ZA200900126B - Novel aminopyridine derivatives having aurora a selective inhibitory action - Google Patents

Novel aminopyridine derivatives having aurora a selective inhibitory action

Info

Publication number: ZA200900126B
Authority: ZA; South Africa
Prior art keywords: aurora; inhibitory action; selective inhibitory; aminopyridine derivatives; novel aminopyridine
Prior art date: 2006-08-31

Application number

ZA200900126A

Other languages

English (en)

Inventor

Yoshikazu Iwasawa

Tetsuya Kato

Nobuhiko Kawanishi

Kouta Masutani

Takashi Mita

Katsumasa Nonoshita

Mitsuru Ohkubo

Original Assignee

Banyu Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-08-31

Filing date

2009-01-07

Publication date

2010-01-27

2009-01-07 Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd

2010-01-27 Publication of ZA200900126B publication Critical patent/ZA200900126B/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
- C07D241/22—Benzenesulfonamido pyrazines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Oncology (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

ZA200900126A 2006-08-31 2009-01-07 Novel aminopyridine derivatives having aurora a selective inhibitory action ZA200900126B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2006236472		2006-08-31

Publications (1)

Publication Number	Publication Date
ZA200900126B true ZA200900126B (en)	2010-01-27

Family

ID=39136042

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200900126A ZA200900126B (en)	2006-08-31	2009-01-07	Novel aminopyridine derivatives having aurora a selective inhibitory action

Country Status (27)

Country	Link
US (2)	US20100016335A1 (xx)
EP (2)	EP2062887B1 (xx)
JP (3)	JP2008081492A (xx)
KR (1)	KR20090055562A (xx)
CN (1)	CN101528731B (xx)
AR (1)	AR062585A1 (xx)
AU (1)	AU2007289609B2 (xx)
CA (1)	CA2657469C (xx)
CL (1)	CL2007002519A1 (xx)
CO (1)	CO6190529A2 (xx)
CR (1)	CR10553A (xx)
EC (1)	ECSP099062A (xx)
ES (1)	ES2389515T3 (xx)
GT (1)	GT200900008A (xx)
HN (1)	HN2009000113A (xx)
IL (1)	IL196497A0 (xx)
MA (1)	MA30719B1 (xx)
MX (1)	MX2009000390A (xx)
NO (1)	NO20091301L (xx)
NZ (1)	NZ574081A (xx)
PE (1)	PE20080835A1 (xx)
RU (1)	RU2437880C2 (xx)
SV (1)	SV2009003152A (xx)
TW (1)	TW200817363A (xx)
UA (1)	UA95972C2 (xx)
WO (2)	WO2008026769A1 (xx)
ZA (1)	ZA200900126B (xx)

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JP5411152B2 (ja) *	2008-02-22	2014-02-12	Ｍｓｄ株式会社	オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
WO2009122436A2 (en) *	2008-03-31	2009-10-08	Sun Pharmaceutical Industries Ltd.	An improved process for the preparation of morphinane analogues
JP5683462B2 (ja) *	2008-07-24	2015-03-11	ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ	オーロラキナーゼ阻害剤および抗増殖剤を含む治療用組み合わせ
KR101906146B1 (ko)	2009-08-17	2018-10-10	메모리얼 슬로안-케터링 캔서 센터	열 충격 단백질 결합 화합물, 조성물, 및 이의 제조 방법 및 사용 방법
JP5878178B2 (ja)	2011-09-30	2016-03-08	大鵬薬品工業株式会社	１，２，４−トリアジン−６−カルボキサミド誘導体
TWI485146B (zh) *	2012-02-29	2015-05-21	Taiho Pharmaceutical Co Ltd	Novel piperidine compounds or salts thereof
US9630896B2 (en)	2013-11-22	2017-04-25	Tansna Therapeutics, Inc.	2,5-dialkyl-4-H/halo/ether-phenol compounds
KR102461419B1 (ko)	2014-05-13	2022-11-02	메모리얼 슬로안 케터링 캔서 센터	Hsp70 조정물질 및 이의 제조 및 이용 방법
TWI693218B (zh) *	2014-11-14	2020-05-11	美商美國禮來大藥廠	極光ａ激酶抑制劑
EP3274859B1 (en) *	2015-03-25	2021-03-10	Intel Corporation	Cluster computing service assurance apparatus and method
CN108250191B (zh) *	2018-03-15	2020-10-20	兰州大学	一种3,5-二取代的2-氨基-吡嗪化合物及其制备工艺与应用
WO2020049208A1 (es)	2018-09-09	2020-03-12	Fundacio Privada Institut De Recerca De La Sida - Caixa	Aurora cinasa como diana para tratar, prevenir o curar una infección por vih o sida
CN112898292A (zh) *	2019-12-03	2021-06-04	微境生物医药科技(上海)有限公司	新型极光激酶抑制剂及其用途
TWI785474B (zh) *	2020-01-22	2022-12-01	大陸商北京加科思新藥研發有限公司	用作選擇性Aurora A抑制劑的新型雜環化合物
EP4504209A1 (en)	2022-04-08	2025-02-12	Eli Lilly and Company	Method of treatment including kras g12c inhibitors and aurora a inhibitors

