UY31053A1 - Derivados heterociclicos, procesos para su produccion, medicamentos que comprende estos compuestos y su uso - Google Patents
Derivados heterociclicos, procesos para su produccion, medicamentos que comprende estos compuestos y su usoInfo
- Publication number
- UY31053A1 UY31053A1 UY31053A UY31053A UY31053A1 UY 31053 A1 UY31053 A1 UY 31053A1 UY 31053 A UY31053 A UY 31053A UY 31053 A UY31053 A UY 31053A UY 31053 A1 UY31053 A1 UY 31053A1
- Authority
- UY
- Uruguay
- Prior art keywords
- compounds
- processes
- production
- derivatives
- heterociclical
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 206010022489 Insulin Resistance Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Derivados heterocíclicos, procesos para su produccion, medicamentos que comprende estos compuestos y su uso. La invencion se refiere a compuestos de formula I en la que los radicales R1, M, A, B, D, L y R son cada uno como se definio anteriormente, y a las sales fisiologicamente compatibles. Los compuestos resultan adecuados, por ejemplo, para el tratamiento del síndrome matabolico, la resistencia a la insulina, la obesidad y la diabetes.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07008646 | 2007-04-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY31053A1 true UY31053A1 (es) | 2008-11-28 |
Family
ID=38473076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY31053A UY31053A1 (es) | 2007-04-27 | 2008-04-25 | Derivados heterociclicos, procesos para su produccion, medicamentos que comprende estos compuestos y su uso |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US8003677B2 (es) |
| EP (1) | EP2152711B1 (es) |
| JP (1) | JP2010524987A (es) |
| KR (1) | KR20100015975A (es) |
| CN (1) | CN101663306A (es) |
| AR (1) | AR066290A1 (es) |
| AT (1) | ATE489389T1 (es) |
| AU (1) | AU2008248996A1 (es) |
| BR (1) | BRPI0810858A2 (es) |
| CA (1) | CA2685543A1 (es) |
| CL (1) | CL2008001215A1 (es) |
| DE (1) | DE502008001903D1 (es) |
| IL (1) | IL201764A0 (es) |
| MX (1) | MX2009011112A (es) |
| TW (1) | TW200911809A (es) |
| UY (1) | UY31053A1 (es) |
| WO (1) | WO2008135141A1 (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2328898B1 (de) | 2008-09-09 | 2014-12-24 | Sanofi | 2-heteroaryl-pyrrolo[3,4-c]pyrrol- derivate und ihre verwendung als scd inhibitoren |
| WO2010108268A1 (en) * | 2009-03-23 | 2010-09-30 | Merck Frosst Canada Ltd. | Heterocyclic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| CN102791133B (zh) | 2010-01-07 | 2015-09-23 | 纳幕尔杜邦公司 | 杀真菌杂环化合物 |
| CN102260265B (zh) * | 2010-05-24 | 2015-09-02 | 上海阳帆医药科技有限公司 | 六氢吡咯[3,4-b]吡咯衍生物、其制备方法及其用途 |
| JP2013538215A (ja) | 2010-08-31 | 2013-10-10 | エスエヌユー アールアンドディービー ファウンデーション | ＰＰＡＲδアゴニストの胎児再プログラミング用途 |
| US8501768B2 (en) * | 2011-05-17 | 2013-08-06 | Hoffmann-La Roche Inc. | Hexahydrocyclopentapyrrolone, hexahydropyrrolopyrrolone, octahydropyrrolopyridinone and octahydropyridinone compounds |
| KR20140084164A (ko) | 2011-10-15 | 2014-07-04 | 제넨테크, 인크. | 암의 치료를 위한 scd1 길항제 |
| BR112014030473A2 (pt) | 2012-06-13 | 2017-06-27 | Hoffmann La Roche | novo diazaespirocicloalcano e azaespirocicloalcano |
| EA036630B1 (ru) | 2012-09-25 | 2020-12-02 | Ф. Хоффманн-Ля Рош Аг | Бициклические производные |
| AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| WO2015078803A1 (en) | 2013-11-26 | 2015-06-04 | F. Hoffmann-La Roche Ag | NEW OCTAHYDRO-CYCLOBUTA [1,2-c;3,4-c']DIPYRROL-2-YL |
| SG11201607845RA (en) | 2014-03-26 | 2016-10-28 | Hoffmann La Roche | Condensed [1,4]diazepine compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors |
| CR20160419A (es) | 2014-03-26 | 2016-11-07 | Hoffmann La Roche | Nuevos compuestos biciclicos |
| WO2016046837A1 (en) | 2014-09-22 | 2016-03-31 | Cadila Healthcare Limited | An improved process for preparation of pyrrolo[3,4- c] pyrrole compounds and intermediates thereof |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| JP6886967B2 (ja) | 2015-09-04 | 2021-06-16 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | フェノキシメチル誘導体 |
