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US20120325228A1 - Alkaloid composition for e-cigarette - Google Patents

Alkaloid composition for e-cigarette Download PDF

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Publication number
US20120325228A1
US20120325228A1 US13/493,132 US201213493132A US2012325228A1 US 20120325228 A1 US20120325228 A1 US 20120325228A1 US 201213493132 A US201213493132 A US 201213493132A US 2012325228 A1 US2012325228 A1 US 2012325228A1
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composition
alkaloid
anatabine
weight
cigarette
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US13/493,132
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Jonnie R. Williams
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Priority to US13/493,132 priority Critical patent/US20120325228A1/en
Publication of US20120325228A1 publication Critical patent/US20120325228A1/en
Priority to US13/946,201 priority patent/US20130298921A1/en
Priority to US14/672,716 priority patent/US20160050968A1/en
Priority to US15/679,731 priority patent/US20180184704A1/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F15/00—Receptacles or boxes specially adapted for cigars, cigarettes, simulated smoking devices or cigarettes therefor
    • A24F15/01—Receptacles or boxes specially adapted for cigars, cigarettes, simulated smoking devices or cigarettes therefor specially adapted for simulated smoking devices or cigarettes therefor
    • A24F15/015—Receptacles or boxes specially adapted for cigars, cigarettes, simulated smoking devices or cigarettes therefor specially adapted for simulated smoking devices or cigarettes therefor with means for refilling of liquid inhalable precursors
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/10—Devices using liquid inhalable precursors

Definitions

  • e-cigarettes Electronic cigarettes (or “e-cigarettes”) have been developed as an alternative to traditional cigarettes as a means for volatizing active components, such as nicotine, for inhalation without combustion, while at the same time providing the user with an oral experience similar to that of traditional cigarette smoking
  • U.S. Pat. No. 7,832,410 B2 to Hon describes an e-cigarette having a liquid supply bottle in communication with an atomizer for volatizing a nicotine-containing solution.
  • U.S. Pat. No. 7,726,320 B2 to Robinson et al. discloses a smoking article having an electrically powered aerosol-generating device which heats tobacco contained within the device to generate an aerosol which is described as being similar to tobacco smoke.
  • Embodiments of the present invention are directed to e-cigarettes, alkaloid compositions for e-cigarettes, and refilling cartridges for e-cigarettes containing certain alkaloid compositions.
  • a refilling cartridge for an e-cigarette contains a liquid alkaloid composition comprising a solvent and at least about 25 wt. % anatabine based on the total alkaloid weight of the composition.
  • a kit for refilling an e-cigarette comprises (i) a liquid alkaloid composition comprising a solvent and at least about 25 wt. % anatabine based on the total alkaloid weight of the composition, and (ii) instructions for filling the liquid alkaloid composition into a liquid receptacle of an e-cigarette.
  • a method of refilling an e-cigarette includes the steps of (i) providing a liquid alkaloid composition comprising a solvent and at least about 25 wt. % anatabine based on the total alkaloid weight of the composition, and (ii) filling the liquid alkaloid composition into a liquid receptacle of an e-cigarette.
  • an e-cigarette comprises a cartridge containing a liquid alkaloid composition comprising a solvent and at least about 25 wt. % anatabine based on the total alkaloid weight of the composition.
  • the e-cigarette may be of a single-use or disposable type, or may be refillable with liquid alkaloid compositions to facilitate reuse.
  • non-tobacco products that contain an alkaloid composition comprising about 25 wt. % to about 95 wt. % anatabine, and about 5 wt. % to about 75 wt. % of a second alkaloid, based on the total alkaloid weight of the composition.
  • the second alkaloid may be nicotine, nornicotine, anabasine, or a combination of two or more of them.
  • the non-tobacco product may be in the form of a solid bit of compressed powder, chewing gum, gelcap, capsule, pill, lozenge, or the like.
  • the alkaloid compositions disclosed herein feature different ranges of alkaloids to provide an attractive alternative to smoking conventional e-cigarettes, in which nicotine makes up about 90 to 100 wt. % of the total alkaloid content.
  • the disclosed alkaloid compositions are characterized by a significant quantity of anatabine, which has lower toxicity and risk of abuse as compared to other alkaloids such as nicotine.
  • the alkaloid compositions enable individuals to experience the pleasure-enhancing attributes of conventional cigarette smoking, while avoiding exposure to combusted materials and other potentially hazardous components present in tobacco. As a result, individuals may be more likely to quit conventional cigarette smoking
  • FIG. 1 is a schematic illustration of one example of an e-cigarette configuration.
  • Tobacco is among the most chemically complex substances known, with tobacco and tobacco smoke containing more than 8,000 compounds.
  • tobacco contains the minor alkaloids nornicotine, anabasine, and anatabine.
  • nicotine is regarded as the principal addictive component in tobacco, a variety of other factors also are believed to contribute to tobacco addiction.
  • tobacco smoke has been reported to have a monoamine oxidase (MAO) inhibitory effect.
  • MAO is an enzyme involved in the breakdown of dopamine, a pleasure-enhancing neurotransmitter. See J. S. Fowler et al., “Inhibition of Monoamine Oxidase B in the Brain of Smokers,” Nature (Lond), 379(6567):733 736 (1996); J. Stephenson, “Clues Found to Tobacco Addiction,” Journal of the American Medical Association, 275(16): 1217-1218 (1996). See also Williams et al. U.S. Pat. No. 6,350,479.
  • the alkaloid composition comprises at least about 25 wt. % anatabine based on the total alkaloid weight.
  • anatabine is the sole alkaloid present in the composition, e.g., anatabine comprises 100 wt. % of the total alkaloid weight.
  • up to about 75 wt. % of one or more other alkaloids, such as nicotine, nornicotine, and/or anabasine, may be present in addition to anatabine.
  • anatabine and nicotine may be combined in a weight ratio (anatabine-to-nicotine) of about 50:1 to about 1:3, or from about 25:1 to about 1:2, from about 10:1 to about 3:2, or from about 5:1 to about 1:1.
  • Anatabine may be prepared synthetically, such as via a benzophenoneimine pathway as described in co-pending application Ser. No. 12/729,346, filed Mar. 23, 2010, the disclosure of which is incorporated herein by reference in its entirety.
  • Anatabine may be present in the form of a racemic mixture or as isolated enantiomer, e.g., R-(+)-anatabine or S-( ⁇ )-anatabine, and/or as one or more pharmaceutically acceptable (or food grade) salts of anatabine.
  • anatabine refers to racemic mixtures of anatabine, enantiomers of anatabine, salt and non-salt forms of anatabine, as well as salt and non-salt forms of anatabine enantiomers.
  • salts are described in P. H.
  • anatabine may be obtained by extraction from tobacco or other plants, such as members of the Solanaceae family, such as datura, mandrake, belladonna, capsicum, potato, tomato, nicotiana, eggplant, and petunia.
  • a tobacco extract may be prepared from cured tobacco stems, lamina, or both. Flue (bright) varieties of tobacco are often used, i.e., Virginia flue. Other tobacco varieties may be used, such as Burley, dark-fired, and/or other commercial tobacco varieties. Two or more tobacco varieties may be combined to form a blend.
  • cured tobacco material is extracted with a solvent, typically water, ethanol, steam, or carbon dioxide.
  • the resulting solution contains the soluble components of the tobacco, including alkaloids such as anatabine.
  • Anatabine may be purified using known techniques such as liquid chromatography.
  • the amount of anatabine present in the composition may vary depending on factors such as the type of e-cigarette and whether other active components, such as nicotine and/or other alkaloids, are present.
  • the amount of anatabine may range from about 0.1 to about 25 mg, from about 0.5 to about 20 mg, or from about 1 to about 10 mg, per total gram of composition.
  • compositions containing anatabine were found to be efficacious for the temporary reduction of tobacco cravings, even without the presence of nicotine.
  • Anatabine and other minor alkaloids also have been reported to bind to nicotinic receptors. See “Receptors for Nicotine in the Central Nervous System: 1 Radioligand Binding Studies,” Group Research & Development Centre, British-American Tobacco Co. Ltd. (1984).
  • the composition may contain up to about 75 wt. % of one or more other alkaloids, such as nicotine, nornicotine, and/or anabasine, based on the total alkaloid weight.
  • alkaloids may be extracted from tobacco or other plant materials and purified using known techniques, and/or prepared synthetically using known synthesis methods.
  • Anatabine and additional alkaloid(s), such as nicotine may be combined in a weight ratio (anatabine-to-total other alkaloids) of about 50:1 to about 1:3, or from about 25:1 to about 1:2, from about 10:1 to about 3:2, or from about 5:1 to about 1:1.
  • the composition typically contains other components such as water, organic solvents, sweetening and/or flavoring agents, and the like.
  • solvents that are commonly used in liquid compositions for e-cigarettes include polyhydric alcohols such as 1,2-propylene glycol (PG or MPG); monohydric alcohols such as ethanol; ethyl acetate; and the like.
  • the amount of water present typically ranges from about 0.1 to about 10 wt. %, usually from about 0.5 to about 5 wt. %.
  • the amount of organic solvent present typically ranges from about 50 to about 99 wt. %, often from about 75 to about 95 wt. %.
  • one or more flavorants may be added to the composition, non-limiting examples of which include peppermint, menthol, wintergreen, spearmint, propolis, eucalyptus, cinnamon, or the like.
  • the total amount of flavorants typically ranges from about 0.5 to about 15 wt. %, often from about 1 to about 10 wt. %, based on the total weight of the composition.
  • the e-cigarette may be of various types of configurations, the details of which form no part of the present invention.
  • e-cigarettes may be of a single-use or disposable type, or may be refillable with liquid alkaloid compositions and/or cartridges containing liquid compositions to facilitate reuse.
  • FIG. 1 An air inlet 4 is provided on the external wall of a shell 14 which houses LED 1 , cell 2 , electronic circuit board 3 , normal pressure cavity 5 , sensor 6 , vapor-liquid separator 7 , atomizer 9 , liquid-supplying bottle 11 , mouthpiece 15 , microswitch 16 , gas vent 17 , and air passage 18 .
  • the electronic circuit board 3 has an electronic switching circuit and a high frequency generator.
  • a negative pressure cavity 8 is provided in the sensor 6 and is separated from the sensor 6 by a ripple film.
  • An atomization cavity 10 is provided in the atomizer 9 .
  • a retaining ring 13 is provided for locking the liquid-supplying bottle 11 between one side of the liquid-supplying bottle 11 and the shell 14 ; and an aerosol passage 12 is provided on the other side of the liquid-supplying bottle.
  • e-cigarettes that reduce cravings for traditional tobacco smoking, while minimizing toxicity and other undesirable side effects associated with nicotine and other tobacco components.
  • the e-cigarette may be used as needed to satisfy cravings, or at intervals such as once daily, twice daily, or three or more times daily, depending on such factors as the concentration of active components and the subject's physiological conditions.
  • a non-tobacco formulation contains an alkaloid composition comprising about 25 wt. % to about 95 wt. % anatabine, and about 5 wt. % to about 75 wt. % of a second alkaloid, based on the total alkaloid weight of the composition.
  • the second alkaloid may be nicotine, nornicotine, anabasine, or a combination of two or more of them.
  • the non-tobacco product may be in the form of a solid bit of compressed powder, chewing gum, capsule, pill, lozenge, or the like.
  • non-tobacco means that the product is essentially free of tobacco leaf or tobacco extract, except however that some or all of the alkaloids present in the non-tobacco product may be extracted from tobacco and purified using conventional techniques such as liquid chromatography.
  • Additional components ingredients may be added to the non-tobacco products to improve taste or stability.
  • additional components include, but are not limited to, sweeteners, natural flavorants, artificial flavorants, colorants, antioxidants, preservatives, chelating agents, viscomodulators, tonicifiers, odorants, opacifiers, suspending agents, binders, thickeners, and mixtures thereof, including, but not limited to, xanthum gum, carboxymethylcellulose, carboxyethylcellulose, hydroxypropylcellulose, methylcellulose, microcrystalline cellulose, starches, dextrins, fermented whey, tofu, maltodextrins, polyols (including sugar alcohols, such as sorbitol or mannitol), carbohydrates (e.g., lactose), propylene hlycol alginate, gellan gum, guar, pectin, tragacanth gum, gum acacia, locust bean gum, gum arabic, gelatin,
  • the non-tobacco products may be in a variety of forms, e.g., to be taken orally, such as pills, tablets, capsules, soft gels, gelcaps, liquids, syrups, suspensions, powders, chews, lozenges, gum, bars, etc., or to be administered by other routes, such as parenterally, by inhalation spray, topically, via an implanted reservoir, etc.
  • the alkaloid compositions also can be prepared to be administered in foods or beverages. For example, they can be supplied as a dried or powdered product for reconstitution with water or other suitable vehicle before use (e.g., milk, fruit juice, and the like).
  • Alkaloid compositions for e-cigarettes may be prepared by combining the components listed in Table 1 below and mixing to form a solution.
  • Anatabine may be prepared synthetically as described in Examples 1-3 of co-pending application Ser. No. 12/729,346. Nicotine, anabasine, and nornicotine may be extracted from tobacco materials and purified using known techniques.
  • compositions described in Examples 1-8 may be filled into refilling cartridges for e-cigarettes, or filled into a liquid container that is used as part of a kit for refilling liquid receptacles in e-cigarettes.
  • the compositions alternatively may be filled into a single-use or disposable type of e-cigarette.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Manufacture Of Tobacco Products (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

