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US5674236A - Lancet for capillary puncture blood samples - Google Patents

Lancet for capillary puncture blood samples Download PDF

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Publication number
US5674236A
US5674236A US08/640,276 US64027696A US5674236A US 5674236 A US5674236 A US 5674236A US 64027696 A US64027696 A US 64027696A US 5674236 A US5674236 A US 5674236A
Authority
US
United States
Prior art keywords
lancet
blood
needle
capillary puncture
coating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US08/640,276
Inventor
Robert F. Baugh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medtronic Electromedics Inc
Medtronic Inc
Original Assignee
Medtronic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic Inc filed Critical Medtronic Inc
Priority to US08/640,276 priority Critical patent/US5674236A/en
Assigned to MEDTRONIC HEMOTEC, INC., A COLORADO CORPORATION reassignment MEDTRONIC HEMOTEC, INC., A COLORADO CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BAUGH, ROBERT F.
Assigned to MEDTRONIC HEMOTEC, INC. reassignment MEDTRONIC HEMOTEC, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BAUGH, ROBERT F., LANE, CAROLE G., WILSON, ADRIAN C.
Priority to PCT/US1997/008574 priority patent/WO1997042873A1/en
Priority to JP9541191A priority patent/JP2000509624A/en
Priority to DE19781863T priority patent/DE19781863T1/en
Priority to DE29723805U priority patent/DE29723805U1/en
Priority to US09/308,414 priority patent/US6468287B1/en
Assigned to MEDTRONIC HEMOTEC, INC., A CORP. OF COLORADO reassignment MEDTRONIC HEMOTEC, INC., A CORP. OF COLORADO ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BAUGH, ROBERT F.
Publication of US5674236A publication Critical patent/US5674236A/en
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15142—Devices intended for single use, i.e. disposable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150412—Pointed piercing elements, e.g. needles, lancets for piercing the skin
    • A61B5/150427—Specific tip design, e.g. for improved penetration characteristics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150503—Single-ended needles
    • A61B5/150511—Details of construction of shaft
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150755—Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101—Details
    • A61B5/15103—Piercing procedure
    • A61B5/15105—Purely manual piercing, i.e. the user pierces the skin without the assistance of any driving means or driving devices

Definitions

  • the present invention relates to lancets or needles for obtaining blood samples by capillary puncture.
  • Lancets or needles have been widely used for puncturing the skin in order to obtain drops of blood for testing purposes.
  • the lancet is generally a spring-loaded needle which is injected into a finger tip by placing the needle holder against the skin from which blood is to be drawn and pressing a release button.
  • the trauma of such needle injection may release tissue juices and the like into the emerging blood and thus modify the blood coagulation characteristics.
  • a related object is to reduce the trauma resulting from capillary puncture and thereby prevent artificial activation of blood emerging from the puncture site.
  • a further object of the present invention is to provide a lancet or needle which produces a drop of blood suitable for diagnostic coagulation tests.
  • the present invention is embodied in a lancet or needle for obtaining a drop of blood by capillary puncture.
  • the blood is obtained principally for clotting analysis.
  • the lancet is formed by a needle having a coating thereon of a composition which precludes contact clotting activation of the blood sample.
  • the coating is intended to preclude fibrinolysis and platelet activation of the blood sample.
  • the composition includes a blood platelet inhibitor, a prostacyclin analog and a monoclonal antibody to thromboplastin, and particularly includes aprotinin.
  • an improved lancet or needle for use in obtaining blood samples by capillary puncture of the skin.
  • the lancet or needle is coated with one or more concentrations or reagents which inhibit systemic contact activation of the blood components and thereby block contact activation in a blood drop sample.
  • aprotinin a serine protease inhibitor which is isolated from bovine lungs and is used to reduce post surgical blood loss in bypass surgery. By coating the lancet or needle with aprotinin, systemic contact activation would be blocked.
  • the lancet could also be coated with any of several different antiplatelet activation compounds which would prevent platelet activation of the blood emerging from the wound as a result of the puncture.
  • tissue factor or thromboplastin in the puncture site could be neutralized using a monoclonal antibody to thromboplastin as a part of the lancet or needle coating.
  • the lancet or needle is dipped into a solution of one or more of the above three agents and the composition allowed to dry on the needle thereby providing an effective coating on the needle for the above purposes.
  • bacteriostatic or antibacterial agent can be included in the coating composition.
  • Other materials could be utilized such as prostacyclin for inhibiting platelets and Reopro or an RGD peptide could be used to block platelet activation.
  • Aprotinin further is known as a good inhibitor of fibrinolysis and thus should inhibit any fibrinolysis at the puncture site.
  • coated lancet needle is that it would insure obtaining a good blood sample for use in point of care diagnostic coagulation testing where the sample is obtained by way of a finger prick. This allows a wide variety of coagulation tests to be performed on blood obtained by capillary puncture.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

A lancet for obtaining a drop of blood by capillary puncture is formed by a needle having a coating thereon of a composition which precludes contact clotting activation of the blood sample.

