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WO2004015089A3 - Polyionic organic acid formulations - Google Patents

Polyionic organic acid formulations Download PDF

Info

Publication number
WO2004015089A3
WO2004015089A3 PCT/US2003/025419 US0325419W WO2004015089A3 WO 2004015089 A3 WO2004015089 A3 WO 2004015089A3 US 0325419 W US0325419 W US 0325419W WO 2004015089 A3 WO2004015089 A3 WO 2004015089A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
organic acid
polyionic organic
acid formulations
polyionic
Prior art date
Application number
PCT/US2003/025419
Other languages
French (fr)
Other versions
WO2004015089A2 (en
Inventor
Michael J Bennett
Yen-Ju Chen
Edmund J Niedzinski
Hsien Tseng
Sean Tucker
Original Assignee
Genteric Inc
Michael J Bennett
Yen-Ju Chen
Edmund J Niedzinski
Hsien Tseng
Sean Tucker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genteric Inc, Michael J Bennett, Yen-Ju Chen, Edmund J Niedzinski, Hsien Tseng, Sean Tucker filed Critical Genteric Inc
Priority to AU2003265432A priority Critical patent/AU2003265432A1/en
Publication of WO2004015089A2 publication Critical patent/WO2004015089A2/en
Publication of WO2004015089A3 publication Critical patent/WO2004015089A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides a nucleic acid transfection composition comprising a polyionic organic acid and a nucleic acid. Preferably, the polyionic organic acid is a dye. Efficient methods are also provided for administering the compositions, increasing the transfection efficiency in a cell (e.g., secretory gland cell), and using the compositions as nucleic acid stabilizers to prevent in vivo and in vitro nucleic acid degradation, thus increasing the half-life and shelf life of a nucleic acid.
PCT/US2003/025419 2002-08-12 2003-08-12 Polyionic organic acid formulations WO2004015089A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003265432A AU2003265432A1 (en) 2002-08-12 2003-08-12 Polyionic organic acid formulations

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US40281102P 2002-08-12 2002-08-12
US60/402,811 2002-08-12
US45399903P 2003-03-11 2003-03-11
US60/453,999 2003-03-11
US47614503P 2003-06-04 2003-06-04
US60/476,145 2003-06-04

Publications (2)

Publication Number Publication Date
WO2004015089A2 WO2004015089A2 (en) 2004-02-19
WO2004015089A3 true WO2004015089A3 (en) 2004-07-15

Family

ID=31721505

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/025419 WO2004015089A2 (en) 2002-08-12 2003-08-12 Polyionic organic acid formulations

Country Status (2)

Country Link
AU (1) AU2003265432A1 (en)
WO (1) WO2004015089A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7625746B2 (en) 2006-07-24 2009-12-01 Nanosphere, Inc. Method of denaturing and fragmenting DNA or RNA using ultrasound
US7888107B2 (en) 2006-07-24 2011-02-15 Nanosphere, Inc. System using self-contained processing module for detecting nucleic acids
CZ301561B6 (en) * 2007-12-04 2010-04-14 Výzkumný ústav živocišné výroby, v. v. i. Pharmaceutical composition to prevent and suppress coccidia
CN110621774A (en) 2016-10-14 2019-12-27 儿童医疗中心有限公司 Compositions and methods for treating central nervous system diseases and disorders
WO2018136435A1 (en) * 2017-01-17 2018-07-26 Children's Medical Center Corporation Compositions and methods for treating lysosomal storage diseases and disorders
US12000843B2 (en) 2017-01-17 2024-06-04 Children's Medical Center Corporation Compositions and methods for diagnosing and treating peroxisomal diseases

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932539A (en) * 1996-10-15 1999-08-03 The Board Of Trustees Of The University Of Illinois Biodegradable polymer matrix for tissue repair
US20010036925A1 (en) * 1995-03-24 2001-11-01 Michael German Gene therapy by secretory gland expression
US6372722B1 (en) * 2000-01-19 2002-04-16 Genteric, Inc. Method for nucleic acid transfection of cells
US20020108132A1 (en) * 2001-02-02 2002-08-08 Avigenics Inc. Production of a monoclonal antibody by a transgenic chicken

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010036925A1 (en) * 1995-03-24 2001-11-01 Michael German Gene therapy by secretory gland expression
US5932539A (en) * 1996-10-15 1999-08-03 The Board Of Trustees Of The University Of Illinois Biodegradable polymer matrix for tissue repair
US6372722B1 (en) * 2000-01-19 2002-04-16 Genteric, Inc. Method for nucleic acid transfection of cells
US20020108132A1 (en) * 2001-02-02 2002-08-08 Avigenics Inc. Production of a monoclonal antibody by a transgenic chicken

Also Published As

Publication number Publication date
AU2003265432A8 (en) 2004-02-25
WO2004015089A2 (en) 2004-02-19
AU2003265432A1 (en) 2004-02-25

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