An alkaloid composition for an e-cigarette contains a solvent and at least about 25 wt. % anatabine based on the total alkaloid weight of the composition. The alkaloid composition may be contained in a refilling cartridge for an e-cigarette, or in a container as part of a kit for refilling an e-cigarette. The alkaloid compositions disclosed herein feature a balanced form of alkaloids to provide an attractive alternative to smoking tobacco, in which nicotine makes up about 90 wt. % of the total alkaloid content. The alkaloid compositions are characterized by a significant quantity of anatabine, which has lower toxicity than other alkaloids such as nicotine. The alkaloid compositions enable individuals to experience the pleasure-enhancing attributes of conventional cigarette smoking, while avoiding exposure to combusted materials and other potentially hazardous components present in tobacco.

Description

    CROSS-REFERENCE TO RELATED APPLICATION
  • This application claims benefit under 35 U.S.C. §119(e) to U.S. Application No. 61/500,237, filed Jun. 23, 2011, the disclosure of which is hereby incorporated by reference in its entirety.
    • BACKGROUND
  • Combustion of organic materials such as tobacco is known to produce tar and other potentially harmful materials. Electronic cigarettes (or “e-cigarettes”) have been developed as an alternative to traditional cigarettes as a means for volatizing active components, such as nicotine, for inhalation without combustion, while at the same time providing the user with an oral experience similar to that of traditional cigarette smoking U.S. Pat. No. 7,832,410 B2 to Hon describes an e-cigarette having a liquid supply bottle in communication with an atomizer for volatizing a nicotine-containing solution. U.S. Pat. No. 7,726,320 B2 to Robinson et al. discloses a smoking article having an electrically powered aerosol-generating device which heats tobacco contained within the device to generate an aerosol which is described as being similar to tobacco smoke.
  • Current e-cigarettes generally use a liquid containing nicotine, a toxic and addictive substance, as the sole active component. It also has been proposed to use so-called whole tobacco alkaloid e-liquid, containing nicotine in proportions similar to those existing in tobacco (e.g., ≧90 wt. % of alkaloid content). The art has recognized a need for non-nicotine or reduced-nicotine alternatives to tobacco and tobacco replacement products. See D. K. Hatsukami et al., “Nicotine reduction revisited: science and future directions,” Tobacco Control 19: e1-e10 (2010). It would be especially desirable to develop non-nicotine or reduced-nicotine alternatives that more effectively achieve the pleasure-enhancing attributes of traditional cigarette smoking, which in turn may assist smokers in quitting traditional cigarette smoking.
    • SUMMARY
  • Embodiments of the present invention are directed to e-cigarettes, alkaloid compositions for e-cigarettes, and refilling cartridges for e-cigarettes containing certain alkaloid compositions. In one aspect, a refilling cartridge for an e-cigarette contains a liquid alkaloid composition comprising a solvent and at least about 25 wt. % anatabine based on the total alkaloid weight of the composition.
  • In another aspect, a kit for refilling an e-cigarette comprises (i) a liquid alkaloid composition comprising a solvent and at least about 25 wt. % anatabine based on the total alkaloid weight of the composition, and (ii) instructions for filling the liquid alkaloid composition into a liquid receptacle of an e-cigarette.
  • In another aspect, a method of refilling an e-cigarette includes the steps of (i) providing a liquid alkaloid composition comprising a solvent and at least about 25 wt. % anatabine based on the total alkaloid weight of the composition, and (ii) filling the liquid alkaloid composition into a liquid receptacle of an e-cigarette.
  • In yet another aspect, an e-cigarette comprises a cartridge containing a liquid alkaloid composition comprising a solvent and at least about 25 wt. % anatabine based on the total alkaloid weight of the composition. The e-cigarette may be of a single-use or disposable type, or may be refillable with liquid alkaloid compositions to facilitate reuse.
  • Other aspects relate to non-tobacco products that contain an alkaloid composition comprising about 25 wt. % to about 95 wt. % anatabine, and about 5 wt. % to about 75 wt. % of a second alkaloid, based on the total alkaloid weight of the composition. The second alkaloid may be nicotine, nornicotine, anabasine, or a combination of two or more of them. The non-tobacco product may be in the form of a solid bit of compressed powder, chewing gum, gelcap, capsule, pill, lozenge, or the like.
  • The alkaloid compositions disclosed herein feature different ranges of alkaloids to provide an attractive alternative to smoking conventional e-cigarettes, in which nicotine makes up about 90 to 100 wt. % of the total alkaloid content. The disclosed alkaloid compositions are characterized by a significant quantity of anatabine, which has lower toxicity and risk of abuse as compared to other alkaloids such as nicotine. The alkaloid compositions enable individuals to experience the pleasure-enhancing attributes of conventional cigarette smoking, while avoiding exposure to combusted materials and other potentially hazardous components present in tobacco. As a result, individuals may be more likely to quit conventional cigarette smoking
    • BRIEF DESCRIPTION OF THE DRAWINGS
  • A more complete understanding of the present invention and certain advantages thereof may be acquired by referring to the following detailed description in consideration with the accompanying drawings, in which:
  • FIG. 1 is a schematic illustration of one example of an e-cigarette configuration.
    •  DETAILED DESCRIPTION
  • Tobacco is among the most chemically complex substances known, with tobacco and tobacco smoke containing more than 8,000 compounds. In addition to nicotine, tobacco contains the minor alkaloids nornicotine, anabasine, and anatabine. While nicotine is regarded as the principal addictive component in tobacco, a variety of other factors also are believed to contribute to tobacco addiction. For example, tobacco smoke has been reported to have a monoamine oxidase (MAO) inhibitory effect. MAO is an enzyme involved in the breakdown of dopamine, a pleasure-enhancing neurotransmitter. See J. S. Fowler et al., “Inhibition of Monoamine Oxidase B in the Brain of Smokers,” Nature (Lond), 379(6567):733 736 (1996); J. Stephenson, “Clues Found to Tobacco Addiction,” Journal of the American Medical Association, 275(16): 1217-1218 (1996). See also Williams et al. U.S. Pat. No. 6,350,479.
  • Aspects of the present invention are directed to alkaloid compositions for e-cigarettes which are designed to provide different ranges of alkaloids to more effectively achieve the pleasure-enhancing effects that smokers obtain through smoking traditional cigarettes, while avoiding or reducing exposure to nicotine. In one embodiment, the alkaloid composition comprises at least about 25 wt. % anatabine based on the total alkaloid weight. In some examples, anatabine is the sole alkaloid present in the composition, e.g., anatabine comprises 100 wt. % of the total alkaloid weight. In other examples, up to about 75 wt. % of one or more other alkaloids, such as nicotine, nornicotine, and/or anabasine, may be present in addition to anatabine. For example, anatabine and nicotine may be combined in a weight ratio (anatabine-to-nicotine) of about 50:1 to about 1:3, or from about 25:1 to about 1:2, from about 10:1 to about 3:2, or from about 5:1 to about 1:1.
  • Unless otherwise clear from context, all percentages referred to herein are expressed as percent by weight based on the total weight of the composition.
  • Anatabine may be prepared synthetically, such as via a benzophenoneimine pathway as described in co-pending application Ser. No. 12/729,346, filed Mar. 23, 2010, the disclosure of which is incorporated herein by reference in its entirety. Anatabine may be present in the form of a racemic mixture or as isolated enantiomer, e.g., R-(+)-anatabine or S-(−)-anatabine, and/or as one or more pharmaceutically acceptable (or food grade) salts of anatabine. Unless otherwise clear from context, “anatabine” as used herein refers to racemic mixtures of anatabine, enantiomers of anatabine, salt and non-salt forms of anatabine, as well as salt and non-salt forms of anatabine enantiomers. Non-limiting examples of possible salts are described in P. H. Stahl et al., Handbook of Pharmaceutical Salts: Properties, Selection and Use, Weinheim/Zürich:Wiley-VCHNHCA, 2002, including salts of 1-hydroxy-2-naphthoic acid, 2,2-dichloroacetic acid, 2-hydroxyethanesulfonic acid, 2-oxoglutaric acid, 4-acetamidobenzoic acid, 4-aminosalicylic acid, acetic acid, adipic acid, ascorbic acid (L), aspartic acid (L), benzenesulfonic acid, benzoic acid, camphoric acid (+), camphor-10-sulfonic acid (+), capric acid (decanoic acid), caproic acid (hexanoic acid), caprylic acid (octanoic acid), carbonic acid, cinnamic acid, citric acid, cyclamic acid, dodecylsulfuric acid, ethane-1,2-disulfonic acid, ethanesulfonic acid, formic acid, fumaric acid, galactaric acid, gentisic acid, glucoheptonic acid (D), gluconic acid (D), glucuronic acid (D), glutamic acid, glutaric acid, glycerophosphoric acid, glycolic acid, hippuric acid, hydrobromic acid, hydrochloric acid, isobutyric acid, lactic acid (DL), lactobionic acid, lauric acid, maleic acid, malic acid (−L), malonic acid, mandelic acid (DL), methanesulfonic acid, naphthalene-1,5-disulfonic acid, naphthalene-2-sulfonic acid, nicotinic acid, nitric acid, oleic acid, oxalic acid, palmitic acid, pamoic acid, phosphoric acid, proprionic acid, pyroglutamic acid (−L), salicylic acid, sebacic acid, stearic acid, succinic acid, sulfuric acid, tartaric acid (+L), thiocyanic acid, toluenesulfonic acid (p), and undecylenic acid.
