+
Skip to main content

Advertisement

Log in

Hantavirus Infection during Pregnancy

  • Review
  • Published:
Virologica Sinica

A Correction to this article was published on 08 July 2021

This article has been updated

Abstract

Hantavirus infection is a global health challenge, causing widespread public concern. In recent years, cases of hantavirus infection in pregnant women have been reported in many countries. The infected pregnant women and their fetuses appear to have more severe clinical symptoms and worse clinical outcomes. Hence, to study the prevalence of hantavirus infection in pregnant women, this study will focus on the epidemiological distribution of the virus, different virus species penetrating the placental barrier, and factors affecting the incidence and clinical outcome of the infection in pregnant women and their fetuses. In addition, this review will also discuss the diagnostic tools and treatments for pregnant patients and provide an overview of the relevant future research.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

Change history

References

  • Avsic-Zupanc T, Saksida A, Korva M (2019) Hantavirus infections. Clin Microbiol Infect 21S:e6–e16

    CAS  PubMed  Google Scholar 

  • Beigh RH (2012) Influenza during pregnancy: a case of serious infection in obstetrics. Clin Obstet Gynecol 55:914–926

    Google Scholar 

  • Beigi RH (2017) Emerging infections and pregnancy. Obstet Gynecol 129:896–906

    PubMed  Google Scholar 

  • Chen GH (2008) A case of pregnancy with epidemic hemorrhagic fever. Chin Gen Pract 11:1001 (in Chinese)

    Google Scholar 

  • Chen GS (1994) Clinical analysis of 17 cases of epidemic hemorrhagic fever with pregnancy. J Hangzhou Med Coll 4:20–21 (in Chinese)

    Google Scholar 

  • Choi EKM, Ro DY, Choi OC, Rho SH, Kim YW, Kim TE, Jung JK, Namkoong SE (2000) A case of hantavirus pulmonary syndrome complicating pregnancy. Obstet Gynecol 43:1282–1285

    Google Scholar 

  • Chun SHCM, Kim YJ, Woo BH (1992) Two cases of Korean hemorrhagic fever complicated with pregnancy. Obstet Gynecol 35:778–782

    Google Scholar 

  • Clement J, Vergote V, Laenen L, Van Ranst M (2013) Letter to the editor: distinguishing between hantavirus-induced haemorrhagic fever with renal syndrome and pregnancy-induced liver pathologies (aflp and hellp syndromes). Eurosurveillance 18:20493

    PubMed  Google Scholar 

  • Connolly-Andersen AM, Hammargren E, Whitaker H, Eliasson M, Holmgren L, Klingström J, Ahlm C (2014) Increased risk of acute myocardial infarction and stroke during hemorrhagic fever with renal syndrome: a self-controlled case series study. Circulation 129:1295–1302

    PubMed  Google Scholar 

  • Cui YJ (2005) Nursing for pregnant women with epidemic hemorrhagic fever. Mod Nurs 2:127 (in Chinese)

    Google Scholar 

  • Dai JY (2004) A case of late pregnancy with epidemic hemorrhagic fever. J Binzhou Med Coll 6:467 (in Chinese)

    Google Scholar 

  • Duan XY, Wang SH, Zhang HJ, Wang CL, Ma FZ (1996) Clinical and serological analysis of 48 patients with epidemic hemorrhagic fever during pregnancy. Prog Obstet Gynecol 2:46–48 (in Chinese)

    Google Scholar 

  • Duchin JS, Koster FT, Peters CJ, Simpson GL, Tempest B, Zaki SR, Ksiazek TG, Rollin PE, Nichol S, Umland ET (1994) Hantavirus pulmonary syndrome: a clinical description of 17 patients with a newly recognized disease. The hantavirus study group. N Engl J Med 330:949–955

    CAS  PubMed  Google Scholar 

  • Gao Y (2013) A case of pregnancy with epidemic hemorrhagic fever. Hainan Med 24:1704–1705 (in Chinese)

    Google Scholar 

  • Gaunt G, Ramin K (2001) Immunological tolerance of the human fetus. Am J Perinatol 18:299–312

    CAS  PubMed  Google Scholar 

  • Georges CG, Artunc F, Weyrich P, Friedrich B, Wolf SC (2008) Nephropathia epidemica as the result of a Puumala virus infection in a pregnant patient. Dtsch Med Wochenschr 133:1830–1832 (in German)

