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US20080033050A1 - Method of treating thermoregulatory disfunction with paroxetine - Google Patents

Method of treating thermoregulatory disfunction with paroxetine Download PDF

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Publication number
US20080033050A1
US20080033050A1 US11/499,586 US49958606A US2008033050A1 US 20080033050 A1 US20080033050 A1 US 20080033050A1 US 49958606 A US49958606 A US 49958606A US 2008033050 A1 US2008033050 A1 US 2008033050A1
Authority
US
United States
Prior art keywords
day
paroxetine
compound
amount
administered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/499,586
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English (en)
Inventor
Patricia Allison Tewes Richards
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guangxi Guoli New Material Technology Co Ltd
Noven Therapeutics LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39030027&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=US20080033050(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Priority to US11/499,586 priority Critical patent/US20080033050A1/en
Assigned to JDS PHARMACEUTICALS, LLC reassignment JDS PHARMACEUTICALS, LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: RICHARDS, PATRICIA ALLISON TEWES
Priority to ES13190594T priority patent/ES2699298T3/es
Priority to UAA200901871A priority patent/UA96770C2/uk
Priority to LTEP07810919.6T priority patent/LT2068881T/lt
Priority to EP07810919.6A priority patent/EP2068881B1/fr
Priority to JP2009522831A priority patent/JP5846717B2/ja
Priority to ES07810919T priority patent/ES2698207T3/es
Priority to PT07810919T priority patent/PT2068881T/pt
Priority to HUE07810919A priority patent/HUE040481T2/hu
Priority to DK07810919.6T priority patent/DK2068881T3/en
Priority to MEP-2009-37A priority patent/ME00592B/fr
Priority to BRPI0715087-3A2A priority patent/BRPI0715087A2/pt
Priority to DK13190594.5T priority patent/DK2719385T3/en
Priority to PL13190594T priority patent/PL2719385T3/pl
Priority to PT13190594T priority patent/PT2719385T/pt
Priority to CNA2007800289306A priority patent/CN101505759A/zh
Priority to SG2011081056A priority patent/SG176452A1/en
Priority to NZ574735A priority patent/NZ574735A/en
Priority to LTEP13190594.5T priority patent/LT2719385T/lt
Priority to PL07810919T priority patent/PL2068881T3/pl
Priority to KR1020097004195A priority patent/KR20090040453A/ko
Priority to PCT/US2007/017062 priority patent/WO2008019010A2/fr
Priority to SI200732079T priority patent/SI2719385T1/sl
Priority to RU2009107739/15A priority patent/RU2478379C2/ru
Priority to CA2659577A priority patent/CA2659577C/fr
Priority to MX2009001275A priority patent/MX2009001275A/es
Priority to RS20181413A priority patent/RS57980B1/sr
Priority to SI200732071T priority patent/SI2068881T1/sl
Priority to HUE13190594A priority patent/HUE040099T2/hu
Priority to KR1020147020772A priority patent/KR20140098865A/ko
Priority to EP13190594.5A priority patent/EP2719385B1/fr
Priority to KR1020157032729A priority patent/KR20150132888A/ko
Priority to RS20181386A priority patent/RS58046B1/sr
Priority to AU2007282065A priority patent/AU2007282065B2/en
Publication of US20080033050A1 publication Critical patent/US20080033050A1/en
Assigned to NOVEN THERAPEUTICS, LLC reassignment NOVEN THERAPEUTICS, LLC CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: JDS PHARMACEUTICALS, LLC
Priority to US12/292,960 priority patent/US8658663B2/en
Priority to IL196844A priority patent/IL196844A/en
Priority to NO20090639A priority patent/NO343176B1/no
Priority to US14/157,992 priority patent/US8946251B2/en
Priority to JP2014021171A priority patent/JP5895009B2/ja
Priority to US14/276,494 priority patent/US8859576B2/en
Priority to US14/577,227 priority patent/US9393237B2/en
Priority to US15/211,074 priority patent/US20170165251A1/en
Priority to US15/785,769 priority patent/US20200268733A9/en
Priority to HRP20181893TT priority patent/HRP20181893T1/hr
Priority to HRP20181925TT priority patent/HRP20181925T1/hr
Priority to CY181101219T priority patent/CY1120867T1/el
Priority to CY181101241T priority patent/CY1120902T1/el
Assigned to GUANGXI GUOLI NEW MATERIAL TECHNOLOGY CO., LTD. reassignment GUANGXI GUOLI NEW MATERIAL TECHNOLOGY CO., LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: GONG, Zuoyu
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Definitions

