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MA39934A - Variants d'anticorps anti-facteur d et leurs utilisations - Google Patents

Variants d'anticorps anti-facteur d et leurs utilisations

Info

Publication number
MA39934A
MA39934A MA039934A MA39934A MA39934A MA 39934 A MA39934 A MA 39934A MA 039934 A MA039934 A MA 039934A MA 39934 A MA39934 A MA 39934A MA 39934 A MA39934 A MA 39934A
Authority
MA
Morocco
Prior art keywords
factor
antibody variants
medicaments
diseases
excessive
Prior art date
Application number
MA039934A
Other languages
English (en)
Inventor
Philip E Hass
Robert F Kelley
Justin M Scheer
Devin Tesar
Lookeren-Campagne Menno Van
Original Assignee
Hoffmann La Roche
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche, Genentech Inc filed Critical Hoffmann La Roche
Publication of MA39934A publication Critical patent/MA39934A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21046—Complement factor D (3.4.21.46)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne des variants d'anticorps anti-facteur d, leur production et leur utilisation dans la préparation de compositions et de médicaments pour le traitement de maladies et de troubles associés à une activation du complément excessive ou incontrôlée.
MA039934A 2014-05-01 2015-04-30 Variants d'anticorps anti-facteur d et leurs utilisations MA39934A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461987298P 2014-05-01 2014-05-01
US201462076372P 2014-11-06 2014-11-06

Publications (1)

Publication Number Publication Date
MA39934A true MA39934A (fr) 2017-03-08

Family

ID=53059539

Family Applications (1)

Application Number Title Priority Date Filing Date
MA039934A MA39934A (fr) 2014-05-01 2015-04-30 Variants d'anticorps anti-facteur d et leurs utilisations

Country Status (19)

Country Link
US (1) US10179821B2 (fr)
EP (1) EP3137503A1 (fr)
JP (1) JP2017515811A (fr)
KR (1) KR20160147855A (fr)
CN (1) CN106536561A (fr)
AU (1) AU2015253042A1 (fr)
BR (1) BR112016025312A2 (fr)
CA (1) CA2944712A1 (fr)
CL (1) CL2016002738A1 (fr)
CR (1) CR20160561A (fr)
EA (1) EA201692109A1 (fr)
IL (1) IL248042A0 (fr)
MA (1) MA39934A (fr)
MX (1) MX2016014160A (fr)
PE (1) PE20161440A1 (fr)
PH (1) PH12016502015A1 (fr)
SG (1) SG11201608868PA (fr)
TW (1) TW201623337A (fr)
WO (1) WO2015168468A1 (fr)

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AU2015253042A1 (en) 2014-05-01 2016-10-20 Genentech, Inc. Anti-factor D antibody variants and uses thereof
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
WO2017075252A1 (fr) * 2015-10-30 2017-05-04 Genentech, Inc. Conjugués de variants d'anticorps anti-facteur d et leurs utilisations
EP3368074A2 (fr) 2015-10-30 2018-09-05 Hoffmann-La Roche AG Anticorps et conjugués anti-facteur d
CA3003647A1 (fr) * 2015-10-30 2017-05-04 Genentech, Inc. Formulations d'anticorps anti-facteur d
CA3010056A1 (fr) 2015-12-30 2017-07-06 Kodiak Sciences Inc. Anticorps et conjugues de ceux-ci
GB2553252B (en) * 2016-01-20 2019-07-31 Vitrisa Therapeutics Inc Aptamers that block the catalytic cleft of complement Factor D
CN107043422B (zh) * 2016-01-28 2022-01-04 成都康弘生物科技有限公司 抗补体因子D的人源化Fab和人源化抗体及其用途
WO2018136827A1 (fr) 2017-01-20 2018-07-26 Vitrisa Therapeutics, Inc. Compositions à boucle en épingle à cheveux et procédés pour inhiber le facteur d
WO2018148486A1 (fr) * 2017-02-10 2018-08-16 The Trustees Of The University Of Pennsylvania Anticorps anti-facteur d et utilisations de ces derniers
CN106905431B (zh) * 2017-04-10 2020-01-17 旭华（上海）生物研发中心有限公司 抗人补体d因子的单克隆抗体及其用途
EP3610010A4 (fr) * 2017-04-14 2021-02-24 Kodiak Sciences Inc. Anticorps antagonistes du facteur d du complément et leurs conjugués
JP2022553640A (ja) 2019-10-10 2022-12-26 コディアック サイエンシーズ インコーポレイテッド 眼障害を処置する方法
KR20230009431A (ko) 2020-05-12 2023-01-17 알렉시온 파마슈티칼스, 인코포레이티드 발작성 야간 혈색소뇨증의 치료를 위한 보체 인자 d 저해제를 단독으로 또는 항-c5 항체와 조합한 용도
CN116635064A (zh) 2020-12-18 2023-08-22 世纪治疗股份有限公司 具有适应性受体特异性的嵌合抗原受体系统
EP4320149A1 (fr) * 2021-04-09 2024-02-14 Takeda Pharmaceutical Company Limited Anticorps ciblant le facteur d du complément et leurs utilisations
WO2025045251A2 (fr) * 2023-09-03 2025-03-06 Kira Pharmaceuticals (Us) Llc Constructions multispécifiques comprenant une fraction anti-facteur d

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PH12016502015A1 (en) 2017-01-16
PE20161440A1 (es) 2017-01-26
IL248042A0 (en) 2016-11-30
AU2015253042A1 (en) 2016-10-20
MX2016014160A (es) 2017-02-16
EP3137503A1 (fr) 2017-03-08
WO2015168468A1 (fr) 2015-11-05
JP2017515811A (ja) 2017-06-15
CR20160561A (es) 2017-05-03
KR20160147855A (ko) 2016-12-23
TW201623337A (zh) 2016-07-01
SG11201608868PA (en) 2016-11-29
BR112016025312A2 (pt) 2017-10-17
AU2015253042A2 (en) 2016-10-27
CN106536561A (zh) 2017-03-22
US20160017052A1 (en) 2016-01-21
EA201692109A1 (ru) 2017-03-31
CL2016002738A1 (es) 2017-06-23
US10179821B2 (en) 2019-01-15

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