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ZA200900905B - Modified-galactosyl ceramides for staining and stimulating Natural Killer T cells - Google Patents

Modified-galactosyl ceramides for staining and stimulating Natural Killer T cells

Info

Publication number
ZA200900905B
ZA200900905B ZA200900905A ZA200900905A ZA200900905B ZA 200900905 B ZA200900905 B ZA 200900905B ZA 200900905 A ZA200900905 A ZA 200900905A ZA 200900905 A ZA200900905 A ZA 200900905A ZA 200900905 B ZA200900905 B ZA 200900905B
Authority
ZA
South Africa
Prior art keywords
staining
cells
modified
natural killer
stimulating natural
Prior art date
Application number
ZA200900905A
Other languages
English (en)
Inventor
Paul B Savage
Luc Teyton
Albert Bendelac
Original Assignee
Scripps Research Inst
Univ Brigham Young
Univ Chicago
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst, Univ Brigham Young, Univ Chicago filed Critical Scripps Research Inst
Publication of ZA200900905B publication Critical patent/ZA200900905B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/06—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical being a hydroxyalkyl group esterified by a fatty acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
ZA200900905A 2006-04-07 2009-02-06 Modified-galactosyl ceramides for staining and stimulating Natural Killer T cells ZA200900905B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79009606P 2006-04-07 2006-04-07

Publications (1)

Publication Number Publication Date
ZA200900905B true ZA200900905B (en) 2010-06-30

Family

ID=38581864

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200900905A ZA200900905B (en) 2006-04-07 2009-02-06 Modified-galactosyl ceramides for staining and stimulating Natural Killer T cells

Country Status (12)

Country Link
US (2) US8227581B2 (xx)
EP (1) EP2056842B1 (xx)
AU (1) AU2007234753B2 (xx)
BR (1) BRPI0710668A2 (xx)
CA (1) CA2661789C (xx)
DK (1) DK2056842T3 (xx)
ES (1) ES2397975T3 (xx)
PL (1) PL2056842T3 (xx)
PT (1) PT2056842E (xx)
SI (1) SI2056842T1 (xx)
WO (1) WO2007118234A2 (xx)
ZA (1) ZA200900905B (xx)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7645873B2 (en) 2003-03-20 2010-01-12 The Scripps Research Institute 6″-amino-6″-deoxygalactosylceramides
PT1848813E (pt) 2005-01-28 2013-07-15 Scripps Research Inst Activação de glicolípidos bacterianos de células nkt restritas ao cd1d
AU2007269299B2 (en) 2006-06-30 2013-01-17 Brigham Young University Adjuvants and methods of use
US8916164B2 (en) * 2007-08-29 2014-12-23 Abivax Methods of enhancing adjuvaticity of vaccine compositions
AU2013202865B2 (en) * 2007-11-07 2015-03-19 Abivax Increase of immune response and targeting by antigens and/or drug linkage
EP2058011A1 (en) * 2007-11-07 2009-05-13 Wittycell Nkt cell activating gycolipids covalently bound antigens and/or drug
CN101917985B (zh) 2007-12-05 2014-07-02 维迪瑟尔公司 糖基神经酰胺增强对抗原的免疫反应的用途
AU2009301167B2 (en) * 2008-10-08 2015-10-29 Abivax Vaccine composition for use against influenza
ES2345377B1 (es) * 2009-03-20 2011-07-21 Consejo Superior De Investigaciones Cientificas (Csis) (51%) Compuestos aminociclitoles, procedimiento de obtencion y usos.
US8835613B2 (en) 2010-03-12 2014-09-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services β-mannosylceramide and stimulation of NKT cell anti-tumor immunity
CA2871584C (en) 2012-04-26 2020-06-30 Riken New carbamate glycolipid and use thereof
WO2014001204A1 (en) 2012-06-28 2014-01-03 Universiteit Gent Galactopyranosyl derivatives useful as medicaments
EP2727929A1 (en) * 2012-10-30 2014-05-07 Wittycell Method of preparation of alpha galactosyl ceramides compounds
WO2014210522A1 (en) * 2013-06-28 2014-12-31 The Scripps Research Institute Nkt cell ligands and methods of use
US10046046B2 (en) * 2014-06-05 2018-08-14 Victoria Link Limited Amino sphingoglycolipid analogues
RU2770432C2 (ru) * 2016-09-14 2022-04-18 Абивакс Комбинации для лечения рака, включающие abx196
EP3774830A1 (en) * 2018-03-26 2021-02-17 The United States of America, as represented by the Secretary, Department of Health and Human Services 3-o-sulfo-galactosylceramide analogs as activators of type ii nkt cells and uses thereof
WO2023121483A1 (en) * 2021-12-24 2023-06-29 Victoria Link Limited Immunostimulatory compositions
CN115286667B (zh) * 2022-08-02 2024-03-26 华中农业大学 一种α-半乳糖基神经酰胺类似物及其制备方法和应用