  • the present invention relates to a method for treating a patient suffering from a thermoregulatory dysfunction, especially hot flashes and flushes associated with hormonal changes due to naturally occurring menopause (whether male or female) or due to chemically or surgically induced menopause.
  • the method is also applicable to treating the hot flashes, hot flushes, or night sweats associated with disease states that disrupt normal hormonal regulation of body temperature.
  • the invention further relates to use of paroxetine or a salt thereof.
  • Hot flashes or flushes are most typically seen in women who are in the process of going through menopause, but are also seen in women who have undergone surgical or chemically induced menopause. They are also seen (less frequently) in men who are undergoing the so-called “male menopause” or who have undergone hormonal ablative therapy.
  • the hot flashes and flushes are connected with a disruption of the hormonal control of thermoregulatory function.
  • disease states which disrupt the normal hormonal control over thermoregulatory function also result in such hot flashes and flushes.
  • thermoregulatory dysfunctions have been hormonal replacement therapy primarily because of the known substantial fluctuations in estrogen levels.
  • serotonergic compounds such as serotonin receptor reuptake inhibitors
  • norepinepherine type compounds particularly norepinepherine uptake inhibitors
  • US 2006-0100263 relates to combinations of bicifadine and another drug for hot flashes.
  • Paroxetine is one of the “other” drugs mentioned as suitable for the combination therapy.
  • US 2006-0020015 claims the use of combinations of norepinepherine reuptake inhibitors in combination with serotonin reuptake inhibitors.
  • the '015 application also mentions that selective serotonin reuptake inhibitors are being clinically evaluated in hot flashes and particularly mentions that fluoxetine is mentioned in this context in WO 9944601. US 2006-0020014 and US 2004-0130987 have similar disclosures.
  • US 2004-1052710 mentions the use of serotonergic reuptake inhibitors in combination with norepinepherine reuptake inhibitors for the treatment of vasomotor symptoms (the class to which hot flashes and flushes belong) with paroxetine being specifically mentioned as one possible serotonin reuptake inhibitor.
  • US 2002-0042432 (now U.S. Pat. No. 6,369,051) claims the combinations of estrogenic substances with a selective serotonin reuptake inhibitor (SSRI) and paroxetine is specifically mentioned as one of the potential SSRIs for use in the claimed invention.
  • SSRI selective serotonin reuptake inhibitor
  • sertraline (another SSRI) was found to be effective to some degree in hot flashes as a standalone therapy in Trott, et al
  • Paroxetine is a well characterized molecule in the pharmaceutical and patent literature. Chemical processes for its manufacture are detailed in U.S. Pat. No. 4,861,893; U.S. Pat. No. 6,172,233; U.S. Pat. No. 6,326,496; U.S. Pat. No. 6,433,179; U.S. Pat. No. 6,541,637 U.S. Pat. No. 6,686,473; U.S. Pat. No. 6,716,985; U.S. Pat. No. 6,881,845; U.S. Pat. No. 6,900,327; and U.S. Pat. No. 6,956,121 to name a few.
  • US 2002/0193406; US 2002/0035130; and US 2001/0023253 disclose particularly the mesylate salt, but also many others.
  • US 2002/0090394 discloses controlled release compositions of paroxetine. Paroxetine has also been indicated for a wide range of treatments ranging from its use as an antidepressant (U.S. Pat. No. 4,007,196) to neurologic and mental disorders, (U.S. Pat. No. 5,470,846) to CNS disorders (U.S. Pat. No. 5,985,322) to treatments for nicotine withdrawal, premenstrual symptoms, post-traumatic stress disorder, heroin addiction, etc.
  • an antidepressant U.S. Pat. No. 4,007,196
  • neurologic and mental disorders U.S. Pat. No. 5,470,846
  • CNS disorders U.S. Pat. No. 5,985,322
  • Another object of the invention is to provide to a patient suffering from a thermoregulatory dysfunction a dosage form of paroxetine suitable for administration of from 0.1 mg/day to less than 10 mg/day.
  • Still another object of the invention is to provide to a patient suffering from a thermoregulatory dysfunction a treatment thereof with paroxetine that substantially avoids most and/or substantially reduces the side effects typically obtained from an antidepressant effective amount of paroxetine.
