WO1999001103A3 - Derives de peptides, sels de ces derives acceptables sur le plan pharmaceutique, procede de production de ces derives, utilisation de ces derniers et composition pharmaceutique - Google Patents
Derives de peptides, sels de ces derives acceptables sur le plan pharmaceutique, procede de production de ces derives, utilisation de ces derniers et composition pharmaceutique Download PDFInfo
- Publication number
- WO1999001103A3 WO1999001103A3 PCT/RU1998/000215 RU9800215W WO9901103A3 WO 1999001103 A3 WO1999001103 A3 WO 1999001103A3 RU 9800215 W RU9800215 W RU 9800215W WO 9901103 A3 WO9901103 A3 WO 9901103A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- derivatives
- acceptable salts
- relates
- producing
- pharmaceutical composition
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 230000001088 anti-asthma Effects 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000002001 anti-metastasis Effects 0.000 abstract 1
- 230000003064 anti-oxidating effect Effects 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 239000000924 antiasthmatic agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UA2000010044A UA70301C2 (ru) | 1997-07-04 | 1998-03-07 | Производные пептидов или их фармацевтически приемлемые соли, способ их получения, применение и фармацевтическая композиция |
| EP98935447A EP1020179B9 (en) | 1997-07-04 | 1998-07-03 | Peptide derivatives or pharmaceutically acceptable salts thereof, method for producing the same, use of said derivatives and pharmaceutical composition |
| AU84694/98A AU8469498A (en) | 1997-07-04 | 1998-07-03 | Peptide derivatives or pharmaceutically acceptable salts thereof, method for producing the same, use of said derivatives and pharmaceutical composition |
| DE69841367T DE69841367D1 (de) | 1997-07-04 | 1998-07-03 | Peptidderivate oder deren pharmazeutisch annehmbare salze, verfahren zu deren herstellung, verwendung dieser derivate und arzneimittel |
| AT98935447T ATE451096T1 (de) | 1997-07-04 | 1998-07-03 | Peptidderivate oder deren pharmazeutisch annehmbare salze, verfahren zu deren herstellung, verwendung dieser derivate und arzneimittel |
| DK98935447.7T DK1020179T3 (da) | 1997-07-04 | 1998-07-03 | Peptidderivater eller farmaceutisk acceptable salte deraf, fremgangsmåde til fremstilling af de samme, anvendelse af derivaterne og farmaceutisk sammensætning |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU97111091 | 1997-07-04 | ||
| RU97111091/04A RU2141483C1 (ru) | 1997-07-04 | 1997-07-04 | Производные пептидов или их фармацевтически приемлемые соли, способ их получения, применение и фармацевтическая композиция |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1999001103A2 WO1999001103A2 (en) | 1999-01-14 |
| WO1999001103A3 true WO1999001103A3 (fr) | 1999-03-25 |
Family
ID=20194786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/RU1998/000215 WO1999001103A2 (en) | 1997-07-04 | 1998-07-03 | Peptide derivatives or pharmaceutically acceptable salts thereof, method for producing the same, use of said derivatives and pharmaceutical composition |
Country Status (11)
| Country | Link |
|---|---|
| EP (2) | EP2229935A1 (ru) |
| AT (1) | ATE451096T1 (ru) |
| AU (1) | AU8469498A (ru) |
| CY (1) | CY1109869T1 (ru) |
| DE (1) | DE69841367D1 (ru) |
| DK (1) | DK1020179T3 (ru) |
| ES (1) | ES2337964T3 (ru) |
| PT (1) | PT1020179E (ru) |
| RU (1) | RU2141483C1 (ru) |
| UA (1) | UA70301C2 (ru) |
| WO (1) | WO1999001103A2 (ru) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9486441B2 (en) | 2008-04-21 | 2016-11-08 | Signum Biosciences, Inc. | Compounds, compositions and methods for making the same |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001046127A1 (fr) * | 1999-12-22 | 2001-06-28 | Om Pharma | Pseudodipeptides acyles porteurs d'un bras auxiliaire fonctionnalise |
| CA2420045A1 (en) * | 2000-09-27 | 2002-04-04 | The Procter & Gamble Company | Melanocortin receptor ligands |
| RU2178710C1 (ru) * | 2001-02-08 | 2002-01-27 | Кожемякин Леонид Андреевич | Индивидуальные вещества, полученные на основе химического взаимодействия дисульфидсодержащих пептидов с производными пуриновых или пиримидиновых оснований, фармацевтические композиции и препараты на их основе, способы их применения для лечения инфекционных заболеваний и профилактики осложнений |