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242800A (en) * 1990-01-30 1993-09-07 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Receptor for pathogenic fungi
US5936076A (en) * 1991-08-29 1999-08-10 Kirin Beer Kabushiki Kaisha αgalactosylceramide derivatives
TW261533B (xx) * 1992-07-16 1995-11-01 Kirin Brewery
WO1994009020A1 (en) * 1992-10-22 1994-04-28 Kirin Beer Kabushiki Kaisha Novel shingoglycolipid and use thereof
AU683653B2 (en) * 1993-04-15 1997-11-20 Kirin Pharma Kabushiki Kaisha Novel sphingoglycolipid and use thereof
PL176272B1 (pl) * 1993-05-14 1999-05-31 Cytel Corp Analogi sialilowe Le jako inhibitory adhezji komórkowej
US6054433A (en) * 1994-11-03 2000-04-25 The Regents Of The University Of California Methods and compositions for stimulating tissue growth and epithelial moisturization
US5785975A (en) * 1995-06-26 1998-07-28 Research Triangle Pharmaceuticals Adjuvant compositions and vaccine formulations comprising same
EP0821068A3 (en) * 1996-03-29 1999-06-02 Rohm And Haas Company Novel sphingolipids and a process thereto
US6417167B1 (en) * 1997-02-05 2002-07-09 Kirin Beer Kabushiki Kaisha Lyophilized compositions containing shingoglycolipid and process for preparing them
KR100301890B1 (ko) 1997-02-05 2002-01-09 사토 야스히로 스핀고당지질을함유하는동결건조조성물및그의제조방법
WO1998044928A1 (fr) 1997-04-10 1998-10-15 Kirin Beer Kabushiki Kaisha ACTIVATEURS DE CELLULES NKT, CONTENANT DES α-GLYCOSYLCERAMIDES
AU750141B2 (en) 1997-12-30 2002-07-11 A+ Science Invest Ab Galactosylceramide, glucosylceramide, lactosylceramide, and specific catchers therefor for use in the prophylaxis or therapy of prediabetes, diabetes and/or associated complications
DE69943314D1 (de) * 1998-02-12 2011-05-12 Kapil N Bhalla Sphingolipid-derivate und verfahren zu deren verwendung
US20030157113A1 (en) * 1999-12-28 2003-08-21 Terman David S. Compositions and methods for treatment of neoplastic disease
WO2001082935A1 (fr) * 2000-04-28 2001-11-08 Orient Cancer Therapy Co.,Ltd. Remedes contre le cancer
JP4410913B2 (ja) * 2000-06-12 2010-02-10 壽製薬株式会社 新規糖脂質誘導体の製造方法
AU2001268564A1 (en) * 2000-06-22 2002-01-02 The Brigham And Women's Hospital, Inc. Alpha-glycosylceramides for treating bacterial and fungal infections
AU2001286636A1 (en) * 2000-08-25 2002-03-13 Lysometrix Corporation Method for assaying the activity of lysosomal enzymes
AU2002327338A1 (en) 2001-07-25 2003-02-17 New York University Use of glycosylceramides as adjuvants for vaccines against infections and cancer
KR100549866B1 (ko) 2001-08-22 2006-02-08 고려대학교 산학협력단 암치료 및 예방 제제
