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  1. Biorefinery is an innovative concept for resource utilization. To further increase its efficiency, the integration of different biomass conversion technologies (integrated biorefinery) is essential. Biodiesel,...

    Authors: Jose L. Marcos, Gema Cabrera, Daniel F. Hernandez, Beatriz Luque, Antonio Valle and Jorge Bolivar
    Citation: Microbial Cell Factories 2025 24:230
  2. Co-culturing filamentous fungi with microalgae is thought to be a viable method for effective microalgae bioflocculation. Using filamentous fungus makes it possible to produce big, flocculated pellets without ...

    Authors: Abeer Mohamed, Eman Owis, Gamal Abdel-Fattah and Eladl Eltanahy
    Citation: Microbial Cell Factories 2025 24:229
  3. Expanding the promoter toolbox of Komagataella phaffii (K. phaffii) in terms of strength and regulatory flexibility can significantly enhance bioprocess efficiency for recombinant protein and metabolite productio...

    Authors: Katharina Ebner, Núria Bernat-Camps, Simona Scheipel, Corina Dörner, Francisco Valero, Anton Glieder and Xavier Garcia-Ortega
    Citation: Microbial Cell Factories 2025 24:228
  4. Nybomycin is a reverse antibiotic with selective activity against fluoroquinolone-resistant Gram-positive bacteria, including Staphylococcus aureus, making it a promising candidate to fight against antimicrobial ...

    Authors: Wei Shu, Julian Stegmüller, Marta Rodriguez-Estevez, Christian Rückert-Reed, Jörn Kalinowski, Oleksandr Gromyko, Yuriy Rebets, Andriy Luzhetskyy and Christoph Wittmann
    Citation: Microbial Cell Factories 2025 24:227
  5. Phenylspirodrimanes (PSDs) are a unique class of meroterpenoids that have been extensively studied due to their diverse biological activities. These metabolites are supposedly biosynthesized through the farnes...

    Authors: Hui Lv, Bailin Song, Lingjin Bu, Wenni He, Lu Wang, Liyan Yu and Tao Zhang
    Citation: Microbial Cell Factories 2025 24:226
  6. Many research teams have prioritized the investigation of the biotechnological production of carotenoids in the last few decades due to their multipurpose application. In this review, the bioproduction of the ...

    Authors: Khaled B. Al-Monofy, Mahmoud H. Farghali, Lamiaa A. Al-Madboly, Amal M. Abo Kamer and Ahmed A. Abdelaziz
    Citation: Microbial Cell Factories 2025 24:225
  7. Precision fermentation offers a sustainable alternative production route for proteins but still suffers from moderate productivities and low yields. Especially compared to biomass yields, recombinant protein y...

    Authors: Nuran Temelli, Willem H. Baris, Ruud A. Weusthuis and Markus M. M. Bisschops
    Citation: Microbial Cell Factories 2025 24:224
  8. β-Galactosidases are widely used in the dairy industry to produce lactose-free milk and prebiotics such as galacto-oligosaccharides and lactulose. Since commercial β-galactosidases have optimal activity at 35 ...

    Authors: Fernando Gutierrez, Jennifer Alcaino, Victor Cifuentes and Marcelo Baeza
    Citation: Microbial Cell Factories 2025 24:223
  9. Surfactants are an important chemical in the industry due to their unique properties to reduce surface tension between fluids. To date, raw materials involved for the synthesis of surfactants are mostly derive...

    Authors: Yan Jer Ng, Kuan Shiong Khoo, Kit Wayne Chew, Doris Ying Ying Tang, Sarah Alharthi, Andres Philip Mayol and Pau Loke Show
    Citation: Microbial Cell Factories 2025 24:220
  10. Bloodstream infections caused by carbapenem-resistant Acinetobacter baumannii (CRAB) are a significant public health problem, with high morbidity and mortality. Detection and identification of CRAB is essential f...

    Authors: Lin Yu, Jingzhi Zhang, Ze Liu, Chushi Guan, Siyi Liu, Yandong Zhang, Ziman Wu, Xiaodan Zheng, Xianling Zhou and Baoqing Sun
    Citation: Microbial Cell Factories 2025 24:219
  11. Xenobiotic response element (XRE) regulator proteins play an important role in gene regulation in Streptomyces. In these bacteria, they are often encoded together with a small protein containing a DUF397 domain. ...

    Authors: Carolina Riascos, Gemma Fernández-García, Javier García-Martín, Ángel Manteca, Ramón I. Santamaría and Margarita Díaz
    Citation: Microbial Cell Factories 2025 24:218
  12. Streptomyces rimosus is renowned for complex metabolic pathways and the ability to produce diverse bioactive secondary metabolites, including antibiotics, antifungals, and other biologically active compounds. Des...