  • thermoregulatory dysfunction treatment using paroxetine as free base or a pharmaceutically acceptable salt thereof, in an anhydrate, a hydrate, or solvate form, in any non-crystalline or any crystalline polymorphic form of any of the foregoing in a dosage of from about 0.1 mg/day up to less than an antidepressant therapeutically effective amount of paroxetine.
  • the present invention is a method of treating a thermoregulatory dysfunction treatment using paroxetine as free base or a pharmaceutically acceptable salt thereof, in an anhydrate, a hydrate, or solvate form, in any non-crystalline or any crystalline polymorphic form of any of the foregoing in a dosage of from about 0.1 mg/day up to less than an antidepressant therapeutically effective amount of paroxetine.
  • the invention is also a dosage form of paroxetine in a dose which is less than that effective for its use as an antidepressant.
  • paroxetine may be in the form of the free base or any pharmaceutically acceptable salt thereof.
  • Pharmaceutically acceptable salts include, but are not limited to, hydohalides (such as hydrochloride, hydrobromide, hydroiodide), sufates (such as sulfate, bisulfate), phosphates (such as mono, di, or tri basic phosphate), oxalate, mesylate, tosylate, pamoate, citrate, carbonate, bicarbonate, maleate, malate, fumarate, as well as many others set forth in the patent references indicated in paragraph 0010 above.
  • the paroxetine is present as the free base, the hydrochloride salt, or the mesylate salt or mixtures thereof. Most preferably the paroxetine is present as the hydrochloride salt or the mesylate salt.
  • Paroxetine for use in the present invention may be in the anhydrate, hemihydrate, monohydrate, or higher hydrate forms. Paroxetine for use in the present invention may also be either amorphous or crystalline, the choice being made by the formulator depending upon the formulation and dissolution characteristics desired. Crystalline forms have better stability, but amorphous forms have faster dissolution profiles.
  • the dosage is about 0.1 mg/day up to less than an antidepressant effective amount of paroxetine (based on the free base, anhydrate); preferably up to about 9.5 mg/day.
  • the paroxetine can be administered to achieve the invention in amounts of at least 0.5 mg/day, more preferably at least 1 mg/day, still more preferably at least 2 mg/day, even more preferably at least 4 mg/day, up to preferably not more than about 9 mg/day, more preferably not more than about 8.5 mg/day, still more preferably not more than 8 mg/day.
  • Non-limiting dosages that are specifically suitable for the present invention include 2 mg/day, 2.5 mg/day, 3 mg/day, 3.5 mg/day, 4 mg/day, 4.5 mg/day, 5 mg/day, 5.5 mg/day, 6 mg/day, 6.5 mg/day, 7 mg/day, 7.5 mg/day, 8 mg/day, and 8.5 mg/day.
  • thermoregulatory dysfunction is applicable to the treatment of thermoregulatory dysfunction and in particular to such conditions (without limitation) as hot flushes, hot flashes, night sweats, etc. whether or not related to menopause (female or male), perimenopause, hormone ablative therapy (including, but not limited to, anti-estrogenic therapy and antiandrogenic therapy), treatments with other chemical agent or therapeutic agents that are antiestrogenic or antiandrogenic or interfere with thermoregulatory function, surgical procedures (such as, without limitation castration, hysterectomy, ooectomy, etc), and disease states interfering with normal thermoregulatory functioning.
  • hormone ablative therapy including, but not limited to, anti-estrogenic therapy and antiandrogenic therapy
  • treatments with other chemical agent or therapeutic agents that are antiestrogenic or antiandrogenic or interfere with thermoregulatory function surgical procedures (such as, without limitation castration, hysterectomy, ooectomy, etc), and disease states interfering with normal thermoregulatory functioning.
  • the present invention is directed to the treatment of perimenopausal and postmenopausal hot flashes, hot flushes and night sweats in women, whether due to aging, therapeutically induced menopause, or surgically induced menopause.
  • the invention is also preferably directed to hot flashes or hot flushes or night sweats in men whether such symptoms are due to aging, chemical castration, hormonal ablative therapy, or surgical castration.
  • paroxetine based on free base non-solvate, anhydrate
  • paroxetine based on free base non-solvate, anhydrate

