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US1510260A - Capsule - Google Patents

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Publication number
US1510260A
US1510260A US481684A US48168421A US1510260A US 1510260 A US1510260 A US 1510260A US 481684 A US481684 A US 481684A US 48168421 A US48168421 A US 48168421A US 1510260 A US1510260 A US 1510260A
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United States
Prior art keywords
bodies
capsule
series
open
hollow
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Expired - Lifetime
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US481684A
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Lloyd W Cyrenius
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Individual
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Priority to US481684A priority Critical patent/US1510260A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S206/00Special receptacle or package
    • Y10S206/82Separable, striplike plural articles
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S220/00Receptacles
    • Y10S220/34Anti-tamper pharmaceutical capsules, e.g. tamper indicating or resistant

Definitions

  • the present invention relates to improve-. ments in capsules or containers for medicaments and more particularly the invention refersto certain improvements in capsules or the like by which the capsule issealed and the contents thereof hermetically enclosed to avoid the possibility of contam- With the foregoing and other objects in view, the invention will be more fully described hereinafter, and will be more particularly pointed out in the claims appended hereto.
  • Fig. 1 is a perspective view of an im-' proved capsule constructed according to the present invention
  • Fig. 2 is a side viewthereof
  • Fig. 3 is a longitudinal sectional view therethrough
  • Fig. 4 is a plan view of'a built up series of the capsule elements
  • Fig. 5 is a similar vlew showing a portion of the device broken away and one of the" cagsule bodies detached.
  • gelatine body 2 is of a construction and form corresponding, substantially to one of the complemental parts of capsules as now con--.
  • the end wall 4 is rounded or constructed on a section of a sphere as is usual in capsules, the other end being left open.
  • a second gelatine body similar to the body 2 having an open mouth fitted within or about the open mouth of said body12 and cooperating therewith to provide an inner chamber of sufiicient size to accommodate the dose.
  • the cap piece 3 is of a relatively infcrior length as compared with the body 2' Unlike this customary construe and is formed with a rounded or spherical closed end wall 5 adapted to be fitted within the open mouth of the capsule body 2 and to have a tight frictional fit therein to effectively hold the capvpiece in place.
  • the curvature of the end wall 5 will guide the cap piece into the mouth of the body and desirably a slight extension, such as indicated in Fig. 3, will take place in the mouth of the body 2 to afford a better gripping action of the body on the cap piece.
  • the piece 3 is also preferably made of'gelatine and is hollow inside. After the cap piece 3 is in place, the outer openend thereof is preferably sealed over by a gelatin layer 6 or other suitable material to prevent the entrance of foreign matter into the hollow interior of the cap piece which might make the appearance of the article unsanitary.
  • a coating or annular 'oint 7 of gelatin or some other sealing su stance is placed about the mouth of the body 2 at the meeting point therewith of the cap piece 3.
  • the function of this joint is to hermetically seal the capsule body and to avoid the entrance of foreign materials or harmful bacteria which would interfere with the sterile condition of the medicament within, and to hold the parts together.
  • a number of the bodies 2 are shown fitted in series with the rounded ends 4 projecting into the mouths of adjacent bodies substantially the same distance as the cap piece.
  • Each of the bodies is sealed by a ring 7 of gelatin or the like.
  • Sucha construction provides a series of compartments or containing chambers in which successive doses may be placed and all held in an integral unitary. containing capsule.
  • bodies may he slipped uponone another to greater or less extent in order that the coma single article and cap pieces are dispensed with for all of the bodies except the last in the series, thus economizing to a large extent in the matter of material .and making it possible to commercially put up medic-a5 ments at lower cost.
  • gelatine bodies 2 are broken off from the left side of the built up capsule, Fig.5 showing the first in the series to have been removed. In like manner the remaining bodies are detached from-time to time until the whole is consumed, the last dose for instance being procured by the removal of the cap piece 3.
  • the annular coating 7 may with advantage be asolution of celluloid as this material is very effective in its adherence to gelatine .and will unite and incorporate the parts very closely, and it moreover possesses advantages in its resistance to climatic and atmospheric conditions and it is impervious to water, mois ture and most foreign substances.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Description