  • As an alternative to synthetic preparation, anatabine may be obtained by extraction from tobacco or other plants, such as members of the Solanaceae family, such as datura, mandrake, belladonna, capsicum, potato, tomato, nicotiana, eggplant, and petunia. A tobacco extract may be prepared from cured tobacco stems, lamina, or both. Flue (bright) varieties of tobacco are often used, i.e., Virginia flue. Other tobacco varieties may be used, such as Burley, dark-fired, and/or other commercial tobacco varieties. Two or more tobacco varieties may be combined to form a blend. In the extraction process, cured tobacco material is extracted with a solvent, typically water, ethanol, steam, or carbon dioxide. The resulting solution contains the soluble components of the tobacco, including alkaloids such as anatabine. Anatabine may be purified using known techniques such as liquid chromatography.
  • The amount of anatabine present in the composition may vary depending on factors such as the type of e-cigarette and whether other active components, such as nicotine and/or other alkaloids, are present. By way of example, the amount of anatabine may range from about 0.1 to about 25 mg, from about 0.5 to about 20 mg, or from about 1 to about 10 mg, per total gram of composition.
  • As described in co-pending application Ser. No. 12/826,985, compositions containing anatabine were found to be efficacious for the temporary reduction of tobacco cravings, even without the presence of nicotine. Anatabine and other minor alkaloids also have been reported to bind to nicotinic receptors. See “Receptors for Nicotine in the Central Nervous System: 1 Radioligand Binding Studies,” Group Research & Development Centre, British-American Tobacco Co. Ltd. (1984).
  • In addition to anatabine, the composition may contain up to about 75 wt. % of one or more other alkaloids, such as nicotine, nornicotine, and/or anabasine, based on the total alkaloid weight. Such alkaloids may be extracted from tobacco or other plant materials and purified using known techniques, and/or prepared synthetically using known synthesis methods. Anatabine and additional alkaloid(s), such as nicotine, may be combined in a weight ratio (anatabine-to-total other alkaloids) of about 50:1 to about 1:3, or from about 25:1 to about 1:2, from about 10:1 to about 3:2, or from about 5:1 to about 1:1.
  • The composition typically contains other components such as water, organic solvents, sweetening and/or flavoring agents, and the like. Examples of solvents that are commonly used in liquid compositions for e-cigarettes include polyhydric alcohols such as 1,2-propylene glycol (PG or MPG); monohydric alcohols such as ethanol; ethyl acetate; and the like. The amount of water present typically ranges from about 0.1 to about 10 wt. %, usually from about 0.5 to about 5 wt. %. The amount of organic solvent present typically ranges from about 50 to about 99 wt. %, often from about 75 to about 95 wt. %.
  • If desired, one or more flavorants may be added to the composition, non-limiting examples of which include peppermint, menthol, wintergreen, spearmint, propolis, eucalyptus, cinnamon, or the like. The total amount of flavorants typically ranges from about 0.5 to about 15 wt. %, often from about 1 to about 10 wt. %, based on the total weight of the composition.
  • The e-cigarette may be of various types of configurations, the details of which form no part of the present invention. In general, e-cigarettes may be of a single-use or disposable type, or may be refillable with liquid alkaloid compositions and/or cartridges containing liquid compositions to facilitate reuse. One example of an e-cigarette is shown in FIG. 1. An air inlet 4 is provided on the external wall of a shell 14 which houses LED 1, cell 2, electronic circuit board 3, normal pressure cavity 5, sensor 6, vapor-liquid separator 7, atomizer 9, liquid-supplying bottle 11, mouthpiece 15, microswitch 16, gas vent 17, and air passage 18. The electronic circuit board 3 has an electronic switching circuit and a high frequency generator. A negative pressure cavity 8 is provided in the sensor 6 and is separated from the sensor 6 by a ripple film. An atomization cavity 10 is provided in the atomizer 9. A retaining ring 13 is provided for locking the liquid-supplying bottle 11 between one side of the liquid-supplying bottle 11 and the shell 14; and an aerosol passage 12 is provided on the other side of the liquid-supplying bottle. Other details are described in U.S. Pat. No. 7,832,410 B2 to Hon, the disclosure of which is hereby incorporated by reference in its entirety.
  • By providing a balanced alkaloid composition containing anatabine as a significant alkaloid component, it is possible to prepare e-cigarettes that reduce cravings for traditional tobacco smoking, while minimizing toxicity and other undesirable side effects associated with nicotine and other tobacco components. The e-cigarette may be used as needed to satisfy cravings, or at intervals such as once daily, twice daily, or three or more times daily, depending on such factors as the concentration of active components and the subject's physiological conditions.
  • In an alternative embodiment, a non-tobacco formulation contains an alkaloid composition comprising about 25 wt. % to about 95 wt. % anatabine, and about 5 wt. % to about 75 wt. % of a second alkaloid, based on the total alkaloid weight of the composition. The second alkaloid may be nicotine, nornicotine, anabasine, or a combination of two or more of them. The non-tobacco product may be in the form of a solid bit of compressed powder, chewing gum, capsule, pill, lozenge, or the like. The term “non-tobacco” means that the product is essentially free of tobacco leaf or tobacco extract, except however that some or all of the alkaloids present in the non-tobacco product may be extracted from tobacco and purified using conventional techniques such as liquid chromatography.
  • Additional components ingredients may be added to the non-tobacco products to improve taste or stability. Such additional components include, but are not limited to, sweeteners, natural flavorants, artificial flavorants, colorants, antioxidants, preservatives, chelating agents, viscomodulators, tonicifiers, odorants, opacifiers, suspending agents, binders, thickeners, and mixtures thereof, including, but not limited to, xanthum gum, carboxymethylcellulose, carboxyethylcellulose, hydroxypropylcellulose, methylcellulose, microcrystalline cellulose, starches, dextrins, fermented whey, tofu, maltodextrins, polyols (including sugar alcohols, such as sorbitol or mannitol), carbohydrates (e.g., lactose), propylene hlycol alginate, gellan gum, guar, pectin, tragacanth gum, gum acacia, locust bean gum, gum arabic, gelatin, mannitol, natural and/or artificial mint flavors, sucralose, silicon dioxide, stearic acid, hydroxypropyl methylcellulose, magnesium stearate, titanium dioxide, natural glaze, methylparaben, propylparabens, triethyl citrate, citric acid, butylated hydroxytoluene (BHT), mono and diglycerides, polysorbate 80, and the like.
  • The non-tobacco products may be in a variety of forms, e.g., to be taken orally, such as pills, tablets, capsules, soft gels, gelcaps, liquids, syrups, suspensions, powders, chews, lozenges, gum, bars, etc., or to be administered by other routes, such as parenterally, by inhalation spray, topically, via an implanted reservoir, etc. The alkaloid compositions also can be prepared to be administered in foods or beverages. For example, they can be supplied as a dried or powdered product for reconstitution with water or other suitable vehicle before use (e.g., milk, fruit juice, and the like).
    • EXAMPLES 1-8
  • Alkaloid compositions for e-cigarettes may be prepared by combining the components listed in Table 1 below and mixing to form a solution. Anatabine may be prepared synthetically as described in Examples 1-3 of co-pending application Ser. No. 12/729,346. Nicotine, anabasine, and nornicotine may be extracted from tobacco materials and purified using known techniques.
  • TABLE 1
    Example
    1 2 3 4 5 6 7 8
    Anatabine (mg) 10 8 4 6 7 12 8 6
    Nicotine (mg) — 4 8 4 5 6 — 4
    Nornicotine — — — — — — 4 2
    (mg)
    Anabasine — — — 3 1 1 — 2
    (mg)
    Polyethylene 91 90 92 93 92 94 91 90
    Glycol (g)
    Ethyl acetate 0.5 0.5 — 0.5 0.4 0.5 — 0.4
    (g)
    Water (g) 4 4.5 3.5 4 2.5 3.5 5 4.5
    Flavors (g) 1 1.25 1.5 1 1 1.5 0.75 1.25
  • The compositions described in Examples 1-8 may be filled into refilling cartridges for e-cigarettes, or filled into a liquid container that is used as part of a kit for refilling liquid receptacles in e-cigarettes. The compositions alternatively may be filled into a single-use or disposable type of e-cigarette.
  • While the invention has been described with respect to specific examples, those skilled in the art will appreciate that there are numerous variations and permutations of the above described systems and techniques that fall within the spirit and scope of the invention as set forth in the appended claims.