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
US11/499,586 2006-08-04 2006-08-04 Method of treating thermoregulatory disfunction with paroxetine Abandoned US20080033050A1 (en)

Priority Applications (47)

Application Number Priority Date Filing Date Title
US11/499,586 US20080033050A1 (en) 2006-08-04 2006-08-04 Method of treating thermoregulatory disfunction with paroxetine
ES13190594T ES2699298T3 (es) 2006-08-04 2007-07-31 Método de tratamiento de la disfunción termorreguladora con paroxetina
UAA200901871A UA96770C2 (uk) 2006-08-04 2007-07-31 Спосіб лікування розладу терморегуляторної функції за допомогою пароксетину
LTEP07810919.6T LT2068881T (lt) 2006-08-04 2007-07-31 Termoreguliacinės disfunkcijos gydymo būdas su paroksetinu
EP07810919.6A EP2068881B1 (fr) 2006-08-04 2007-07-31 Méthode pour traiter un dysfonctionnement de thermorégulation avec de la paroxétine
JP2009522831A JP5846717B2 (ja) 2006-08-04 2007-07-31 パロキセチンによる体温調節機能障害の治療方法
ES07810919T ES2698207T3 (es) 2006-08-04 2007-07-31 Método de tratamiento de la disfunción termorreguladora con paroxetina
PT07810919T PT2068881T (pt) 2006-08-04 2007-07-31 Método de tratamento de disfunção termorreguladora com paroxetina
HUE07810919A HUE040481T2 (hu) 2006-08-04 2007-07-31 Eljárás hõszabályozás rendellenes mûködésének kezelésére paroxetinnel
DK07810919.6T DK2068881T3 (en) 2006-08-04 2007-07-31 PROCEDURE FOR TREATING TERMOREGULATORY DYSFUNCTION WITH PAROXETIN
MEP-2009-37A ME00592B (fr) 2006-08-04 2007-07-31 Méthode pour traiter un dysfonctionnement de thermorégulation avec de la paroxétine
BRPI0715087-3A2A BRPI0715087A2 (pt) 2006-08-04 2007-07-31 Método de tratamento de disfunção termoregulatória com paroxetina
DK13190594.5T DK2719385T3 (en) 2006-08-04 2007-07-31 Method of treating thermoregulatory dysfunction with paroxetine
PL13190594T PL2719385T3 (pl) 2006-08-04 2007-07-31 Sposób leczenia dysfunkcji termoregulacji za pomocą paroksetyny
PT13190594T PT2719385T (pt) 2006-08-04 2007-07-31 Método de tratamento de disfunção termorreguladora com paroxetina
CNA2007800289306A CN101505759A (zh) 2006-08-04 2007-07-31 使用帕罗西汀治疗体温调节障碍的方法
SG2011081056A SG176452A1 (en) 2006-08-04 2007-07-31 Method of treating thermoregulatory disfunction with paroxetine
NZ574735A NZ574735A (en) 2006-08-04 2007-07-31 Method of treating thermoregulatory disfunction with paroxetine
LTEP13190594.5T LT2719385T (lt) 2006-08-04 2007-07-31 Termoreguliacinės disfunkcijos gydymas paroksetinu
PL07810919T PL2068881T3 (pl) 2006-08-04 2007-07-31 Sposób leczenia dysfunkcji termoregulacji za pomocą paroksetyny
KR1020097004195A KR20090040453A (ko) 2006-08-04 2007-07-31 파록세틴으로 체온 조절 기능 이상을 치료하는 방법
PCT/US2007/017062 WO2008019010A2 (fr) 2006-08-04 2007-07-31 Méthode pour traiter un dysfonctionnement de thermorégulation avec de la paroxétine
SI200732079T SI2719385T1 (sl) 2006-08-04 2007-07-31 Metoda zdravljenja termoregulatorne disfunkcije s paroksetinom
RU2009107739/15A RU2478379C2 (ru) 2006-08-04 2007-07-31 Способ лечения расстройства терморегуляции
CA2659577A CA2659577C (fr) 2006-08-04 2007-07-31 Methode pour traiter un dysfonctionnement de thermoregulation avec de la paroxetine
MX2009001275A MX2009001275A (es) 2006-08-04 2007-07-31 Método para el tratamiento de disfunción termorreguladora con paroxetina.
RS20181413A RS57980B1 (sr) 2006-08-04 2007-07-31 Postupak lečenja termoregulacione disfunkcije paroksetinom
SI200732071T SI2068881T1 (sl) 2006-08-04 2007-07-31 Metoda za zdravljenje termoregulatorne disfunkcije s paroksetinom
HUE13190594A HUE040099T2 (hu) 2006-08-04 2007-07-31 Eljárás termoregulációs zavar kezelésére paroxetinnel
KR1020147020772A KR20140098865A (ko) 2006-08-04 2007-07-31 파록세틴으로 체온 조절 기능 이상을 치료하는 방법
EP13190594.5A EP2719385B1 (fr) 2006-08-04 2007-07-31 Méthode pour traiter un dysfonctionnement de thermorégulation avec de la paroxétine
KR1020157032729A KR20150132888A (ko) 2006-08-04 2007-07-31 파록세틴으로 체온 조절 기능 이상을 치료하는 방법
RS20181386A RS58046B1 (sr) 2006-08-04 2007-07-31 Postupak lečenja termoregulacione disfunkcije paroksetinom
AU2007282065A AU2007282065B2 (en) 2006-08-04 2007-07-31 Method of treating thermoregulatory disfunction with paroxetine
US12/292,960 US8658663B2 (en) 2006-08-04 2008-12-01 Method of treating thermoregulatory disfunction with paroxetine
IL196844A IL196844A (en) 2006-08-04 2009-02-02 Paroxetine for use in the treatment of out-of-control thermal disorders
NO20090639A NO343176B1 (no) 2006-08-04 2009-02-10 Fremgangsmåte for å behandle termoregulatorisk dysfunksjon med paroksetin
US14/157,992 US8946251B2 (en) 2006-08-04 2014-01-17 Method of treating thermoregulatory dysfunction with paroxetine
JP2014021171A JP5895009B2 (ja) 2006-08-04 2014-02-06 パロキセチンによる体温調節機能障害の治療方法
US14/276,494 US8859576B2 (en) 2006-08-04 2014-05-13 Method of treating thermoregulatory dysfunction with paroxetine
US14/577,227 US9393237B2 (en) 2006-08-04 2014-12-19 Method of treating thermoregulatory dysfunction with paroxetine
US15/211,074 US20170165251A1 (en) 2006-08-04 2016-07-15 Method of treating thermoregulatory dysfunction with paroxetine
US15/785,769 US20200268733A9 (en) 2006-08-04 2017-10-17 Method of treating thermoregulatory dysfunction with paroxetine
HRP20181893TT HRP20181893T1 (hr) 2006-08-04 2018-11-14 Metoda za liječenje termoregulatorne disfunkcije paroksetinom
HRP20181925TT HRP20181925T1 (hr) 2006-08-04 2018-11-19 Metoda za liječenje termoregulatorne disfunkcije paroksetinom
CY181101219T CY1120867T1 (el) 2006-08-04 2018-11-19 Μεθοδος αντιμετωπισης θερμορυθμιστικης δυσλειτουργιας με παροξετινη
CY181101241T CY1120902T1 (el) 2006-08-04 2018-11-23 Μεθοδος αντιμετωπισης θερμορυθμιστικης δυσλειτουργιας με παροξετινη

