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US3266492A - Cryosurgery probe device - Google Patents

Cryosurgery probe device Download PDF

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Publication number
US3266492A
US3266492A US307208A US30720863A US3266492A US 3266492 A US3266492 A US 3266492A US 307208 A US307208 A US 307208A US 30720863 A US30720863 A US 30720863A US 3266492 A US3266492 A US 3266492A
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tubular member
interior
extending
needle tip
probe device
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US307208A
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Samuel B Steinberg
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques

Definitions

  • This invention relates generally to surgical instruments, and more particularly it pertains to a cryosurgical probe device with interchangeable tips.
  • cryosurgery or locally freezing living tissue has become an important aid to the treatment of many diseases including brain disorders and cancer.
  • Another object of this invention is to provide a tissue freezing instrument which is small and light weight for easy manipula-tion and which can be readily adapted for relatively small or large area treatment by quick interchange of tip.
  • Still other objects of this invention are to provide a tissue freezing instrument which has great mobility, such that the user of the instrument may move it about from one area to another, and, additionally, it may be retracted due to the holding device similar to that of a dental drill holder.
  • reference numeral indicates generally the surgical instrument incorporating the novel features of this invention.
  • This instrument 10 is intended for connection to a source of liquid gas such as nitrogen (N2) which is conducted over a thermally insulated convoluted flexible tube 112 of stainless steel.
  • This tube 12 is joined by means of a union 14 to a small diameter stainless steel delivery tuibe 16.
  • the union 14 and flexible tubing 12 is covered with expanded plastic insulation 18 such as Dow Styrofoam for example.
  • the delivery tube 16 axially traverses the length of the instrument 10 to be loosely received Within the hollow interior of a tool tip 20.
  • This tip 20 may take many forms depending on the prospective use, with a wedge type being illustrated.
  • the tips 20 are easily interchanged on the instrument 10 by means of a nut 22 which threads on an expansion chamber shell 26 and incorporates a clamping ferrule 24 which embraces the tip 20.
  • Chamber shell 26 is coaxial with the delivery tube 16, the latter entering the former through a closed end wall.
  • the previously mentioned tips 20 are made of sterling silver which is an excellent conductor of heat. Therefore, the full cooling effect of the liquid gas as i-t Vaporizes and expands on -leaving the end of the delivery tube 16 can be fully utilized at the application end of the tip 20. Temperatures as low as minus 100 degrees centigrade are quite readily attainable.
  • a surgical tool comprising insulating handle means havin-g an axial passage, a tubular member mounted within said axial passage recessed from one end of said handle ymeans and extending from the lother end thereof, needle tip means removably secured to the extending end of said tubular member and having an interior passage communicating with the interior of said tubular member, and delivery tube means extending longitudinally Within the interior of said tubular member and extending and opening into said interior passage for supplying a cooling medium thereto for cooling said needle tip means.
  • a surgical tool comprising insulating handle means having an axial passage, a rst tubular member mounted within said axial passage recessed from one end of said handle means and extending from the other end thereof, the extending portion of said first tubular member having external threads, needle tip means removably positioned within said extending portion and extending therefrom, means engaging said threads of said first tubular member and clamping said tip means to the extending portion thereof, a second tubular member defining an expansion chamber mounted within said handle means and encompassing the end of said rst tubular member contained therein, said tip means having an interior passage cornmunicating with the interior of said iirst tubular member and said rst tubular member having spaced apertures in its lateral surface communicating with the interior of said second tubular member, exhaust means connecting the interior of said second tubular member with the exterior of said surgical tool, and delivery tube means extending longitudinally within the respective interiors of said irst and second tubular members and the interior passage of said tip means to supply a cooling

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Otolaryngology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)