Claims (30)

1. A refilling cartridge for an e-cigarette containing a liquid alkaloid composition comprising a solvent and at least about 25 wt. % anatabine based on the total alkaloid weight of the composition.
2. The refilling cartridge of claim 1, wherein the anatabine is synthetic anatabine.
3. The refilling cartridge of claim 1 wherein anatabine is provided in the form of an extract of a plant selected from the group consisting of tobacco, datura, mandrake, belladonna, capsicum, potato, tomato, nicotiana, eggplant, and petunia.
4. The refilling cartridge of claim 1, wherein the solvent is 1,2-polyethylene glycol.
5. The refilling cartridge of claim 1, wherein the solvent further comprises ethyl acetate.
6. The refilling cartridge of claim 1, wherein the liquid alkaloid composition further comprises an alkaloid selected from the group consisting of nicotine, nornicotine, anabasine, and combinations thereof.
7. The refilling cartridge of claim 1, wherein anatabine comprises at least about 50 wt. % of the total alkaloid weight of the composition.
8. The refilling cartridge of claim 1, wherein anatabine comprises at least about 75 wt. % of the total alkaloid weight of the composition.
9. The refilling cartridge of claim 1, wherein anatabine comprises 100 wt. % of the total alkaloid weight of the composition.
10. An e-cigarette comprising the refilling cartridge of claim 1.
11. A kit for refilling an e-cigarette comprising:
a liquid alkaloid composition comprising a solvent and at least about 25 wt. % anatabine based on the total alkaloid weight of the composition; and
instructions for filling the liquid alkaloid composition into a liquid receptacle of an e-cigarette.
12. The kit of claim 11, wherein the liquid alkaloid composition further comprises an alkaloid selected from the group consisting of nicotine, nornicotine, anabasine, and combinations thereof.
13. The kit of claim 11, wherein anatabine comprises at least about 50 wt. % of the total alkaloid weight of the composition.
14. The kit of claim 11, wherein anatabine comprises at least about 75 wt. % of the total alkaloid weight of the composition.
15. The kit of claim 11, wherein anatabine comprises 100 wt. % of the total alkaloid weight of the composition.
16. A method of refilling an e-cigarette comprising
providing a liquid alkaloid composition comprising a solvent and at least about 25 wt. % anatabine based on the total alkaloid weight of the composition; and
filling the liquid alkaloid composition into a liquid receptacle of an e-cigarette.
17. The method of claim 16, wherein the liquid alkaloid composition further comprises an alkaloid selected from the group consisting of nicotine, nornicotine, anabasine, and combinations thereof.
18. The method of claim 16, wherein anatabine comprises at least about 50 wt. % of the total alkaloid weight of the composition.
19. The method of claim 16, wherein anatabine comprises at least about 75 wt. % of the total alkaloid weight of the composition.
20. The method of claim 16, wherein anatabine comprises 100 wt. % of the total alkaloid weight of the composition.
21. An e-cigarette comprising a cartridge containing a liquid alkaloid composition comprising a solvent and at least about 25 wt. % anatabine based on the total alkaloid weight of the composition.
22. The e-cigarette of claim 21, wherein the liquid alkaloid composition further comprises an alkaloid selected from the group consisting of nicotine, nornicotine, anabasine, and combinations thereof.
23. The e-cigarette of claim 21, wherein anatabine comprises at least about 50 wt. % of the total alkaloid weight of the composition.
24. The e-cigarette of claim 21, wherein anatabine comprises at least about 75 wt. % of the total alkaloid weight of the composition.
25. The e-cigarette of claim 21, wherein anatabine comprises 100 wt. % of the total alkaloid weight of the composition.
26. A non-tobacco product containing an alkaloid composition comprising about 25 wt. % to about 95 wt. % anatabine and about 5 wt. % to about 75 wt. % of a second alkaloid, based on the total alkaloid weight of the composition, wherein the second alkaloid is selected from the group consisting of nicotine, nornicotine, anabasine, and combinations thereof; and wherein the product is in a form selected from the group consisting of pills, tablets, capsules, soft gels, gelcaps, liquids, syrups, suspensions, powders, chews, lozenges, gum, bars, inhalation spray, and implanted reservoir.
27. The non-tobacco product of claim 26, wherein the second alkaloid is nicotine.
28. The non-tobacco product of claim 26, wherein anatabine comprises at least about 50 wt. % of the total alkaloid weight of the composition.
29. The non-tobacco product of claim 26, wherein anatabine comprises at least about 75 wt. % of the total alkaloid weight of the composition.
30. The non-tobacco product of claim 26, wherein anatabine comprises about 95 wt. % of the total alkaloid weight of the composition.
US13/493,132 2011-06-23 2012-06-11 Alkaloid composition for e-cigarette Abandoned US20120325228A1 (en)