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2007
- 2007-04-26 JP JP2007116649A patent/JP2008081492A/ja not_active Withdrawn
- 2007-08-29 CA CA2657469A patent/CA2657469C/en not_active Expired - Fee Related
- 2007-08-29 CN CN200780032242.7A patent/CN101528731B/zh not_active Expired - Fee Related
- 2007-08-29 ES ES07806706T patent/ES2389515T3/es active Active
- 2007-08-29 AR ARP070103835A patent/AR062585A1/es unknown
- 2007-08-29 RU RU2009111599/04A patent/RU2437880C2/ru not_active IP Right Cessation
- 2007-08-29 WO PCT/JP2007/067251 patent/WO2008026769A1/ja active Application Filing
- 2007-08-29 US US12/310,307 patent/US20100016335A1/en not_active Abandoned
- 2007-08-29 TW TW096132117A patent/TW200817363A/zh unknown
- 2007-08-29 US US11/897,272 patent/US7915263B2/en active Active
- 2007-08-29 CL CL200702519A patent/CL2007002519A1/es unknown
- 2007-08-29 EP EP07806706A patent/EP2062887B1/en active Active
- 2007-08-29 PE PE2007001171A patent/PE20080835A1/es not_active Application Discontinuation
- 2007-08-29 AU AU2007289609A patent/AU2007289609B2/en not_active Ceased
- 2007-08-29 EP EP07806705A patent/EP2061782A4/en not_active Withdrawn
- 2007-08-29 MX MX2009000390A patent/MX2009000390A/es active IP Right Grant
- 2007-08-29 KR KR1020097004339A patent/KR20090055562A/ko not_active Ceased
- 2007-08-29 JP JP2008532150A patent/JP4466782B2/ja active Active
- 2007-08-29 NZ NZ574081A patent/NZ574081A/en not_active IP Right Cessation
- 2007-08-29 UA UAA200902851A patent/UA95972C2/ru unknown
- 2007-08-29 WO PCT/JP2007/067250 patent/WO2008026768A1/en active Application Filing
2009
- 2009-01-07 ZA ZA200900126A patent/ZA200900126B/xx unknown
- 2009-01-13 CR CR10553A patent/CR10553A/es not_active Application Discontinuation
- 2009-01-13 IL IL196497A patent/IL196497A0/en unknown
- 2009-01-13 HN HN2009000113A patent/HN2009000113A/es unknown
- 2009-01-13 GT GT200900008A patent/GT200900008A/es unknown
- 2009-01-13 EC EC2009009062A patent/ECSP099062A/es unknown
- 2009-01-14 SV SV2009003152A patent/SV2009003152A/es unknown
- 2009-01-14 CO CO09002429A patent/CO6190529A2/es not_active Application Discontinuation
- 2009-03-20 MA MA31731A patent/MA30719B1/fr unknown
- 2009-03-30 NO NO20091301A patent/NO20091301L/no not_active Application Discontinuation
- 2009-10-29 JP JP2009248400A patent/JP5256168B2/ja active Active