    Authors: Anna Ścigaczewska, Tomasz Boruta and Marcin Bizukojć
    Citation: Microbial Cell Factories 2025 24:217
  13. The marine diatom Phaeodactylum tricornutum plays a crucial role in global carbon and nitrogen cycling. Previous work revealed that lactate regulates carbon and nitrogen metabolism of P. tricornutum through prote...

    Authors: Jiawen Duan, Yi Zhang, Chenhui Li, Yimeng Zheng, Yanhua Zeng, Xin Zhang, Xiaoni Cai, Hao Long, Wei Ren, Zhenyu Xie and Aiyou Huang
    Citation: Microbial Cell Factories 2025 24:216
  14. Triacetic acid lactone (TAL) is a promising platform chemical to produce valuable compounds. The development of engineered microbial hosts to efficiently produce TAL from lipid-containing waste streams could b...

    Authors: Saptarshi Ghosh, Alex Hutagalung, Yuqian Gao, Javier E. Flores, Yichao Han, Joonhoon Kim, Meagan C. Burnet, Young-Mo Kim and Alberto Rodriguez
    Citation: Microbial Cell Factories 2025 24:215
  15. In an array to check microbial resistance against generally used antibiotics, it is essential to create innovative and efficient antimicrobial agents. Therefore, nanoparticles (NPs) with their antimicrobial ac...

    Authors: Amira Mohamed, El-Sayed R. El-Sayed, Zainab Zakaria, Mona H. Mohamed and Heba K. A. Elhakim
    Citation: Microbial Cell Factories 2025 24:214
  16. Perylenequinones, such as hypocrellins and hypomycins, are fungal secondary metabolites with potential for pharmaceutical and industrial applications due to both their physical and biological properties. This ...

    Authors: Reema A. Al-Qiam, Sachin Dumbare, Tyler N. Graf, Warren S. Vidar, Huzefa A. Raja, Cedric J. Pearce, Shabnam Hematian and Nicholas H. Oberlies
    Citation: Microbial Cell Factories 2025 24:213
  17. Ganoderma lingzhi (G. lingzhi) is a Basidiomycete macrofungus valued for its secondary metabolites with pharmacological activity. To enhance the biosynthesis of secondary metabolites, various exogenous additives ...

    Authors: Mengqiu Luo, Muling Shi, Yang Li, Yiqing Yang, Hanqi Wei, Shengwen Luo, Wenhuan Huang, Yida Deng and Gao-Qiang Liu
    Citation: Microbial Cell Factories 2025 24:211
  18. Polyhydroxyalkanoates (PHA) are sustainable alternatives to conventional plastics due to biodegradability and biocompatibility. However, most PHA-producing strains are Gram-negative, which co-produce endotoxin...

    Authors: Xinyi Bai, Libo Xu, Kang Li, Guangbao Zhang, Mengjun Zhang and Yi Huang
    Citation: Microbial Cell Factories 2025 24:210
  19. Lignin holds great potential as an abundant and sustainable source of aromatic compounds, offering a viable alternative to fossil-based resources for producing chemicals and materials. Biological upgrading of ...

    Authors: Heidi Tuomela, Johanna Koivisto, Elena Efimova and Suvi Santala
    Citation: Microbial Cell Factories 2025 24:209
  20. Thymol and carvacrol are natural phenolic compounds with various biological activities. They are widely used in the spice and medicine industries. Production of thymol and carvacrol using microbial cell factor...

    Authors: Junkai Zhu, Yi Zhang, Haibo Jiang, Mingming Zheng and Yangmin Gong
    Citation: Microbial Cell Factories 2025 24:208
  21. Traditional chemotherapy, a prevalent cancer treatment modality, is associated with significant side effects and often leads to treatment failure. Non-specific drug distribution and chemoresistance are the mai...

    Authors: Mostafa Akbariqomi, Peyman Kheirandish Zarandi, Azam Abedi, Mehrdad Moosazadeh Moghaddam and Abbas Ali Imani Fooladi
    Citation: Microbial Cell Factories 2025 24:207
  22. Short-chain carboxylic acids are important chemical intermediates in anaerobic treatment or thermal hydrolysis of biowaste. They are a crucial precursor for the production of Polyhydroxyalkanoate (PHA) by vari...

    Authors: Steven Leonhardt, Pravesh Tamang, Günter E. M. Tovar and Susanne Zibek
    Citation: Microbial Cell Factories 2025 24:206
  23. Polyhydroxyalkanoate synthase (phaC) gene encodes for PHA synthase enzyme which plays a key role in PHA polymerisation. To screen, unknown bacterial strains for their potential to produce PHAs, the presence of ph...