    CAS  PubMed  Google Scholar 

  • Gilson GJ, Maciulla JA, Nevils BG, Izquierdo LE, Chatterjee MS, Curet LB (1994) Hantavirus pulmonary syndrome complicating pregnancy. Am J Obstet Gynecol 171:550–554

    CAS  PubMed  Google Scholar 

  • Guimarães T, Magalhães A, Veiga A, Fiuza M, Ávila W, Pinto FJ (2019) Heart disease and pregnancy: state of the art. Rev Port Cardiol 38:373–383

    PubMed  Google Scholar 

  • Hallin GW, Simpson SQ, Crowell RE, James DS, Koster FT, Mertz GJ, Levy H (1996) Cardiopulmonary manifestations of hantavirus pulmonary syndrome. Crit Care Med 24:252–258

    CAS  PubMed  Google Scholar 

  • Hao CY (1997) A case of severe epidemic hemorrhagic fever in pregnancy. Prog Mod Obstet Gynecol 2:46 (in Chinese)

    Google Scholar 

  • Haram K, Svendsen E, Abildgaard U (2009) The hellp syndrome: clinical issues and management. Rev BMC Pregnancy Childbirth 9:8

    Google Scholar 

  • Hofmann J, Führer A, Bolz M, Waldschläger-Terpe J, Meier M, Lüdders D, Enders M, Oltmann A, Meisel H, Krüger DH (2012) Hantavirus infections by Puumala or Dobrava-Belgrade virus in pregnant women. J Clin Virol 55:266–269

    PubMed  Google Scholar 

  • Howard MJ, Doyle TJ, Koster FT, Zaki SR, Khan AS, Petersen EA, Peters CJ, Bryan RT (1999) Hantavirus pulmonary syndrome in pregnancy. Indian J Crit Care Med 29:1538–1544

    CAS  Google Scholar 

  • Hedman K, Vaheri A, Brummer-Korvenkontio M (1991) Rapid diagnosis of hantavirus disease with an IgG-avidity assay. Lancet (Lond Engl) 338:1353–1356

    CAS  Google Scholar 

  • Hjertqvist M, Klein SL, Ahlm C, Klingstrom J (2010) Mortality rate patterns for hemorrhagic fever with renal syndrome caused by Puumala virus. Emerg Infect Dis 16:1584–1586

    PubMed  PubMed Central  Google Scholar 

  • Jamieson DJ, Theiler RN, Rasmussen SA (2006) Emerging infections and pregnancy. Emerg Infect Dis 12:1638–1643

    PubMed  PubMed Central  Google Scholar 

  • Jiang H, Zheng X, Wang L, Du H, Wang P, Bai XF (2017) Hantavirus infection: a global zoonotic challenge. Virol Sin 32:32–43

    PubMed  PubMed Central  Google Scholar 

  • Ji F, Zhao W, Liu H, Zheng H, Wang S, He C, Wang W, Zhang R, Bai D, Tian C, Zhao W, Deng H (2017) Hemorrhagic fever with renal syndrome caused by Hantaan virus infection in four pregnant Chinese women. J Med Virol 89:1865–1870

    PubMed  Google Scholar 

  • Jing PT, Jing H (1994) Impact of pregnancy infection EHF virus on pregnant women, fetuses, newborns, infants. Shandong Med 34:3 (in Chinese)

    Google Scholar 

  • Jonsson CB, Figueiredo LT, Vapalahti O (2010) A global perspective on hantavirus ecology, epidemiology, and disease. Clin Microbiol Rev 23:412–441

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kariwa H, Yoshimatsu K, Arikawa J (2007) Hantavirus infection in east Asia. Comp Immunol Microbiol Infect Dis 30:341–356

    PubMed  Google Scholar 

  • Kariwa H (2017) Rodent associated hantaviruses and hantavirus infections. Uirusu 67:25–32 (in Japanese)

    PubMed  Google Scholar 

  • Khan AS, Khabbaz RF, Armstrong LR, Holman RC, Bauer SP, Graber J, Strine T, Miller G, Reef S, Tappero J, Rollin PE, Nichol ST, Zaki SR, Bryan RT, Chapman LE, Peters CJ, Ksiazek TG (1996) Hantavirus pulmonary syndrome: the first 100 us cases. J Infect Dis 173:1297–1303