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US14/672,716 US20160050968A1 (en) 2011-06-23 2015-03-30 Alkaloid Composition for E-Cigarette
US15/679,731 US20180184704A1 (en) 2011-06-23 2017-08-17 Alkaloid Composition for E-Cigarette

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Cited By (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103876273A (en) * 2014-03-12 2014-06-25 红塔烟草(集团)有限责任公司 Mixed type electronic cigarette tobacco juice and preparing method
CN103932382A (en) * 2014-03-12 2014-07-23 红塔烟草(集团)有限责任公司 Fresh scent electronic cigarette nicotine liquid and preparation method thereof
WO2014150881A1 (en) * 2013-03-15 2014-09-25 Dongmei Xu Nicotine and anatabine containing products and methods of making
CN104087414A (en) * 2014-07-28 2014-10-08 嘉兴市得百科新材料科技有限公司 Electronic cigarette liquid with blueberry flavor and preparation method thereof
CN104172463A (en) * 2014-08-07 2014-12-03 江苏中烟工业有限责任公司 Electronic cigarette smoke solution solvent and electronic cigarette smoke solution
ITBO20130504A1 (en) * 2013-09-18 2015-03-19 Gd Spa METHOD AND FILLING UNIT OF A DISPOSABLE CARTRIDGE FOR ELECTRONIC CIGARETTES WITH A LIQUID SUBSTANCE.
US20150083146A1 (en) * 2013-09-23 2015-03-26 Verso PV, LLC Personal vaporizer liquid for emulsifying oil-soluble compounds and resins
US20150128966A1 (en) * 2012-05-14 2015-05-14 Nicoventures Holdings Limited Electronic vapor provision device
US9095175B2 (en) 2010-05-15 2015-08-04 R. J. Reynolds Tobacco Company Data logging personal vaporizing inhaler
WO2015117243A1 (en) * 2014-02-07 2015-08-13 Bellerose Samuel Liquid formulation for e-cigarettes
WO2015149330A1 (en) * 2014-04-03 2015-10-08 吉瑞高新科技股份有限公司 Electronic cigarette
WO2015157928A1 (en) * 2014-04-16 2015-10-22 吉瑞高新科技股份有限公司 Electronic cigarette
CN105124763A (en) * 2015-09-06 2015-12-09 叶菁 Phase-change temperature control type fuel assembly for non-combustion type low temperature cigarette and preparing method thereof
US9259035B2 (en) 2010-05-15 2016-02-16 R. J. Reynolds Tobacco Company Solderless personal vaporizing inhaler
CN105559148A (en) * 2016-02-27 2016-05-11 卓尔悦（常州）电子科技有限公司 Atomizer and electronic cigarette thereof
US9352288B2 (en) 2010-05-15 2016-05-31 Rai Strategic Holdings, Inc. Vaporizer assembly and cartridge
WO2016133890A1 (en) * 2015-02-19 2016-08-25 Srq Patent Holdings, Llc Compositions for e-cigarettes
CN106072767A (en) * 2016-06-28 2016-11-09 卓尔悦欧洲控股有限公司 Atomising head, nebulizer and electronic cigarette thereof
US9743691B2 (en) 2010-05-15 2017-08-29 Rai Strategic Holdings, Inc. Vaporizer configuration, control, and reporting
WO2017210968A1 (en) * 2016-06-08 2017-12-14 卓尔悦（常州）电子科技有限公司 Electronic cigarette
WO2018073261A1 (en) * 2016-10-18 2018-04-26 Philip Morris Products S.A. Methods and systems for improving stability of the pre-vapor formulation of an e-vaping device
US9999250B2 (en) 2010-05-15 2018-06-19 Rai Strategic Holdings, Inc. Vaporizer related systems, methods, and apparatus
US10034988B2 (en) 2012-11-28 2018-07-31 Fontem Holdings I B.V. Methods and devices for compound delivery
USD825102S1 (en) 2016-07-28 2018-08-07 Juul Labs, Inc. Vaporizer device with cartridge
US10045568B2 (en) 2013-12-23 2018-08-14 Juul Labs, Inc. Vaporization device systems and methods
US10045567B2 (en) 2013-12-23 2018-08-14 Juul Labs, Inc. Vaporization device systems and methods
US10058130B2 (en) 2013-12-23 2018-08-28 Juul Labs, Inc. Cartridge for use with a vaporizer device
US10076139B2 (en) 2013-12-23 2018-09-18 Juul Labs, Inc. Vaporizer apparatus
WO2018176676A1 (en) * 2017-03-31 2018-10-04 纳智源科技（唐山）有限责任公司 Smoking quantity monitoring device and system
US10092713B2 (en) 2010-05-15 2018-10-09 Rai Strategic Holdings, Inc. Personal vaporizing inhaler with translucent window
US10104915B2 (en) 2013-12-23 2018-10-23 Juul Labs, Inc. Securely attaching cartridges for vaporizer devices
US10111470B2 (en) 2013-12-23 2018-10-30 Juul Labs, Inc. Vaporizer apparatus
US10136672B2 (en) 2010-05-15 2018-11-27 Rai Strategic Holdings, Inc. Solderless directly written heating elements
USD836541S1 (en) 2016-06-23 2018-12-25 Pax Labs, Inc. Charging device
US10159278B2 (en) 2010-05-15 2018-12-25 Rai Strategic Holdings, Inc. Assembly directed airflow
US10194693B2 (en) 2013-09-20 2019-02-05 Fontem Holdings 1 B.V. Aerosol generating device
USD842536S1 (en) 2016-07-28 2019-03-05 Juul Labs, Inc. Vaporizer cartridge
US10244793B2 (en) 2005-07-19 2019-04-02 Juul Labs, Inc. Devices for vaporization of a substance
US10251422B2 (en) 2013-07-22 2019-04-09 Altria Client Services Llc Electronic smoking article
USD848057S1 (en) 2016-06-23 2019-05-07 Pax Labs, Inc. Lid for a vaporizer
US10279934B2 (en) 2013-03-15 2019-05-07 Juul Labs, Inc. Fillable vaporizer cartridge and method of filling
USD849996S1 (en) 2016-06-16 2019-05-28 Pax Labs, Inc. Vaporizer cartridge
KR20190062396A (en) * 2016-10-18 2019-06-05 필립모리스 프로덕츠 에스.에이. Method and system for increasing the stability of a pre-vapor preparation of an E-belling machine
USD851830S1 (en) 2016-06-23 2019-06-18 Pax Labs, Inc. Combined vaporizer tamp and pick tool
US10334887B1 (en) 2016-06-08 2019-07-02 Joyetech Europe Holding Gmbh Atomizer and electronic cigarette
US10405582B2 (en) 2016-03-10 2019-09-10 Pax Labs, Inc. Vaporization device with lip sensing
US10471052B2 (en) 2015-02-19 2019-11-12 Mymd Pharmaceuticals, Inc. Method of treating addictions to opioids
US10512282B2 (en) 2014-12-05 2019-12-24 Juul Labs, Inc. Calibrated dose control
USD887632S1 (en) 2017-09-14 2020-06-16 Pax Labs, Inc. Vaporizer cartridge
FR3089761A1 (en) * 2018-12-12 2020-06-19 E-Rag Liquid composition of electronic cigarette
US10865001B2 (en) 2016-02-11 2020-12-15 Juul Labs, Inc. Fillable vaporizer cartridge and method of filling
US10874139B2 (en) 2015-07-07 2020-12-29 Altria Client Services Llc E-vapor device including capsule containing pre-vapor formulation
US20210007397A1 (en) * 2016-05-31 2021-01-14 Altria Client Services Llc Refillable aerosol-generating article
CN113163845A (en) * 2018-12-31 2021-07-23 菲利普莫里斯生产公司 Liquid nicotine formulation comprising a partially water soluble solvent
CN113208148A (en) * 2021-05-12 2021-08-06 云南中烟工业有限责任公司 Supramolecular gel for synergistically releasing nicotine and aroma components
GB2595967A (en) * 2020-05-01 2021-12-15 Exhale Tech Ltd Composition and use thereof
US20220273019A1 (en) * 2018-11-01 2022-09-01 Nicoventures Trading Limited Gel and crystalline powder
CN115166070A (en) * 2022-06-16 2022-10-11 深圳萨特瓦生物科技有限公司 Method for testing nicotine content in tobacco tar or aerosol and method for preparing electronic cigarette tobacco tar
IT202100027086A1 (en) * 2021-10-21 2023-04-21 Alberto Patarchi PORTABLE REGULATOR FOR THE TREATMENT OR PREVENTION OF AN INFECTION OR DISEASE CAUSED BY A VIRUS
US20230157347A1 (en) * 2013-12-05 2023-05-25 Juul Labs, Inc. Nicotine liquid formulations for aerosol devices and methods thereof
JP2023157820A (en) * 2022-04-15 2023-10-26 汪冶 Atomized solution used in atomized electron delivery product
JP2023158617A (en) * 2022-04-18 2023-10-30 汪冶 Use of anabasine in heating-type non-combustion electronic delivery product, solid flake, and method for producing the same
US11819608B2 (en) 2017-12-22 2023-11-21 Nicoventures Trading Limited Electronic aerosol provision system
USD1028336S1 (en) 2021-06-22 2024-05-21 Pax Labs, Inc. Vaporizer cartridge
US12133952B2 (en) 2010-05-15 2024-11-05 Rai Strategic Holdings, Inc. Vaporizer related systems, methods, and apparatus
US12156533B2 (en) 2013-05-06 2024-12-03 Juul Labs, Inc. Nicotine salt formulations for aerosol devices and methods thereof
US12279647B2 (en) 2019-12-23 2025-04-22 Pax Labs, Inc. Vaporizer cartridge

