NO20013666L - Heterocykliske peptidylketoner med anvendelse som tryptase- inhibitorer - Google Patents

Heterocykliske peptidylketoner med anvendelse som tryptase- inhibitorer

Info

Publication number: NO20013666L
Authority: NO; Norway
Prior art keywords: heterocyclic; tryptase inhibitors; peptidyl; ketones; peptidyl ketones
Prior art date: 1999-01-27

Application number

NO20013666A

Other languages

English (en)

Norwegian (no)

Other versions

NO20013666D0 (no

Inventor

Michael J Costanzo

Bruce E Maryanoff

Stephen C Yabut

Original Assignee

Ortho Mcneil Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-27

Filing date

2001-07-26

Publication date

2001-09-26

2001-07-26 Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc

2001-07-26 Publication of NO20013666D0 publication Critical patent/NO20013666D0/no

2001-09-26 Publication of NO20013666L publication Critical patent/NO20013666L/no

Links

-1 Heterocyclic peptidyl ketones Chemical class 0.000 title 1
239000002750 tryptase inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Pulmonology (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Ophthalmology & Optometry (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Plural Heterocyclic Compounds (AREA)

NO20013666A 1999-01-27 2001-07-26 Heterocykliske peptidylketoner med anvendelse som tryptase- inhibitorer NO20013666L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US11760299P	1999-01-27	1999-01-27
PCT/US2000/000883 WO2000044733A1 (fr)	1999-01-27	2000-01-13	Peptidylcetones heterocycliques inhibitrices de la tryptase

Publications (2)

Publication Number	Publication Date
NO20013666D0 NO20013666D0 (no)	2001-07-26
NO20013666L true NO20013666L (no)	2001-09-26

Family

ID=22373811

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20013666A NO20013666L (no)	1999-01-27	2001-07-26	Heterocykliske peptidylketoner med anvendelse som tryptase- inhibitorer

Country Status (24)

Country	Link
US (2)	US6469036B1 (fr)
EP (1)	EP1147097A1 (fr)
JP (1)	JP2002535394A (fr)
KR (1)	KR20010110422A (fr)
CN (1)	CN1353701A (fr)
AR (1)	AR022427A1 (fr)
AU (1)	AU3208500A (fr)
BG (1)	BG105762A (fr)
BR (1)	BR0007778A (fr)
CA (1)	CA2361479A1 (fr)
CZ (1)	CZ20012722A3 (fr)
EA (1)	EA200100815A1 (fr)
EE (1)	EE200100391A (fr)
HK (1)	HK1038561A1 (fr)
HR (1)	HRP20010601A2 (fr)
HU (1)	HUP0201295A3 (fr)
IL (1)	IL144577A0 (fr)
NO (1)	NO20013666L (fr)
SK (1)	SK10742001A3 (fr)
TR (1)	TR200102766T2 (fr)
TW (1)	TWI229669B (fr)
WO (1)	WO2000044733A1 (fr)
YU (1)	YU61401A (fr)
ZA (1)	ZA200106995B (fr)

