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WO2002000145A1 - Procede et dispositif de chauffage non invasif externe d"implants metalliques au moyen de champs magnetiques alternatifs - Google Patents

Procede et dispositif de chauffage non invasif externe d"implants metalliques au moyen de champs magnetiques alternatifs Download PDF

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Publication number
WO2002000145A1
WO2002000145A1 PCT/IB2000/000864 IB0000864W WO0200145A1 WO 2002000145 A1 WO2002000145 A1 WO 2002000145A1 IB 0000864 W IB0000864 W IB 0000864W WO 0200145 A1 WO0200145 A1 WO 0200145A1
Authority
WO
WIPO (PCT)
Prior art keywords
heating
magnetic field
alternating magnetic
metals
invasive
Prior art date
Application number
PCT/IB2000/000864
Other languages
English (en)
Inventor
Leonidas Diamantopoulos
Original Assignee
BVBA Flux Medical Systems Therapeutic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BVBA Flux Medical Systems Therapeutic filed Critical BVBA Flux Medical Systems Therapeutic
Priority to PCT/IB2000/000864 priority Critical patent/WO2002000145A1/fr
Priority to AU56999/00A priority patent/AU5699900A/en
Publication of WO2002000145A1 publication Critical patent/WO2002000145A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/009—Heating or cooling appliances for medical or therapeutic treatment of the human body with a varying magnetic field acting upon the human body, e.g. an implant therein

Definitions

  • the temperature at the surface of intravascular intraluminal metallic implants is the same as the surrounding medium, ie. blood, at approximately 37 degrees.
  • Experimental work has shown that increase of temperature of the atheromatous plaque ⁇ n the vascular tree induces apoptosis, thereby reducing the speed and importance of atherosclerotic development and thus possibly reducing the whole process of atheromatosis.
  • the technology that we are introducing is precisely filling the gap to induce such focal rise in temperature. Based on the properties of metals when they are inside an alternating magnetic field, this method succeeds in heating the metallic implants (for example stents) from a distance of several centimeters without affecting the intermediate tissues.
  • the application of the invention in animals as well as in humans takes place externally without any kind of danger to the subject or without introducing any foreign body into the subject.
  • the frequency of the field equals the frequency of the current. If we put again the metallic cylinder into the field, then on it appears a current of energy loss which is called hysteresis, and is due to the magnetic "memory" of the metallic cylinder.
  • plan 1b one can appreciate 2 graphical plots; the left one shows the density of the magnetic lines inside the metal, that can be increased up to a certain point, after which a plateau forms, which is the point when the metal is saturated.
  • the right plot shows the changes of the magnetic flux density in relation to the changes of the magnetic force: starting from point A (zero magnetic flux) the flux reaches the maximal value at point B, which corresponds to the maximal magnetic force.
  • plan 4 the basic plan of the invention is shown.
  • the thermal induction coil L is connected in parallel with a vacuum capacitor C to form a Thomson circuit (LC).
  • LC Thomson circuit
  • the synchronized delivery of electrical energy to the Thomson circuit is achieved by using a power triode electronic tube type 3CX5,000H3 (Eimac, USA).
  • the voltage +Vcc is 8 KV and is filtered from RF return by the capacitors C3 and C4. Each of them consists of 4 ceramic capacitors 4,7 nF/3KV.
  • the voltage passes through the RFC choke, which consists of 70 turns of enamel wires 1 cm in diameter, and is applied to the LC circuit , and then to the anode of the triode tube.
  • the grid of the tube is connected through a feedback capacitor 680 pF/ 10 KV of porcelain type to the active part of the LC, and on the other hand it has a stable polarization with ground through a resistor 47 KOhm/50W and accepts the negative voltage -Vneg.
  • the triode tube operates as a high power self- oscillator with adjustable frequency.
  • the prototype of the invention drained 25KW of electrical power and produced electrical oscillation of 20 MHz and usable power 18 KW, which is converted to a magnetic field at the thermal induction coil L.
  • the prototype of the invention was constructed in an air-shielded, closed aluminum chassis for the creation of high air pressure at the tube compartment that is air-cooled. The air compression is achieved with 2 powerful air compressors while a third one is creating negative pressure at the thermal induction coil compartment so that the air flow at the coil is directed from the outside to the inside zeroing the heat emission due to hot air.
  • Plan 2 shows the electronic circuit for the power supply of the invention.
  • the 220 V net voltage is being raised from the transformer TR1 which as it is shown on the plan, has a secondary with multiple points 1500/2500/3500/5500 Volts, with a maximum current of 3 Amp.
  • the transfer switch SW1 selects the active secondary circuit and the alternating high voltage is forwarded to an AC to DC converting apparatus.
  • At the primary of TR1 there is a special set-up: in order to confront the peak current when the transformer is switched on, due to the self-induction of the primary circuit, there is a time-delay circuit which puts resistances R1 and R2 in series to the primary for 3 seconds and then bypasses them with a high power relay.
  • the AC to DC conversion is achieved by the diode system 1 N5408.
  • the DC is driven to capacitors C1-C2 for smoothening, then through the fuse and the Amp meter it is directed to the rest of the invention as the anode voltage +Vcc.
  • the prototype was constructed as two connected devices: the power supply and the magnetic generator where the tube, the coil and the corresponding circuits are included ( plans 5 and 6).
  • the connection between the two devices happens with special cables that are inside a PVC tube for security reasons.
  • the power supply is fully controlled by a computer through an interface that is an analog-to-digital and vice-versa converter. In this way, the magnetic field strength and heating time and therefore the temperature of the implant are precisely controlled while the correct operation of the system is monitored.
  • the computer software was constructed in programming language C++. It provides continuous information on the magnetic field strength, the temperatures of the vital parts of the invention, the operation of air compressors and the estimated temperature of the implant. Also, there is the capability of connecting an infrared camera for the objective evaluation of the implants' temperature.
  • the programming from the invention operator allows full control of the device concerning the time and strength of the magnetic field.
  • several thermal induction coils with different turns and diameters Some of them are shown in plans 5 to 7.
  • Regarding the position of the coil relative to the metallic implant we can describe 2 basic variations of the invention. This patent application covers both variations but also any other variation that regards external heating of metallic implants using magnetic field energy.
  • the coil has a great diameter (>20cm) , resulting the patient's entering the device as in a life tire. In this case
  • the metallic implant (stent) is at the centre of the coil and therefore the heating phenomenon is much more intense because the implant is crossed by many dense field magnetic lines.
  • the coil has a smaller diameter ( ⁇ 20cm) and it is placed in such a way that the stent is along the axial line of the coil and at a distance 1-10 cm from the first turn (plan 5, plans 7a,b).
  • the invention has a special cooling system of the thermal induction coil which enables continuous flow of cold air which keeps the coil and its surroundings within reasonable temperatures ( ⁇ 60 degrees Celsius).
  • the temperature of the coil and of the tube is continuously monitored by an automated circuit which informs of correct operation and automatically switches of in case of emergency.
  • the invention is equipped with a low-power laser beam which always points to the right area of maximal heating.
  • the previous description is one way of heating metallic implants externally using alternating magnetic fields.
  • the current patent application covers any other way of heating a metallic implant inside the human body or an animal by using magnetic, electromagnetic or other type of radiation.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Induction Heating (AREA)
  • Magnetic Treatment Devices (AREA)