Description

BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to lancets or needles for obtaining blood samples by capillary puncture.
2. Description of the Prior Art
Lancets or needles have been widely used for puncturing the skin in order to obtain drops of blood for testing purposes. The lancet is generally a spring-loaded needle which is injected into a finger tip by placing the needle holder against the skin from which blood is to be drawn and pressing a release button. The trauma of such needle injection may release tissue juices and the like into the emerging blood and thus modify the blood coagulation characteristics.
OBJECTS OF THE INVENTION
It is the principal object of the present invention to reduce the trauma resulting from skin puncture by a lancet or needle for obtaining blood samples. A related object is to reduce the trauma resulting from capillary puncture and thereby prevent artificial activation of blood emerging from the puncture site.
A further object of the present invention is to provide a lancet or needle which produces a drop of blood suitable for diagnostic coagulation tests.
SUMMARY OF THE INVENTION
In accordance with the foregoing objects, the present invention is embodied in a lancet or needle for obtaining a drop of blood by capillary puncture. The blood is obtained principally for clotting analysis. The lancet is formed by a needle having a coating thereon of a composition which precludes contact clotting activation of the blood sample. The coating is intended to preclude fibrinolysis and platelet activation of the blood sample. The composition includes a blood platelet inhibitor, a prostacyclin analog and a monoclonal antibody to thromboplastin, and particularly includes aprotinin.
DESCRIPTION OF THE PREFERRED EMBODIMENT
In accordance with the present invention, an improved lancet or needle is provided for use in obtaining blood samples by capillary puncture of the skin. In order to prevent or reduce the introduction of coagulation factors into the drop of blood emerging from the puncture site, the lancet or needle is coated with one or more concentrations or reagents which inhibit systemic contact activation of the blood components and thereby block contact activation in a blood drop sample.
One such coating material is aprotinin, a serine protease inhibitor which is isolated from bovine lungs and is used to reduce post surgical blood loss in bypass surgery. By coating the lancet or needle with aprotinin, systemic contact activation would be blocked.
Additionally, the lancet could also be coated with any of several different antiplatelet activation compounds which would prevent platelet activation of the blood emerging from the wound as a result of the puncture.
Further, the tissue factor or thromboplastin in the puncture site could be neutralized using a monoclonal antibody to thromboplastin as a part of the lancet or needle coating.
In practice the lancet or needle is dipped into a solution of one or more of the above three agents and the composition allowed to dry on the needle thereby providing an effective coating on the needle for the above purposes.
Additionally, a bacteriostatic or antibacterial agent can be included in the coating composition. Other materials could be utilized such as prostacyclin for inhibiting platelets and Reopro or an RGD peptide could be used to block platelet activation. Aprotinin further is known as a good inhibitor of fibrinolysis and thus should inhibit any fibrinolysis at the puncture site.
The benefit of the coated lancet needle is that it would insure obtaining a good blood sample for use in point of care diagnostic coagulation testing where the sample is obtained by way of a finger prick. This allows a wide variety of coagulation tests to be performed on blood obtained by capillary puncture.

Claims (3)

I claim:
1. A lancet for obtaining a drop of blood for analysis by capillary puncture comprising a needle having a coating thereon of a composition which precludes contact activation, platelet activation, and fibrinolysis of a blood sample obtained by capillary puncture.
2. A lancet for obtaining blood samples by capillary puncture comprising a lancet and a coating on the surface of said lancet of a composition including a blood platelet inhibitor, a prostacyclin analog and a monoclonal antibody to thromboplastin.
3. A lancet as defined in claim 2 wherein said composition includes aprotinin.
US08/640,276 1996-04-30 1996-04-30 Lancet for capillary puncture blood samples Expired - Lifetime US5674236A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US08/640,276 US5674236A (en) 1996-04-30 1996-04-30 Lancet for capillary puncture blood samples
US09/308,414 US6468287B1 (en) 1996-04-30 1997-04-30 Lancet for capillary puncture blood samples
DE19781863T DE19781863T1 (en) 1996-04-30 1997-04-30 Lancet for the collection of capillary puncture blood samples
JP9541191A JP2000509624A (en) 1996-04-30 1997-04-30 Lancet for blood sample capillary puncture
PCT/US1997/008574 WO1997042873A1 (en) 1996-04-30 1997-04-30 Lancet for capillary puncture blood samples
DE29723805U DE29723805U1 (en) 1996-04-30 1997-04-30 Lancet for the collection of capillary puncture blood samples