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PT1268418E (pt) *	2000-03-27	2006-08-31	Applied Research Systems	Derivados da pirrolidina farmacologicamente activos com inibidores bax
US6589978B2 (en) *	2000-06-30	2003-07-08	Hoffman-La Roche Inc.	1-sulfonyl pyrrolidine derivatives
US6960597B2 (en) *	2000-06-30	2005-11-01	Orth-Mcneil Pharmaceutical, Inc.	Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists
US6797461B2 (en) *	2000-10-27	2004-09-28	Promega Corporation	Tryptase substrates and assay for tryptase activity using same
CA2433713A1 (fr) *	2001-01-05	2002-07-18	Kyowa Hakko Kogyo Co., Ltd.	Agents prophylactiques de l'arthrite
CA2436774A1 (fr)	2001-01-30	2002-08-08	R. Michael Lawrence	Lactames sulfonamide inhibiteurs de facteur xa
GB0103765D0 (en)	2001-02-15	2001-04-04	Affitech As	Assay
US20060183664A1 (en) *	2001-12-13	2006-08-17	Toshiaki Takizawa	Pharmaceutical composition for delayed hypersensitivity
AU2003237224A1 (en) *	2002-05-29	2003-12-19	Merck And Co., Inc.	1,2 diamido cycloalkyl sodium channel blockers
DE10249304B4 (de) *	2002-10-22	2006-09-28	Cytec Surface Specialties Germany Gmbh & Co. Kg	Wäßrige Beschichtungsmittel
US7205384B2 (en)	2003-08-05	2007-04-17	Ortho-Mcneil Pharmaceutical Inc.	Process for preparing peptidyl heterocyclic ketone derivatives
US20050176755A1 (en) *	2003-10-31	2005-08-11	Dyatkin Alexey B.	Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists
WO2005077914A1 (fr) *	2004-02-10	2005-08-25	Janssen Pharmaceutica, N.V.	Urees de pyridazinone utilisees en tant qu'antagonistes des integrines $g(a)4
WO2006023844A2 (fr) *	2004-08-20	2006-03-02	Entremed, Inc.	Compositions et procedes comportant des antagonistes de recepteur active par la proteinase
GB0507577D0 (en) *	2005-04-14	2005-05-18	Novartis Ag	Organic compounds
CA2651043A1 (fr) *	2006-05-23	2007-12-06	David C. Tully	Composes et compositions inhibant les proteases activatrices de canaux
JP2009538327A (ja) *	2006-05-23	2009-11-05	アイアールエム・リミテッド・ライアビリティ・カンパニー	チャネル活性化プロテアーゼ阻害剤である化合物および組成物
JP2010518099A (ja)	2007-02-09	2010-05-27	アイアールエム・リミテッド・ライアビリティ・カンパニー	チャネル活性化プロテアーゼ阻害剤としての化合物および組成物
KR101131238B1 (ko)	2007-02-09	2012-03-30	아이알엠 엘엘씨	채널 활성화 프로테아제 억제제로서의 화합물 및 조성물
CN101646437A (zh) *	2007-02-09	2010-02-10	Irm责任有限公司	作为通道活化蛋白酶抑制剂的化合物和组合物
ES2351323B1 (es) *	2009-06-26	2011-10-05	Institut Univ. De Ciència I Tecnologia, S.A.	Bibliotecas de n-fenil-1-sulfonil-2-pirrolidinacarboxamidas para el descubrimiento de farmacos.
US9365853B2 (en)	2011-06-02	2016-06-14	SOCPRA Sciences Sante et Humaines S.E.C.	Matriptase inhibitors and uses thereof against orthomyxoviridae infections
CN103145598B (zh) *	2011-12-07	2014-10-15	北京京卫顺康医药科技发展有限公司	一种奥沙西罗晶体及含有该晶体的组合物
SI3063141T1 (sl) *	2013-10-29	2018-11-30	Biomarin Pharmaceutical Inc.	N-(1-hidroksi-3-(pirolidinil)propan-2-il)pirolidin-3-karboksamidni derivati kot inhibitorji glukozilceramid sintaze
CN111349053A (zh) *	2014-10-06	2020-06-30	库特克希米公司	赖氨酸牙龈卟啉菌蛋白酶的抑制剂
US11130780B2 (en) *	2015-03-09	2021-09-28	Washington University	Inhibitors of growth factor activation enzymes
WO2017083433A1 (fr)	2015-11-09	2017-05-18	Cortexyme, Inc.	Inhibiteurs d'arginine gingipaïne
EP4480541A3 (fr)	2016-09-16	2025-04-30	Lighthouse Pharmaceuticals, Inc.	Inhibiteurs cétoniques de lysine gingipaïne
AU2018265397A1 (en)	2017-05-10	2019-11-28	Cortexyme, Inc.	Aminopyridine compounds and methods for the preparation and use thereof
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US5525623A (en)	1993-03-12	1996-06-11	Arris Pharmaceutical Corporation	Compositions and methods for the treatment of immunomediated inflammatory disorders
JPH0820597A (ja)	1994-07-07	1996-01-23	Meiji Seika Kaisha Ltd	トロンビン阻害作用を有する複素環カルボニル化合物
WO1996019491A1 (fr)	1994-12-22	1996-06-27	Biochem Pharma Inc.	Peptides de cetoarginine heterocycliques utilises comme inhibiteurs de thrombine
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DE69735545T2 (de)	1996-08-05	2006-08-10	Myriad Genetics, Inc., Salt Lake City	Verwendung von beta-blatt mimetika als protease und kinase hemmer und alshemmer eines transkriptionsfaktors
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WO1999026925A1 (fr)	1997-11-26	1999-06-03	Yoshitomi Pharmaceutical Industries, Ltd.	Inhibiteurs de tryptase comprenant des composants d'amide heterocycliques
KR100601810B1 (ko)	1997-12-16	2006-07-19	죤슨 앤드 죤슨 컨써머 캄파니스 인코포레이티드	식작용 및 ｉｃａｍ-1 발현을 조절하기 위한 조성물 및 방법

