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Biorefinery is an innovative concept for resource utilization. To further increase its efficiency, the integration of different biomass conversion technologies (integrated biorefinery) is essential. Biodiesel,...
Co-culturing filamentous fungi with microalgae is thought to be a viable method for effective microalgae bioflocculation. Using filamentous fungus makes it possible to produce big, flocculated pellets without ...
Expanding the promoter toolbox of Komagataella phaffii (K. phaffii) in terms of strength and regulatory flexibility can significantly enhance bioprocess efficiency for recombinant protein and metabolite productio...
Nybomycin is a reverse antibiotic with selective activity against fluoroquinolone-resistant Gram-positive bacteria, including Staphylococcus aureus, making it a promising candidate to fight against antimicrobial ...
Phenylspirodrimanes (PSDs) are a unique class of meroterpenoids that have been extensively studied due to their diverse biological activities. These metabolites are supposedly biosynthesized through the farnes...
Many research teams have prioritized the investigation of the biotechnological production of carotenoids in the last few decades due to their multipurpose application. In this review, the bioproduction of the ...
Precision fermentation offers a sustainable alternative production route for proteins but still suffers from moderate productivities and low yields. Especially compared to biomass yields, recombinant protein y...
β-Galactosidases are widely used in the dairy industry to produce lactose-free milk and prebiotics such as galacto-oligosaccharides and lactulose. Since commercial β-galactosidases have optimal activity at 35 ...
The diverse metabolic mechanisms underlying bacterial extracellular polymeric substances give rise to a wide array of components with distinct functionalities, including exopolysaccharides (EPS) and poly-γ-glu...
Kojic acid, a significant secondary metabolite primarily synthesized by Aspergillus oryzae, has extensive applications across various industries. It is imperative to identify effective gene targets that can enhan...
Surfactants are an important chemical in the industry due to their unique properties to reduce surface tension between fluids. To date, raw materials involved for the synthesis of surfactants are mostly derive...
Bloodstream infections caused by carbapenem-resistant Acinetobacter baumannii (CRAB) are a significant public health problem, with high morbidity and mortality. Detection and identification of CRAB is essential f...
Xenobiotic response element (XRE) regulator proteins play an important role in gene regulation in Streptomyces. In these bacteria, they are often encoded together with a small protein containing a DUF397 domain. ...
Streptomyces rimosus is renowned for complex metabolic pathways and the ability to produce diverse bioactive secondary metabolites, including antibiotics, antifungals, and other biologically active compounds. Des...
The marine diatom Phaeodactylum tricornutum plays a crucial role in global carbon and nitrogen cycling. Previous work revealed that lactate regulates carbon and nitrogen metabolism of P. tricornutum through prote...
Triacetic acid lactone (TAL) is a promising platform chemical to produce valuable compounds. The development of engineered microbial hosts to efficiently produce TAL from lipid-containing waste streams could b...
In an array to check microbial resistance against generally used antibiotics, it is essential to create innovative and efficient antimicrobial agents. Therefore, nanoparticles (NPs) with their antimicrobial ac...
Perylenequinones, such as hypocrellins and hypomycins, are fungal secondary metabolites with potential for pharmaceutical and industrial applications due to both their physical and biological properties. This ...
Tauroursodeoxycholic acid (TUDCA) is a microbial bile acid known for its diverse yet still largely unexplored biological activities. Traditionally used in Asian medicine, TUDCA and the taurine-free form, ursod...
Ganoderma lingzhi (G. lingzhi) is a Basidiomycete macrofungus valued for its secondary metabolites with pharmacological activity. To enhance the biosynthesis of secondary metabolites, various exogenous additives ...
Polyhydroxyalkanoates (PHA) are sustainable alternatives to conventional plastics due to biodegradability and biocompatibility. However, most PHA-producing strains are Gram-negative, which co-produce endotoxin...
Lignin holds great potential as an abundant and sustainable source of aromatic compounds, offering a viable alternative to fossil-based resources for producing chemicals and materials. Biological upgrading of ...
Thymol and carvacrol are natural phenolic compounds with various biological activities. They are widely used in the spice and medicine industries. Production of thymol and carvacrol using microbial cell factor...
Traditional chemotherapy, a prevalent cancer treatment modality, is associated with significant side effects and often leads to treatment failure. Non-specific drug distribution and chemoresistance are the mai...
Short-chain carboxylic acids are important chemical intermediates in anaerobic treatment or thermal hydrolysis of biowaste. They are a crucial precursor for the production of Polyhydroxyalkanoate (PHA) by vari...