    CAS  PubMed  Google Scholar 

  • Kim CHRM, Moon YJ, Hwang JH, Kim SR, Hwang YY (1997) A case of pregnancy complicated with Korean hemorrhagic fever. Obstet Gynecol 40:2892–2897

    Google Scholar 

  • Kim BN, Choi BD (2006) Hemorrhagic fever with renal syndrome complicated with pregnancy: a case report. Korean J Intern Med 21:150–153

    PubMed  PubMed Central  Google Scholar 

  • Kim WD, Park YK, Lee HW, Moon GJ (1978) A case of fetal death after maternal infection of Korean hemorrhagic fever. Korean J Infect Dis 10:36–40

    Google Scholar 

  • Kruger DH, Figueiredo LT, Song JW, Klempa B (2015) Hantaviruses—globally emerging pathogens. J Clin Virol 64:128–136

    PubMed  Google Scholar 

  • Latus J, Kitterer D, Kimmel M, Alscher MD, Braun N (2013) The case: fever, myalgia, visual disorders, and acute kidney failure in a pregnant woman. Diagnosis: severe acute hantavirus infection. Kidney Int 84:629–631

    PubMed  Google Scholar 

  • Latus J, Schwab M, Tacconelli E, Pieper FM, Wegener D, Dippon J, Müller S, Zakim D, Segerer S, Kitterer D, Priwitzer M, Mezger B, Walter-Frank B, Corea A, Wiedenmann A, Brockmann S, Pöhlmann C, Alscher MD, Braun N (2015) Clinical course and long-term outcome of hantavirus-associated nephropathia epidemica, Germany. Emerg Infect Dis 21:76–83

    CAS  PubMed  PubMed Central  Google Scholar 

  • Lazzerini K, Gutierrez-Quintana R, Jose-Lopez R, McConnell F, Gonçalves R, McMurrough J, De Decker S, Muir C, Priestnall SL, Mari L, Stabile F, De Risio L, Loeffler C, Tauro A, Rusbridge C, Rodenas S, Añor S, de la Fuente C, Fischer A, Bruehschwein A, Penderis J, Guevar J (2017) Clinical features, imaging characteristics, and long-term outcome of dogs with cranial meningocele or meningoencephalocele. J Vet Intern Med 31:505–512

    CAS  PubMed  PubMed Central  Google Scholar 

  • Lee HW, Lee PW, Johnson KM (1978) Isolation of the etiologic agent of Korean hemorrhagic fever. J Infect Dis 137:298–308

    CAS  PubMed  Google Scholar 

  • Lee HW (1989) Hemorrhagic fever with renal syndrome in Korea. Rev Infect Dis Suppl 4:S864–S876

    Google Scholar 

  • Li G (2019) A case of pregnancy with epidemic hemorrhagic fever. Int J Obstet Gynecol 46:85–87 (in Chinese)

    Google Scholar 

  • Liu YF, Yan PS, Wang BY, Liu J, Wang N-P, Zhu X-S, Huang M, Chen BQ (1987) Intrauterine infection of epidemic hemorrhagic fever (ehf) via placenta. Chin Med J 100:756–758 (in Chinese)

    CAS  PubMed  Google Scholar 

  • Liu X, He GW, Chen XQ, Li XH, Wang K, Huang J (2013) Epidemic hemorrhagic fever in pregnancy: a case report and literature review. Bio-IT World 2:86 (in Chinese)

    Google Scholar 

  • Liu XL, Hao D, Wang XZ, Wang T, Lu F, Liu W, Lv LB, Lv CJ (2017) Epidemic hemorrhagic fever complicated with late pregnancy: a case report. Medicine 96:e8137

    PubMed  PubMed Central  Google Scholar 

  • Liu ZF, Bai XF, He WG, Yang WS (2003) The 2263 cases of hemorrhagic fever with renal syndrome. Infect Dis 21:365–368 (in Chinese)

    CAS  Google Scholar 

  • Lu ZJ, He QJ, Ming X (2018) Clinical analysis of 18 cases of hemorrhagic fever with renal syndrome during pregnancy. Endem Dis Control 33:461 (in Chinese)

    Google Scholar 

  • Ma RM, Xiao H, Jing XT, Lao TT (2003) Hemorrhagic fever with renal syndrome presenting with intrauterine fetal death a case report. J Reprod Med 48:661–664