Also Published As

Publication number	Publication date
RU2437880C2 (ru)	2011-12-27
CL2007002519A1 (es)	2008-02-08
CA2657469C (en)	2013-07-02
ES2389515T3 (es)	2012-10-26
WO2008026769A1 (fr)	2008-03-06
US7915263B2 (en)	2011-03-29
US20080058347A1 (en)	2008-03-06
WO2008026768A1 (en)	2008-03-06
AR062585A1 (es)	2008-11-19
CR10553A (es)	2009-06-28
AU2007289609B2 (en)	2012-02-02
EP2061782A4 (en)	2010-03-31
EP2062887B1 (en)	2012-07-04
JP5256168B2 (ja)	2013-08-07
ECSP099062A (es)	2009-02-27
MX2009000390A (es)	2009-01-29
HN2009000113A (es)	2014-01-06
CA2657469A1 (en)	2008-03-06
IL196497A0 (en)	2009-09-22
UA95972C2 (ru)	2011-09-26
MA30719B1 (fr)	2009-09-01
EP2062887A4 (en)	2010-03-31
JP2008081492A (ja)	2008-04-10
JP2010047602A (ja)	2010-03-04
PE20080835A1 (es)	2008-06-14
NO20091301L (no)	2009-04-30
JP4466782B2 (ja)	2010-05-26
GT200900008A (es)	2010-10-04
RU2009111599A (ru)	2010-10-10
EP2062887A1 (en)	2009-05-27
JPWO2008026769A1 (ja)	2010-01-21
US20100016335A1 (en)	2010-01-21
NZ574081A (en)	2011-08-26
TW200817363A (en)	2008-04-16
CN101528731B (zh)	2014-05-07
EP2061782A1 (en)	2009-05-27
SV2009003152A (es)	2009-04-28
CO6190529A2 (es)	2010-08-19
KR20090055562A (ko)	2009-06-02
CN101528731A (zh)	2009-09-09
AU2007289609A1 (en)	2008-03-06

Publication	Publication Date	Title
ZA200900126B (en)	2010-01-27	Novel aminopyridine derivatives having aurora a selective inhibitory action
IL182684A0 (en)	2007-09-20	Novel aminopyridine derivatives having aurora a selective inhibitory action
AU2009216062A8 (en)	2010-09-09	Novel aminopyridine derivatives having Aurora A selective inhibitory action
HRP20130626T1 (xx)	2013-08-31	Spojevi piridinona
HK1107347A1 (en)	2008-04-03	3-arylamino pyridine derivatives 3-
IL180430A0 (en)	2007-06-03	Pyridine derivatives
IL195730A0 (en)	2009-09-01	New pyridine analogues
EP2027357A4 (en)	2015-07-29	DEHINABLE DRILLING TOOL
HK1132637A1 (en)	2010-03-05	Patterning technique
ZA200806809B (en)	2009-10-28	Pyridine-2-carboxamide derivatives
GB2455919B (en)	2011-12-28	Downhole tool
ZA200810646B (en)	2010-05-26	New pyridine analogues
IL195981A0 (en)	2009-09-01	New pyridine analogues
ZA200810647B (en)	2009-12-30	New pyridine analogues
GB2441151B (en)	2008-07-16	Wellbore tools
EP2036894A4 (en)	2011-01-12	AURORA INHIBITOR
AP2006003824A0 (en)	2006-12-31	Aminopyridine derivatives as selective dopamine D3agonists
IL195982A0 (en)	2009-09-01	New pyridine analogues
HK1164868A1 (en)	2012-09-28	Substituted pyridine derivatives
TH0701004346A (th)	2015-06-12	อนุพันธ์ อะมิโนไพริดีนใหม่ ซึ่งมีการกระทำซึ่งยับยั้งแสงออโรรา a อย่างเลือกสรร
GB0716904D0 (en)	2007-10-10	Pyridine derivatives
GB0716462D0 (en)	2007-10-03	Pyridine derivatives
GB0416524D0 (en)	2004-08-25	Pyridine derivatives
AU309736S (en)	2006-09-12	A drill
ZA200810645B (en)	2010-05-26	New pyridine analogues