Description

Aug; 16, 1966 s. B. STEINBERG CHYOSURGERY PROBE DEVICE Filed Sept. 6. 1965 SAMUEL B. STE/NBER@ INV ENT OR wf w United States Patent 3,266,492 CRYOSURGERY PROBE DEVICE Samuel B. Steinberg, 534 W. Franklin St., Baltimore, Md. Filed Sept. 6, 1963, Ser. No. 307,203 4 Claims. (Cl. 12S-303) This invention relates generally to surgical instruments, and more particularly it pertains to a cryosurgical probe device with interchangeable tips.
The art of cryosurgery or locally freezing living tissue has become an important aid to the treatment of many diseases including brain disorders and cancer.
It is an object of t-his invention, therefore, to provide a surgical probe of the liquid gas freezing type which is capable of deep or shallow work of all kinds.
Another object of this invention is to provide a tissue freezing instrument which is small and light weight for easy manipula-tion and which can be readily adapted for relatively small or large area treatment by quick interchange of tip.
To provide a highly etiicient surgical tool tip arrangement for extreme cold application to tissue, is yet another object of this invention.
Still other objects of this invention are to provide a tissue freezing instrument which has great mobility, such that the user of the instrument may move it about from one area to another, and, additionally, it may be retracted due to the holding device similar to that of a dental drill holder.
These and other objects and attendant advantages of this invention -will become more readily apparent and understood from the following detailed specication and accompanying drawing.
In the drawing, reference numeral indicates generally the surgical instrument incorporating the novel features of this invention.
This instrument 10 is intended for connection to a source of liquid gas such as nitrogen (N2) which is conducted over a thermally insulated convoluted flexible tube 112 of stainless steel. This tube 12 is joined by means of a union 14 to a small diameter stainless steel delivery tuibe 16. The union 14 and flexible tubing 12 is covered with expanded plastic insulation 18 such as Dow Styrofoam for example.
The delivery tube 16 axially traverses the length of the instrument 10 to be loosely received Within the hollow interior of a tool tip 20. This tip 20 may take many forms depending on the prospective use, with a wedge type being illustrated.
The tips 20 are easily interchanged on the instrument 10 by means of a nut 22 which threads on an expansion chamber shell 26 and incorporates a clamping ferrule 24 which embraces the tip 20.
Chamber shell 26 is coaxial with the delivery tube 16, the latter entering the former through a closed end wall.
Near this same end wall, there are provided a plurality of holes 28 which allow the vaporized gas in the expansion chamber shell 26 to escape into an exhaust manifold 30 therearound.
` An exhaust line 32 connected to the manifold 30 discharges t-o the atmosphere or to a vacuum line (not shown) paralleling the liquid gas tube 12.
The previously mentioned tips 20 are made of sterling silver which is an excellent conductor of heat. Therefore, the full cooling effect of the liquid gas as i-t Vaporizes and expands on -leaving the end of the delivery tube 16 can be fully utilized at the application end of the tip 20. Temperatures as low as minus 100 degrees centigrade are quite readily attainable.
Patented August 16, 1956 To protec-t the hand of the surgeon from the cold, the shell 26 and manifold 30 are covered with an insulating cover 34 of balsa wood which also provides a non-slipping finger grip surface.
Obviously many modifications and variations of the present invention are possible in light of the above teachings. It is, therefore, to be understood that within the scope of the appended claims t-he invention may be practiced otherwise than as specifically described.
What is claimed is:
1. A surgical tool comprising insulating handle means havin-g an axial passage, a tubular member mounted within said axial passage recessed from one end of said handle ymeans and extending from the lother end thereof, needle tip means removably secured to the extending end of said tubular member and having an interior passage communicating with the interior of said tubular member, and delivery tube means extending longitudinally Within the interior of said tubular member and extending and opening into said interior passage for supplying a cooling medium thereto for cooling said needle tip means.
2. The surgical tool of claim 1 and additionally another tubular member defining an expansion chamber mounted within said axial passage and having its interi-or communicating with the interior of said first mentioned tubular member and means communicating the interior of said other tubular member with the exterior of said surgical tool.
3. The surgical tool of claim 1, wherein said needle tip means extends from the interior of the extending end of said tubular member and said extending end has external threads, a ferrule member is provided encompassing said needle tip means, and means including a nut engaging said external threads and clamping said ferrule member against said needle tip means is provided to secure said needle tip means to said tubular member.
4. A surgical tool comprising insulating handle means having an axial passage, a rst tubular member mounted within said axial passage recessed from one end of said handle means and extending from the other end thereof, the extending portion of said first tubular member having external threads, needle tip means removably positioned within said extending portion and extending therefrom, means engaging said threads of said first tubular member and clamping said tip means to the extending portion thereof, a second tubular member defining an expansion chamber mounted within said handle means and encompassing the end of said rst tubular member contained therein, said tip means having an interior passage cornmunicating with the interior of said iirst tubular member and said rst tubular member having spaced apertures in its lateral surface communicating with the interior of said second tubular member, exhaust means connecting the interior of said second tubular member with the exterior of said surgical tool, and delivery tube means extending longitudinally within the respective interiors of said irst and second tubular members and the interior passage of said tip means to supply a cooling medium thereto.
References Cited by the Examiner UNITED STATES PATENTS 2,645,097 7/1953 Posch 128-400 X 2,672,032 3/ 1954 Towse 12S-400 X 2,816,550 12/1957 Hudson 12S-400 X ROBERT E. MORGAN, Primary Examiner. G. E. MCNEILL, Assistant Examiner.