Sept. 30, 1924.
L. w. CYRENIUS CAPSULE Filed Jun e Patented Sept. 30, 1924.
eia.
an ice.
LLOYD CYRENIUS, OF NEW YORK, N.
CAPSULE.
Application filed June so, 1921. Serial No. 481,684.
. To all whom it may concern:
Be it known that LLOYD W. CYRENIUS, a citizen of the United States, residing at New York, in the county of New York and State of New York, has invented new and useful Improvements inCapsules, of which the following is a specification.
The present invention relates to improve-. ments in capsules or containers for medicaments and more particularly the invention refersto certain improvements in capsules or the like by which the capsule issealed and the contents thereof hermetically enclosed to avoid the possibility of contam- With the foregoing and other objects in view, the invention will be more fully described hereinafter, and will be more particularly pointed out in the claims appended hereto.
In the drawings, wherein like symbols refer to like or corresponding parts throughout the several views,
Fig. 1 is a perspective view of an im-' proved capsule constructed according to the present invention;
Fig. 2 is a side viewthereof;
Fig. 3 is a longitudinal sectional view therethrough Fig. 4 is a plan view of'a built up series of the capsule elements; and Fig. 5 is a similar vlew showing a portion of the device broken away and one of the" cagsule bodies detached.
eferring more particularly to the drawings, in Figs. 1, 2 and 3, I have illustrated.
a form of the invention in which a single compartment 1 is furnished for but one dose of the medicament which is filled therein through the mouth of the gelatine body 2 before the cap 3 is put in place. The
gelatine body 2 is of a construction and form corresponding, substantially to one of the complemental parts of capsules as now con--.
structed, except that in most'instances the body 2 will be of a greater length in order to hold the desired dose. The end wall 4 is rounded or constructed on a section of a sphere as is usual in capsules, the other end being left open.
As capsules are at present constructed, a second gelatine body similar to the body 2 is used having an open mouth fitted within or about the open mouth of said body12 and cooperating therewith to provide an inner chamber of sufiicient size to accommodate the dose.
tion, the cap piece 3 is of a relatively infcrior length as compared with the body 2' Unlike this customary construe and is formed with a rounded or spherical closed end wall 5 adapted to be fitted within the open mouth of the capsule body 2 and to have a tight frictional fit therein to effectively hold the capvpiece in place. The curvature of the end wall 5 will guide the cap piece into the mouth of the body and desirably a slight extension, such as indicated in Fig. 3, will take place in the mouth of the body 2 to afford a better gripping action of the body on the cap piece.' The cap,
piece 3 is also preferably made of'gelatine and is hollow inside. After the cap piece 3 is in place, the outer openend thereof is preferably sealed over by a gelatin layer 6 or other suitable material to prevent the entrance of foreign matter into the hollow interior of the cap piece which might make the appearance of the article unsanitary.
Furthermore a coating or annular 'oint 7 of gelatin or some other sealing su stance is placed about the mouth of the body 2 at the meeting point therewith of the cap piece 3. The function of this joint is to hermetically seal the capsule body and to avoid the entrance of foreign materials or harmful bacteria which would interfere with the sterile condition of the medicament within, and to hold the parts together.
Referring more particularly to Figs. 4 and 5, a number of the bodies 2 are shown fitted in series with the rounded ends 4 projecting into the mouths of adjacent bodies substantially the same distance as the cap piece. Each of the bodies is sealed by a ring 7 of gelatin or the like. Sucha construction provides a series of compartments or containing chambers in which successive doses may be placed and all held in an integral unitary. containing capsule. If desired, bodies may he slipped uponone another to greater or less extent in order that the coma single article and cap pieces are dispensed with for all of the bodies except the last in the series, thus economizing to a large extent in the matter of material .and making it possible to commercially put up medic-a5 ments at lower cost. The gelatine bodies 2 are broken off from the left side of the built up capsule, Fig.5 showing the first in the series to have been removed. In like manner the remaining bodies are detached from-time to time until the whole is consumed, the last dose for instance being procured by the removal of the cap piece 3.
Of course the order may be reversed and the cap piece 3 initially removed thus progressing from right to left as shown in Figs. 4 and 5, but this is not believed to be asdesirable an arrangement, as the open ends of the bodies from which a dose has just been delivered are apt to form pockets for foreign matter and contamination and on the whole the sanitary purpose of the article will not be so well subserved. The annular coating 7 may with advantage be asolution of celluloid as this material is very effective in its adherence to gelatine .and will unite and incorporate the parts very closely, and it moreover possesses advantages in its resistance to climatic and atmospheric conditions and it is impervious to water, mois ture and most foreign substances.
It is obvious that various changes and modifications may be made in the details of construction and design of the above specifias my bodies throughout the series, and aclosure member for the last body of the series.
2.- A package containing a plurality of gelatinous hollow bodies, each closed at one end and open at its other end and having an enlarged diameter thereat extending for a portion of the length of the hollow body, said hollow bodies being adapted to be interfitted with the closed end of one body in the open enlarged end of the adjacent body to close said bodies ,one with the other throughout the series, a hollow gelatinous plug having a closed end and fitting there- 'at in the open end of the last body of the series for closing the same, and a closure for the open end of said plug.
3. A package containing a plurality of gelatinous hollow bodies closed at one end' and open at their other ends andenlarged thereat for interfitting with the closed ends in the enlarged ends throughout the series for closing the hollow bodies one with the other, a hollow gelatinous plug having a closed end fitting in the open end of the last hollow body of the series, a closure for the open end of said plug, and a layer of sealing material arranged between the contacting surfaces of said bodies, plug and closure for. sealing the interiors of the same.
In testimony that I claim the foregoing hereunder.
- LLOYD W. CYRENIUS.
invention, I have signed my name
US481684A 1921-06-30 1921-06-30 Capsule Expired - Lifetime US1510260A (en)

