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NO20006600L - Ikke-peptidylinhibitorer av VLA-4-avhengig cellebinding nyttig for behandling av inflammatoriske, autoimmune og respiratoriske sykdommer - Google Patents

Ikke-peptidylinhibitorer av VLA-4-avhengig cellebinding nyttig for behandling av inflammatoriske, autoimmune og respiratoriske sykdommer

Info

Publication number
NO20006600L
NO20006600L NO20006600A NO20006600A NO20006600L NO 20006600 L NO20006600 L NO 20006600L NO 20006600 A NO20006600 A NO 20006600A NO 20006600 A NO20006600 A NO 20006600A NO 20006600 L NO20006600 L NO 20006600L
Authority
NO
Norway
Prior art keywords
vla
autoimmune
inflammatory
treatment
cell binding
Prior art date
Application number
NO20006600A
Other languages
English (en)
Norwegian (no)
Other versions
NO20006600D0 (no
Inventor
Allen Jacob Duplantier
Anthony John Milici
Louis Stanley Chupak
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NO20006600D0 publication Critical patent/NO20006600D0/no
Publication of NO20006600L publication Critical patent/NO20006600L/no

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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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NO20006600A 1998-06-30 2000-12-22 Ikke-peptidylinhibitorer av VLA-4-avhengig cellebinding nyttig for behandling av inflammatoriske, autoimmune og respiratoriske sykdommer NO20006600L (no)

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US9118098P 1998-06-30 1998-06-30
PCT/IB1999/000973 WO2000000477A1 (fr) 1998-06-30 1999-05-31 Inhibiteurs non peptidyle de la liaison cellulaire dependant de vla-4 utiles dans le traitement des maladies inflammatoires, auto-immunes et respiratoires

