NO20030475L - Ikke-peptid CCR1-reseptorantagonist i kombinasjon med syclosporin A for behandling av hjertetransplantatforkastning - Google Patents

Ikke-peptid CCR1-reseptorantagonist i kombinasjon med syclosporin A for behandling av hjertetransplantatforkastning

Info

Publication number: NO20030475L
Authority: NO; Norway
Prior art keywords: receptor antagonist; transplant rejection; syclosporin; heart transplant; treatment
Prior art date: 2000-07-31

Application number

NO20030475A

Other languages

English (en)

Norwegian (no)

Other versions

NO20030475D0 (no

Inventor

Richard Horuk

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-31

Filing date

2003-01-30

Publication date

2003-03-28

2003-01-30 Application filed by Schering Ag filed Critical Schering Ag

2003-01-30 Publication of NO20030475D0 publication Critical patent/NO20030475D0/no

2003-03-28 Publication of NO20030475L publication Critical patent/NO20030475L/no

Links

102000004500 CCR1 Receptors Human genes 0.000 title abstract 2
108010017319 CCR1 Receptors Proteins 0.000 title abstract 2
206010019315 Heart transplant rejection Diseases 0.000 title abstract 2
239000002464 receptor antagonist Substances 0.000 title abstract 2
229940044551 receptor antagonist Drugs 0.000 title abstract 2
229930105110 Cyclosporin A Natural products 0.000 abstract 1
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 1
108010036949 Cyclosporine Proteins 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
229960001265 ciclosporin Drugs 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000546 pharmaceutical excipient Substances 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Transplantation (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO20030475A 2000-07-31 2003-01-30 Ikke-peptid CCR1-reseptorantagonist i kombinasjon med syclosporin A for behandling av hjertetransplantatforkastning NO20030475L (no)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US22205300P	2000-07-31	2000-07-31
US23128200P	2000-09-08	2000-09-08
US09/915,411 US6740636B2 (en)	2000-07-31	2001-07-25	Non-peptide CCR1 receptor antagonists in combination with cyclosporin A for the treatment of heart transplant rejection
PCT/US2001/023862 WO2002009762A2 (fr)	2000-07-31	2001-07-31	Antagonistes non peptidiques des recepteurs ccr1 combines a la cyclosporine a en vue de combattre une reaction de rejet apres une transplantation cardiaque

Publications (2)

Publication Number	Publication Date
NO20030475D0 NO20030475D0 (no)	2003-01-30
NO20030475L true NO20030475L (no)	2003-03-28

Family

ID=27397025

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20030475A NO20030475L (no)	2000-07-31	2003-01-30	Ikke-peptid CCR1-reseptorantagonist i kombinasjon med syclosporin A for behandling av hjertetransplantatforkastning

Country Status (28)

Country	Link
US (1)	US6740636B2 (fr)
EP (1)	EP1305047B1 (fr)
JP (1)	JP2004530630A (fr)
KR (1)	KR20030048000A (fr)
CN (1)	CN1655818A (fr)
AT (1)	ATE330634T1 (fr)
AU (2)	AU7807301A (fr)
BG (1)	BG107502A (fr)
BR (1)	BR0113140A (fr)
CA (1)	CA2417636A1 (fr)
CY (1)	CY1105321T1 (fr)
DE (1)	DE60120986T2 (fr)
DK (1)	DK1305047T3 (fr)
EE (1)	EE200300047A (fr)
ES (1)	ES2261447T3 (fr)
HR (1)	HRP20030121A2 (fr)
HU (1)	HUP0300686A3 (fr)
IL (1)	IL153933A0 (fr)
LV (1)	LV13033B (fr)
MX (1)	MXPA03000836A (fr)
NO (1)	NO20030475L (fr)
NZ (1)	NZ523688A (fr)
PL (1)	PL364521A1 (fr)
PT (1)	PT1305047E (fr)
SI (1)	SI21123A (fr)
SK (1)	SK1222003A3 (fr)
WO (1)	WO2002009762A2 (fr)
YU (1)	YU6703A (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003032949A1 (fr)	2001-10-19	2003-04-24	Isotechnika Inc.	Nouveaux preconcentres en microemulsion d'analogues de cyclosporine
BRPI0413846A (pt) *	2003-08-22	2006-10-24	Schering Aktiengellschaft	derivados de piperazina inibidores de quimiocina e seu uso para tratar miocardite
US10499828B2 (en) *	2004-03-05	2019-12-10	Lifescience Solutions, Llc	System and method for heart monitoring
US7917195B2 (en)	2004-03-05	2011-03-29	Lifesciences Solutions LLC	Systems, methods and computer program products for heart monitoring
US8103065B2 (en) *	2006-01-05	2012-01-24	Lifescience Solutions Llc	Assessment of medical conditions
US20110009758A1 (en) *	2009-07-10	2011-01-13	Lifescience Solutions Llc	System and method for heart monitoring