Claims (1)

1. A SURGICAL TOOL COMPRISING INSULATING HANDLE MEANS HAVING AN AXIAL PASSAGE, A TUBULAR MEMBER MOUNTED WITHIN SAID AXIAL PASSAGE RECESSED FROM ONE END OF SAID HANDLE MEANS AND EXTENDING FROM THE OTHER END THEREOF, NEEDLE TIP MEANS REMOVABLY SECURED TO THE EXTENDING END OF SAID TUBULAR MEMBER AND HAVING AN INTERIOR PASSAGE COMMUNICATING WITH THE INTERIOR OF SAID TUBULAR MEMBER, AND DELIVERY TUBE MEANS EXTENDING LONGITUDINALLY WITHIN THE INTERIOR OF SAID TUBULAR MEMBER AND EXTENDING AND OPENING INTO SAID INTERIOR PASSAGE FOR SUPPLYING A COOLING MEDIUM THERETO FOR COOLING SAID NEEDLE TIP MEANS.
US307208A 1963-09-06 1963-09-06 Cryosurgery probe device Expired - Lifetime US3266492A (en)

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Cited By (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3658066A (en) * 1970-03-09 1972-04-25 Farrokh Saidi Cryosurgical appliance
US3662755A (en) * 1968-08-08 1972-05-16 Leybold Heracus Gmbh & Co Kg Cryo-scalpel
US3664344A (en) * 1970-09-15 1972-05-23 Brymill Corp Tyned cryosurgical probe
US3971383A (en) * 1974-05-07 1976-07-27 Erbe Elektromedizin Kg Cryogenic surgical instrument
US4919129A (en) * 1987-11-30 1990-04-24 Celebration Medical Products, Inc. Extendable electrocautery surgery apparatus and method
US5078713A (en) * 1988-12-01 1992-01-07 Spembly Medical Limited Cryosurgical probe
US5176686A (en) * 1987-03-26 1993-01-05 Poley Brooks J Apparatus for packaging, folding, rigidifying and inserting an intraocular lens
US5192267A (en) * 1989-01-23 1993-03-09 Nadiv Shapira Vortex smoke remover for electrosurgical devices
US5334181A (en) * 1990-09-26 1994-08-02 Cryomedical Sciences, Inc. Cryosurgical system for destroying tumors by freezing
US5400602A (en) * 1993-07-08 1995-03-28 Cryomedical Sciences, Inc. Cryogenic transport hose
US6280439B1 (en) 1999-07-12 2001-08-28 Cryocath Technologies, Inc. Adjustable position injection tubing
US20070088247A1 (en) * 2000-10-24 2007-04-19 Galil Medical Ltd. Apparatus and method for thermal ablation of uterine fibroids
US20070167938A1 (en) * 2000-10-24 2007-07-19 Galil Medical Ltd. Multiple cryoprobe delivery apparatus
US20080045934A1 (en) * 2000-10-24 2008-02-21 Galil Medical Ltd. Device and method for coordinated insertion of a plurality of cryoprobes
US20080051776A1 (en) * 2001-05-21 2008-02-28 Galil Medical Ltd. Thin uninsulated cryoprobe and insulating probe introducer
US20080051774A1 (en) * 2001-05-21 2008-02-28 Galil Medical Ltd. Device and method for coordinated insertion of a plurality of cryoprobes
US20080300586A1 (en) * 2000-10-24 2008-12-04 Galil Medical Ltd. Apparatus and method for compressing a gas, and cryosurgery system and method utilizing same
US20090292279A1 (en) * 2006-01-26 2009-11-26 Galil Medical Ltd. Device and Method for Coordinated Insertion of a Plurality of Cryoprobes