US20040266726A1 (en) * 2001-11-06 2004-12-30 Akikuni Yagita Anticancer compositions
US7273853B2 (en) * 2002-05-13 2007-09-25 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
AU2003251518B2 (en) 2002-06-13 2009-07-02 New York University Synthetic C-glycolipid and its use for treating cancer infectious diseases and autoimmune diseases
CA2519568C (en) 2003-03-20 2012-01-03 Brigham Young University 6"-amino-6"-deoxygalactosylceramides
US7645873B2 (en) * 2003-03-20 2010-01-12 The Scripps Research Institute 6″-amino-6″-deoxygalactosylceramides
GB0314682D0 (en) 2003-06-24 2003-07-30 Isis Innovation Materials and methods relating to the modulation of T cell response to soluble antigen
US7771726B2 (en) * 2003-10-08 2010-08-10 New York University Use of synthetic glycolipids as universal adjuvants for vaccines against cancer and infectious diseases
CA2560969A1 (en) 2004-03-31 2005-11-03 New York University Novel synthetic c-glycolipids, their synthesis and use to treat infections, cancer and autoimmune diseases
CN101010086B (zh) 2004-08-27 2013-05-29 耶希瓦大学艾伯塔·爱恩斯坦医学院 作为免疫和自身免疫调节剂的神经酰胺衍生物
ES2344740T3 (es) * 2004-09-03 2010-09-06 The University Of Chicago Metodos para activar celulas nkt.
EP1833489A4 (en) * 2004-12-28 2011-08-03 Univ Rockefeller GLYCOLIPIDES AND ANALOGUE THEREOF AS ANTIGENS FOR NK-T CELLS
PT1848813E (pt) 2005-01-28 2013-07-15 Scripps Research Inst Activação de glicolípidos bacterianos de células nkt restritas ao cd1d
KR100764678B1 (ko) 2005-07-13 2007-10-09 재단법인서울대학교산학협력재단 알파-갈락토실세라마이드를 아쥬반트로 포함하는 비강투여용 백신 조성물
JP2009513646A (ja) 2005-10-25 2009-04-02 ルードヴィッヒ インスティテュート フォー キャンサー リサーチ α‐ガラクトシルセラミドのアナログ及びその使用
AU2007269299B2 (en) 2006-06-30 2013-01-17 Brigham Young University Adjuvants and methods of use
EP1938836A1 (en) 2006-12-28 2008-07-02 Universite Rene Descartes (Paris V) Compositions comprising a B subunit of shiga toxin and a means stimulating NKT cells

Also Published As

Publication number Publication date
AU2007234753A1 (en) 2007-10-18
DK2056842T3 (da) 2013-01-14
US20120270815A1 (en) 2012-10-25
ES2397975T3 (es) 2013-03-12
US20090047299A1 (en) 2009-02-19
CA2661789A1 (en) 2007-10-18
WO2007118234A2 (en) 2007-10-18
BRPI0710668A2 (pt) 2011-08-16
US8765692B2 (en) 2014-07-01
WO2007118234A3 (en) 2007-12-06
PL2056842T3 (pl) 2013-03-29
CA2661789C (en) 2014-06-03
EP2056842A4 (en) 2010-10-06
US8227581B2 (en) 2012-07-24
SI2056842T1 (sl) 2013-02-28
EP2056842A2 (en) 2009-05-13
EP2056842B1 (en) 2012-10-17
PT2056842E (pt) 2013-01-24
AU2007234753B2 (en) 2013-02-21

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