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NO20030033L - Pyrido[2,3-D]pyrimidin- og pyrimido[4,5-D]pyrimidin- nukleosider - Google Patents

Pyrido[2,3-D]pyrimidin- og pyrimido[4,5-D]pyrimidin- nukleosider

Info

Publication number
NO20030033L
NO20030033L NO20030033A NO20030033A NO20030033L NO 20030033 L NO20030033 L NO 20030033L NO 20030033 A NO20030033 A NO 20030033A NO 20030033 A NO20030033 A NO 20030033A NO 20030033 L NO20030033 L NO 20030033L
Authority
NO
Norway
Prior art keywords
pyrimidine
pyrimido
pyrido
nucleosides
pyrimidine nucleosides
Prior art date
Application number
NO20030033A
Other languages
English (en)
Norwegian (no)
Other versions
NO20030033D0 (no
Inventor
Guangyi Wang
Jean-Luc Girardet
Esmir Gunic
Johnson Luc
Zbigniew Pietrzkowski
Original Assignee
Ribapharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ribapharm Inc filed Critical Ribapharm Inc
Publication of NO20030033D0 publication Critical patent/NO20030033D0/no
Publication of NO20030033L publication Critical patent/NO20030033L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20030033A 2000-07-06 2003-01-03 Pyrido[2,3-D]pyrimidin- og pyrimido[4,5-D]pyrimidin- nukleosider NO20030033L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21641800P 2000-07-06 2000-07-06
PCT/US2001/041242 WO2002003997A1 (fr) 2000-07-06 2001-07-03 Nucleosides de pyrido[2,3-d]pyrimidine et de pyrimido[4,5-d]pyrimidine

Publications (2)

Publication Number Publication Date
NO20030033D0 NO20030033D0 (no) 2003-01-03
NO20030033L true NO20030033L (no) 2003-01-03

Family

ID=22806989

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20030033A NO20030033L (no) 2000-07-06 2003-01-03 Pyrido[2,3-D]pyrimidin- og pyrimido[4,5-D]pyrimidin- nukleosider

Country Status (19)

