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WO2001020004A3 - Protein phosphatase and kinase proteins - Google Patents

Protein phosphatase and kinase proteins Download PDF

Info

Publication number
WO2001020004A3
WO2001020004A3 PCT/US2000/025515 US0025515W WO0120004A3 WO 2001020004 A3 WO2001020004 A3 WO 2001020004A3 US 0025515 W US0025515 W US 0025515W WO 0120004 A3 WO0120004 A3 WO 0120004A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein phosphatase
kinase proteins
pphkp
provides
expression
Prior art date
Application number
PCT/US2000/025515
Other languages
French (fr)
Other versions
WO2001020004A2 (en
Inventor
Henry Yue
Y Tom Tang
Olga Bandman
Jennifer L Hillman
Mariah R Baughn
Yalda Azimzai
Dyung Aina M Lu
Original Assignee
Incyte Genomics Inc
Henry Yue
Y Tom Tang
Olga Bandman
Jennifer L Hillman
Mariah R Baughn
Yalda Azimzai
Dyung Aina M Lu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc, Henry Yue, Y Tom Tang, Olga Bandman, Jennifer L Hillman, Mariah R Baughn, Yalda Azimzai, Dyung Aina M Lu filed Critical Incyte Genomics Inc
Priority to AU78297/00A priority Critical patent/AU7829700A/en
Priority to JP2001523775A priority patent/JP2003509053A/en
Priority to EP00968368A priority patent/EP1212436A2/en
Priority to CA002383927A priority patent/CA2383927A1/en
Publication of WO2001020004A2 publication Critical patent/WO2001020004A2/en
Publication of WO2001020004A3 publication Critical patent/WO2001020004A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention provides human protein phosphatase and kinase proteins (PPHKP) and polynucleotides which identify and encode PPHKP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of PPHKP.
PCT/US2000/025515 1999-09-15 2000-09-14 Protein phosphatase and kinase proteins WO2001020004A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU78297/00A AU7829700A (en) 1999-09-15 2000-09-14 Protein phosphatase and kinase proteins
JP2001523775A JP2003509053A (en) 1999-09-15 2000-09-14 Protein phosphatase and protein kinase
EP00968368A EP1212436A2 (en) 1999-09-15 2000-09-14 Protein phosphatase and kinase proteins
CA002383927A CA2383927A1 (en) 1999-09-15 2000-09-14 Protein phosphatase and kinase proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15414199P 1999-09-15 1999-09-15
US60/154,141 1999-09-15

Publications (2)

Publication Number Publication Date
WO2001020004A2 WO2001020004A2 (en) 2001-03-22
WO2001020004A3 true WO2001020004A3 (en) 2001-10-18

Family

ID=22550173

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/025515 WO2001020004A2 (en) 1999-09-15 2000-09-14 Protein phosphatase and kinase proteins

Country Status (5)

Country Link
EP (1) EP1212436A2 (en)
JP (1) JP2003509053A (en)
AU (1) AU7829700A (en)
CA (1) CA2383927A1 (en)
WO (1) WO2001020004A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6905827B2 (en) 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US7026121B1 (en) 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6903800A (en) * 1999-08-13 2001-03-13 Sugen, Inc. Novel protein phosphatases and diagnosis and treatment of phosphatase-related disorders
AU2001241880A1 (en) 2000-02-29 2001-09-12 Millennium Pharmaceuticals, Inc. 2504, 15977, and 14760, novel protein kinase family members and uses therefor
AU2001247782A1 (en) * 2000-03-24 2001-10-08 Millennium Pharmaceuticals, Inc. 18221, dual specificity phosphatase and uses thereof
JP2003530112A (en) * 2000-04-10 2003-10-14 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング Identification of the dual specificity phosphatase DUSP-10
US6461846B2 (en) * 2000-05-30 2002-10-08 Pe Corporation Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
US20030170856A1 (en) * 2000-09-07 2003-09-11 Jiing-Ren Liou Regulation of human map kinase phosphatase-like enzyme
US6825021B2 (en) 2000-09-19 2004-11-30 Ceptyr, Inc. DSP-15 dual-specificity phosphatase
WO2002026997A2 (en) * 2000-09-26 2002-04-04 Ceptyr, Inc. Dsp-16 dual-specificity phosphatase
JP2004514434A (en) * 2000-11-20 2004-05-20 ピーイー　コーポレーション　（エヌワイ） Isolated human phosphatase protein, nucleic acid molecule encoding human phosphatase protein and uses thereof
EP1346053A2 (en) 2000-12-20 2003-09-24 Bristol-Myers Squibb Company Polynucleotides encoding human phosphatases
EP1694701A2 (en) * 2003-12-16 2006-08-30 Ares Trading S.A. Pp2a/bgamma subunits, modulators thereof, and their uses in the treatment of mental disorders
EP2185176B1 (en) 2007-08-10 2016-07-06 Agency for Science, Technology And Research Vhz for diagnosis and treatment of cancer
US9580513B2 (en) 2008-08-08 2017-02-28 Agency For Science, Technology And Research (A*Star) VHZ for diagnosis and treatment of cancers
JP6472075B2 (en) * 2015-02-26 2019-02-20 学校法人順天堂 Diagnosis of prognosis or resistance to treatment of GIST

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999009199A2 (en) * 1997-08-20 1999-02-25 University Of Medicine And Dentistry Of New Jersey Elongation factor-2 kinase (ef-2 kinase) and methods of use therefor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999009199A2 (en) * 1997-08-20 1999-02-25 University Of Medicine And Dentistry Of New Jersey Elongation factor-2 kinase (ef-2 kinase) and methods of use therefor

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KUHEN K L ET AL: "Mechanism of interferon action Sequence of the human interferon-inducible RNA-dependent protein kinase (PKR) deduced from genomic clones", GENE: AN INTERNATIONAL JOURNAL ON GENES AND GENOMES,GB,ELSEVIER SCIENCE PUBLISHERS, BARKING, vol. 178, no. 1, 31 October 1996 (1996-10-31), pages 191 - 193, XP004043360, ISSN: 0378-1119 *
MARTELL K J ET AL: "HVH-5: A PROTEIN TYROSINE PHOSPHATASE ABUNDANT IN BRAIN THAT INACTIVATES MITOGEN-ACTIVATED PROTEIN KINASE", JOURNAL OF NEUROCHEMISTRY,US,NEW YORK, NY, vol. 65, no. 4, 1995, pages 1823 - 1833, XP000196676, ISSN: 0022-3042 *
STONE S R ET AL: "THE NUCLEOTIDE SEQUENCE OF THE COMPLEMENTARY DNA ENCODING THE HUMAN LUNG PROTEIN PHOSPHATASE 2A-ALPHA CATALYTIC SUBUNIT", NUCLEIC ACIDS RESEARCH, vol. 16, no. 23, 1988, pages 11365, XP002160654, ISSN: 0305-1048 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6905827B2 (en) 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US7026121B1 (en) 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US7579148B2 (en) 2001-06-08 2009-08-25 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring autoimmune and chronic inflammatory diseases
US7604936B2 (en) 2002-04-24 2009-10-20 Xdx, Inc. Methods and compositions for diagnosis and monitoring auto immune and chronic inflammatory diseases

Also Published As

Publication number Publication date
EP1212436A2 (en) 2002-06-12
JP2003509053A (en) 2003-03-11
CA2383927A1 (en) 2001-03-22
WO2001020004A2 (en) 2001-03-22
AU7829700A (en) 2001-04-17

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