Neural mechanisms underlying sensory-guided motor control

Behavioral variation is thought to result from noise in sensory representations or final motor commands. In this study, the authors investigate variability in eye movements and model that variability as resulting from noisy sensorimotor transformations occurring in the middle temporal visual area.

Here the authors record the responses evoked in the hand and arm representations of M1 during intracortical microstimulation in the hand representation of S1, and show somatotopically organized connections with motor cortex. The resulting interference with motor decoding is task dependent but can be alleviated by using biomimetic stimulation.

Electrical signals with characteristic parameters for reconstructing neural circuits remain incompletely understood, limiting the therapeutic potential of electrical neuromodulation techniques. Here, the authors demonstrate that dual electrical stimulation at 10–20 Hz rebuilds the spinal sensorimotor neural circuit after spinal cord injury, indicating the characteristic signals of circuit remodeling.

An analysis of eye movements and EEG activity during a smooth pursuit eye movement task suggests that the process of reliability-based optimal information integration occurs in sensorimotor behaviors.

An evaluation of predictions from the proposed BRAC framework of sensorimotor integration suggests that the catecholaminergic system might impact sensorimotor integration during response inhibition by modulating the stability of the representational content.

In a mouse model of spinal cord injury, the developmental stage of transplanted neural progenitor cells is shown to influence anatomical and behavioral outcomes after spinal cord injury