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EMD-48227

Single-particle
3.23 Å

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Deposition: 09/12/2024
Map released: 05/11/2025
Last modified: 05/11/2025

Overview 3D View Sample Experiment Validation Additional data Links

EMD-48227

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Structure of zebrafish OTOP1 in nanodisc in complex with inhibitor C2.2

EMD-48227

Single-particle
3.23 Å
EMD-48227

3D View Gallery

Deposition: 09/12/2024
Map released: 05/11/2025
Last modified: 05/11/2025

Overview 3D View Sample Experiment Validation Additional data Links

Sample Organism: Danio rerio
Sample: zebrafish OTOP1 in MSP2N2 nanodisc
Fitted models: 9mff

Deposition Authors: Burendei B, Ward AB

Structure-guided discovery of Otopetrin 1 inhibitors reveals druggable binding sites at the intrasubunit interface.

Burendei B, Kaplan JP, Orellana GM, Liman ER, Forli S, Ward AB
(2025) Nat Commun , 16 , 9362 - 9362

PUBMED: 41130946
DOI: doi:10.1038/s41467-025-64392-0
ISSN: 2041-1723

Grant Support:

Not funded: (United States)