+

ZA200900836B - Process for the purification of FC-fusion proteins - Google Patents

Process for the purification of FC-fusion proteins

Info

Publication number
ZA200900836B
ZA200900836B ZA200900836A ZA200900836A ZA200900836B ZA 200900836 B ZA200900836 B ZA 200900836B ZA 200900836 A ZA200900836 A ZA 200900836A ZA 200900836 A ZA200900836 A ZA 200900836A ZA 200900836 B ZA200900836 B ZA 200900836B
Authority
ZA
South Africa
Prior art keywords
purification
fusion proteins
fusion
proteins
Prior art date
Application number
ZA200900836A
Other languages
English (en)
Inventor
Alex Eon-Duval
Alain Lamproye
Original Assignee
Ares Trading Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ares Trading Sa filed Critical Ares Trading Sa
Publication of ZA200900836B publication Critical patent/ZA200900836B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/24—Extraction; Separation; Purification by electrochemical means
    • C07K1/26—Electrophoresis
    • C07K1/28—Isoelectric focusing
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
ZA200900836A 2006-08-28 2007-08-27 Process for the purification of FC-fusion proteins ZA200900836B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06119610 2006-08-28

Publications (1)

Publication Number Publication Date
ZA200900836B true ZA200900836B (en) 2010-05-26

Family

ID=37038258

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200900836A ZA200900836B (en) 2006-08-28 2007-08-27 Process for the purification of FC-fusion proteins

Country Status (15)