US20090299357A1 (en) * 2006-04-24 2009-12-03 Thomas Jefferson University Cryoneedle and cryotheraphy system
US20110144631A1 (en) * 2005-05-20 2011-06-16 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US8007847B2 (en) 2004-01-13 2011-08-30 Eytan Biderman Feeding formula appliance
US9017318B2 (en) 2012-01-20 2015-04-28 Myoscience, Inc. Cryogenic probe system and method
US9066712B2 (en) 2008-12-22 2015-06-30 Myoscience, Inc. Integrated cryosurgical system with refrigerant and electrical power source
US9101346B2 (en) 2007-11-14 2015-08-11 Myoscience, Inc. Pain management using cryogenic remodeling
US9113855B2 (en) 2007-02-16 2015-08-25 Myoscience, Inc. Replaceable and/or easily removable needle systems for dermal and transdermal cryogenic remodeling
US9155584B2 (en) 2012-01-13 2015-10-13 Myoscience, Inc. Cryogenic probe filtration system
US9241753B2 (en) 2012-01-13 2016-01-26 Myoscience, Inc. Skin protection for subdermal cryogenic remodeling for cosmetic and other treatments
US9295512B2 (en) 2013-03-15 2016-03-29 Myoscience, Inc. Methods and devices for pain management
US9314290B2 (en) 2012-01-13 2016-04-19 Myoscience, Inc. Cryogenic needle with freeze zone regulation
US9345526B2 (en) 2005-05-20 2016-05-24 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US9610112B2 (en) 2013-03-15 2017-04-04 Myoscience, Inc. Cryogenic enhancement of joint function, alleviation of joint stiffness and/or alleviation of pain associated with osteoarthritis
US9668800B2 (en) 2013-03-15 2017-06-06 Myoscience, Inc. Methods and systems for treatment of spasticity
US10130409B2 (en) 2013-11-05 2018-11-20 Myoscience, Inc. Secure cryosurgical treatment system
US10888366B2 (en) 2013-03-15 2021-01-12 Pacira Cryotech, Inc. Cryogenic blunt dissection methods and devices
US11134998B2 (en) 2017-11-15 2021-10-05 Pacira Cryotech, Inc. Integrated cold therapy and electrical stimulation systems for locating and treating nerves and associated methods
US11311327B2 (en) 2016-05-13 2022-04-26 Pacira Cryotech, Inc. Methods and systems for locating and treating nerves with cold therapy
US12256970B2 (en) 2018-05-01 2025-03-25 The Johns Hopkins University Carbon dioxide-based percutaneous cryosurgical system

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2645097A (en) * 1950-11-09 1953-07-14 William F Teague Thermal tooth testing instrument
US2672032A (en) * 1951-10-19 1954-03-16 Towse Robert Albert Edward Carcass freezing device
US2816550A (en) * 1955-11-14 1957-12-17 Milton A Lapin Dispensing cap

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2645097A (en) * 1950-11-09 1953-07-14 William F Teague Thermal tooth testing instrument
US2672032A (en) * 1951-10-19 1954-03-16 Towse Robert Albert Edward Carcass freezing device
US2816550A (en) * 1955-11-14 1957-12-17 Milton A Lapin Dispensing cap