| CN107614505B (zh) | 2015-09-24 | 2021-05-07 | 豪夫迈·罗氏有限公司 | 作为双重atx/ca抑制剂的新型二环化合物 |
| BR112018006034A2 (pt) * | 2015-09-24 | 2018-10-09 | Hoffmann La Roche | compostos bicíclicos como inibidores de atx |
| RU2018114289A (ru) | 2015-09-24 | 2019-10-24 | Ф. Хоффманн-Ля Рош Аг | Бициклические соединения в качестве ингибиторов аутотаксина (atx) |
| BR112018006080A2 (pt) | 2015-09-24 | 2018-10-09 | F. Hoffmann-La Roche Ag | novos compostos bicíclicos como inibidores de dupla ação de atx/ca |
| CN108299437B (zh) * | 2017-01-13 | 2022-07-08 | 广东东阳光药业有限公司 | 八氢吡咯并[3,4-c]吡咯衍生物及其用途 |
| AU2018233079B9 (en) | 2017-03-16 | 2021-07-22 | F. Hoffmann-La Roche Ag | Heterocyclic compounds useful as dual ATX/CA inhibitors |
| JP7090099B2 (ja) | 2017-03-16 | 2022-06-23 | エフ．ホフマン－ラ ロシュ アーゲー | Ａｔｘインヒビターとしての新規二環式化合物 |
| RS59306B1 (sr) | 2017-03-20 | 2019-10-31 | Forma Therapeutics Inc | Kompozicije pirolopirola kao aktivatori piruvat kinaze (pkr) |
| US12122778B2 (en) | 2018-09-19 | 2024-10-22 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
| WO2020061378A1 (en) | 2018-09-19 | 2020-03-26 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
| CA3151612A1 (en) | 2019-09-19 | 2021-03-25 | George P. Luke | Pyruvate kinase r (pkr) activating compositions |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
| WO2024112764A1 (en) | 2022-11-21 | 2024-05-30 | Novo Nordisk Health Care Ag | Synthesis of pyrrolo[3,4-c]pyrroles |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006034315A2 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes |
| BRPI0515482A (pt) * | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e seus usos como agentes terapêuticos |
-
2008
- 2008-04-16 AU AU2008248996A patent/AU2008248996A1/en not_active Abandoned
- 2008-04-16 CA CA002685543A patent/CA2685543A1/en not_active Abandoned
- 2008-04-16 AT AT08735269T patent/ATE489389T1/de active
- 2008-04-16 CN CN200880012991A patent/CN101663306A/zh active Pending
- 2008-04-16 MX MX2009011112A patent/MX2009011112A/es not_active Application Discontinuation
- 2008-04-16 JP JP2010504505A patent/JP2010524987A/ja not_active Withdrawn
- 2008-04-16 WO PCT/EP2008/003019 patent/WO2008135141A1/de active Application Filing
- 2008-04-16 EP EP08735269A patent/EP2152711B1/de not_active Not-in-force
- 2008-04-16 BR BRPI0810858-7A2A patent/BRPI0810858A2/pt not_active Application Discontinuation
- 2008-04-16 DE DE502008001903T patent/DE502008001903D1/de active Active
- 2008-04-16 KR KR1020097022497A patent/KR20100015975A/ko not_active Withdrawn
- 2008-04-24 TW TW097114960A patent/TW200911809A/zh unknown
- 2008-04-24 AR ARP080101740A patent/AR066290A1/es unknown
- 2008-04-25 CL CL200801215A patent/CL2008001215A1/es unknown
- 2008-04-25 UY UY31053A patent/UY31053A1/es not_active Application Discontinuation
-
2009
- 2009-10-26 US US12/605,631 patent/US8003677B2/en not_active Expired - Fee Related
- 2009-10-26 IL IL201764A patent/IL201764A0/en unknown
-
2011
- 2011-06-15 US US13/160,705 patent/US20110245263A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN101663306A (zh) | 2010-03-03 |
| IL201764A0 (en) | 2010-06-16 |
| EP2152711A1 (de) | 2010-02-17 |
| AU2008248996A1 (en) | 2008-11-13 |
| WO2008135141A1 (de) | 2008-11-13 |
| CA2685543A1 (en) | 2008-11-13 |
| CL2008001215A1 (es) | 2008-09-22 |
| JP2010524987A (ja) | 2010-07-22 |
| US20100144594A1 (en) | 2010-06-10 |
| BRPI0810858A2 (pt) | 2014-10-29 |
| KR20100015975A (ko) | 2010-02-12 |
| AR066290A1 (es) | 2009-08-12 |
| MX2009011112A (es) | 2009-10-28 |
| ATE489389T1 (de) | 2010-12-15 |
| US8003677B2 (en) | 2011-08-23 |
| EP2152711B1 (de) | 2010-11-24 |
| US20110245263A1 (en) | 2011-10-06 |
| TW200911809A (en) | 2009-03-16 |
| DE502008001903D1 (de) | 2011-01-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 109 | Application deemed to be withdrawn |
Effective date: 20130408 |