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/499,586 US20080033050A1 (en) 2006-08-04 2006-08-04 Method of treating thermoregulatory disfunction with paroxetine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/292,960 Continuation US8658663B2 (en) 2006-08-04 2008-12-01 Method of treating thermoregulatory disfunction with paroxetine

Publications (1)

Publication Number Publication Date
US20080033050A1 true US20080033050A1 (en) 2008-02-07

Family

ID=39030027

Family Applications (7)

Application Number Title Priority Date Filing Date
US11/499,586 Abandoned US20080033050A1 (en) 2006-08-04 2006-08-04 Method of treating thermoregulatory disfunction with paroxetine
US12/292,960 Active 2029-04-06 US8658663B2 (en) 2006-08-04 2008-12-01 Method of treating thermoregulatory disfunction with paroxetine
US14/157,992 Active US8946251B2 (en) 2006-08-04 2014-01-17 Method of treating thermoregulatory dysfunction with paroxetine
US14/276,494 Active US8859576B2 (en) 2006-08-04 2014-05-13 Method of treating thermoregulatory dysfunction with paroxetine
US14/577,227 Active US9393237B2 (en) 2006-08-04 2014-12-19 Method of treating thermoregulatory dysfunction with paroxetine
US15/211,074 Abandoned US20170165251A1 (en) 2006-08-04 2016-07-15 Method of treating thermoregulatory dysfunction with paroxetine
US15/785,769 Abandoned US20200268733A9 (en) 2006-08-04 2017-10-17 Method of treating thermoregulatory dysfunction with paroxetine

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US14/276,494 Active US8859576B2 (en) 2006-08-04 2014-05-13 Method of treating thermoregulatory dysfunction with paroxetine
US14/577,227 Active US9393237B2 (en) 2006-08-04 2014-12-19 Method of treating thermoregulatory dysfunction with paroxetine
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Cited By (4)

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US8859576B2 (en) 2006-08-04 2014-10-14 Noven Therapeutics, Llc Method of treating thermoregulatory dysfunction with paroxetine
US8946251B2 (en) 2006-08-04 2015-02-03 Noven Therapeutics, Llc Method of treating thermoregulatory dysfunction with paroxetine
US9393237B2 (en) 2006-08-04 2016-07-19 Noven Therapeutics, Llc Method of treating thermoregulatory dysfunction with paroxetine
US20160136148A1 (en) * 2012-12-31 2016-05-19 Noven Therapeutics, Llc Solid dispersions of amorphous paroxetine mesylate

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