ZA200802225B - Interleukin-1 conjugates and uses thereof - Google Patents
Interleukin-1 conjugates and uses thereofInfo
- Publication number
- ZA200802225B ZA200802225B ZA200802225A ZA200802225A ZA200802225B ZA 200802225 B ZA200802225 B ZA 200802225B ZA 200802225 A ZA200802225 A ZA 200802225A ZA 200802225 A ZA200802225 A ZA 200802225A ZA 200802225 B ZA200802225 B ZA 200802225B
- Authority
- ZA
- South Africa
- Prior art keywords
- conjugates
- interleukin
- Prior art date
Links
- 102000000589 Interleukin-1 Human genes 0.000 title 1
- 108010002352 Interleukin-1 Proteins 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/545—IL-1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
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- A61P17/04—Antipruritics
-
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6075—Viral proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/18011—Details ssRNA Bacteriophages positive-sense
- C12N2795/18111—Leviviridae
- C12N2795/18122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/18011—Details ssRNA Bacteriophages positive-sense
- C12N2795/18111—Leviviridae
- C12N2795/18123—Virus like particles [VLP]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72110605P | 2005-09-28 | 2005-09-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200802225B true ZA200802225B (en) | 2009-10-28 |
Family
ID=37497973
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200802225A ZA200802225B (en) | 2005-09-28 | 2006-09-28 | Interleukin-1 conjugates and uses thereof |
Country Status (13)
Country | Link |
---|---|
US (3) | US20110027220A1 (xx) |
EP (2) | EP2431468A1 (xx) |
JP (1) | JP5312028B2 (xx) |
KR (1) | KR20080047564A (xx) |
CN (2) | CN101267834B (xx) |
AU (1) | AU2006298767B2 (xx) |
BR (1) | BRPI0616446A2 (xx) |
CA (1) | CA2623287A1 (xx) |
IL (1) | IL189245A0 (xx) |
NZ (1) | NZ566971A (xx) |
RU (1) | RU2441067C2 (xx) |
WO (1) | WO2007039552A1 (xx) |
ZA (1) | ZA200802225B (xx) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2335979T3 (es) | 2001-09-14 | 2010-04-07 | Cytos Biotechnology Ag | Empaquetamiento de cpg inmunoestimuladores en particulas similares a virus: metodo de preparacion y su uso. |
WO2007015128A1 (en) | 2005-08-02 | 2007-02-08 | Xbiotech Inc. | DIAGNOSIS, TREATMENT, AND PREVENTION OF VASCULAR DISORDERS USING IL-1α AUTOANTIBODIES |
AU2007251239B2 (en) * | 2006-05-15 | 2013-08-22 | Xbiotech Inc. | IL-1alpha immunization induces autoantibodies protective against atherosclerosis |
US20110008282A1 (en) * | 2006-05-15 | 2011-01-13 | Xbiotech, Inc. | IL-1alpha immunization induces autoantibodies protective against atherosclerosis |
ES2738986T3 (es) | 2006-06-12 | 2020-01-28 | Kuros Biosciences Ag | Procesos para empaquetar oligonucleótidos en partículas de tipo viral de bacteriófagos de ARN |
WO2008071774A1 (en) * | 2006-12-14 | 2008-06-19 | Cytos Biotechnology Ag | Purification process for coat protein of rna bacteriophages |
BRPI0817705A2 (pt) * | 2007-09-25 | 2015-03-31 | Intervet Int Bv | Vacina para o tratamento de osteoatrite em um vertebrado, uso de citocinas il-ibeta e opcionalmente inf-alfa, e, tratamento de osteoartrite em um vertebrado. |
BRPI0909096A2 (pt) * | 2008-03-05 | 2015-12-01 | Cytos Biotechnology Ag | uso de conjugados de interleicna-1 no tratamento de diabetes |
EP2285409B1 (en) | 2008-05-30 | 2016-04-20 | XBiotech, Inc | Il-1 alpha antibodies |
WO2010030979A2 (en) | 2008-09-12 | 2010-03-18 | Xbiotech, Inc. | Targeting pathogenic monocytes |
PL222496B1 (pl) * | 2009-04-10 | 2016-08-31 | Inst Biochemii I Biofizyki Pan | Wektorowa cząsteczka wirusopodobna, sposób jej wytwarzania oraz kompozycja farmaceutyczna zawierająca wektorową cząsteczkę wirusopodobną |
US8993715B2 (en) * | 2009-07-06 | 2015-03-31 | Canon Kabushiki Kaisha | Labeled protein and method for obtaining the same |
CA2773426A1 (en) * | 2009-09-10 | 2011-03-17 | Cytos Biotechnology Ag | Use of interleukin-1 beta mutein conjugates in the treatment of diabetes |