Abstract

L"invention concerne un système produisant un champ magnétique alternatif de puissance et de fréquence appropriées puis acheminant ce champ magnétique vers un corps humain ou un corps animal dans lequel un implant métallique (un stent) ou un autre objet métallique a été préalablement introduit. La puissance du champ magnétique est commandée en continu par un ordinateur équipé d"un logiciel spécial. L"intensité du champ magnétique changeant périodiquement, le flux magnétique à l"intérieur du métal accuse un certain retard à cause de sa persistance magnétique. Ainsi, pour surmonter cette résistance, on utilise de la puissance, laquelle apparaît sur le métal sous forme de chaleur. Cette production de chaleur concerne uniquement les métaux et n"affecte en rien les tissus intermédiaires et les matériaux non métalliques. En d"autres termes, le procédé et le système décrits dans cette invention consistent à chauffer à une température désirée et de manière non invasive des objets métalliques implantés. Le chauffage de ces objets métalliques implantés, tels que des stents, peut permettre d"inverser la resténose dans des vaisseaux dans lesquels un stent a été implanté. Le chauffage peut modifier la géométrie de certains métaux; cette propriété peut être utile en médecine. Enfin, le chauffage non invasif pourrait être utilisé pour traiter d"autres affections, tels que le cancer, etc.
PCT/IB2000/000864 2000-06-26 2000-06-26 Procede et dispositif de chauffage non invasif externe d"implants metalliques au moyen de champs magnetiques alternatifs WO2002000145A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/IB2000/000864 WO2002000145A1 (fr) 2000-06-26 2000-06-26 Procede et dispositif de chauffage non invasif externe d"implants metalliques au moyen de champs magnetiques alternatifs
AU56999/00A AU5699900A (en) 2000-06-26 2000-06-26 Method and apparatus for external non-invasive heating of metallic implants by use of alternating magnetic fields

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2000/000864 WO2002000145A1 (fr) 2000-06-26 2000-06-26 Procede et dispositif de chauffage non invasif externe d"implants metalliques au moyen de champs magnetiques alternatifs

Publications (1)

Publication Number Publication Date
WO2002000145A1 true WO2002000145A1 (fr) 2002-01-03

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PCT/IB2000/000864 WO2002000145A1 (fr) 2000-06-26 2000-06-26 Procede et dispositif de chauffage non invasif externe d"implants metalliques au moyen de champs magnetiques alternatifs

Country Status (2)

