NO20030033L - Pyrido[2,3-D]pyrimidin- og pyrimido[4,5-D]pyrimidin- nukleosider - Google Patents
Pyrido[2,3-D]pyrimidin- og pyrimido[4,5-D]pyrimidin- nukleosiderInfo
- Publication number
- NO20030033L NO20030033L NO20030033A NO20030033A NO20030033L NO 20030033 L NO20030033 L NO 20030033L NO 20030033 A NO20030033 A NO 20030033A NO 20030033 A NO20030033 A NO 20030033A NO 20030033 L NO20030033 L NO 20030033L
- Authority
- NO
- Norway
- Prior art keywords
- pyrimidine
- pyrimido
- pyrido
- nucleosides
- pyrimidine nucleosides
- Prior art date
Links
- UDJFFSGCRRMVFH-UHFFFAOYSA-N pyrido[2,3-d]pyrimidine Chemical compound N1=CN=CC2=CC=CN=C21 UDJFFSGCRRMVFH-UHFFFAOYSA-N 0.000 title 1
- 239000002718 pyrimidine nucleoside Substances 0.000 title 1
- QGDYVSSVBYMOJN-UHFFFAOYSA-N pyrimido[4,5-d]pyrimidine Chemical compound C1=NC=NC2=NC=NC=C21 QGDYVSSVBYMOJN-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21641800P | 2000-07-06 | 2000-07-06 | |
PCT/US2001/041242 WO2002003997A1 (fr) | 2000-07-06 | 2001-07-03 | Nucleosides de pyrido[2,3-d]pyrimidine et de pyrimido[4,5-d]pyrimidine |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20030033D0 NO20030033D0 (no) | 2003-01-03 |
NO20030033L true NO20030033L (no) | 2003-01-03 |
Family
ID=22806989
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20030033A NO20030033L (no) | 2000-07-06 | 2003-01-03 | Pyrido[2,3-D]pyrimidin- og pyrimido[4,5-D]pyrimidin- nukleosider |
Country Status (19)
Country | Link |
---|---|
US (1) | US7081449B2 (fr) |
EP (1) | EP1303282A4 (fr) |
JP (1) | JP2004522694A (fr) |
KR (1) | KR20030032944A (fr) |
CN (1) | CN1440292A (fr) |
AU (2) | AU7367001A (fr) |
BR (1) | BR0111531A (fr) |
CA (1) | CA2405798A1 (fr) |
CZ (1) | CZ20024052A3 (fr) |
HU (1) | HUP0301614A3 (fr) |
IL (1) | IL151849A0 (fr) |
MX (1) | MXPA02012156A (fr) |
NO (1) | NO20030033L (fr) |
NZ (1) | NZ521457A (fr) |
PL (1) | PL359559A1 (fr) |
SK (1) | SK112003A3 (fr) |
UA (1) | UA72612C2 (fr) |
WO (1) | WO2002003997A1 (fr) |
ZA (1) | ZA200208010B (fr) |
Families Citing this family (74)
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CN100457118C (zh) | 2000-04-13 | 2009-02-04 | 法玛塞特有限公司 | 用于治疗肝炎病毒感染的3′-或2′-羟甲基取代的核苷衍生物 |
MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
PL359169A1 (en) | 2000-05-26 | 2004-08-23 | Idenix (Cayman) Limited | Methods and compositions for treating flaviviruses and pestiviruses |
MXPA04010528A (es) | 2002-04-26 | 2005-05-27 | Gilead Sciences Inc | Inhibidores de transcriptasa inversa no nucleosidos. |
AU2003248748A1 (en) | 2002-06-28 | 2004-01-19 | Idenix (Cayman) Limited | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
CN101172993A (zh) | 2002-06-28 | 2008-05-07 | 埃迪尼克斯(开曼)有限公司 | 用于治疗黄病毒感染的2′-c-甲基-3′-o-l-缬氨酸酯核糖呋喃基胞苷 |
JP2006507235A (ja) | 2002-08-01 | 2006-03-02 | フアーマセツト・インコーポレイテツド | フラビウイルス科ウイルス感染治療のためのビシクロ[4.2.1]ノナン系を有する化合物 |
BR0316363A (pt) | 2002-11-15 | 2005-10-04 | Idenix Cayman Ltd | Nucleosìdeos 2'-ramificado e mutação de flaviviridae |
RU2005121904A (ru) | 2002-12-12 | 2006-01-20 | Айденикс (Кайман) Лимитед (Ky) | Способ получения 2`-разветвленных нуклеозидов |
US7429565B2 (en) | 2003-04-25 | 2008-09-30 | Gilead Sciences, Inc. | Antiviral phosphonate analogs |
CA2522845A1 (fr) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Analogues de phosphonate inhibiteurs de kinase |