AU2011268229B2 (en) | 2010-06-18 | 2015-04-16 | Xbiotech Inc. | Arthritis treatment |
MX388939B (es) | 2010-08-23 | 2025-03-20 | Xbiotech Inc | Anticuerpo anti-il-1a para usarse en el tratamiento de cáncer metastásico. |
US9724409B2 (en) | 2011-04-01 | 2017-08-08 | Xbiotech, Inc. | Treatment of inflammatory skin disease |
US9809649B2 (en) | 2011-09-23 | 2017-11-07 | Xbiotech, Inc. | Cachexia treatment |
EP4545964A2 (en) | 2012-02-23 | 2025-04-30 | Juno Therapeutics GmbH | Chromatographic isolation of cells and other complex biological materials |
US9545441B2 (en) | 2012-09-18 | 2017-01-17 | Xbiotech, Inc. | Treatment of diabetes |
GB201300684D0 (en) | 2013-01-15 | 2013-02-27 | Apitope Int Nv | Peptide |
WO2015130843A2 (en) * | 2014-02-25 | 2015-09-03 | The Regents Of The University Of California | Phage wrapping |
EP3244915A1 (en) * | 2015-01-15 | 2017-11-22 | University of Copenhagen | Virus-like particle with efficient epitope display |
MA45488A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés, kits et appareil de culture de cellules |
MA45489A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés de culture de cellules, kits et appareil associés |
KR20180108567A (ko) * | 2015-10-22 | 2018-10-04 | 주노 테라퓨틱스 게엠베하 | 형질도입을 위한 방법, 키트, 제제 및 장치 |
EP3368068B1 (en) | 2015-10-30 | 2020-11-18 | University of Copenhagen | Virus like particle with efficient epitope display |
WO2018150265A1 (en) | 2017-02-16 | 2018-08-23 | Xbiotech, Inc. | Treatment of hidradenitis suppurativa |
AU2018260380B2 (en) | 2017-04-27 | 2025-02-13 | Juno Therapeutics Gmbh | Oligomeric particle reagents and methods of use thereof |
US12246031B2 (en) | 2018-02-13 | 2025-03-11 | Checkmate Pharmaceuticals, Inc. | Compositions and methods for tumor immunotherapy |
BR112020020479A2 (pt) | 2018-04-09 | 2021-01-12 | Checkmate Pharmaceuticals | Empacotamento de oligonucleotídeos em partículas similares a vírus |
EP3845556A1 (fr) * | 2019-12-31 | 2021-07-07 | Peptinov SAS | Conjugue immunogene destine a induire une reponse immunitaire dirigee contre l interleukine-6 |
CA3224376A1 (en) * | 2021-07-08 | 2023-01-12 | Nikolai Kley | Interleukin-1 alpha chimeric protein |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5374426A (en) | 1986-09-03 | 1994-12-20 | University Of Saskatchewan | Rotavirus nucleocapsid protein VP6 in vaccine compositions |
CA2046303C (en) | 1989-02-27 | 2001-05-01 | Lee Gehrke | Il-1 biological activity inhibitors |
WO1992011291A1 (en) | 1990-12-20 | 1992-07-09 | Smithkline Beecham Biologicals (S.A.) | Vaccines based on hepatitis b surface antigen |
GB9101550D0 (en) | 1991-01-24 | 1991-03-06 | Mastico Robert A | Antigen-presenting chimaeric protein |
FR2677654B1 (fr) | 1991-06-17 | 1995-11-17 | Pasteur Merieux Serums Vacc | Composes a effet immunogene anti-cytokine, a effet immunogene anticytostatique ou a effet vaccinal anti-infection a hiv. |
GB9114003D0 (en) | 1991-06-28 | 1991-08-14 | Mastico Robert A | Chimaeric protein |
CN101361972B (zh) * | 1994-10-07 | 2011-05-25 | 中外制药株式会社 | 以il-6拮抗剂作为有效成分治疗慢性类风湿性关节炎 |
CN1185811A (zh) | 1995-03-31 | 1998-06-24 | H·沃尔夫 | 依赖于逆转录病毒样颗粒的抗原呈递系统 |
GB9621091D0 (en) | 1996-10-09 | 1996-11-27 | Fondation Pour Le Perfectionem | Attenuated microorganisms strains and their uses |
CA2347411C (en) | 1998-10-21 | 2012-04-03 | The Government Of The United States Of America | Virus-like particles for the induction of autoantibodies |
CN100534529C (zh) | 1998-11-30 | 2009-09-02 | 希托斯生物技术股份公司 | 抗原的有序分子呈递,制备及使用的方法 |
ATE413191T1 (de) | 1999-12-03 | 2008-11-15 | Celltech Chiroscience Ltd | Verwendung of interleukin-1 mutein als impfstoffadjuvans |
DE10004232A1 (de) | 2000-02-01 | 2001-08-02 | Megamat Gmbh Buero Und Lagerte | Antriebseinrichtung für eine Lagervorrichtung |
US6843987B2 (en) * | 2000-02-02 | 2005-01-18 | Schering Corporation | Mammalian cytokines; receptors; related reagents and methods |