Cited By (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3662755A (en) * 1968-08-08 1972-05-16 Leybold Heracus Gmbh & Co Kg Cryo-scalpel
US3658066A (en) * 1970-03-09 1972-04-25 Farrokh Saidi Cryosurgical appliance
US3664344A (en) * 1970-09-15 1972-05-23 Brymill Corp Tyned cryosurgical probe
US3971383A (en) * 1974-05-07 1976-07-27 Erbe Elektromedizin Kg Cryogenic surgical instrument
US5176686A (en) * 1987-03-26 1993-01-05 Poley Brooks J Apparatus for packaging, folding, rigidifying and inserting an intraocular lens
US4919129A (en) * 1987-11-30 1990-04-24 Celebration Medical Products, Inc. Extendable electrocautery surgery apparatus and method
US5078713A (en) * 1988-12-01 1992-01-07 Spembly Medical Limited Cryosurgical probe
US5192267A (en) * 1989-01-23 1993-03-09 Nadiv Shapira Vortex smoke remover for electrosurgical devices
US5334181A (en) * 1990-09-26 1994-08-02 Cryomedical Sciences, Inc. Cryosurgical system for destroying tumors by freezing
US5674218A (en) * 1990-09-26 1997-10-07 Cryomedical Sciences, Inc. Cryosurgical instrument and system and method of cryosurgery
US5400602A (en) * 1993-07-08 1995-03-28 Cryomedical Sciences, Inc. Cryogenic transport hose
US6280439B1 (en) 1999-07-12 2001-08-28 Cryocath Technologies, Inc. Adjustable position injection tubing
US20080045934A1 (en) * 2000-10-24 2008-02-21 Galil Medical Ltd. Device and method for coordinated insertion of a plurality of cryoprobes
US20080300586A1 (en) * 2000-10-24 2008-12-04 Galil Medical Ltd. Apparatus and method for compressing a gas, and cryosurgery system and method utilizing same
US20070088247A1 (en) * 2000-10-24 2007-04-19 Galil Medical Ltd. Apparatus and method for thermal ablation of uterine fibroids
US8066697B2 (en) * 2000-10-24 2011-11-29 Galil Medical Ltd. Multiple cryoprobe delivery apparatus
US20070167938A1 (en) * 2000-10-24 2007-07-19 Galil Medical Ltd. Multiple cryoprobe delivery apparatus
US20080051774A1 (en) * 2001-05-21 2008-02-28 Galil Medical Ltd. Device and method for coordinated insertion of a plurality of cryoprobes
US20080051776A1 (en) * 2001-05-21 2008-02-28 Galil Medical Ltd. Thin uninsulated cryoprobe and insulating probe introducer
US8007847B2 (en) 2004-01-13 2011-08-30 Eytan Biderman Feeding formula appliance
US20110144631A1 (en) * 2005-05-20 2011-06-16 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US11963706B2 (en) 2005-05-20 2024-04-23 Pacira Cryotech, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US9345526B2 (en) 2005-05-20 2016-05-24 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US9072498B2 (en) * 2005-05-20 2015-07-07 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US10363080B2 (en) 2005-05-20 2019-07-30 Pacira Cryotech, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US20090292279A1 (en) * 2006-01-26 2009-11-26 Galil Medical Ltd. Device and Method for Coordinated Insertion of a Plurality of Cryoprobes
US20090299357A1 (en) * 2006-04-24 2009-12-03 Thomas Jefferson University Cryoneedle and cryotheraphy system
US9113855B2 (en) 2007-02-16 2015-08-25 Myoscience, Inc. Replaceable and/or easily removable needle systems for dermal and transdermal cryogenic remodeling
US10869779B2 (en) 2007-11-14 2020-12-22 Pacira Cryotech, Inc. Pain management using cryogenic remodeling
US12178746B2 (en) 2007-11-14 2024-12-31 Pacira Cryotech, Inc. Pain management using cryogenic remodeling
US10864112B2 (en) 2007-11-14 2020-12-15 Pacira Cryotech, Inc. Pain management using cryogenic remodeling
US9101346B2 (en) 2007-11-14 2015-08-11 Myoscience, Inc. Pain management using cryogenic remodeling