2000
- 2000-01-13 CA CA002361479A patent/CA2361479A1/fr not_active Abandoned
- 2000-01-13 KR KR1020017009542A patent/KR20010110422A/ko not_active Ceased
- 2000-01-13 BR BR0007778-0A patent/BR0007778A/pt not_active IP Right Cessation
- 2000-01-13 TR TR2001/02766T patent/TR200102766T2/xx unknown
- 2000-01-13 YU YU61401A patent/YU61401A/sh unknown
- 2000-01-13 AU AU32085/00A patent/AU3208500A/en not_active Abandoned
- 2000-01-13 EE EEP200100391A patent/EE200100391A/xx unknown
- 2000-01-13 EP EP00909902A patent/EP1147097A1/fr not_active Withdrawn
- 2000-01-13 CZ CZ20012722A patent/CZ20012722A3/cs unknown
- 2000-01-13 CN CN00805510A patent/CN1353701A/zh active Pending
- 2000-01-13 HU HU0201295A patent/HUP0201295A3/hu unknown
- 2000-01-13 SK SK1074-2001A patent/SK10742001A3/sk unknown
- 2000-01-13 WO PCT/US2000/000883 patent/WO2000044733A1/fr not_active Application Discontinuation
- 2000-01-13 IL IL14457700A patent/IL144577A0/xx unknown
- 2000-01-13 EA EA200100815A patent/EA200100815A1/ru unknown
- 2000-01-13 US US09/482,802 patent/US6469036B1/en not_active Expired - Lifetime
- 2000-01-13 JP JP2000595989A patent/JP2002535394A/ja not_active Withdrawn
- 2000-01-26 AR ARP000100333A patent/AR022427A1/es unknown
- 2000-02-24 TW TW089101335A patent/TWI229669B/zh not_active IP Right Cessation
2001
- 2001-07-26 NO NO20013666A patent/NO20013666L/no not_active Application Discontinuation
- 2001-08-01 BG BG105762A patent/BG105762A/xx unknown
- 2001-08-13 HR HR20010601A patent/HRP20010601A2/hr not_active Application Discontinuation
- 2001-08-23 ZA ZA200106995A patent/ZA200106995B/en unknown
2002
- 2002-01-07 HK HK02100110.3A patent/HK1038561A1/zh unknown
- 2002-07-25 US US10/205,355 patent/US7132418B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
SK10742001A3 (sk)	2002-08-06
HUP0201295A3 (en)	2002-10-28
HUP0201295A2 (en)	2002-09-28
BG105762A (en)	2002-03-29
HK1038561A1 (zh)	2002-03-22
US7132418B2 (en)	2006-11-07
EP1147097A1 (fr)	2001-10-24
US20030008829A1 (en)	2003-01-09
CA2361479A1 (fr)	2000-08-03
TR200102766T2 (tr)	2001-12-21
WO2000044733A1 (fr)	2000-08-03
IL144577A0 (en)	2002-05-23
HRP20010601A2 (en)	2002-08-31
AU3208500A (en)	2000-08-18
KR20010110422A (ko)	2001-12-13
BR0007778A (pt)	2002-06-04
AR022427A1 (es)	2002-09-04
EE200100391A (et)	2002-10-15
EA200100815A1 (ru)	2002-08-29
CN1353701A (zh)	2002-06-12
JP2002535394A (ja)	2002-10-22
CZ20012722A3 (cs)	2002-08-14
NO20013666D0 (no)	2001-07-26
TWI229669B (en)	2005-03-21
ZA200106995B (en)	2002-11-25
YU61401A (sh)	2005-07-19
US6469036B1 (en)	2002-10-22

Legal Events

Date	Code	Title	Description
2005-10-31	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO20013666L (no)	2001-09-26	Heterocykliske peptidylketoner med anvendelse som tryptase- inhibitorer
DK1244647T3 (da)	2006-09-25	Quinzolinderivater som VIGF-inhibitorer
CY2016002I2 (el)	2016-10-05	Ν-υποκατεστημενο καρβαμουλοξυαλκυλιο - παραγωγα αζολιου
IL152830A0 (en)	2003-06-24	Arylmethylamine derivatives for use as tryptase inhibitors
NO20034439L (no)	2003-12-02	Benzamidinderivater
NO20025696L (no)	2002-11-27	Indolderivater med vaskul¶r skadende aktivitet
EE200100486A (et)	2003-02-17	Amiinderivaadid proteaasi inhibiitoritena
EE200100492A (et)	2002-12-16	Ensüümi IMPDH inhibiitorid
DE60002193D1 (de)	2003-05-22	Metalloprotease inhibitoren
NO20021329L (no)	2002-05-21	Kinaseinhibitorer som terapeutiske midler
NO20014642L (no)	2001-11-28	Aminopyrimidiner som sorbitol-dehydrogenase-inhibitorer
DE60008527D1 (de)	2004-04-01	Zellproliferation inhibitoren
NO20014243D0 (no)	2001-08-31	Dihetero-substituerte metalloprotease inhibitorer
NO20016201D0 (no)	2001-12-18	Tienopyrimidiner som fosfodiesteraseinhibitorer
NO20021959L (no)	2002-05-29	Tetrahydrotiopyranftalazinon-derivater som PDE4-inhibitorer
DE60024101D1 (de)	2005-12-22	Enzyminhibitoren
GB0026578D0 (en)	2000-12-13	Heterocyclic derivatives useful as pharmaceutical agents
EE200200432A (et)	2003-12-15	Heterotsüklilised amiidderivaadid
NO20022682L (no)	2002-07-17	Heterosykliske derivater
DK1200409T3 (da)	2004-06-28	Substituerede isoquinolinderivater og deres anvendelse som krampestillende midler
NO20020592D0 (no)	2002-02-06	Fluorenderivater som integrininhibitorer
GB0226609D0 (en)	2002-12-24	Heterocyclic derivatives
GB0220961D0 (en)	2002-10-23	Heterocyclic derivatives
GB0206859D0 (en)	2002-05-01	Heterocyclic derivatives
GB0209994D0 (en)	2002-06-12	heterocyclic derivatives