Polyhydroxyalkanoate synthase (phaC) gene encodes for PHA synthase enzyme which plays a key role in PHA polymerisation. To screen, unknown bacterial strains for their potential to produce PHAs, the presence of ph...
The bacterial production of polyhydroxyalkanoates (PHAs), a class of non-toxic, biodegradable, and bio-based polymers, has gained increasing attention as a sustainable alternative to petrochemical plastics. Am...
Microbial-induced calcium carbonate precipitation (MICP) has garnered significant attention for its construction and geotechnical engineering applications. In this study, 24 bacterial isolates were obtained fr...
The Egyptian cotton leafworm (Spodoptera littoralis) is a highly destructive, pesticide-resistant pest affecting over 80 economically important crops across the Mediterranean and African regions. While chemical i...
Synthetic dyes in the textile industry pose risks to human health and environmental safety. The current study aims to examine the efficacy of a novel esterase derived from an endophyte fungus in decolorizing d...
Diminishing the productivity of Taxol by the potential fungi with storage is the key hurdle that impedes their applications to be an industrial platform for Taxol production. Thus, exploring of a fungal isolat...
In the existing literature, there is ample information available concerning the analogs constituting linear Gramicidin (Gramicidin A). However, the literature lacks information regarding the microbial producti...
Cyanobacteria are emerging as a promising platform for whole-cell biotransformation, harnessing solar energy to drive biocatalytic reactions through recombinant enzymes. However, optimisation remains challengi...
One of the inherent problems of activated sludge processes (ASPs) is the production of large volumes of sludge, which creates issues in secondary clarifiers regarding sludge settling. The application of physic...
Bacterial cellulose (BC)-based dressings exhibit favorable hydrogel characteristics, including high biocompatibility, moisture regulation, and mechanical adaptability, making them suitable candidates for biome...
Glyphosate is widely used as an herbicide around the world. The extensive application of glyphosate, however, has serious adverse effects on living systems. Therefore, the elimination of residual glyphosate po...
Microalgae are promising sustainable feedstocks for biodiesel production. Among the primary carbon reservoirs in microalgae, starch and lipids are the main targets for metabolic engineering aimed at enhancing ...
Paenibacillus polymyxa WLY78, a Gram-positive diazotroph with plant growth promotion and phytopathogen suppression, represents a promising candidate for agricultural biofertilizers. However, its nitrogen fixation...
Genome-scale mutagenesis integrated with high-throughput phenotypic screening and causal mutation mapping serves as a robust paradigm for systemic genetic dissection. Despite the application of non-homologous ...
Cellulase can degrade cellulose into reducing sugar, participating in the natural carbon cycle. Simultaneously, cellulase enhances the efficiency and quality of industrial production while also demonstrating s...
Peanut meal, a high-protein agricultural by-product, faces challenges as animal feed due to anti-nutritional factors, poor protein digestibility, aflatoxin contamination, and imbalanced amino acids. Microbial ...
Silver nanoparticles (AgNPs) have attracted considerable interest for their distinctive physicochemical properties and wide-ranging applications in nanomedicine, environmental catalysis, and antimicrobial appl...
Enzyme production is crucial for biorefinery applications and the valorization of agricultural residues. However, real-time monitoring of pH and temperature in enzyme-producing solid-state fermentation (SSF) i...
Starch is a carbohydrate polymer, made up of multiple glucose units, connected through glycosidic bonds. Starch nanoparticles (StNPs) are characterized as particles that possess at least one dimension measurin...
Microbial carotenoids have gained industry interest due to their safety and diverse biological activities; however, the low yield of carotenoids hinders their applications. Hence, this study focused on optimiz...
Gluten proteins from wheat, rye, and barley play a substantial role in human nutrition. At the same time, they can trigger several different immune reactions. This, together with their influence on the quality...
Hypersaline environments are ecologically, industrially, and scientifically important because they host unique extremophiles used in biotechnology, bioremediation, and enzyme production. These habitats are ser...
Plasmid DNA (pDNA) is a cost-driving reagent for the production of gene therapies and DNA vaccines. Improving pDNA production in the most common production host (E. coli) has faced obstacles arising from the comp...
Bacillus subtilis, a key model strain in microbial physiology and biochemistry research, is non-pathogenic, secretes proteins efficiently, and has a clear genetic background, making it an ideal host for producing...
Producing bio-based chemicals using a straightforward and ecologically responsible biotechnological method is intriguing. Maltobionic acid (MBA) is an aldobionic acid obtained from maltose oxidation and is an ...
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Microbial Cell Factories is a companion journal to:
Biotechnology for Biofuels and Bioproducts
Biotechnology for the Environment
Biotechnology for Sustainable Materials
Fungal Biology and Biotechnology