US9066712B2 (en) 2008-12-22 2015-06-30 Myoscience, Inc. Integrated cryosurgical system with refrigerant and electrical power source
US10213244B2 (en) 2012-01-13 2019-02-26 Myoscience, Inc. Cryogenic needle with freeze zone regulation
US9314290B2 (en) 2012-01-13 2016-04-19 Myoscience, Inc. Cryogenic needle with freeze zone regulation
US9155584B2 (en) 2012-01-13 2015-10-13 Myoscience, Inc. Cryogenic probe filtration system
US11857239B2 (en) 2012-01-13 2024-01-02 Pacira Cryotech, Inc. Cryogenic needle with freeze zone regulation
US9241753B2 (en) 2012-01-13 2016-01-26 Myoscience, Inc. Skin protection for subdermal cryogenic remodeling for cosmetic and other treatments
US10188444B2 (en) 2012-01-13 2019-01-29 Myoscience, Inc. Skin protection for subdermal cryogenic remodeling for cosmetic and other treatments
US9017318B2 (en) 2012-01-20 2015-04-28 Myoscience, Inc. Cryogenic probe system and method
US10596030B2 (en) 2013-03-15 2020-03-24 Pacira Cryotech, Inc. Cryogenic enhancement of joint function, alleviation of joint stiffness and/or alleviation of pain associated with osteoarthritis
US9668800B2 (en) 2013-03-15 2017-06-06 Myoscience, Inc. Methods and systems for treatment of spasticity
US9295512B2 (en) 2013-03-15 2016-03-29 Myoscience, Inc. Methods and devices for pain management
US10085881B2 (en) 2013-03-15 2018-10-02 Myoscience, Inc. Methods, systems, and devices for treating neuromas, fibromas, nerve entrapment, and/or pain associated therewith
US10085789B2 (en) 2013-03-15 2018-10-02 Myoscience, Inc. Methods and systems for treatment of occipital neuralgia
US10314739B2 (en) 2013-03-15 2019-06-11 Myoscience, Inc. Methods and devices for pain management
US10016229B2 (en) 2013-03-15 2018-07-10 Myoscience, Inc. Methods and systems for treatment of occipital neuralgia
US10888366B2 (en) 2013-03-15 2021-01-12 Pacira Cryotech, Inc. Cryogenic blunt dissection methods and devices
US11134999B2 (en) 2013-03-15 2021-10-05 Pacira Cryotech, Inc. Methods and systems for treatment of occipital neuralgia
US9610112B2 (en) 2013-03-15 2017-04-04 Myoscience, Inc. Cryogenic enhancement of joint function, alleviation of joint stiffness and/or alleviation of pain associated with osteoarthritis
US11253393B2 (en) 2013-03-15 2022-02-22 Pacira Cryotech, Inc. Methods, systems, and devices for treating neuromas, fibromas, nerve entrapment, and/or pain associated therewith
US11865038B2 (en) 2013-03-15 2024-01-09 Pacira Cryotech, Inc. Methods, systems, and devices for treating nerve spasticity
US10864033B2 (en) 2013-11-05 2020-12-15 Pacira Cryotech, Inc. Secure cryosurgical treatment system
US11690661B2 (en) 2013-11-05 2023-07-04 Pacira Cryotech, Inc. Secure cryosurgical treatment system
US10130409B2 (en) 2013-11-05 2018-11-20 Myoscience, Inc. Secure cryosurgical treatment system
US11311327B2 (en) 2016-05-13 2022-04-26 Pacira Cryotech, Inc. Methods and systems for locating and treating nerves with cold therapy
US12076069B2 (en) 2016-05-13 2024-09-03 Pacira Cryotech, Inc. Methods and systems for locating and treating nerves with cold therapy
US11134998B2 (en) 2017-11-15 2021-10-05 Pacira Cryotech, Inc. Integrated cold therapy and electrical stimulation systems for locating and treating nerves and associated methods
US12167881B2 (en) 2017-11-15 2024-12-17 Pacira Cryotech, Inc. Integrated cold therapy and electrical stimulation systems for locating and treating nerves and associated methods
US12256970B2 (en) 2018-05-01 2025-03-25 The Johns Hopkins University Carbon dioxide-based percutaneous cryosurgical system

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