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6323206B1 (en)	1996-07-12	2001-11-27	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
KR100447553B1 (ko)	1997-02-26	2004-09-08	화이자 인코포레이티드	헤테로아릴-헥사노산 아미드 유도체, 그의 제조 방법 및 ｍｉｐ-1 알파의 ｃｃｒ1 수용체로의 결합에 대한 선택적 저해제로서의 용도
US6207665B1 (en) *	1997-06-12	2001-03-27	Schering Aktiengesellschaft	Piperazine derivatives and their use as anti-inflammatory agents
WO1999037619A1 (fr)	1998-01-21	1999-07-29	Millennium Pharmaceuticals, Inc.	Antagonistes du recepteur de la chemokine et procedes d'emploi desdits antagonistes
HUP0101320A3 (en)	1998-01-21	2002-11-28	Kyowa Hakko Kogyo Kk	Benzo- and pyridobenzoxepine and -benzazepine derivatives and use thereof
PL342817A1 (en)	1998-02-05	2001-07-02	Pfizer Prod Inc	Novel derivatives of dihydroxyhexanic acid
EP1000626A1 (fr)	1998-09-18	2000-05-17	Applied Research Systems ARS Holding N.V.	Antagoniste de récepteur de chemokine et cyclosporine en thérapie combinée
EP1152752A1 (fr)	1999-01-29	2001-11-14	Millennium Pharmaceuticals, Inc.	Methodes de prevention des rejets de greffes et des lesions par ischemie/reperfusion

2001
- 2001-07-25 US US09/915,411 patent/US6740636B2/en not_active Expired - Fee Related
- 2001-07-31 NZ NZ523688A patent/NZ523688A/en unknown
- 2001-07-31 AT AT01956035T patent/ATE330634T1/de not_active IP Right Cessation
- 2001-07-31 WO PCT/US2001/023862 patent/WO2002009762A2/fr active IP Right Grant
- 2001-07-31 DE DE60120986T patent/DE60120986T2/de not_active Expired - Fee Related
- 2001-07-31 YU YU6703A patent/YU6703A/sh unknown
- 2001-07-31 PL PL01364521A patent/PL364521A1/xx not_active Application Discontinuation
- 2001-07-31 KR KR10-2003-7001483A patent/KR20030048000A/ko not_active Withdrawn
- 2001-07-31 EP EP01956035A patent/EP1305047B1/fr not_active Expired - Lifetime
- 2001-07-31 CN CNA018138004A patent/CN1655818A/zh active Pending
- 2001-07-31 IL IL15393301A patent/IL153933A0/xx unknown
- 2001-07-31 JP JP2002515314A patent/JP2004530630A/ja not_active Withdrawn
- 2001-07-31 CA CA002417636A patent/CA2417636A1/fr not_active Abandoned
- 2001-07-31 SI SI200120045A patent/SI21123A/sl not_active IP Right Cessation
- 2001-07-31 SK SK122-2003A patent/SK1222003A3/sk unknown
- 2001-07-31 EE EEP200300047A patent/EE200300047A/xx unknown
- 2001-07-31 BR BR0113140-0A patent/BR0113140A/pt not_active IP Right Cessation
- 2001-07-31 AU AU7807301A patent/AU7807301A/xx active Pending
- 2001-07-31 DK DK01956035T patent/DK1305047T3/da active
- 2001-07-31 MX MXPA03000836A patent/MXPA03000836A/es unknown
- 2001-07-31 HU HU0300686A patent/HUP0300686A3/hu unknown
- 2001-07-31 PT PT01956035T patent/PT1305047E/pt unknown
- 2001-07-31 ES ES01956035T patent/ES2261447T3/es not_active Expired - Lifetime
- 2001-07-31 AU AU2001278073A patent/AU2001278073B2/en not_active Expired - Fee Related
2003
- 2003-01-27 BG BG107502A patent/BG107502A/xx unknown
- 2003-01-30 NO NO20030475A patent/NO20030475L/no not_active Application Discontinuation
- 2003-02-19 HR HR20030121A patent/HRP20030121A2/hr not_active Application Discontinuation
- 2003-02-28 LV LVP-03-25A patent/LV13033B/en unknown
2006
- 2006-09-05 CY CY20061101266T patent/CY1105321T1/el unknown