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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CN104489901B (en) * 2014-12-03 2016-06-29 河南中烟工业有限责任公司 One grows tobacco taste tobacco juice for electronic smoke
JP7292035B2 (en) 2015-06-26 2023-06-16 アルトリア クライアント サーヴィシーズ リミテッド ライアビリティ カンパニー Compositions and methods for producing alkaloid level-modified tobacco plants and products
CN105029681B (en) * 2015-07-14 2017-10-31 中国烟草总公司郑州烟草研究院 Natural perfume material refined liquid, tobacco juice suitable for tobacco juice for electronic smoke and preparation method thereof
CN108077992B (en) * 2017-12-18 2019-01-18 山东精彩香料科技开发有限公司 It is a kind of to heat do not burn cigarette suction particle and manufacturing method
US20200035118A1 (en) 2018-07-27 2020-01-30 Joseph Pandolfino Methods and products to facilitate smokers switching to a tobacco heating product or e-cigarettes
US10897925B2 (en) 2018-07-27 2021-01-26 Joseph Pandolfino Articles and formulations for smoking products and vaporizers
CN108968138B (en) * 2018-10-09 2021-02-02 湖北中烟工业有限责任公司 Flavor for improving heat-not-burn tobacco smoke state and preparation method and application thereof
BR112021009580A2 (en) 2018-12-17 2021-08-17 Philip Morris Products S.A. 3-(1,2,3,6-tetrahydropyridin-2-yl)pyridine glutarate or a pharmaceutically acceptable solvate thereof

Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6041789A (en) * 1999-01-28 2000-03-28 K&B Technologies, L.L.C. Cigarette substitute device and composition for use therein
US20020054926A1 (en) * 1998-06-05 2002-05-09 Regent Court Technologies Monoamine oxidase (MAO) inhibitors and uses thereof
US20040013752A1 (en) * 2002-07-05 2004-01-22 Wolfson Philip E. Buccal and sublingual mucosally absorbed herbal compositions for relieving nicotine withdrawal symptoms and craving for nicotine and nicotine containing substances
US20050172976A1 (en) * 2002-10-31 2005-08-11 Newman Deborah J. Electrically heated cigarette including controlled-release flavoring
US20050260420A1 (en) * 2003-04-01 2005-11-24 Collins Martha J Low dielectric materials and methods for making same
US20070267031A1 (en) * 2004-04-14 2007-11-22 Lik Hon Electronic Atomization Cigarette
US20080156336A1 (en) * 2006-08-25 2008-07-03 Philip Morris Usa Inc. Smoking article with encapsulated flavourant
US20080257367A1 (en) * 2007-04-23 2008-10-23 Greg Paterno Electronic evaporable substance delivery device and method
US20090126745A1 (en) * 2006-05-16 2009-05-21 Lik Hon Emulation Aerosol Sucker
WO2009105919A1 (en) * 2008-02-29 2009-09-03 Xiu Yunqiang Electronic simulated cigarette and atomizing liquid thereof, smoking set for electronic simulated cigarette and smoking liquid capsule thereof
US20090272379A1 (en) * 2008-04-30 2009-11-05 Philip Morris Usa Inc. Electrically heated smoking system having a liquid storage portion
US20100236562A1 (en) * 2007-06-25 2010-09-23 Alex Hearn Inhalable composition
US20110265806A1 (en) * 2010-04-30 2011-11-03 Ramon Alarcon Electronic smoking device
US20120186594A1 (en) * 2009-09-18 2012-07-26 Minilogic Device Corporation Ltd. Electronic smoke

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6534527B2 (en) * 2000-06-02 2003-03-18 Phytos, Inc. Edible herbal compositions for relieving nicotine craving
US7458374B2 (en) * 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US6552035B2 (en) * 2001-09-13 2003-04-22 Hwa-Mok Park Composition for inducing smoking cessation comprising alkaloids from Radix ipecauanhae
US20100160376A1 (en) * 2001-12-10 2010-06-24 Marshall Anlauf Thompson Nicotine-alternative compositions and methods of producing such compositions

Patent Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020054926A1 (en) * 1998-06-05 2002-05-09 Regent Court Technologies Monoamine oxidase (MAO) inhibitors and uses thereof
US6041789A (en) * 1999-01-28 2000-03-28 K&B Technologies, L.L.C. Cigarette substitute device and composition for use therein
US20040013752A1 (en) * 2002-07-05 2004-01-22 Wolfson Philip E. Buccal and sublingual mucosally absorbed herbal compositions for relieving nicotine withdrawal symptoms and craving for nicotine and nicotine containing substances
US20050172976A1 (en) * 2002-10-31 2005-08-11 Newman Deborah J. Electrically heated cigarette including controlled-release flavoring
US20050260420A1 (en) * 2003-04-01 2005-11-24 Collins Martha J Low dielectric materials and methods for making same
US20070267031A1 (en) * 2004-04-14 2007-11-22 Lik Hon Electronic Atomization Cigarette
US20090126745A1 (en) * 2006-05-16 2009-05-21 Lik Hon Emulation Aerosol Sucker
US20080156336A1 (en) * 2006-08-25 2008-07-03 Philip Morris Usa Inc. Smoking article with encapsulated flavourant
US20080257367A1 (en) * 2007-04-23 2008-10-23 Greg Paterno Electronic evaporable substance delivery device and method
US20100236562A1 (en) * 2007-06-25 2010-09-23 Alex Hearn Inhalable composition
WO2009105919A1 (en) * 2008-02-29 2009-09-03 Xiu Yunqiang Electronic simulated cigarette and atomizing liquid thereof, smoking set for electronic simulated cigarette and smoking liquid capsule thereof
US20110005535A1 (en) * 2008-02-29 2011-01-13 Yunqiang Xiu Electronic simulated cigarette and atomizing liquid thereof, smoking set for electronic simulated cigarette and smoking liquid capsule thereof
US20090272379A1 (en) * 2008-04-30 2009-11-05 Philip Morris Usa Inc. Electrically heated smoking system having a liquid storage portion
US20120186594A1 (en) * 2009-09-18 2012-07-26 Minilogic Device Corporation Ltd. Electronic smoke
US20110265806A1 (en) * 2010-04-30 2011-11-03 Ramon Alarcon Electronic smoking device