    Authors: Abdiqani Ibrahim Osman, Brendon Noble, Linda Percy and Pooja Basnett
    Citation: Microbial Cell Factories 2025 24:205
  24. The bacterial production of polyhydroxyalkanoates (PHAs), a class of non-toxic, biodegradable, and bio-based polymers, has gained increasing attention as a sustainable alternative to petrochemical plastics. Am...

    Authors: Edward Attenborough, Farin Yazdan Parast, Reza Nosrati, Mark M. Banaszak Holl and Leonie van ‘t Hag
    Citation: Microbial Cell Factories 2025 24:204
  25. Microbial-induced calcium carbonate precipitation (MICP) has garnered significant attention for its construction and geotechnical engineering applications. In this study, 24 bacterial isolates were obtained fr...

    Authors: Dalia Said, Sahar M. Ibrahim, Mohamed Heikal, Mohamed O. Abdel-Monem and Ghada E. Dawwam
    Citation: Microbial Cell Factories 2025 24:203
  26. The Egyptian cotton leafworm (Spodoptera littoralis) is a highly destructive, pesticide-resistant pest affecting over 80 economically important crops across the Mediterranean and African regions. While chemical i...

    Authors: Nehal A. Atta, Abdelmegid I. Fahmi, Khalid S. Abdel-Lateif, Hesham H. Nagaty and Enas M. Abd EL-Ghany
    Citation: Microbial Cell Factories 2025 24:202
  27. Synthetic dyes in the textile industry pose risks to human health and environmental safety. The current study aims to examine the efficacy of a novel esterase derived from an endophyte fungus in decolorizing d...

    Authors: Yehia A. -G. Mahmoud, Nisrin S. Alamin, Tarek M. Mohamed, Nesma A. El-Zawawy and Maha M. Salem
    Citation: Microbial Cell Factories 2025 24:201
  28. Diminishing the productivity of Taxol by the potential fungi with storage is the key hurdle that impedes their applications to be an industrial platform for Taxol production. Thus, exploring of a fungal isolat...

    Authors: Asmaa Gamal, Ashraf S. A. El-Sayed, Eman Fikry, Nora Tawfeek, Azza M. El-Shafae and Maher M. El-Domiaty
    Citation: Microbial Cell Factories 2025 24:200
  29. In the existing literature, there is ample information available concerning the analogs constituting linear Gramicidin (Gramicidin A). However, the literature lacks information regarding the microbial producti...

    Authors: Ksenia Lvova, Manuel Marcos, Benita Pérez-Cid, Xanel Vecino, José Manuel Cruz and Ana Belén Moldes
    Citation: Microbial Cell Factories 2025 24:199
  30. Cyanobacteria are emerging as a promising platform for whole-cell biotransformation, harnessing solar energy to drive biocatalytic reactions through recombinant enzymes. However, optimisation remains challengi...

    Authors: Michal Hubáček, Lauri Nikkanen and Yagut Allahverdiyeva
    Citation: Microbial Cell Factories 2025 24:198
  31. One of the inherent problems of activated sludge processes (ASPs) is the production of large volumes of sludge, which creates issues in secondary clarifiers regarding sludge settling. The application of physic...

    Authors: Ramin Khoshniyat, Ghorban Asgari, Esmaeil Ghahramani and Glen T. Daigger
    Citation: Microbial Cell Factories 2025 24:197
  32. Bacterial cellulose (BC)-based dressings exhibit favorable hydrogel characteristics, including high biocompatibility, moisture regulation, and mechanical adaptability, making them suitable candidates for biome...

    Authors: Ghada E. Dawwam, Naglaa Salem El-Sayed and Mona T. Al-Shemy
    Citation: Microbial Cell Factories 2025 24:196
  33. Glyphosate is widely used as an herbicide around the world. The extensive application of glyphosate, however, has serious adverse effects on living systems. Therefore, the elimination of residual glyphosate po...

    Authors: Wen-Juan Chen, Mingqiu Liu, Shao-Fang Chen, Yuming Zhang, Haoran Song, Maman Hassan Abdoulahi, Kalpana Bhatt, Sandhya Mishra, Mohamed A. Ghorab, Wenping Zhang and Shaohua Chen
    Citation: Microbial Cell Factories 2025 24:195
  34. Microalgae are promising sustainable feedstocks for biodiesel production. Among the primary carbon reservoirs in microalgae, starch and lipids are the main targets for metabolic engineering aimed at enhancing ...