| JP4156825B2 (ja) * | 2001-11-01 | 2008-09-24 | 株式会社ロッテ | 抗鬱・抗ストレス剤及びそれを含有する組成物 |
| RU2217196C2 (ru) * | 2002-02-28 | 2003-11-27 | Небольсин Владимир Евгеньевич | Способ индукции дифференцировки клеток |
| MC200060A1 (fr) * | 2002-10-04 | 2003-05-28 | M Exsymol Sa | Produit de couplage entre la tryptamine et un alpha-aminoacide son procédé de préparation et son application dans le domaine de la neuro-cosmétique |
| JP2006143667A (ja) * | 2004-11-22 | 2006-06-08 | Ube Ind Ltd | ピペコリン酸アミド誘導体及び抗菌剤 |
| RU2335495C2 (ru) * | 2005-06-15 | 2008-10-10 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | N-ацильные производные аминокислот, их фармацевтически приемлевые соли, фармацевтическая композиция и применение в качестве гиполипидемических средств |
| RU2330680C2 (ru) * | 2005-12-09 | 2008-08-10 | Государственное учреждение Научно-исследовательский институт фармакологии имени В.В. Закусова Российской академии медицинских наук | Инъекционная лекарственная форма для лечения острого инсульта, способ ее изготовления и применение |
| RU2308966C1 (ru) * | 2006-05-18 | 2007-10-27 | Институт физиологически активных веществ Российской Академии Наук (ИФАВ РАН) | Антиметастатическая композиция |
| WO2008100458A2 (en) | 2007-02-13 | 2008-08-21 | Sciclone Pharmaceuticals, Inc. | Method of treating or preventing tissue deterioration, injury or damage due to disease of mucosa |
| GB2437429A (en) * | 2007-06-11 | 2007-10-24 | Valletta Health Bv | Urocanic acid derivatives |
| RU2327486C1 (ru) * | 2007-07-04 | 2008-06-27 | Валентина Васильевна Малиновская | Лекарственное средство для лечения инфекционно-воспалительных заболеваний, обладающее иммуномодулирующим, антивирусным, антибактериальным, антиоксидантным, мембраностабилизирующим, противовоспалительным, антитоксическим свойствами |
| RU2326688C1 (ru) * | 2007-08-13 | 2008-06-20 | Валентина Васильевна Малиновская | Гипоаллергенное лекарственное средство для лечения инфекционно-воспалительных заболеваний различной этиологии |
| CA2697261A1 (en) * | 2007-08-23 | 2009-02-26 | Sciclone Pharmaceuticals, Inc. | Treatment of lung cancer |
| RU2378284C2 (ru) * | 2008-02-13 | 2010-01-10 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Способы получения n-ацильных производных аминокислот (варианты) |
| RU2406727C2 (ru) * | 2008-02-13 | 2010-12-20 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Фармацевтическая композиция, содержащая n-ацильные производные аминокислот, и их применение в качестве противоаллергических, антианафилактических и противовоспалительных средств |
| RU2373934C1 (ru) * | 2008-03-19 | 2009-11-27 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Применение производных глутаровой кислоты или их фармацевтически приемлемых солей в качестве противоаритмических средств |
| FR2942625B1 (fr) * | 2009-03-02 | 2013-11-22 | Centre Nat Rech Scient | Derives indoliques pour le traitement de maladies neurodegeneratives |
| US9504673B2 (en) * | 2009-05-21 | 2016-11-29 | LTD “Valenta-Intellekt” | Agent for the prophylaxis and treatment of highly pathogenic infectious diseases |
| WO2011047156A1 (en) * | 2009-10-15 | 2011-04-21 | Hercules Technology Management Co V, Inc. | Sepiapterin reductase inhibitors for the treatment of pain |
| JP2012097068A (ja) * | 2010-10-04 | 2012-05-24 | Sumitomo Chemical Co Ltd | 植物の水分ストレスによる影響を軽減する方法 |
| AU2012234680A1 (en) * | 2011-03-31 | 2013-10-17 | Apotex Technologies Inc. | Prodrugs of D-isoglutamyl-[D/L]-tryptophan |
| UA115431C2 (ru) | 2011-10-11 | 2017-11-10 | Общєство С Огранічєнной Отвєтствєнностью "Валєнта-Інтєллєкт" | Применение глутарилгистамина для лечения заболеваний дыхательных путей |
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| RU2518314C2 (ru) * | 2012-08-30 | 2014-06-10 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Способ и средство активации irf-3 для лечения и профилактики заболеваний, вызываемых (+) phk-содержащими вирусами |
| EP3929217A3 (en) | 2013-02-08 | 2022-03-02 | Novartis AG | Specific sites for modifying antibodies to make immunoconjugates |
| EP3722290B1 (en) | 2013-04-12 | 2023-06-21 | VALENTA-INTELLEKT Limited | Glutarimide derivative, use thereof, pharmaceutical composition based thereon and methods for producing the glutarimide derivative |