Cited By (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10244793B2 (en) 2005-07-19 2019-04-02 Juul Labs, Inc. Devices for vaporization of a substance
US9743691B2 (en) 2010-05-15 2017-08-29 Rai Strategic Holdings, Inc. Vaporizer configuration, control, and reporting
US9259035B2 (en) 2010-05-15 2016-02-16 R. J. Reynolds Tobacco Company Solderless personal vaporizing inhaler
US12246129B2 (en) 2010-05-15 2025-03-11 Rai Strategic Holdings, Inc. Vaporizing unit with use authorization
US12233202B2 (en) 2010-05-15 2025-02-25 Rai Strategic Holdings, Inc. Vaporizing unit with dry wick indication
US9999250B2 (en) 2010-05-15 2018-06-19 Rai Strategic Holdings, Inc. Vaporizer related systems, methods, and apparatus
US10092713B2 (en) 2010-05-15 2018-10-09 Rai Strategic Holdings, Inc. Personal vaporizing inhaler with translucent window
US9861772B2 (en) 2010-05-15 2018-01-09 Rai Strategic Holdings, Inc. Personal vaporizing inhaler cartridge
US9352288B2 (en) 2010-05-15 2016-05-31 Rai Strategic Holdings, Inc. Vaporizer assembly and cartridge
US9095175B2 (en) 2010-05-15 2015-08-04 R. J. Reynolds Tobacco Company Data logging personal vaporizing inhaler
US9861773B2 (en) 2010-05-15 2018-01-09 Rai Strategic Holdings, Inc. Communication between personal vaporizing inhaler assemblies
US9427711B2 (en) 2010-05-15 2016-08-30 Rai Strategic Holdings, Inc. Distal end inserted personal vaporizing inhaler cartridge
US12138384B1 (en) 2010-05-15 2024-11-12 Rai Strategic Holdings, Inc. Vaporizer related systems, methods, and apparatus
US12133952B2 (en) 2010-05-15 2024-11-05 Rai Strategic Holdings, Inc. Vaporizer related systems, methods, and apparatus
US9555203B2 (en) 2010-05-15 2017-01-31 Rai Strategic Holdings, Inc. Personal vaporizing inhaler assembly
US10159278B2 (en) 2010-05-15 2018-12-25 Rai Strategic Holdings, Inc. Assembly directed airflow
US10136672B2 (en) 2010-05-15 2018-11-27 Rai Strategic Holdings, Inc. Solderless directly written heating elements
US12246128B2 (en) 2010-05-15 2025-03-11 Rai Strategic Holdings, Inc. Vaporizer related systems, methods, and apparatus
US20150128966A1 (en) * 2012-05-14 2015-05-14 Nicoventures Holdings Limited Electronic vapor provision device
US9955724B2 (en) * 2012-05-14 2018-05-01 Nicoventures Holdings Limited Electronic vapor provision device
US10034988B2 (en) 2012-11-28 2018-07-31 Fontem Holdings I B.V. Methods and devices for compound delivery
WO2014150881A1 (en) * 2013-03-15 2014-09-25 Dongmei Xu Nicotine and anatabine containing products and methods of making
US10279934B2 (en) 2013-03-15 2019-05-07 Juul Labs, Inc. Fillable vaporizer cartridge and method of filling
US10638792B2 (en) 2013-03-15 2020-05-05 Juul Labs, Inc. Securely attaching cartridges for vaporizer devices
US12156533B2 (en) 2013-05-06 2024-12-03 Juul Labs, Inc. Nicotine salt formulations for aerosol devices and methods thereof
US10251422B2 (en) 2013-07-22 2019-04-09 Altria Client Services Llc Electronic smoking article
US9668520B2 (en) 2013-09-18 2017-06-06 G.D Societa' Per Azioni Method and unit for filling a disposable electronic-cigarette cartridge with a liquid substance
CN105658523A (en) * 2013-09-18 2016-06-08 吉第联合股份公司 Method and unit for filling a disposable electronic- cigarette cartridge with a liquid substance
WO2015040568A1 (en) * 2013-09-18 2015-03-26 G.D Societa' Per Azioni Method and unit for filling a disposable electronic- cigarette cartridge with a liquid substance
ITBO20130504A1 (en) * 2013-09-18 2015-03-19 Gd Spa METHOD AND FILLING UNIT OF A DISPOSABLE CARTRIDGE FOR ELECTRONIC CIGARETTES WITH A LIQUID SUBSTANCE.
US10194693B2 (en) 2013-09-20 2019-02-05 Fontem Holdings 1 B.V. Aerosol generating device
US20150083146A1 (en) * 2013-09-23 2015-03-26 Verso PV, LLC Personal vaporizer liquid for emulsifying oil-soluble compounds and resins
US12167744B2 (en) 2013-12-05 2024-12-17 Juul Labs, Inc. Nicotine liquid formulations for aerosol devices and methods thereof
US20230157347A1 (en) * 2013-12-05 2023-05-25 Juul Labs, Inc. Nicotine liquid formulations for aerosol devices and methods thereof
US11744277B2 (en) * 2013-12-05 2023-09-05 Juul Labs, Inc. Nicotine liquid formulations for aerosol devices and methods thereof
US10264823B2 (en) 2013-12-23 2019-04-23 Juul Labs, Inc. Vaporization device systems and methods
US10159282B2 (en) 2013-12-23 2018-12-25 Juul Labs, Inc. Cartridge for use with a vaporizer device
US10058129B2 (en) 2013-12-23 2018-08-28 Juul Labs, Inc. Vaporization device systems and methods
US10058130B2 (en) 2013-12-23 2018-08-28 Juul Labs, Inc. Cartridge for use with a vaporizer device
US10070669B2 (en) 2013-12-23 2018-09-11 Juul Labs, Inc. Cartridge for use with a vaporizer device
US10076139B2 (en) 2013-12-23 2018-09-18 Juul Labs, Inc. Vaporizer apparatus
US10667560B2 (en) 2013-12-23 2020-06-02 Juul Labs, Inc. Vaporizer apparatus
US10045567B2 (en) 2013-12-23 2018-08-14 Juul Labs, Inc. Vaporization device systems and methods
US10104915B2 (en) 2013-12-23 2018-10-23 Juul Labs, Inc. Securely attaching cartridges for vaporizer devices
US10111470B2 (en) 2013-12-23 2018-10-30 Juul Labs, Inc. Vaporizer apparatus
US10117466B2 (en) 2013-12-23 2018-11-06 Juul Labs, Inc. Vaporization device systems and methods
US10117465B2 (en) 2013-12-23 2018-11-06 Juul Labs, Inc. Vaporization device systems and methods
US10045568B2 (en) 2013-12-23 2018-08-14 Juul Labs, Inc. Vaporization device systems and methods
US10701975B2 (en) 2013-12-23 2020-07-07 Juul Labs, Inc. Vaporization device systems and methods
US10058124B2 (en) 2013-12-23 2018-08-28 Juul Labs, Inc. Vaporization device systems and methods
US10912331B2 (en) 2013-12-23 2021-02-09 Juul Labs, Inc. Vaporization device systems and methods
US11752283B2 (en) 2013-12-23 2023-09-12 Juul Labs, Inc. Vaporization device systems and methods
US10201190B2 (en) 2013-12-23 2019-02-12 Juul Labs, Inc. Cartridge for use with a vaporizer device
WO2015117243A1 (en) * 2014-02-07 2015-08-13 Bellerose Samuel Liquid formulation for e-cigarettes
CN103876273A (en) * 2014-03-12 2014-06-25 红塔烟草(集团)有限责任公司 Mixed type electronic cigarette tobacco juice and preparing method
CN103932382A (en) * 2014-03-12 2014-07-23 红塔烟草(集团)有限责任公司 Fresh scent electronic cigarette nicotine liquid and preparation method thereof
CN106413441A (en) * 2014-04-03 2017-02-15 吉瑞高新科技股份有限公司 Electronic cigarette
WO2015149330A1 (en) * 2014-04-03 2015-10-08 吉瑞高新科技股份有限公司 Electronic cigarette