Country Link
AU (1) AU5699900A (fr)
WO (1) WO2002000145A1 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1449485A3 (fr) * 2003-02-04 2004-09-08 Zimmer Technology, Inc. Dispositif d'enregistrement d'implant pour un système de navigation pour applications chirurgicales
US6988009B2 (en) 2003-02-04 2006-01-17 Zimmer Technology, Inc. Implant registration device for surgical navigation system
US7887579B2 (en) 2004-09-29 2011-02-15 Merit Medical Systems, Inc. Active stent
WO2012017394A3 (fr) * 2010-08-04 2012-05-18 Nicola Nasser Dispositif permettant de préserver la fécondité
US8273010B2 (en) 2010-06-14 2012-09-25 Coloplast A/S Incontinence treatment device
EP2868299A2 (fr) 2009-08-24 2015-05-06 New Phase Ltd Matériaux de changement de phase et de changement de forme
US9532901B2 (en) 2013-02-05 2017-01-03 Mor Research Applications Ltd. Fertility preservation device
WO2018013935A1 (fr) 2016-07-14 2018-01-18 The Board Of Regents Of The University Of Texas System Procédés, appareils et systèmes de chauffage inductif d'implants métalliques.
US9872902B2 (en) 2014-11-25 2018-01-23 New Phase Ltd. Phase-change nanoparticle

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4503569A (en) * 1983-03-03 1985-03-12 Dotter Charles T Transluminally placed expandable graft prosthesis
US4545368A (en) * 1983-04-13 1985-10-08 Rand Robert W Induction heating method for use in causing necrosis of neoplasm
WO1993007731A1 (fr) * 1991-10-10 1993-04-15 Metcal, Inc. Element chauffant par induction
US5441516A (en) * 1994-03-03 1995-08-15 Scimed Lifesystems Inc. Temporary stent

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4503569A (en) * 1983-03-03 1985-03-12 Dotter Charles T Transluminally placed expandable graft prosthesis
US4545368A (en) * 1983-04-13 1985-10-08 Rand Robert W Induction heating method for use in causing necrosis of neoplasm
WO1993007731A1 (fr) * 1991-10-10 1993-04-15 Metcal, Inc. Element chauffant par induction
US5441516A (en) * 1994-03-03 1995-08-15 Scimed Lifesystems Inc. Temporary stent

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PAULUS J A ET AL: "EVALUATION OF INDUCTIVELY HEATED FERROMAGNETIC ALLOY IMPLANTS FOR THERAPEUTIC INTERSTITIAL HYPERTHERMIA", IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING,US,IEEE INC. NEW YORK, vol. 43, no. 4, 1 April 1996 (1996-04-01), pages 406 - 413, XP000599960, ISSN: 0018-9294 *

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6925339B2 (en) 2003-02-04 2005-08-02 Zimmer Technology, Inc. Implant registration device for surgical navigation system
US6988009B2 (en) 2003-02-04 2006-01-17 Zimmer Technology, Inc. Implant registration device for surgical navigation system
EP1449485A3 (fr) * 2003-02-04 2004-09-08 Zimmer Technology, Inc. Dispositif d'enregistrement d'implant pour un système de navigation pour applications chirurgicales
US7887579B2 (en) 2004-09-29 2011-02-15 Merit Medical Systems, Inc. Active stent
US10492935B2 (en) 2009-08-24 2019-12-03 New Phase Ltd Phase-change materials
EP2868299A2 (fr) 2009-08-24 2015-05-06 New Phase Ltd Matériaux de changement de phase et de changement de forme
US9572695B2 (en) 2009-08-24 2017-02-21 New Phase Ltd Phase-change and shape-change materials
US8273010B2 (en) 2010-06-14 2012-09-25 Coloplast A/S Incontinence treatment device
US8550979B2 (en) 2010-06-15 2013-10-08 Coloplast A/S Method of treating incontinence
WO2012017394A3 (fr) * 2010-08-04 2012-05-18 Nicola Nasser Dispositif permettant de préserver la fécondité
US9532901B2 (en) 2013-02-05 2017-01-03 Mor Research Applications Ltd. Fertility preservation device
US9872902B2 (en) 2014-11-25 2018-01-23 New Phase Ltd. Phase-change nanoparticle
US10172939B2 (en) 2014-11-25 2019-01-08 New Phase Ltd. Phase-change nanoparticle
WO2018013935A1 (fr) 2016-07-14 2018-01-18 The Board Of Regents Of The University Of Texas System Procédés, appareils et systèmes de chauffage inductif d'implants métalliques.
EP3484350A4 (fr) * 2016-07-14 2020-12-23 The Board of Regents of The University of Texas System Procédés, appareils et systèmes de chauffage inductif d'implants métalliques.
US11510615B2 (en) 2016-07-14 2022-11-29 The Board Of Regents Of The University Of Texas System Methods, apparatuses, and systems for inductive heating of foreign metallic implants
US11864911B2 (en) 2016-07-14 2024-01-09 The Board Of Regents Of The University Of Texas System Methods, apparatuses, and systems for inductive heating of foreign metallic implants

Also Published As

Publication number Publication date
AU5699900A (en) 2002-01-08

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