Also Published As

Publication number	Publication date
CN1655818A (zh)	2005-08-17
EP1305047B1 (fr)	2006-06-21
ES2261447T3 (es)	2006-11-16
AU2001278073B2 (en)	2005-06-30
AU7807301A (en)	2002-02-13
KR20030048000A (ko)	2003-06-18
US20020039997A1 (en)	2002-04-04
EP1305047A2 (fr)	2003-05-02
DK1305047T3 (da)	2006-10-23
EE200300047A (et)	2004-10-15
WO2002009762A3 (fr)	2003-01-09
CY1105321T1 (el)	2010-03-03
IL153933A0 (en)	2003-07-31
MXPA03000836A (es)	2003-06-06
NO20030475D0 (no)	2003-01-30
DE60120986D1 (de)	2006-08-03
BG107502A (en)	2003-07-31
NZ523688A (en)	2005-04-29
HRP20030121A2 (en)	2005-02-28
PT1305047E (pt)	2006-11-30
JP2004530630A (ja)	2004-10-07
ATE330634T1 (de)	2006-07-15
SI21123A (sl)	2003-08-31
WO2002009762A2 (fr)	2002-02-07
US6740636B2 (en)	2004-05-25
HUP0300686A2 (hu)	2003-08-28
CA2417636A1 (fr)	2002-02-07
LV13033B (en)	2004-02-20
YU6703A (sh)	2006-05-25
HUP0300686A3 (en)	2005-03-29
DE60120986T2 (de)	2006-11-23
BR0113140A (pt)	2003-06-24
PL364521A1 (en)	2004-12-13
SK1222003A3 (en)	2003-09-11

Legal Events

Date	Code	Title	Description
2006-02-27	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
DE60318891D1 (de)	2008-03-13	Cyclopropylverbindungen als ccr5 antagonisten
DE60323133D1 (de)	2008-10-02	Cyclohexylverbindungen als ccr5-antagonisten
TW200624427A (en)	2006-07-16	Heterocyclic derivatives and their use as therapeutic agents
TW200626138A (en)	2006-08-01	Heterocyclic derivatives and their use as therapeutic agents
TW200626572A (en)	2006-08-01	Heterocyclic derivatives and their use as therapeutic agents
TW200626155A (en)	2006-08-01	Heterocyclic derivatives and their use as therapeutic agents
TW200626592A (en)	2006-08-01	Heterocyclic derivatives and their use as therapeutic agents
TW200626139A (en)	2006-08-01	Heterocyclic derivatives and their use as therapeutic agents
ATE402176T1 (de)	2008-08-15	Pyrrolidin- und azetidinverbindungen alsccr5- antagonisten
ATE218581T1 (de)	2002-06-15	Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung
ATE410426T1 (de)	2008-10-15	Heterocyclische verbindungen alsccr5-antagonisten
CY1105321T1 (el)	2010-03-03	Μη πεπτιδικοι ανταγωνιστες υποδοχεα ccr1 σε συνδυασμο με κυκλοσπορινη α για τη θepαπεια της απορριψης καρδιακου μοσχευματος
NO20013414D0 (no)	2001-07-10	Ny anvendelse av melagatran
HRP20010133B1 (en)	2005-02-28	Optically active pyridyl-4h-1,2,4-oxadiazine derivative and its use in the treatment of vascular diseases
IL154358A0 (en)	2003-09-17	Treatment of hiv-1 infection and inflammatory disease using cyclophilin receptor antagonists
CY1105302T1 (el)	2010-03-03	Μη-πεπτιδιο ανταγωνιστες υποδοχεα ccr1 για την θepαπεια προϊουσης νεφρικης ινωσης
LT2003015A (en)	2004-01-26	Non-peptide ccr1 receptor antagonists in combination with cyclosporin a for the treatment of heart transplant rejection
BG105984A (bg)	2002-04-30	Използване на озанетант за приготвяне на лекарствени средства полезни за лечение на разстройства на настроението
AR018825A1 (es)	2001-12-12	Antagonistas del receptor de bradiquinina no peptidica para uso en el tratamiento de trastornos y enfermedades oftalmicas
PE20001336A1 (es)	2000-12-13	Composicion que contiene un miorelajante y un antiinflamatorio no esteroideo para el tratamiento de afecciones dolorosas asociadas a contracturas o espamos musculares