Country Link
US (1) US20100267932A1 (xx)
EP (1) EP2061802A1 (xx)
KR (1) KR20090058532A (xx)
CN (1) CN101541825B (xx)
AR (1) AR062569A1 (xx)
AU (1) AU2007291282B2 (xx)
BR (1) BRPI0716139A2 (xx)
CA (1) CA2661872A1 (xx)
EA (1) EA017733B1 (xx)
IL (1) IL197221A (xx)
MX (1) MX2009002013A (xx)
NZ (1) NZ574623A (xx)
UA (1) UA99263C2 (xx)
WO (1) WO2008025747A1 (xx)
ZA (1) ZA200900836B (xx)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
DK1969007T3 (da) 2005-12-20 2013-11-25 Bristol Myers Squibb Co Sammensætninger og fremgangsmåder til fremstilling af en sammensætning
WO2008049106A2 (en) 2006-10-19 2008-04-24 Centocor Ortho Biotech Inc. Process for preparing unaggregated antibody fc domains
US20080167450A1 (en) * 2007-01-05 2008-07-10 Hai Pan Methods of purifying proteins
WO2011015926A1 (en) * 2009-08-03 2011-02-10 Avesthagen Limited A process of fermentation, purification and production of recombinant soluble tumour necrosis factor alfa receptor (tnfr) - human igg fc fusion protein
EP3309168A1 (en) 2009-08-06 2018-04-18 F. Hoffmann-La Roche AG Method to improve virus removal in protein purification
JP5791602B2 (ja) * 2009-08-07 2015-10-07 イー・エム・デイー・ミリポア・コーポレイシヨン 試料中の１つ以上の不純物から標的タンパク質を精製するための方法
WO2011028753A1 (en) * 2009-09-01 2011-03-10 Genentech, Inc. Enhanced protein purification through a modified protein a elution
US20120178910A1 (en) 2009-09-23 2012-07-12 Medarex, Inc. Cation exchange chromatography (methods)
US20130178608A1 (en) * 2009-12-29 2013-07-11 Samir Kulkarni Protein purification by ion exchange
EP2534169A1 (en) 2010-02-12 2012-12-19 DSM IP Assets B.V. Single unit antibody purification
WO2012030512A1 (en) * 2010-09-03 2012-03-08 Percivia Llc. Flow-through protein purification process
EA201300524A1 (ru) * 2010-11-01 2013-08-30 ДСМ АйПи АССЕТС Б.В. Очистка антител ионообменной хроматографией в едином блоке
JP6147726B2 (ja) 2011-03-29 2017-06-14 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ タンパク質精製のためのバッファー系
SG194176A1 (en) * 2011-05-27 2013-12-30 Glaxo Group Ltd Bcma (cd269/tnfrsf17) -binding proteins
UA112434C2 (uk) 2011-05-27 2016-09-12 Ґлаксо Ґруп Лімітед Антигензв'язувальний білок, який специфічно зв'язується з всма
WO2012176158A1 (en) * 2011-06-24 2012-12-27 Dr. Reddy's Laboratories Limited Purification of chimeric protein
KR102231139B1 (ko) 2011-06-28 2021-03-24 인히브릭스, 인크. 세르핀 융합 폴리펩타이드 및 이의 이용 방법
AU2012282960A1 (en) 2011-07-08 2014-01-16 Merck Sharp & Dohme Corp. Method for purifying Fc-fusion protein
US9096648B2 (en) * 2011-08-19 2015-08-04 Emd Millipore Corporation Methods of reducing level of one or more impurities in a sample during protein purification
LT3257564T (lt) * 2011-11-02 2019-04-10 F. Hoffmann-La Roche Ag Perkrovos ir eliuentinė chromatografija
EP2682168A1 (en) 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
CN104861060A (zh) * 2014-02-21 2015-08-26 神州细胞工程有限公司 一种纯化凝血因子viii的方法
US11566082B2 (en) 2014-11-17 2023-01-31 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
US20200283472A1 (en) * 2016-03-29 2020-09-10 Navya Biologicals Pvt. Ltd A process for purification of fc-fusion proteins
ES2874974T3 (es) 2016-05-11 2021-11-05 Cytiva Bioprocess R & D Ab Matriz de separación
EP3455241B1 (en) 2016-05-11 2022-02-23 Cytiva BioProcess R&D AB Method of cleaning and/or sanitizing a separation matrix
US10889615B2 (en) 2016-05-11 2021-01-12 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
US10730908B2 (en) 2016-05-11 2020-08-04 Ge Healthcare Bioprocess R&D Ab Separation method
JP7031934B2 (ja) 2016-05-11 2022-03-08 サイティバ・バイオプロセス・アールアンドディ・アクチボラグ 分離マトリックス
US10703774B2 (en) 2016-09-30 2020-07-07 Ge Healthcare Bioprocess R&D Ab Separation method
US10654887B2 (en) 2016-05-11 2020-05-19 Ge Healthcare Bio-Process R&D Ab Separation matrix
US11708390B2 (en) 2016-05-11 2023-07-25 Cytiva Bioprocess R&D Ab Method of storing a separation matrix
KR20190039978A (ko) * 2016-08-12 2019-04-16 브리스톨-마이어스 스큅 컴퍼니 단백질 정제 방법
JP7065105B2 (ja) * 2017-02-09 2022-05-11 ブラッコ・スイス・ソシエテ・アノニム 可溶性ｐｓｇｌ－１タンパク質変異体の精製のための方法
CN107151673A (zh) * 2017-03-10 2017-09-12 上海埃文生物科技有限公司 巴斯德毕赤酵母中人rank胞外段蛋白的表达纯化及其应用
WO2019043096A1 (en) * 2017-08-30 2019-03-07 Fresenius Kabi Deutschland Gmbh METHOD FOR PURIFYING IL-6 ANTI-RECEPTOR ANTIBODIES
JP2020531557A (ja) * 2017-08-30 2020-11-05 アレス トレーディング ソシエテ アノニム タンパク質の精製方法
CA3085177A1 (en) * 2018-01-31 2019-08-08 Regeneron Pharamaceuticals, Inc. System and method for characterizing size and charge variant drug product impurities
US20240228573A9 (en) * 2019-10-17 2024-07-11 Jcr Pharmaceuticals Co., Ltd. Method for producing fusion protein of serum albumin and growth hormone
EP4524148A2 (en) 2019-12-06 2025-03-19 Regeneron Pharmaceuticals, Inc. Anti-vegf protein compositions and methods for producing the same
AU2021231083A1 (en) * 2020-03-06 2022-09-29 Aleta Biotherapeutics, Inc. Compositions and methods for treatment of cancer
MX2022013998A (es) 2020-05-08 2023-02-16 Alpine Immune Sciences Inc Proteinas inmunomoduladoras inhibidoras de april y baff con y sin una proteina inhibidora de celulas t y metodos de uso de las mismas.
WO2021226444A2 (en) 2020-05-08 2021-11-11 Regeneron Pharmaceuticals, Inc. Vegf traps and mini-traps and methods for treating ocular disorders and cancer
CN112574321B (zh) * 2020-12-30 2023-10-20 上海赛金生物医药有限公司 一种捕获单克隆抗体-肿瘤坏死因子融合蛋白的亲和纯化方法
CN114292328A (zh) * 2021-12-30 2022-04-08 武汉原谷生物科技有限责任公司 一种来源于美洲羊驼中天然抗体的纯化方法及其应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5447851B1 (en) * 1992-04-02 1999-07-06 Univ Texas System Board Of Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
EP0620739A4 (en) * 1992-09-15 1997-01-15 Immunex Corp Method of treating tnf-dependent inflammation using tumor necrosis factor antagonists.
EP0659767B2 (de) * 1993-12-27 2002-11-06 ZLB Bioplasma AG Verfahren zur Herstellung eines Konzentrates von Anti-D-Immunoglobulin G und pharmazeutische Zusammensetzung, die dieses enthält
PT830130E (pt) * 1995-06-08 2004-11-30 Immunex Corp Enzima de conversao de tnf-alfa
US6406901B1 (en) * 1995-06-08 2002-06-18 Immunex Corporation TNF-a converting enzyme
US5969102A (en) * 1997-03-03 1999-10-19 St. Jude Children's Research Hospital Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof
CN100404547C (zh) * 1998-05-06 2008-07-23 基因技术股份有限公司 用离子交换层析纯化蛋白质
WO2001087977A2 (en) * 2000-05-12 2001-11-22 Amgen Inc. Methods and compositions of matter concerning april/g70, bcma, blys/agp-3, and taci
US20030103986A1 (en) * 2001-05-24 2003-06-05 Rixon Mark W. TACI-immunoglobulin fusion proteins
ATE425989T1 (de) * 2001-12-21 2009-04-15 Immunex Corp Proteinreinigungsverfahren
JP4319979B2 (ja) * 2002-04-26 2009-08-26 ジェネンテック・インコーポレーテッド タンパク質の非アフィニティ精製
EP1561756B1 (en) * 2002-09-11 2015-12-23 Chugai Seiyaku Kabushiki Kaisha Method of purifying protein
WO2004087761A1 (ja) * 2003-03-31 2004-10-14 Kirin Beer Kabushiki Kaisha ヒトモノクローナル抗体およびヒトポリクローナル抗体の精製
TWI353991B (en) * 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
JP5004586B2 (ja) * 2003-10-27 2012-08-22 ワイス・エルエルシー ヒドロキシアパタイトクロマトグラフィーを用いる高分子量凝集体の取り出し
CN1234725C (zh) * 2004-04-07 2006-01-04 陈志南 一种高效快速纯化制备片段抗体的方法
BRPI0611599A2 (pt) * 2005-06-17 2011-02-22 Elan Pharma Int Ltd método para purificar uma protéina de ligação a beta, e, proteìna de ligação a beta
JP2010516651A (ja) * 2007-01-17 2010-05-20 メルク セローノ ソシエテ アノニム Ｆｃ含有タンパク質の精製のための方法

