010-11-04 Boehringer Ingelheim International Gmbh Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
EP2324017B1 (fr) 2008-07-25 2014-12-31 Boehringer Ingelheim International GmbH INHIBITEURS DE LA 11 bêta-HYDROXYSTÉROÏDE DÉSHYDROGÉNASE 1
US8114868B2 (en) 2008-07-25 2012-02-14 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
CN102159546A (zh) * 2008-08-06 2011-08-17 沃泰克斯药物股份有限公司 氨基吡啶激酶抑制剂
US8637505B2 (en) 2009-02-04 2014-01-28 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
TW201039034A (en) * 2009-04-27 2010-11-01 Chunghwa Picture Tubes Ltd Pixel structure and the method of forming the same
US8680093B2 (en) 2009-04-30 2014-03-25 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2760705A1 (fr) 2009-05-06 2010-11-11 Vertex Pharmaceuticals Incorporated Pyrazolopyridines
EP2440537A1 (fr) 2009-06-11 2012-04-18 Vitae Pharmaceuticals, Inc. Inhibiteurs cycliques de la 11-bêta-hydroxystéroïde déshydrogénase 1 basée sur la structure 1,3-oxazinan-2-one
JP5749263B2 (ja) 2009-07-01 2015-07-15 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
WO2011094290A1 (fr) 2010-01-27 2011-08-04 Vertex Pharmaceuticals Incorporated Inhibiteurs des kinases à base de pyrazolopyrimidine
JP2013518113A (ja) 2010-01-27 2013-05-20 バーテックス ファーマシューティカルズ インコーポレイテッド ピラゾロピラジンキナーゼ阻害剤
WO2011094273A1 (fr) 2010-01-27 2011-08-04 Vertex Pharmaceuticals Incorporated Inhibiteurs de la pyrazolopyridine kinase
WO2011159760A1 (fr) 2010-06-16 2011-12-22 Vitae Pharmaceuticals, Inc. Hétérocycles à 5, 6 et 7 chaînons substitués, médicaments contenant ces composés et leur utilisation
JP5813106B2 (ja) 2010-06-25 2015-11-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 代謝障害の処置のための１１−β−ＨＳＤ１のインヒビターとしてのアザスピロヘキサノン
KR20130137628A (ko) 2010-11-02 2013-12-17 베링거 인겔하임 인터내셔날 게엠베하 대사 장애를 치료하기 위한 약제학적 병용물

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EP0318235A3 (fr) * 1987-11-25 1991-05-02 Takeda Chemical Industries, Ltd. Composés de pipérazine PAF-antagoniste 1,4-disubstitués et leur production
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Also Published As

Publication number Publication date
WO2002008190A3 (fr) 2002-08-01
ZA200300545B (en) 2003-02-12
HUP0300743A2 (hu) 2003-10-28
KR20030015894A (ko) 2003-02-25
US20020111354A1 (en) 2002-08-15
RU2003105238A (ru) 2004-08-10
CA2353353A1 (fr) 2002-01-21
JP2004516243A (ja) 2004-06-03
SK1942003A3 (en) 2003-12-02
AU2001281989B2 (en) 2005-05-12
BR0112711A (pt) 2003-05-20
BG107506A (bg) 2003-09-30
DE10035908A1 (de) 2002-03-07
MXPA03000596A (es) 2003-05-14
PL361354A1 (en) 2004-10-04
US6638935B2 (en) 2003-10-28
EP1305289A2 (fr) 2003-05-02
NO20030302D0 (no) 2003-01-20
AR032467A1 (es) 2003-11-12
AU8198901A (en) 2002-02-05
NZ524156A (en) 2005-10-28
CN1447796A (zh) 2003-10-08
WO2002008190A2 (fr) 2002-01-31
IL153931A0 (en) 2003-07-31

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