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/640,276 US5674236A (en) 1996-04-30 1996-04-30 Lancet for capillary puncture blood samples

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/308,414 Continuation-In-Part US6468287B1 (en) 1996-04-30 1997-04-30 Lancet for capillary puncture blood samples

Publications (1)

Publication Number Publication Date
US5674236A true US5674236A (en) 1997-10-07

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
US08/640,276 Expired - Lifetime US5674236A (en) 1996-04-30 1996-04-30 Lancet for capillary puncture blood samples
US09/308,414 Expired - Lifetime US6468287B1 (en) 1996-04-30 1997-04-30 Lancet for capillary puncture blood samples

Family Applications After (1)

Application Number Title Priority Date Filing Date
US09/308,414 Expired - Lifetime US6468287B1 (en) 1996-04-30 1997-04-30 Lancet for capillary puncture blood samples

Country Status (4)

Country Link
US (2) US5674236A (en)
JP (1) JP2000509624A (en)
DE (2) DE29723805U1 (en)
WO (1) WO1997042873A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6010911A (en) * 1997-04-30 2000-01-04 Medtronic, Inc. Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique
US20040249405A1 (en) * 2002-04-04 2004-12-09 Motokazu Watanabe Lancet device
US7699966B2 (en) 2004-05-17 2010-04-20 Medtronic, Inc. Point of care heparin determination system

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE556645T1 (en) * 2001-12-07 2012-05-15 Micronix Inc CONSOLIDATED BODY FLUID TEST APPARATUS AND METHOD
US10022078B2 (en) 2004-07-13 2018-07-17 Dexcom, Inc. Analyte sensor
US8858434B2 (en) 2004-07-13 2014-10-14 Dexcom, Inc. Transcutaneous analyte sensor
AU2003297853A1 (en) * 2002-12-24 2004-07-29 F. Hoffmann-La Roche Ag A sampling device utilizing biased capillary action
US7393339B2 (en) 2003-02-21 2008-07-01 C. R. Bard, Inc. Multi-lumen catheter with separate distal tips
US20040243095A1 (en) 2003-05-27 2004-12-02 Shekhar Nimkar Methods and apparatus for inserting multi-lumen spit-tip catheters into a blood vessel
US7761130B2 (en) 2003-07-25 2010-07-20 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US11633133B2 (en) 2003-12-05 2023-04-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8423114B2 (en) 2006-10-04 2013-04-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
DE602004029092D1 (en) 2003-12-05 2010-10-21 Dexcom Inc CALIBRATION METHODS FOR A CONTINUOUSLY WORKING ANALYTIC SENSOR
US8992454B2 (en) 2004-06-09 2015-03-31 Bard Access Systems, Inc. Splitable tip catheter with bioresorbable adhesive
US7695676B2 (en) * 2004-08-11 2010-04-13 Hans Kloepfer Methods and apparatus for analyzing an analysis fluid
US7604604B2 (en) * 2004-09-09 2009-10-20 Roche Diagnostics Operations, Inc. Device for sampling bodily fluids
US7645241B2 (en) * 2004-09-09 2010-01-12 Roche Diagnostics Operations, Inc. Device for sampling bodily fluids
US20080200838A1 (en) * 2005-11-28 2008-08-21 Daniel Goldberger Wearable, programmable automated blood testing system
US8066660B2 (en) 2007-10-26 2011-11-29 C. R. Bard, Inc. Split-tip catheter including lateral distal openings
US8292841B2 (en) 2007-10-26 2012-10-23 C. R. Bard, Inc. Solid-body catheter including lateral distal openings
US9579485B2 (en) 2007-11-01 2017-02-28 C. R. Bard, Inc. Catheter assembly including a multi-lumen configuration
WO2009059220A1 (en) 2007-11-01 2009-05-07 C.R. Bard, Inc. Catheter assembly including triple lumen tip
CA2829037C (en) 2011-03-09 2022-05-17 Csl Behring Gmbh Factor xii inhibitors for the administration with medical procedures comprising contact with artificial surfaces
US20130085349A1 (en) 2011-06-21 2013-04-04 Yofimeter, Llc Analyte testing devices
US20120330188A1 (en) 2011-06-21 2012-12-27 Gadlight, Inc. Cocking and Advancing Mechanism for Analyte Testing Device
US8333716B1 (en) 2011-06-21 2012-12-18 Yofimeter, Llc Methods for using an analyte testing device
USD748252S1 (en) * 2013-02-08 2016-01-26 C. R. Bard, Inc. Multi-lumen catheter tip
KR102403299B1 (en) 2013-03-08 2022-06-03 체에스엘 베링 게엠베하 Treatment and prevention of remote ischemia-reperfusion injury
WO2016011091A1 (en) 2014-07-14 2016-01-21 C. R. Bard, Inc. Apparatuses, systems, and methods for inserting split tip catheters having enhanced stiffening and guiding features
US10154809B2 (en) 2015-06-24 2018-12-18 University Of Virginia Patent Foundation Test strip device and related methods thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5029583A (en) * 1986-07-22 1991-07-09 Personal Diagnostics, Inc. Optical analyzer
US5167960A (en) * 1988-08-03 1992-12-01 New England Deaconess Hospital Corporation Hirudin-coated biocompatible substance
US5182317A (en) * 1988-06-08 1993-01-26 Cardiopulmonics, Inc. Multifunctional thrombo-resistant coatings and methods of manufacture
US5275953A (en) * 1991-04-22 1994-01-04 Bull Brian S Apparatus and method for in vitro manipulation of blood
US5492763A (en) * 1992-06-08 1996-02-20 Spire Corporation Infection resistant medical devices and process