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Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6992107B1 (en) 1995-03-10 2006-01-31 Photocure Asa Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy
CZ20004568A3 (cs) 1998-06-12 2001-11-14 Societe De Conseils De Recherches Et D'application Sloučenina imidazolylu, farmaceutický prostředek a způsob výroby
CZ20004909A3 (cs) * 1998-06-30 2002-04-17 Pfizer Products Inc. Nepeptidové inhibitory VLA-4 dependentní buněčné vazby pouľitelné při léčení zánětlivých, autoimunitních a respiračních chorob
US6518292B1 (en) * 1999-03-12 2003-02-11 Bristol-Myers Squibb Co. Heterocyclic aromatic compounds usefuls as growth hormone secretagogues
US6756378B2 (en) * 1999-06-30 2004-06-29 Pharmacopeia Drug Discovery, Inc. VLA-4 inhibitor compounds
CN1391473A (zh) * 1999-06-30 2003-01-15 第一制药株式会社 Vla－4抑制剂化合物
WO2001051487A1 (fr) * 1999-12-28 2001-07-19 Pfizer Products Inc. Inhibiteurs non peptidyle de liaison cellulaire dependant de vla-4 utiles pour le traitement de maladies inflammatoires, auto-immunes et respiratoires
WO2001056994A1 (fr) * 2000-02-04 2001-08-09 Biogen, Inc. Antagonistes de l'integrine
JP2004516237A (ja) 2000-06-21 2004-06-03 ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー ケモカイン受容体活性調節剤としてのピペリジンアミド類
ATE360620T1 (de) 2000-08-01 2007-05-15 Sod Conseils Rech Applic Imidazolderivate
GB2367816A (en) * 2000-10-09 2002-04-17 Bayer Ag Urea- and thiourea-containing derivatives of beta-amino acids
AU2002219555B2 (en) 2000-12-28 2006-11-30 Daiichi Pharmaceutical Co., Ltd. VLA-4 Inhibitors
DE10111877A1 (de) * 2001-03-10 2002-09-12 Aventis Pharma Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
ATE408593T1 (de) * 2001-05-03 2008-10-15 Galileo Lab Inc Pyruvatderivate
DE60224664T2 (de) * 2001-06-06 2009-01-08 Aventis Pharma Ltd., West Malling Substituierte tetrhydroisochinolin-derivate zur behandlung von entzündlichen erkrankungen
GB2377933A (en) 2001-07-06 2003-01-29 Bayer Ag Succinic acid derivatives useful as integrin antagonists
DE10137595A1 (de) 2001-08-01 2003-02-13 Aventis Pharma Gmbh Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung
US6974869B2 (en) * 2001-09-18 2005-12-13 Bristol-Myers Squibb Pharma Company Piperizinones as modulators of chemokine receptor activity
JP2005533058A (ja) 2002-06-17 2005-11-04 メルク　エンド　カムパニー　インコーポレーテッド Ｅｄｇ受容体アゴニストとしての１−（（５−アリール−１，２，４−オキサジアゾール−３−イル）ベンジル）アゼチジン−３−カルボキシラートおよび１−（（５−アリール−１，２，４−オキサジアゾール−３−イル）ベンジル）ピロリジン−３−カルボキシラート
PL374860A1 (en) 2002-07-09 2005-11-14 Bristol-Myers Squibb Company Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
US7691894B2 (en) 2003-07-24 2010-04-06 Daiichi Pharmaceutical Co., Ltd. Cyclohexanecarboxylic acid compound
GB0402812D0 (en) * 2004-02-09 2004-03-10 Tanabe Seiyaku Co Novel compounds
US7309709B2 (en) * 2004-04-01 2007-12-18 Pfizer Inc. Thiazole sulfonamide compounds for the treatment of neurodegenerative disorders
TW200610754A (en) * 2004-06-14 2006-04-01 Daiichi Seiyaku Co Vla-4 inhibitor
US7453002B2 (en) 2004-06-15 2008-11-18 Bristol-Myers Squibb Company Five-membered heterocycles useful as serine protease inhibitors
WO2007069635A1 (fr) 2005-12-13 2007-06-21 Daiichi Sankyo Company, Limited Médicament inhibiteur de vla-4
WO2011020874A1 (fr) 2009-08-20 2011-02-24 Inserm (Institut National De La Sante Et De La Recherche Medicale) Vla-4 en tant que biomarqueur pour le pronostic et le ciblage pour thérapie dans la dystrophie musculaire de duchenne
EP4494698A3 (fr) 2017-08-04 2025-04-23 Takeda Pharmaceutical Company Limited Inhibiteurs de la kallicréine plasmatique et leurs utilisations
US20240301512A1 (en) 2021-01-29 2024-09-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of assessing the risk of developing progressive multifocal leukoencephalopathy in patients treated with vla-4 antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5294713A (en) * 1991-08-23 1994-03-15 Takeda Chemical Industries, Ltd. 2-piperazinone compounds and their use
US6306840B1 (en) * 1995-01-23 2001-10-23 Biogen, Inc. Cell adhesion inhibitors
CZ20004909A3 (cs) * 1998-06-30 2002-04-17 Pfizer Products Inc. Nepeptidové inhibitory VLA-4 dependentní buněčné vazby pouľitelné při léčení zánětlivých, autoimunitních a respiračních chorob

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SK20052000A3 (sk) 2002-08-06
CZ20004909A3 (cs) 2002-04-17
AP1236A (en) 2004-01-14
CO5320599A1 (es) 2003-09-30
IS5720A (is) 2000-11-21
NZ508033A (en) 2002-12-20
ID27414A (id) 2001-04-05
NO20006600D0 (no) 2000-12-22
PE20000762A1 (es) 2000-08-24
HUP0102477A2 (hu) 2002-05-29
GT199900101A (es) 2000-12-16
AU3841699A (en) 2000-01-17
KR20010083081A (ko) 2001-08-31
HRP20000917A2 (en) 2002-02-28
IL139584A0 (en) 2002-02-10
AU758939B2 (en) 2003-04-03
BR9911701A (pt) 2001-03-20
JP2002519344A (ja) 2002-07-02
TNSN99110A1 (fr) 2005-11-10
HUP0102477A3 (en) 2002-08-28
DE69928667D1 (de) 2006-01-05
UA66864C2 (uk) 2004-06-15
AR015312A1 (es) 2001-04-18
US6306887B1 (en) 2001-10-23
AP9901561A0 (en) 1999-06-30
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TR200003848T2 (tr) 2001-06-21
ATE311371T1 (de) 2005-12-15
WO2000000477A1 (fr) 2000-01-06
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