US7300924B2 (en) | 2003-04-25 | 2007-11-27 | Gilead Sciences, Inc. | Anti-infective phosphonate analogs |
US7432261B2 (en) | 2003-04-25 | 2008-10-07 | Gilead Sciences, Inc. | Anti-inflammatory phosphonate compounds |
US7470724B2 (en) | 2003-04-25 | 2008-12-30 | Gilead Sciences, Inc. | Phosphonate compounds having immuno-modulatory activity |
US7452901B2 (en) | 2003-04-25 | 2008-11-18 | Gilead Sciences, Inc. | Anti-cancer phosphonate analogs |
US7407965B2 (en) | 2003-04-25 | 2008-08-05 | Gilead Sciences, Inc. | Phosphonate analogs for treating metabolic diseases |
US7427636B2 (en) | 2003-04-25 | 2008-09-23 | Gilead Sciences, Inc. | Inosine monophosphate dehydrogenase inhibitory phosphonate compounds |
WO2005002626A2 (fr) | 2003-04-25 | 2005-01-13 | Gilead Sciences, Inc. | Composes de phosphonate therapeutiques |
US7550442B2 (en) * | 2003-05-20 | 2009-06-23 | The Board Of Trustees Of The University Of Illinois | Nucleoside analog inhibitors of reverse transcriptase |
MXPA05012788A (es) * | 2003-05-30 | 2006-02-22 | Pharmasset Inc | Analogos de nucleosidos fluorados modificados. |
WO2005009418A2 (fr) | 2003-07-25 | 2005-02-03 | Idenix (Cayman) Limited | Analogues des nucleosides puriques pour traiter flaviviridae et notamment l'hepatite c |
WO2005044308A1 (fr) | 2003-10-24 | 2005-05-19 | Gilead Sciences, Inc. | Analogues phosphonates d'antimetabolites |
EP1678321A1 (fr) | 2003-10-24 | 2006-07-12 | Gilead Sciences, Inc. | Procedes et compositions permettant d'identifier des composes therapeutiques |
US7427624B2 (en) | 2003-10-24 | 2008-09-23 | Gilead Sciences, Inc. | Purine nucleoside phosphorylase inhibitory phosphonate compounds |
CA2548753A1 (fr) | 2003-12-22 | 2005-07-14 | Gilead Sciences, Inc. | Derives de carbovir et d'abacavir 4'-substitues et composes associes dotes d'une activite antivirale dirigee contre le vih et le vhc |
US20050182252A1 (en) | 2004-02-13 | 2005-08-18 | Reddy K. R. | Novel 2'-C-methyl nucleoside derivatives |
US7378423B2 (en) | 2004-06-11 | 2008-05-27 | Japan Tobacco Inc. | Pyrimidine compound and medical use thereof |
CN101006086B (zh) * | 2004-06-11 | 2010-09-29 | 日本烟草产业株式会社 | 用于治疗癌症的5-氨基-2,4,7-三氧代-3,4,7,8-四氢-2H-吡啶并[2,3-d]嘧啶衍生物和相关化合物 |
CN101023094B (zh) * | 2004-07-21 | 2011-05-18 | 法莫赛特股份有限公司 | 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备 |
DK1778251T3 (da) | 2004-07-27 | 2011-07-18 | Gilead Sciences Inc | Nukleosidphosphatkonjugater som anti-HIV-midler |
KR101177590B1 (ko) | 2004-09-14 | 2012-08-27 | 파마셋 인코포레이티드 | 2'-플루오로-2'-알킬 치환되거나 또는 다른 선택적으로치환된 리보퓨라노실 피리미딘 및 퓨린 및 그 유도체의제조 |
JP2008532950A (ja) * | 2005-03-08 | 2008-08-21 | バイオタ サイエンティフィック マネージメント ピーティーワイ リミテッド | 治療薬としての二環式ヌクレオシドおよび二環式ヌクレオチド |
US20080261913A1 (en) * | 2006-12-28 | 2008-10-23 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of liver disorders |
US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
US8183249B2 (en) | 2007-07-12 | 2012-05-22 | University Of South Florida | Inhibitors of AKT/PKB with anti-tumor activity |
US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
UA103329C2 (ru) | 2008-07-08 | 2013-10-10 | Гилиад Сайенсиз, Инк. | Соли соединений-ингибиторов вич |
AU2009329872B2 (en) | 2008-12-23 | 2016-07-07 | Gilead Pharmasset Llc | Synthesis of purine nucleosides |