Country Link
US (1) US7081449B2 (fr)
EP (1) EP1303282A4 (fr)
JP (1) JP2004522694A (fr)
KR (1) KR20030032944A (fr)
CN (1) CN1440292A (fr)
AU (2) AU7367001A (fr)
BR (1) BR0111531A (fr)
CA (1) CA2405798A1 (fr)
CZ (1) CZ20024052A3 (fr)
HU (1) HUP0301614A3 (fr)
IL (1) IL151849A0 (fr)
MX (1) MXPA02012156A (fr)
NO (1) NO20030033L (fr)
NZ (1) NZ521457A (fr)
PL (1) PL359559A1 (fr)
SK (1) SK112003A3 (fr)
UA (1) UA72612C2 (fr)
WO (1) WO2002003997A1 (fr)
ZA (1) ZA200208010B (fr)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100457118C (zh) 2000-04-13 2009-02-04 法玛塞特有限公司 用于治疗肝炎病毒感染的3′-或2′-羟甲基取代的核苷衍生物
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
PL359169A1 (en) 2000-05-26 2004-08-23 Idenix (Cayman) Limited Methods and compositions for treating flaviviruses and pestiviruses
MXPA04010528A (es) 2002-04-26 2005-05-27 Gilead Sciences Inc Inhibidores de transcriptasa inversa no nucleosidos.
AU2003248748A1 (en) 2002-06-28 2004-01-19 Idenix (Cayman) Limited 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
CN101172993A (zh) 2002-06-28 2008-05-07 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2′-c-甲基-3′-o-l-缬氨酸酯核糖呋喃基胞苷
JP2006507235A (ja) 2002-08-01 2006-03-02 フアーマセツト・インコーポレイテツド フラビウイルス科ウイルス感染治療のためのビシクロ[4.2.1]ノナン系を有する化合物
BR0316363A (pt) 2002-11-15 2005-10-04 Idenix Cayman Ltd Nucleosìdeos 2'-ramificado e mutação de flaviviridae
RU2005121904A (ru) 2002-12-12 2006-01-20 Айденикс (Кайман) Лимитед (Ky) Способ получения 2`-разветвленных нуклеозидов
US7429565B2 (en) 2003-04-25 2008-09-30 Gilead Sciences, Inc. Antiviral phosphonate analogs
CA2522845A1 (fr) 2003-04-25 2004-11-11 Gilead Sciences, Inc. Analogues de phosphonate inhibiteurs de kinase
US7300924B2 (en) 2003-04-25 2007-11-27 Gilead Sciences, Inc. Anti-infective phosphonate analogs
US7432261B2 (en) 2003-04-25 2008-10-07 Gilead Sciences, Inc. Anti-inflammatory phosphonate compounds
US7470724B2 (en) 2003-04-25 2008-12-30 Gilead Sciences, Inc. Phosphonate compounds having immuno-modulatory activity
US7452901B2 (en) 2003-04-25 2008-11-18 Gilead Sciences, Inc. Anti-cancer phosphonate analogs
US7407965B2 (en) 2003-04-25 2008-08-05 Gilead Sciences, Inc. Phosphonate analogs for treating metabolic diseases
US7427636B2 (en) 2003-04-25 2008-09-23 Gilead Sciences, Inc. Inosine monophosphate dehydrogenase inhibitory phosphonate compounds
WO2005002626A2 (fr) 2003-04-25 2005-01-13 Gilead Sciences, Inc. Composes de phosphonate therapeutiques
US7550442B2 (en) * 2003-05-20 2009-06-23 The Board Of Trustees Of The University Of Illinois Nucleoside analog inhibitors of reverse transcriptase
MXPA05012788A (es) * 2003-05-30 2006-02-22 Pharmasset Inc Analogos de nucleosidos fluorados modificados.
WO2005009418A2 (fr) 2003-07-25 2005-02-03 Idenix (Cayman) Limited Analogues des nucleosides puriques pour traiter flaviviridae et notamment l'hepatite c
WO2005044308A1 (fr) 2003-10-24 2005-05-19 Gilead Sciences, Inc. Analogues phosphonates d'antimetabolites
EP1678321A1 (fr) 2003-10-24 2006-07-12 Gilead Sciences, Inc. Procedes et compositions permettant d'identifier des composes therapeutiques
US7427624B2 (en) 2003-10-24 2008-09-23 Gilead Sciences, Inc. Purine nucleoside phosphorylase inhibitory phosphonate compounds
CA2548753A1 (fr) 2003-12-22 2005-07-14 Gilead Sciences, Inc. Derives de carbovir et d'abacavir 4'-substitues et composes associes dotes d'une activite antivirale dirigee contre le vih et le vhc
US20050182252A1 (en) 2004-02-13 2005-08-18 Reddy K. R. Novel 2'-C-methyl nucleoside derivatives
US7378423B2 (en) 2004-06-11 2008-05-27 Japan Tobacco Inc. Pyrimidine compound and medical use thereof
CN101006086B (zh) * 2004-06-11 2010-09-29 日本烟草产业株式会社 用于治疗癌症的5-氨基-2,4,7-三氧代-3,4,7,8-四氢-2H-吡啶并[2,3-d]嘧啶衍生物和相关化合物
CN101023094B (zh) * 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
DK1778251T3 (da) 2004-07-27 2011-07-18 Gilead Sciences Inc Nukleosidphosphatkonjugater som anti-HIV-midler
KR101177590B1 (ko) 2004-09-14 2012-08-27 파마셋 인코포레이티드 2'-플루오로-2'-알킬 치환되거나 또는 다른 선택적으로치환된 리보퓨라노실 피리미딘 및 퓨린 및 그 유도체의제조
JP2008532950A (ja) * 2005-03-08 2008-08-21 バイオタ サイエンティフィック マネージメント ピーティーワイ リミテッド 治療薬としての二環式ヌクレオシドおよび二環式ヌクレオチド
US20080261913A1 (en) * 2006-12-28 2008-10-23 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of liver disorders
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
US8183249B2 (en) 2007-07-12 2012-05-22 University Of South Florida Inhibitors of AKT/PKB with anti-tumor activity
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
UA103329C2 (ru) 2008-07-08 2013-10-10 Гилиад Сайенсиз, Инк. Соли соединений-ингибиторов вич
AU2009329872B2 (en) 2008-12-23 2016-07-07 Gilead Pharmasset Llc Synthesis of purine nucleosides
