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WO2004113389A3 - High capacity poly(alkylene)glycol based amino polymers - Google Patents

High capacity poly(alkylene)glycol based amino polymers Download PDF

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Publication number
WO2004113389A3
WO2004113389A3 PCT/DK2004/000461 DK2004000461W WO2004113389A3 WO 2004113389 A3 WO2004113389 A3 WO 2004113389A3 DK 2004000461 W DK2004000461 W DK 2004000461W WO 2004113389 A3 WO2004113389 A3 WO 2004113389A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymer matrix
alkylene
high capacity
poly
macromonomers
Prior art date
Application number
PCT/DK2004/000461
Other languages
French (fr)
Other versions
WO2004113389A2 (en
Inventor
Roice Michael
Ib Johannsen
Morten Meldal
Original Assignee
Versamatrix As
Roice Michael
Ib Johannsen
Morten Meldal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Versamatrix As, Roice Michael, Ib Johannsen, Morten Meldal filed Critical Versamatrix As
Publication of WO2004113389A2 publication Critical patent/WO2004113389A2/en
Publication of WO2004113389A3 publication Critical patent/WO2004113389A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/3332—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing carboxamide group
    • C08G65/33324—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing carboxamide group acyclic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/321—Polymers modified by chemical after-treatment with inorganic compounds
    • C08G65/322—Polymers modified by chemical after-treatment with inorganic compounds containing hydrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polyethers (AREA)

Abstract

The present invention relates to a cross-linked and beaded, stable and high loading capacity polymer matrix for affinity chromatography applications and for solid phase synthesis. The polymer matrix can be obtained by a method comprising the steps of providing a plurality of macromonomers each comprising a poly(oxalkylene) chain terminated with an acylamide functional group, polymerising said macromonomers using a free radical initiator or an ionic initiator, optionally with the addition of copolymerizing agents, and converting in the beaded polymer matrix at least 50% of the amide groups to amine functional groups by reduction of the amide groups with a suitable reducing agent.
PCT/DK2004/000461 2003-06-26 2004-06-28 High capacity poly(alkylene)glycol based amino polymers WO2004113389A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US48245203P 2003-06-26 2003-06-26
DKPA200300963 2003-06-26
US60/482,452 2003-06-26
DKPA200300963 2003-06-26

Publications (2)

Publication Number Publication Date
WO2004113389A2 WO2004113389A2 (en) 2004-12-29
WO2004113389A3 true WO2004113389A3 (en) 2005-01-27

Family

ID=33542437

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2004/000461 WO2004113389A2 (en) 2003-06-26 2004-06-28 High capacity poly(alkylene)glycol based amino polymers

Country Status (1)

Country Link
WO (1) WO2004113389A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1558491A (en) * 1975-09-03 1980-01-03 Bayer Ag Hydrogenation of polymers
US4745134A (en) * 1984-06-27 1988-05-17 Rohm And Haas Co. Inert separator beads for regeneration of mixed bed-ion exchange resins
WO1999001469A1 (en) * 1997-07-03 1999-01-14 University Of Nottingham A method for attaching polyethylene glycol to macromolecules
WO2000018823A2 (en) * 1998-09-28 2000-04-06 Carlsberg A/S Peg-based macromonomers, chemically inert polymers prepared therefrom and the use of these polymers for organic synthesis and enzyme reactions
WO2003031489A2 (en) * 2001-10-12 2003-04-17 Carlsberg A/S Matrix for solid-phase organic synthesis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1558491A (en) * 1975-09-03 1980-01-03 Bayer Ag Hydrogenation of polymers
US4745134A (en) * 1984-06-27 1988-05-17 Rohm And Haas Co. Inert separator beads for regeneration of mixed bed-ion exchange resins
WO1999001469A1 (en) * 1997-07-03 1999-01-14 University Of Nottingham A method for attaching polyethylene glycol to macromolecules
WO2000018823A2 (en) * 1998-09-28 2000-04-06 Carlsberg A/S Peg-based macromonomers, chemically inert polymers prepared therefrom and the use of these polymers for organic synthesis and enzyme reactions
WO2003031489A2 (en) * 2001-10-12 2003-04-17 Carlsberg A/S Matrix for solid-phase organic synthesis

Also Published As

Publication number Publication date
WO2004113389A2 (en) 2004-12-29

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