TW201026715A (en) | 2008-12-23 | 2010-07-16 | Pharmasset Inc | Nucleoside phosphoramidates |
EP2376514A2 (fr) | 2008-12-23 | 2011-10-19 | Pharmasset, Inc. | Analogues de nucléoside |
WO2010108140A1 (fr) | 2009-03-20 | 2010-09-23 | Alios Biopharma, Inc. | Nucleoside substitue et analogues nucleotidiques |
TWI576352B (zh) | 2009-05-20 | 2017-04-01 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
US8563530B2 (en) | 2010-03-31 | 2013-10-22 | Gilead Pharmassel LLC | Purine nucleoside phosphoramidate |
WO2011123645A2 (fr) | 2010-03-31 | 2011-10-06 | Pharmasset, Inc. | Phosphoramidates de nucléosides |
CN103209987B (zh) | 2010-09-22 | 2017-06-06 | 艾丽奥斯生物制药有限公司 | 取代的核苷酸类似物 |
WO2012158197A2 (fr) * | 2010-11-11 | 2012-11-22 | Lyndor Biosciences L.L.C. | Composés utiles en tant que modulateurs akt/pkb et leurs utilisations |
EP3042910B1 (fr) | 2010-11-30 | 2019-01-09 | Gilead Pharmasset LLC | 2'-spiro-nucléosides pour le traitement de l'hépatite c |
BR112014006324B8 (pt) | 2011-09-16 | 2019-02-12 | Gilead Pharmassett Llc | composição e seu uso para o tratamento de hcv |
US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
SI2794627T1 (sl) | 2011-12-22 | 2019-02-28 | Alios Biopharma, Inc. | Substituirani nukleozidi, nukleotidi in njihovi analogi |
EP2794630A4 (fr) | 2011-12-22 | 2015-04-01 | Alios Biopharma Inc | Analogues de nucléotide phosphorothioate substitués |
CU24272B1 (es) * | 2012-03-14 | 2017-08-08 | Lupin Ltd | Derivados de tetrahidropirido-pirimidina como inhibidores de mek |
US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
US8916538B2 (en) | 2012-03-21 | 2014-12-23 | Vertex Pharmaceuticals Incorporated | Solid forms of a thiophosphoramidate nucleotide prodrug |
EP2827876A4 (fr) | 2012-03-22 | 2015-10-28 | Alios Biopharma Inc | Combinaisons pharmaceutiques comprenant un analogue thionucléotidique |
EP2861611B1 (fr) | 2012-05-25 | 2016-07-13 | Janssen Sciences Ireland UC | Nucléosides dýuracyle spirooxetane |
CN102816197B (zh) * | 2012-08-24 | 2015-04-29 | 四川大学华西医院 | 一种新的嘧啶并嘧啶类核苷类似物、制备方法及其形成的超分子结构和应用 |
SMT202100259T1 (it) | 2012-12-21 | 2021-07-12 | Janssen Biopharma Inc | 4'-fluoro-nucleosidi, 4'-fluoro-nucleotidi e loro analoghi per il trattamento di hcv s |
MY172166A (en) | 2013-01-31 | 2019-11-15 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds |
WO2015030853A1 (fr) | 2013-08-27 | 2015-03-05 | Gilead Pharmasset Llc | Préparation combinée de deux composés antiviraux |
WO2015054465A1 (fr) | 2013-10-11 | 2015-04-16 | Alios Biopharma, Inc. | Nucléosides substitués, nucléotides substitués et analogues de ceux-ci |
CA2937548C (fr) | 2014-02-13 | 2022-10-25 | Ligand Pharmaceuticals, Inc. | Composes de promedicaments et leurs utilisations |
CN106687118A (zh) | 2014-07-02 | 2017-05-17 | 配体药物公司 | 前药化合物及其用途 |
CA2962770C (fr) * | 2014-09-26 | 2023-08-22 | Riboscience Llc | Derives de nucleoside 4'-vinyle substitues utiles en tant qu'inhibiteurs de la replication due l'arn du virus respiratoire syncytial |
US10851125B2 (en) | 2017-08-01 | 2020-12-01 | Gilead Sciences, Inc. | Crystalline forms of ethyl ((S)-((((2R,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)methyl)(phenoxy)phosphoryl(-L-alaninate |
JP2021509907A (ja) | 2018-01-09 | 2021-04-08 | リガンド・ファーマシューティカルズ・インコーポレイテッド | アセタール化合物およびその治療的使用 |