WO2001085208A2 (en) | 2000-05-05 | 2001-11-15 | Cytos Biotechnology Ag | Molecular antigen arrays and vaccines |
WO2003031466A2 (en) * | 2001-10-05 | 2003-04-17 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
US7320793B2 (en) * | 2001-01-19 | 2008-01-22 | Cytos Biotechnology Ag | Molecular antigen array |
ES2335979T3 (es) | 2001-09-14 | 2010-04-07 | Cytos Biotechnology Ag | Empaquetamiento de cpg inmunoestimuladores en particulas similares a virus: metodo de preparacion y su uso. |
MXPA04003901A (es) * | 2001-11-07 | 2004-07-08 | Cytos Biotechnology Ag | Disposiciones de antigenos para el tratamiento de enfermedades eosinofilicas alergicas. |
EP1443960B1 (en) * | 2001-11-07 | 2008-12-31 | Cytos Biotechnology AG | Antigen arrays presenting il-5, il-13 or eotaxin for treatment of allergic eosinophilic diseases |
JP4658475B2 (ja) * | 2001-11-07 | 2011-03-23 | サイトス バイオテクノロジー アーゲー | 骨疾患治療用の抗原アレイ |
FR2838444B1 (fr) | 2002-04-10 | 2016-01-01 | Neovacs | Nouveaux peptides et leur application en therapeutique |
MXPA05000277A (es) | 2002-07-17 | 2005-03-31 | Cytos Biotechnology Ag | Configuraciones de antigenos moleculares de usan una particula tipo virus derivada de la proteina de recurimiento ap205. |
US6932971B2 (en) * | 2002-07-18 | 2005-08-23 | Cytos Biotechnology Ag | Hapten-carrier conjugates and uses thereof |
JP2006504653A (ja) * | 2002-07-19 | 2006-02-09 | サイトス バイオテクノロジー アーゲー | グレリン−担体複合体 |
RU2006130006A (ru) * | 2004-01-20 | 2008-02-27 | Цитос Биотехнологи Аг (Ch) | Конъюгаты грелин-носитель |
US20080292652A1 (en) | 2004-09-21 | 2008-11-27 | Cytos Biotechnology Ag | Virus-Like Particles Comprising a Fusion Protein of the Coat Protein of Ap205 and an Antigenic Polypeptide |
WO2006037787A2 (en) | 2004-10-05 | 2006-04-13 | Cytos Biotechnology Ag | Vlp-antigen conjugates and their uses as vaccines |
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2006
- 2006-09-28 ZA ZA200802225A patent/ZA200802225B/xx unknown
- 2006-09-28 AU AU2006298767A patent/AU2006298767B2/en not_active Ceased
- 2006-09-28 EP EP11175319A patent/EP2431468A1/en not_active Withdrawn
- 2006-09-28 CN CN2006800343698A patent/CN101267834B/zh not_active Expired - Fee Related
- 2006-09-28 BR BRPI0616446-3A patent/BRPI0616446A2/pt not_active IP Right Cessation
- 2006-09-28 CA CA002623287A patent/CA2623287A1/en not_active Abandoned
- 2006-09-28 WO PCT/EP2006/066866 patent/WO2007039552A1/en active Application Filing
- 2006-09-28 NZ NZ566971A patent/NZ566971A/en not_active IP Right Cessation
- 2006-09-28 KR KR1020087006840A patent/KR20080047564A/ko not_active Withdrawn
- 2006-09-28 US US11/992,731 patent/US20110027220A1/en not_active Abandoned
- 2006-09-28 JP JP2008532788A patent/JP5312028B2/ja not_active Expired - Fee Related
- 2006-09-28 CN CN2013101441929A patent/CN103230590A/zh active Pending
- 2006-09-28 EP EP06793894A patent/EP1931383A1/en not_active Withdrawn
- 2006-09-28 RU RU2008116323/10A patent/RU2441067C2/ru not_active IP Right Cessation
-
2007
- 2007-03-29 US US12/443,344 patent/US8449874B2/en not_active Expired - Fee Related
-
2008
- 2008-02-04 IL IL189245A patent/IL189245A0/en unknown
-
2012
- 2012-08-01 US US13/564,576 patent/US20130230484A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2006298767B2 (en) | 2013-01-10 |
AU2006298767A1 (en) | 2007-04-12 |
CN103230590A (zh) | 2013-08-07 |
US20110027220A1 (en) | 2011-02-03 |
US20110091411A1 (en) | 2011-04-21 |
US8449874B2 (en) | 2013-05-28 |
NZ566971A (en) | 2011-06-30 |
EP1931383A1 (en) | 2008-06-18 |
JP2009510025A (ja) | 2009-03-12 |
CN101267834B (zh) | 2013-06-05 |
US20130230484A1 (en) | 2013-09-05 |
WO2007039552A1 (en) | 2007-04-12 |
CA2623287A1 (en) | 2007-04-12 |
RU2441067C2 (ru) | 2012-01-27 |
CN101267834A (zh) | 2008-09-17 |
KR20080047564A (ko) | 2008-05-29 |
BRPI0616446A2 (pt) | 2011-06-21 |
EP2431468A1 (en) | 2012-03-21 |
JP5312028B2 (ja) | 2013-10-09 |
IL189245A0 (en) | 2008-08-07 |
RU2008116323A (ru) | 2009-11-10 |
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