Also Published As

Publication number Publication date
CN101541825B (zh) 2013-08-14
CN101541825A (zh) 2009-09-23
IL197221A0 (en) 2009-12-24
NZ574623A (en) 2011-12-22
WO2008025747A1 (en) 2008-03-06
EA200970230A1 (ru) 2009-08-28
KR20090058532A (ko) 2009-06-09
EP2061802A1 (en) 2009-05-27
IL197221A (en) 2013-06-27
AU2007291282B2 (en) 2011-10-20
CA2661872A1 (en) 2008-03-06
UA99263C2 (ru) 2012-08-10
MX2009002013A (es) 2009-03-09
EA017733B1 (ru) 2013-02-28
BRPI0716139A2 (pt) 2013-09-17
AU2007291282A1 (en) 2008-03-06
AR062569A1 (es) 2008-11-19
US20100267932A1 (en) 2010-10-21

Similar Documents

Publication Publication Date Title
ZA200900836B (en) Process for the purification of FC-fusion proteins
HK1131400A1 (en) Process for the purification of fc-containing proteins
IL199753A0 (en) Process for the purification of fc-containing proteins
IL205107A0 (en) Method for purifying fc-fusion proteins
IL197765A0 (en) Methods for purification of polypeptide conjugates
IL187642A0 (en) METHODS FOR PURIFYING PROTEINS HAVING Fc REGIONS
ZA200905167B (en) Process for the purification of water
HUE042402T2 (hu) Eljárás polipeptid töményítésére
EP1922345A4 (en) PROCESS FOR THE PREPARATION OF COPOLYMER-1
IL204949A0 (en) Method for purifying an fc- containing protein
EP1869230A4 (en) PROCESS FOR PURIFYING PROTEINS
ZA200607439B (en) Process for gas purification
GB0624227D0 (en) Protein purification
GB0604236D0 (en) Adsorbents for protein purification
ZA200900837B (en) Process for the purification of FC-containing proteins
ZA200810485B (en) Process for the manufacture of olefin oligomers
PL1973563T3 (pl) Sposób oczyszczania alfa-1-antytrypsyny
EP1899375A4 (en) NEW METHOD FOR THE PURIFICATION OF LACTOFERRIN
ZA201200420B (en) Method for the purification of protein complexes
GB0503942D0 (en) Purification process
IL185146A0 (en) Process for the purification of substituted benzoxazole compounds
HK1137378A1 (en) Process for the purification of combustion fumes
GB0523257D0 (en) Purification process
ZA200708802B (en) An improved process for the purification of perindopril
PL2079758T3 (pl) Sposób oczyszczania DnaK
点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载