ES2968459T3 (es) * | 2018-05-15 | 2024-05-09 | Illumina Inc | Composiciones y métodos para escisión química y desprotección de oligonucleótidos unidos a superficie |
JP2022522534A (ja) | 2019-04-02 | 2022-04-19 | アリゴス セラピューティクス インコーポレイテッド | Prmt5を標的にする化合物 |
CN111995649A (zh) * | 2020-04-09 | 2020-11-27 | 瀚海新拓(杭州)生物医药有限公司 | 一种蝶啶酮核苷酸类似物及其药物组合物、制备方法和医药用途 |
CN117120090A (zh) | 2021-02-12 | 2023-11-24 | 林伯士萨顿公司 | Hpk1拮抗剂和其用途 |
CN117295737A (zh) | 2021-03-05 | 2023-12-26 | 林伯士萨顿公司 | Hpk1拮抗剂和其用途 |
JP2024513011A (ja) | 2021-03-29 | 2024-03-21 | ニンバス サターン, インコーポレイテッド | Hpk1アンタゴニスト及びその使用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3423398A (en) | 1965-05-10 | 1969-01-21 | Pfizer & Co C | Sangivamycin and derivatives thereof |
DE3686150T2 (de) * | 1985-09-09 | 1993-03-04 | Teijin Ltd | Pyridopyrimidin-nukleotid-abkoemmlinge. |
US5034393A (en) * | 1989-07-27 | 1991-07-23 | Dowelanco | Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives |
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2001
- 2001-03-07 UA UA2002119182A patent/UA72612C2/uk unknown
- 2001-07-03 AU AU7367001A patent/AU7367001A/xx active Pending
- 2001-07-03 EP EP01952967A patent/EP1303282A4/fr not_active Withdrawn
- 2001-07-03 AU AU2001273670A patent/AU2001273670B2/en not_active Expired - Fee Related
- 2001-07-03 MX MXPA02012156A patent/MXPA02012156A/es unknown
- 2001-07-03 JP JP2002508451A patent/JP2004522694A/ja not_active Withdrawn
- 2001-07-03 CA CA002405798A patent/CA2405798A1/fr not_active Abandoned
- 2001-07-03 PL PL01359559A patent/PL359559A1/xx not_active Application Discontinuation
- 2001-07-03 HU HU0301614A patent/HUP0301614A3/hu unknown
- 2001-07-03 IL IL15184901A patent/IL151849A0/xx unknown
- 2001-07-03 CN CN01812327A patent/CN1440292A/zh active Pending
- 2001-07-03 BR BR0111531-6A patent/BR0111531A/pt not_active IP Right Cessation
- 2001-07-03 NZ NZ521457A patent/NZ521457A/en unknown
- 2001-07-03 US US10/221,397 patent/US7081449B2/en not_active Expired - Fee Related
- 2001-07-03 WO PCT/US2001/041242 patent/WO2002003997A1/fr not_active Application Discontinuation
- 2001-07-03 CZ CZ20024052A patent/CZ20024052A3/cs unknown
- 2001-07-03 SK SK11-2003A patent/SK112003A3/sk unknown
- 2001-07-03 KR KR1020027014601A patent/KR20030032944A/ko not_active Abandoned
-
2002
- 2002-10-04 ZA ZA200208010A patent/ZA200208010B/en unknown
-
2003
- 2003-01-03 NO NO20030033A patent/NO20030033L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2405798A1 (fr) | 2002-01-17 |
WO2002003997A1 (fr) | 2002-01-17 |
KR20030032944A (ko) | 2003-04-26 |
JP2004522694A (ja) | 2004-07-29 |
ZA200208010B (en) | 2004-04-28 |
BR0111531A (pt) | 2004-07-06 |
HUP0301614A3 (en) | 2005-02-28 |
NZ521457A (en) | 2005-03-24 |
IL151849A0 (en) | 2003-04-10 |
AU2001273670B2 (en) | 2005-07-14 |
CN1440292A (zh) | 2003-09-03 |
HUP0301614A2 (hu) | 2003-09-29 |
EP1303282A4 (fr) | 2004-04-07 |
EP1303282A1 (fr) | 2003-04-23 |
PL359559A1 (en) | 2004-08-23 |
AU7367001A (en) | 2002-01-21 |
US20030144502A1 (en) | 2003-07-31 |
NO20030033D0 (no) | 2003-01-03 |
MXPA02012156A (es) | 2004-08-19 |
UA72612C2 (en) | 2005-03-15 |
US7081449B2 (en) | 2006-07-25 |
CZ20024052A3 (cs) | 2003-03-12 |
SK112003A3 (en) | 2003-04-01 |
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Legal Events
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