| CN103382179A (zh) * | 2013-06-05 | 2013-11-06 | 四川百利药业有限责任公司 | 英加韦林的多晶型物及其制备方法 |
| RU2613314C2 (ru) * | 2013-06-28 | 2017-03-15 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" | Малые молекулы с NGF-подобной активностью, обладающие антидиабетическими свойствами |
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| CN105418512B (zh) * | 2014-09-19 | 2018-05-01 | 江苏正大丰海制药有限公司 | 英加韦林的单晶、制备方法及其药物组合物 |
| KR101861081B1 (ko) * | 2015-08-05 | 2018-05-28 | 인제대학교 산학협력단 | 멜라토닌 유도체를 포함하는 염증성 질환, 알러지 질환 또는 암 질환 예방 또는 치료용 조성물 |
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| CH631446A5 (de) * | 1976-03-16 | 1982-08-13 | Santen Pharmaceutical Co Ltd | Verfahren zur herstellung von neuen n-(benzoylmercaptoacyl)-histidinen und n-(mercaptoacyl)-histidinen. |
| EP0584694A1 (de) * | 1992-08-28 | 1994-03-02 | Hoechst Aktiengesellschaft | Imidazolidin-Derivate |
| WO1994019325A1 (fr) * | 1993-02-22 | 1994-09-01 | Exsymol Societe Anonyme Monegasque | Produit de couplage de l'histamine et d'un acide amine |
| WO1995010294A1 (en) * | 1993-10-15 | 1995-04-20 | Bruschettini S.R.L. | Pharmaceutical compositions containing n-acetylcarnosine for the treatment of cataract |
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| RU2080120C1 (ru) * | 1994-07-19 | 1997-05-27 | Совместное русско-американское акционерное общество закрытого типа "Неофарм" | Средство, обладающее иммуномодулирующей активностью |
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- 1997-07-04 RU RU97111091/04A patent/RU2141483C1/ru active Protection Beyond IP Right Term
-
1998
- 1998-03-07 UA UA2000010044A patent/UA70301C2/ru unknown
- 1998-07-03 AU AU84694/98A patent/AU8469498A/en not_active Abandoned
- 1998-07-03 EP EP08006502A patent/EP2229935A1/en not_active Withdrawn
- 1998-07-03 DE DE69841367T patent/DE69841367D1/de not_active Expired - Lifetime
- 1998-07-03 DK DK98935447.7T patent/DK1020179T3/da active
- 1998-07-03 PT PT98935447T patent/PT1020179E/pt unknown
- 1998-07-03 WO PCT/RU1998/000215 patent/WO1999001103A2/ru active Application Filing
- 1998-07-03 AT AT98935447T patent/ATE451096T1/de active
- 1998-07-03 ES ES98935447T patent/ES2337964T3/es not_active Expired - Lifetime
- 1998-07-03 EP EP98935447A patent/EP1020179B9/en not_active Expired - Lifetime
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2010
- 2010-03-04 CY CY20101100206T patent/CY1109869T1/el unknown
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| GB2090831A (en) * | 1980-12-18 | 1982-07-21 | Ajinomo Co Inc | A process for preparing n-acylcarnosine |
| EP0584694A1 (de) * | 1992-08-28 | 1994-03-02 | Hoechst Aktiengesellschaft | Imidazolidin-Derivate |
| WO1994019325A1 (fr) * | 1993-02-22 | 1994-09-01 | Exsymol Societe Anonyme Monegasque | Produit de couplage de l'histamine et d'un acide amine |
| WO1995010294A1 (en) * | 1993-10-15 | 1995-04-20 | Bruschettini S.R.L. | Pharmaceutical compositions containing n-acetylcarnosine for the treatment of cataract |
| RU2080120C1 (ru) * | 1994-07-19 | 1997-05-27 | Совместное русско-американское акционерное общество закрытого типа "Неофарм" | Средство, обладающее иммуномодулирующей активностью |
| WO1996036348A1 (en) * | 1995-05-19 | 1996-11-21 | Farmila-Farmaceutici Milano S.R.L. | Pharmaceutical and/or dietetic compositions with antioxidant activity containing carnosine or derivatives and branched amino acids |
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| US9486441B2 (en) | 2008-04-21 | 2016-11-08 | Signum Biosciences, Inc. | Compounds, compositions and methods for making the same |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE451096T1 (de) | 2009-12-15 |
| RU2141483C1 (ru) | 1999-11-20 |
| ES2337964T3 (es) | 2010-04-30 |
| EP1020179B9 (en) | 2011-02-02 |
| PT1020179E (pt) | 2010-03-15 |
| WO1999001103A2 (en) | 1999-01-14 |
| EP1020179B1 (en) | 2009-12-09 |
| AU8469498A (en) | 1999-01-25 |
| EP1020179A4 (en) | 2003-02-19 |
| CY1109869T1 (el) | 2014-09-10 |
| EP2229935A1 (en) | 2010-09-22 |
| EP1020179A2 (en) | 2000-07-19 |
| DE69841367D1 (de) | 2010-01-21 |
| UA70301C2 (ru) | 2004-10-15 |
| DK1020179T3 (da) | 2010-04-19 |
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