    PubMed  Google Scholar 

  • Mace G, Feyeux C, Mollard N, Chantegret C, Audia S, Rebibou JM, Spagnolo G, Bour JB, Denoyel GA, Sagot P, Reynes JM (2013) Severe Seoul hantavirus infection in a pregnant woman, France, October 2012. Euro Surveill 18:20464

    CAS  PubMed  Google Scholar 

  • Macneil A, Nichol ST, Spiropoulou CF (2011) Hantavirus pulmonary syndrome. Virus Res 162:138–147

    CAS  PubMed  Google Scholar 

  • Martinuč Bergoč M, Lindič J, Kovač D, Ferluga D, Pajek J (2013) Successful treatment of severe hantavirus nephritis with corticosteroids: a case report and literature review. Ther Apher Dial 17:402–406

    PubMed  Google Scholar 

  • Ming T (2017) Observation of EB virus infection and pregnancy outcome in pregnant women and newborns at different gestational weeks. Chin Med Sci 7:62–65 (in Chinese)

    Google Scholar 

  • Murthy PR, Ucchil R, Shah U, Chaudhari D (2016) Hantavirus pulmonary syndrome in a postpartum woman. Indian J Crit Care Med 20:551–553

    CAS  PubMed  PubMed Central  Google Scholar 

  • Nowakowska A, Heyman P, Knap JP, Burzynski W, Witas M (2009) The first established focus of hantavirus infection in Poland, 2007. Ann Agric Environ Med 16:79–85

    PubMed  Google Scholar 

  • Park SMKS, Kim HM, Son YS (1998) A case of Korean hemorrhagic fever complicated with pregnancy. Obstet Gynecol 41:1220–1224

    Google Scholar 

  • Partanen S, Kahanpaa K, Peltola J, Lahdevirta J (1990) Infection with the Puumala virus in pregnancy. Case report. Br J Obstet Gynaecol 97:274–275

    CAS  PubMed  Google Scholar 

  • Partanen S, Sariola A, Lahdevirta J (1993) Lack of evidence of Puumala virus infection in patients with spontaneous abortion. Eur J Clin Microbiol Infect Dis 12:142–143

    CAS  PubMed  Google Scholar 

  • Pedrosa PB, Cardoso TA (2011) Viral infections in workers in hospital and research biosafety aspects. Int J Infect Dis 15:E366–E376

    PubMed  PubMed Central  Google Scholar 

  • Prebensen D (1997) Nephropathia epidemica infection during first trimester of pregnancy—normal fetal outcome. Acta Obstet Gynecol Scand 76:884–885

    CAS  PubMed  Google Scholar 

  • Peters CJ, Simpson GL, Levy H (1999) Spectrum of hantavirus infection: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. Annu Rev Med 50:531–545

    CAS  PubMed  Google Scholar 

  • Schneider F, Vidal L, Auvray C, Khider Y, Graesslin O (2009) The first French hemorrhagic fever with renal syndrome in pregnant woman. J Gynecol Obstet Biol Reprod 38:440–442

    CAS  Google Scholar 

  • Schönrich G, Rang A, Lütteke N, Raftery MJ, Charbonnel N, Ulrich RG (2008) Hantavirus-induced immunity in rodent reservoirs and humans. Immunol Rev 225:163–189

    PubMed  Google Scholar 

  • Seferovic M, Sánchez-San Martín C, Tardif SD, Rutherford J, Castro ECC, Li T, Hodara VL, Parodi LM, Giavedoni L, Layne-Colon D, Tamhankar M, Yagi S, Martyn C, Reyes K, Suter MA, Aagaard KM, Chiu CY, Patterson JL (2018) Experimental Zika virus infection in the pregnant common marmoset induces spontaneous fetal loss and neurodevelopmental abnormalities. Sci Rep 8:6851

    PubMed  PubMed Central  Google Scholar 

  • Sha Q, Cheng HZ, Cui FQ (2000) Clinical analysis of 21 cases of hemorrhagic fever with pregnancy renal syndrome. Shandong Med 40:3 (in Chinese)

    Google Scholar 

  • Silberberg L, Rollin PE, Kerouani G, Courdrier D (1993) Haemorrhagic fever with renal syndrome and pregnancy: a case report. Trans R Soc Trop Med Hyg 87:65