    Authors: Minjae Kim, Ji Yeon Kim, Kyong Ha Han, Hyeon Ho Shin and EonSeon Jin
    Citation: Microbial Cell Factories 2025 24:194
  35. Paenibacillus polymyxa WLY78, a Gram-positive diazotroph with plant growth promotion and phytopathogen suppression, represents a promising candidate for agricultural biofertilizers. However, its nitrogen fixation...

    Authors: Haowei Zhang, Yuxing Han, Hui Tan, Qin Li and Sanfeng Chen
    Citation: Microbial Cell Factories 2025 24:193
  36. Genome-scale mutagenesis integrated with high-throughput phenotypic screening and causal mutation mapping serves as a robust paradigm for systemic genetic dissection. Despite the application of non-homologous ...

    Authors: Zhenxia Li, Bo Liu, Rongtao Lv, Zhe Sun, QingYan Li and XueLi Zhang
    Citation: Microbial Cell Factories 2025 24:192
  37. Cellulase can degrade cellulose into reducing sugar, participating in the natural carbon cycle. Simultaneously, cellulase enhances the efficiency and quality of industrial production while also demonstrating s...

    Authors: Yefan Li, Zi Wang, Zhouyu Li, Xin Tang, Tianyu Ji, Rui Liu and Mingwen Zhao
    Citation: Microbial Cell Factories 2025 24:191
  38. Peanut meal, a high-protein agricultural by-product, faces challenges as animal feed due to anti-nutritional factors, poor protein digestibility, aflatoxin contamination, and imbalanced amino acids. Microbial ...

    Authors: Youwei Chen, Hao Huang, Dan Li, Limei Zou, Wendi Yu, Weiwei Dong, Xiang Yu, Yanli Feng, Jun Liu, Shumiao Zhao, Yunxiang Liang, Yuanliang Hu and Nan Peng
    Citation: Microbial Cell Factories 2025 24:190
  39. Silver nanoparticles (AgNPs) have attracted considerable interest for their distinctive physicochemical properties and wide-ranging applications in nanomedicine, environmental catalysis, and antimicrobial appl...

    Authors: Alessia Di Fraia, Giovanni Dal Poggetto, Michela Salamone, Federica Carraturo, Patrizia Contursi, Marco Guida, Danila Limauro, Viviana Scognamiglio, Manuela Rossi and Gabriella Fiorentino
    Citation: Microbial Cell Factories 2025 24:189
  40. Enzyme production is crucial for biorefinery applications and the valorization of agricultural residues. However, real-time monitoring of pH and temperature in enzyme-producing solid-state fermentation (SSF) i...

    Authors: Md Fauzul Kabir, Afranul Qader Ovi and Lu-Kwang Ju
    Citation: Microbial Cell Factories 2025 24:188
  41. Starch is a carbohydrate polymer, made up of multiple glucose units, connected through glycosidic bonds. Starch nanoparticles (StNPs) are characterized as particles that possess at least one dimension measurin...

    Authors: Mohamed S. Hasanin and Mohamed A. A. Abdella
    Citation: Microbial Cell Factories 2025 24:187
  42. Microbial carotenoids have gained industry interest due to their safety and diverse biological activities; however, the low yield of carotenoids hinders their applications. Hence, this study focused on optimiz...

    Authors: Khaled B. Al-Monofy, Ahmed A. Abdelaziz, Amal M. Abo-Kamar, Lamiaa A. Al-Madboly and Mahmoud H. Farghali
    Citation: Microbial Cell Factories 2025 24:186
  43. Gluten proteins from wheat, rye, and barley play a substantial role in human nutrition. At the same time, they can trigger several different immune reactions. This, together with their influence on the quality...

    Authors: Kai Büchner, Christina Ludwig, Roland Kerpes and Thomas Becker
    Citation: Microbial Cell Factories 2025 24:185
  44. Hypersaline environments are ecologically, industrially, and scientifically important because they host unique extremophiles used in biotechnology, bioremediation, and enzyme production. These habitats are ser...

    Authors: Zeinab Rezaei, Mohammad Ali Amoozegar and Hamid Moghimi
    Citation: Microbial Cell Factories 2025 24:184
  45. Producing bio-based chemicals using a straightforward and ecologically responsible biotechnological method is intriguing. Maltobionic acid (MBA) is an aldobionic acid obtained from maltose oxidation and is an ...

    Authors: Soad M. Yehia, Yousseria M. Shetaia, Ghoson M. Daba, Faten A. Mostafa, Ali A. Ali and Hassaan El-Menoufy
    Citation: Microbial Cell Factories 2025 24:181

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