WO2015157928A1 (en) * 2014-04-16 2015-10-22 吉瑞高新科技股份有限公司 Electronic cigarette
CN104087414A (en) * 2014-07-28 2014-10-08 嘉兴市得百科新材料科技有限公司 Electronic cigarette liquid with blueberry flavor and preparation method thereof
CN104172463A (en) * 2014-08-07 2014-12-03 江苏中烟工业有限责任公司 Electronic cigarette smoke solution solvent and electronic cigarette smoke solution
US10512282B2 (en) 2014-12-05 2019-12-24 Juul Labs, Inc. Calibrated dose control
WO2016133890A1 (en) * 2015-02-19 2016-08-25 Srq Patent Holdings, Llc Compositions for e-cigarettes
US10471052B2 (en) 2015-02-19 2019-11-12 Mymd Pharmaceuticals, Inc. Method of treating addictions to opioids
US11331310B2 (en) 2015-02-19 2022-05-17 MyMD Pharmaceuticals (Florida), Inc. Method of treating cocaine addiction
US10874139B2 (en) 2015-07-07 2020-12-29 Altria Client Services Llc E-vapor device including capsule containing pre-vapor formulation
CN105124763A (en) * 2015-09-06 2015-12-09 叶菁 Phase-change temperature control type fuel assembly for non-combustion type low temperature cigarette and preparing method thereof
US10865001B2 (en) 2016-02-11 2020-12-15 Juul Labs, Inc. Fillable vaporizer cartridge and method of filling
US10874137B2 (en) 2016-02-27 2020-12-29 Changzhou Jwei Intelligent Technology Co., Ltd. Atomizer and electronic cigarette thereof
WO2017143953A1 (en) * 2016-02-27 2017-08-31 常州聚为智能科技有限公司 Atomizer and electronic cigarette thereof
CN105559148A (en) * 2016-02-27 2016-05-11 卓尔悦（常州）电子科技有限公司 Atomizer and electronic cigarette thereof
US10405582B2 (en) 2016-03-10 2019-09-10 Pax Labs, Inc. Vaporization device with lip sensing
US12023439B2 (en) * 2016-05-31 2024-07-02 Altria Client Services Llc Refillable aerosol-generating article
US20210007397A1 (en) * 2016-05-31 2021-01-14 Altria Client Services Llc Refillable aerosol-generating article
WO2017210968A1 (en) * 2016-06-08 2017-12-14 卓尔悦（常州）电子科技有限公司 Electronic cigarette
US10334887B1 (en) 2016-06-08 2019-07-02 Joyetech Europe Holding Gmbh Atomizer and electronic cigarette
USD849996S1 (en) 2016-06-16 2019-05-28 Pax Labs, Inc. Vaporizer cartridge
USD913583S1 (en) 2016-06-16 2021-03-16 Pax Labs, Inc. Vaporizer device
USD929036S1 (en) 2016-06-16 2021-08-24 Pax Labs, Inc. Vaporizer cartridge and device assembly
USD848057S1 (en) 2016-06-23 2019-05-07 Pax Labs, Inc. Lid for a vaporizer
USD851830S1 (en) 2016-06-23 2019-06-18 Pax Labs, Inc. Combined vaporizer tamp and pick tool
USD836541S1 (en) 2016-06-23 2018-12-25 Pax Labs, Inc. Charging device
CN106072767A (en) * 2016-06-28 2016-11-09 卓尔悦欧洲控股有限公司 Atomising head, nebulizer and electronic cigarette thereof
USD842536S1 (en) 2016-07-28 2019-03-05 Juul Labs, Inc. Vaporizer cartridge
USD825102S1 (en) 2016-07-28 2018-08-07 Juul Labs, Inc. Vaporizer device with cartridge
KR102524201B1 (en) * 2016-10-18 2023-04-21 필립모리스 프로덕츠 에스.에이. Method and system for improving the stability of pre-vapor formulations of E-vaping devices
JP2019531766A (en) * 2016-10-18 2019-11-07 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム Method and system for improving the stability of pre-vapor formulation of e-vapor equipment
JP7123949B2 (en) 2016-10-18 2022-08-23 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム Method and system for increasing the stability of pre-vapor formulations in e-vaping devices
JP2019531097A (en) * 2016-10-18 2019-10-31 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム Method and system for increasing the stability of a pre-vapor formulation of an e-vapouring device
KR20190062396A (en) * 2016-10-18 2019-06-05 필립모리스 프로덕츠 에스.에이. Method and system for increasing the stability of a pre-vapor preparation of an E-belling machine
WO2018073261A1 (en) * 2016-10-18 2018-04-26 Philip Morris Products S.A. Methods and systems for improving stability of the pre-vapor formulation of an e-vaping device
KR20190062398A (en) * 2016-10-18 2019-06-05 필립모리스 프로덕츠 에스.에이. METHOD AND SYSTEM FOR IMPROVING THE STABILITY OF PRE-VARIATION FORMULATIONS OF E-BREAKING EQUIPMENT
CN109788794A (en) * 2016-10-18 2019-05-21 菲利普莫里斯生产公司 The method and system of the stability of composite before steam for improving electrical steam cigarette device
KR102604390B1 (en) * 2016-10-18 2023-11-21 필립모리스 프로덕츠 에스.에이. Method and system for increasing the stability of pre-vaporization formulations of E-vaping devices
WO2018176676A1 (en) * 2017-03-31 2018-10-04 纳智源科技（唐山）有限责任公司 Smoking quantity monitoring device and system
USD927061S1 (en) 2017-09-14 2021-08-03 Pax Labs, Inc. Vaporizer cartridge
USD887632S1 (en) 2017-09-14 2020-06-16 Pax Labs, Inc. Vaporizer cartridge
US11819608B2 (en) 2017-12-22 2023-11-21 Nicoventures Trading Limited Electronic aerosol provision system
US12114689B2 (en) * 2018-11-01 2024-10-15 Nicoventures Trading Limited Gel and crystalline powder
US20220273019A1 (en) * 2018-11-01 2022-09-01 Nicoventures Trading Limited Gel and crystalline powder
FR3089761A1 (en) * 2018-12-12 2020-06-19 E-Rag Liquid composition of electronic cigarette
CN113163845A (en) * 2018-12-31 2021-07-23 菲利普莫里斯生产公司 Liquid nicotine formulation comprising a partially water soluble solvent
US11992038B2 (en) 2018-12-31 2024-05-28 Philip Morris Products S.A. Liquid nicotine formulation comprising partially water-soluble solvent
US12279647B2 (en) 2019-12-23 2025-04-22 Pax Labs, Inc. Vaporizer cartridge
GB2595967A (en) * 2020-05-01 2021-12-15 Exhale Tech Ltd Composition and use thereof
CN113208148A (en) * 2021-05-12 2021-08-06 云南中烟工业有限责任公司 Supramolecular gel for synergistically releasing nicotine and aroma components
USD1028336S1 (en) 2021-06-22 2024-05-21 Pax Labs, Inc. Vaporizer cartridge
IT202100027086A1 (en) * 2021-10-21 2023-04-21 Alberto Patarchi PORTABLE REGULATOR FOR THE TREATMENT OR PREVENTION OF AN INFECTION OR DISEASE CAUSED BY A VIRUS
JP7436587B2 (en) 2022-04-15 2024-02-21 汪冶 Atomizing solutions used in atomized electronic delivery products
JP2023157820A (en) * 2022-04-15 2023-10-26 汪冶 Atomized solution used in atomized electron delivery product
JP7436590B2 (en) 2022-04-18 2024-02-21 汪冶 Solid flakes and their manufacturing method
JP2023158617A (en) * 2022-04-18 2023-10-30 汪冶 Use of anabasine in heating-type non-combustion electronic delivery product, solid flake, and method for producing the same
CN115166070A (en) * 2022-06-16 2022-10-11 深圳萨特瓦生物科技有限公司 Method for testing nicotine content in tobacco tar or aerosol and method for preparing electronic cigarette tobacco tar

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