    CAS  PubMed  Google Scholar 

  • Silasi M, Cardenas I, Kwon JY, Racicot K, Aldo P, Mor G (2015) Viral infections during pregnancy. Am J Reprod Immunol 73:199–213

    PubMed  PubMed Central  Google Scholar 

  • Tiilikainen T, Jouppila P (1989) Epidemic hemorrhagic fever during pregnancy. Duodecim 105:1916–1919 (in Finnish)

    CAS  PubMed  Google Scholar 

  • Todorovic Z, Canovic P, Gajovic O, Mijailovic Z (2010) Hemorrhagic fever with renal syndrome during pregnancy: case report. Med Pregl 63:280–284

    PubMed  Google Scholar 

  • Wang LZ, Zhang QD, Zhu KL, Gao WZ, Li SW, Wu SY, Chen SJ, Li TT, Hu GY (1992) Study on the influence of epidemic hemorrhagic fever on pregnancy outcome and childbirth. Shandong Med 7:1–2 (in Chinese)

    CAS  Google Scholar 

  • Wang YL (2014) Epidemic hemorrhagic fever in pregnancy: report of 7 cases. J Jinan Univ Nat Sci Med 35:397–400 (in Chinese)

    Google Scholar 

  • Watson DC, Sargianou M, Papa A, Chra P, Starakis I, Panos G (2014) Epidemiology of hantavirus infections in humans: a comprehensive, global overview. Crit Rev Microbiol 40:261–272

    PubMed  Google Scholar 

  • Vaheri A, Henttonen H, Voutilainen L, Mustonen J, Sironen T, Vapalahti O (2013) Hantavirus infections in Europe and their impact on public health. Rev Med Virol 23:35–49

    PubMed  Google Scholar 

  • Xia H (2009) Discussion on emergency screening for hemorrhagic fever with renal syndrome. Emerg Med 18:210–212 (in Chinese)

    Google Scholar 

  • Xie XL (1994) Two cases of pregnancy with epidemic hemorrhagic fever. J Guiyang Med Coll 4:389 (in Chinese)

    Google Scholar 

  • Ying K (1984) Epidemic hemorrhagic fever and pregnancy (1 case of stillbirth with autopsy). J Jiangxi Med Coll 4:93–94 (in Chinese)

    Google Scholar 

  • Yun XH (2007) Analysis of 5 cases of atypical epidemic hemorrhagic fever. Chin J Misdiagnosis 7:6157–6158 (in Chinese)

    Google Scholar 

  • Zhang XJ (1995) Pregnancy combined with epidemic hemorrhagic fever clinical features and treatment. Jiang Su Med Med 21:766–767 (in Chinese)

    Google Scholar 

  • Zhang YZ, Zou Y, Fu ZF, Plyusnin A (2010) Hantavirus infections in humans and animals, China. Emerg Infect Dis 16:1195–1203

    PubMed  PubMed Central  Google Scholar 

  • Zhao DN (2017) Human papillomavirus infection in pregnant women and its effect on maternal and infant outcomes. Nosocomiology 27:3554–3570 (in Chinese)

    Google Scholar 

  • Zheng XH (1985) A case report of death from epidemic hemorrhagic fever in late pregnancy. Wuhan Med J 2:118 (in Chinese)

    Google Scholar 

  • Zou LX, Chen MJ, Sun L (2016) Haemorrhagic fever with renal syndrome: literature review and distribution analysis in China. Int J Infect Dis 43:95–100

    PubMed  Google Scholar 

Download references

Acknowledgements

We would like to thank Jiamin Wang from Beijing Foreign Studies University, for improving the English writing. This work was supported by the National Scientific Research Program of China: New technology and project on intervention and elimination of cytokine storm and secondary infection in acute severe respiratory infectious diseases (2017ZX10204401-002-005).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jian-Qi Lian.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Animal and Human Rights

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

The original online version of this article was revised: The original article can be found online at https://doi.org/10.1007/s12250-020-00300-8

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lu, DH., Jiang, H. & Lian, JQ. Hantavirus Infection during Pregnancy. Virol. Sin. 36, 345–353 (2021). https://doi.org/10.1007/s12250-020-00300-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12250-020-00300-8

Keywords

点击 这是indexloc提供的php浏览器服务,不要输入任何密码和下载