TW201026715A (en) 2008-12-23 2010-07-16 Pharmasset Inc Nucleoside phosphoramidates
EP2376514A2 (fr) 2008-12-23 2011-10-19 Pharmasset, Inc. Analogues de nucléoside
WO2010108140A1 (fr) 2009-03-20 2010-09-23 Alios Biopharma, Inc. Nucleoside substitue et analogues nucleotidiques
TWI576352B (zh) 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 核苷磷醯胺
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
US8563530B2 (en) 2010-03-31 2013-10-22 Gilead Pharmassel LLC Purine nucleoside phosphoramidate
WO2011123645A2 (fr) 2010-03-31 2011-10-06 Pharmasset, Inc. Phosphoramidates de nucléosides
CN103209987B (zh) 2010-09-22 2017-06-06 艾丽奥斯生物制药有限公司 取代的核苷酸类似物
WO2012158197A2 (fr) * 2010-11-11 2012-11-22 Lyndor Biosciences L.L.C. Composés utiles en tant que modulateurs akt/pkb et leurs utilisations
EP3042910B1 (fr) 2010-11-30 2019-01-09 Gilead Pharmasset LLC 2'-spiro-nucléosides pour le traitement de l'hépatite c
BR112014006324B8 (pt) 2011-09-16 2019-02-12 Gilead Pharmassett Llc composição e seu uso para o tratamento de hcv
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
SI2794627T1 (sl) 2011-12-22 2019-02-28 Alios Biopharma, Inc. Substituirani nukleozidi, nukleotidi in njihovi analogi
EP2794630A4 (fr) 2011-12-22 2015-04-01 Alios Biopharma Inc Analogues de nucléotide phosphorothioate substitués
CU24272B1 (es) * 2012-03-14 2017-08-08 Lupin Ltd Derivados de tetrahidropirido-pirimidina como inhibidores de mek
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US8916538B2 (en) 2012-03-21 2014-12-23 Vertex Pharmaceuticals Incorporated Solid forms of a thiophosphoramidate nucleotide prodrug
EP2827876A4 (fr) 2012-03-22 2015-10-28 Alios Biopharma Inc Combinaisons pharmaceutiques comprenant un analogue thionucléotidique
EP2861611B1 (fr) 2012-05-25 2016-07-13 Janssen Sciences Ireland UC Nucléosides dýuracyle spirooxetane
CN102816197B (zh) * 2012-08-24 2015-04-29 四川大学华西医院 一种新的嘧啶并嘧啶类核苷类似物、制备方法及其形成的超分子结构和应用
SMT202100259T1 (it) 2012-12-21 2021-07-12 Janssen Biopharma Inc 4'-fluoro-nucleosidi, 4'-fluoro-nucleotidi e loro analoghi per il trattamento di hcv s
MY172166A (en) 2013-01-31 2019-11-15 Gilead Pharmasset Llc Combination formulation of two antiviral compounds
WO2015030853A1 (fr) 2013-08-27 2015-03-05 Gilead Pharmasset Llc Préparation combinée de deux composés antiviraux
WO2015054465A1 (fr) 2013-10-11 2015-04-16 Alios Biopharma, Inc. Nucléosides substitués, nucléotides substitués et analogues de ceux-ci
CA2937548C (fr) 2014-02-13 2022-10-25 Ligand Pharmaceuticals, Inc. Composes de promedicaments et leurs utilisations
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
CA2962770C (fr) * 2014-09-26 2023-08-22 Riboscience Llc Derives de nucleoside 4'-vinyle substitues utiles en tant qu'inhibiteurs de la replication due l'arn du virus respiratoire syncytial
US10851125B2 (en) 2017-08-01 2020-12-01 Gilead Sciences, Inc. Crystalline forms of ethyl ((S)-((((2R,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)methyl)(phenoxy)phosphoryl(-L-alaninate
JP2021509907A (ja) 2018-01-09 2021-04-08 リガンド・ファーマシューティカルズ・インコーポレイテッド アセタール化合物およびその治療的使用
ES2968459T3 (es) * 2018-05-15 2024-05-09 Illumina Inc Composiciones y métodos para escisión química y desprotección de oligonucleótidos unidos a superficie
JP2022522534A (ja) 2019-04-02 2022-04-19 アリゴス セラピューティクス インコーポレイテッド Prmt5を標的にする化合物
CN111995649A (zh) * 2020-04-09 2020-11-27 瀚海新拓(杭州)生物医药有限公司 一种蝶啶酮核苷酸类似物及其药物组合物、制备方法和医药用途
CN117120090A (zh) 2021-02-12 2023-11-24 林伯士萨顿公司 Hpk1拮抗剂和其用途
CN117295737A (zh) 2021-03-05 2023-12-26 林伯士萨顿公司 Hpk1拮抗剂和其用途
JP2024513011A (ja) 2021-03-29 2024-03-21 ニンバス サターン, インコーポレイテッド Hpk1アンタゴニスト及びその使用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3423398A (en) 1965-05-10 1969-01-21 Pfizer & Co C Sangivamycin and derivatives thereof
DE3686150T2 (de) * 1985-09-09 1993-03-04 Teijin Ltd Pyridopyrimidin-nukleotid-abkoemmlinge.
US5034393A (en) * 1989-07-27 1991-07-23 Dowelanco Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives

Also Published As

Publication number Publication date
CA2405798A1 (fr) 2002-01-17
WO2002003997A1 (fr) 2002-01-17
KR20030032944A (ko) 2003-04-26
JP2004522694A (ja) 2004-07-29
ZA200208010B (en) 2004-04-28
BR0111531A (pt) 2004-07-06
HUP0301614A3 (en) 2005-02-28
NZ521457A (en) 2005-03-24
IL151849A0 (en) 2003-04-10
AU2001273670B2 (en) 2005-07-14
CN1440292A (zh) 2003-09-03
HUP0301614A2 (hu) 2003-09-29
EP1303282A4 (fr) 2004-04-07
EP1303282A1 (fr) 2003-04-23
PL359559A1 (en) 2004-08-23
AU7367001A (en) 2002-01-21
US20030144502A1 (en) 2003-07-31
NO20030033D0 (no) 2003-01-03
MXPA02012156A (es) 2004-08-19
UA72612C2 (en) 2005-03-15
US7081449B2 (en) 2006-07-25
CZ20024052A3 (cs) 2003-03-12
SK112003A3 (en) 2003-04-01

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