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE440961C (en) 1925-09-16 1927-02-19 Peter Bamberger Process for improving the tone of string instruments
JPS6182759A (en) * 1984-09-29 1986-04-26 三浦　喜温 Antithrombotic material
US4624256A (en) * 1985-09-11 1986-11-25 Pfizer Hospital Products Group, Inc. Caprolactone polymers for suture coating
JP2741378B2 (en) * 1986-10-17 1998-04-15 バイオ‐メトリック システムズ インコーポレイテッド Improved biocompatibility of solid surfaces
US5014718A (en) * 1988-01-22 1991-05-14 Safety Diagnostics, Inc. Blood collection and testing method
US4967763A (en) * 1989-03-13 1990-11-06 Becton, Dickinson And Company Platelet stable blood collection assembly
GB2232599A (en) 1989-06-08 1990-12-19 Summers Dr Julie Andrea One-step blood to plasma device
JPH0360645A (en) * 1989-07-28 1991-03-15 Safety Diagnostics Inc Method and device for taking blood component from human or animal body, in safety and in painlell state that penetration is minimum
US5026388A (en) * 1989-09-26 1991-06-25 Ingalz Thomas J Single-use skin puncture device
US5525348A (en) * 1989-11-02 1996-06-11 Sts Biopolymers, Inc. Coating compositions comprising pharmaceutical agents
US5156611A (en) * 1990-02-05 1992-10-20 Becton, Dickinson And Company Blood microsampling site preparation method
DE4230513C1 (en) * 1992-09-11 1994-03-31 Fresenius Ag Device for removing aluminum ions from blood and solution for use in the device
US5350800A (en) * 1993-01-19 1994-09-27 Medtronic, Inc. Method for improving the biocompatibility of solid surfaces
JP3393920B2 (en) * 1993-12-09 2003-04-07 富士写真フイルム株式会社 Wearing equipment for small-volume fixed-volume blood sampling points
JPH0819599A (en) * 1994-07-08 1996-01-23 Terumo Corp Medical device having lubricative surface upon wetting and manufacture thereof
US5552323A (en) * 1994-08-03 1996-09-03 Mercereau; Steven F. Method of blending an anticoagulant
US6110483A (en) * 1997-06-23 2000-08-29 Sts Biopolymers, Inc. Adherent, flexible hydrogel and medicated coatings

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5029583A (en) * 1986-07-22 1991-07-09 Personal Diagnostics, Inc. Optical analyzer
US5182317A (en) * 1988-06-08 1993-01-26 Cardiopulmonics, Inc. Multifunctional thrombo-resistant coatings and methods of manufacture
US5167960A (en) * 1988-08-03 1992-12-01 New England Deaconess Hospital Corporation Hirudin-coated biocompatible substance
US5275953A (en) * 1991-04-22 1994-01-04 Bull Brian S Apparatus and method for in vitro manipulation of blood
US5492763A (en) * 1992-06-08 1996-02-20 Spire Corporation Infection resistant medical devices and process

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6010911A (en) * 1997-04-30 2000-01-04 Medtronic, Inc. Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique
US20040249405A1 (en) * 2002-04-04 2004-12-09 Motokazu Watanabe Lancet device
US7699966B2 (en) 2004-05-17 2010-04-20 Medtronic, Inc. Point of care heparin determination system
US8801918B2 (en) 2004-05-17 2014-08-12 Medtronic, Inc. Point of care heparin determination system

Also Published As

Publication number Publication date
JP2000509624A (en) 2000-08-02
DE29723805U1 (en) 1999-08-12
WO1997042873A1 (en) 1997-11-20
DE19781863T1 (en) 2000-03-16
US6468287B1 (en) 2002-10-22

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