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WO2001079230A3 - Haplotypes of the ugt1a1 gene - Google Patents

Haplotypes of the ugt1a1 gene Download PDF

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Publication number
WO2001079230A3
WO2001079230A3 PCT/US2001/012273 US0112273W WO0179230A3 WO 2001079230 A3 WO2001079230 A3 WO 2001079230A3 US 0112273 W US0112273 W US 0112273W WO 0179230 A3 WO0179230 A3 WO 0179230A3
Authority
WO
WIPO (PCT)
Prior art keywords
ugt1a1
haplotypes
gene
ugt1a1 gene
disclosed
Prior art date
Application number
PCT/US2001/012273
Other languages
French (fr)
Other versions
WO2001079230A2 (en
Inventor
Anne Chew
Julie Y Choi
Beena Koshy
Eileen Rounds
Original Assignee
Genaissance Pharmaceuticals
Anne Chew
Julie Y Choi
Beena Koshy
Eileen Rounds
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals, Anne Chew, Julie Y Choi, Beena Koshy, Eileen Rounds filed Critical Genaissance Pharmaceuticals
Priority to AU2001255397A priority Critical patent/AU2001255397A1/en
Publication of WO2001079230A2 publication Critical patent/WO2001079230A2/en
Publication of WO2001079230A3 publication Critical patent/WO2001079230A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Biology (AREA)
  • Zoology (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Novel single nucleotide polymorphisms in the human UDP glycosyltransferase 1 (UGT1A1) gene are described. In addition, various genotypes, haplotypes and haplotype pairs for the UGT1A1 gene that exist in the population are described. Compositions and methods for haplotyping and/or genotyping the UGT1A1 gene in an individual are also disclosed. Polynucleotides containing one or more of the UGT1A1 polymorphisms disclosed herein are also described.
PCT/US2001/012273 2000-04-18 2001-04-13 Haplotypes of the ugt1a1 gene WO2001079230A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001255397A AU2001255397A1 (en) 2000-04-18 2001-04-13 Haplotypes of the ugt1a1 gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19751400P 2000-04-18 2000-04-18
US60/197,514 2000-04-18

Publications (2)

Publication Number Publication Date
WO2001079230A2 WO2001079230A2 (en) 2001-10-25
WO2001079230A3 true WO2001079230A3 (en) 2002-03-21

Family

ID=22729714

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/012273 WO2001079230A2 (en) 2000-04-18 2001-04-13 Haplotypes of the ugt1a1 gene

Country Status (2)

Country Link
AU (1) AU2001255397A1 (en)
WO (1) WO2001079230A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE397091T1 (en) 2003-05-30 2008-06-15 Univ Chicago METHODS AND COMPOSITIONS FOR PREDICTING IRINOTECANTOXICITY
WO2008066136A1 (en) * 2006-11-30 2008-06-05 Arkray, Inc. Primer set for amplification of ugt1a1 gene, reagent for amplification of ugt1a1 gene comprising the same, and use of the same
RU2693462C2 (en) * 2010-05-03 2019-07-03 Курна, Инк. Treatment of sirtuin (sirt) related diseases by inhibition of natural antisense transcript to sirtuin (sirt)
KR101277793B1 (en) 2010-09-24 2013-06-25 대한민국 Methods of estimating ugt1a1 gene experssion using ugt1a1 gene haplotype in korean
KR102661616B1 (en) * 2016-07-28 2024-04-30 리제너론 파마슈티칼스 인코포레이티드 GPR156 variants and their uses

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992012987A1 (en) * 1991-01-10 1992-08-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services The genetic locus ugt1 and a mutation therein
WO1999057322A2 (en) * 1998-05-07 1999-11-11 Axys Pharmaceuticals, Inc. Genotyping the human udp-glucuronosyltransferase 1 (ugt1) gene

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992012987A1 (en) * 1991-01-10 1992-08-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services The genetic locus ugt1 and a mutation therein
WO1999057322A2 (en) * 1998-05-07 1999-11-11 Axys Pharmaceuticals, Inc. Genotyping the human udp-glucuronosyltransferase 1 (ugt1) gene

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BEUTLER ET AL.: "Racial variability in the UDP glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism?", PROC. NATL. ACAD. SCI. USA, vol. 95, July 1998 (1998-07-01), pages 8170 - 8174, XP002949274 *
CANCER RESEARCH, 15 February 2000 (2000-02-15) *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (BETHESDA, MD, USA); GUILLEMETTE ET AL.: "Genetic polymorphisms in uridine diphosphoglucuronosyltransferase 1A1 and association with breast cancer amonf African Americans", XP002949275, Database accession no. 2000168627 *
ERPS ET AL.: "Identification of two single base substitutions in the UGT1 gene locus which abolish bilirubin uridine diphosphate glucuronosyltransferase activity in vitro", J. CLIN. INVEST., vol. 93, February 1994 (1994-02-01), pages 564 - 570, XP002949272 *
MONAGHAN ET AL.: "Genetic variation in bilirubin UDP-glucuronosyltransferase gene promoter and Gilbert's syndrome", LANCET, vol. 347, 2 March 1996 (1996-03-02), pages 578 - 581, XP002949273 *

Also Published As

Publication number Publication date
AU2001255397A1 (en) 2001-10-30
WO2001079230A2 (en) 2001-10-25

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