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Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2473368A (en) * 1944-02-25 1949-06-14 Flintermann Gerhard Suppository
US2640623A (en) * 1951-06-07 1953-06-02 Irvin C Ryder Compartmented container
US2808691A (en) * 1949-05-10 1957-10-08 Moore Howard Nelson Individual packaging machine
US3186910A (en) * 1962-03-08 1965-06-01 Jacob A Glassman Method for producing peroral capsules
US3236369A (en) * 1962-11-09 1966-02-22 George W Moore Compartmented package
EP0274345A1 (en) * 1986-11-13 1988-07-13 Warner-Lambert Company Dividable capsule
US4936461A (en) * 1986-09-18 1990-06-26 Makiej Jr Walter J Multidose capsules
US5042663A (en) * 1989-05-05 1991-08-27 Richard Heinrich Joinable inflatable bladders for packaging
US5074426A (en) * 1986-11-13 1991-12-24 Warner-Lambert Company Dividable capsule
WO2001022914A1 (en) * 1999-09-27 2001-04-05 Badalamenti Michael J Teething gel applicator with cutter, and burstable ampule and method of making the same
US9340004B2 (en) 2011-10-06 2016-05-17 Bio Capsule Pharmaceutical And Nutritional Products (Pty) Ltd. Method and apparatus for manufacturing a capsule
US9456987B2 (en) 2013-04-03 2016-10-04 Binutra, Inc. Capsule with internal diaphragm
US20180289625A1 (en) * 2015-10-09 2018-10-11 Combocap, Inc. Capsule with volume-adjustable internal diaphragm
US20190307699A1 (en) * 2017-07-10 2019-10-10 Gel Cap Technologies, LLC Dual release dosage form capsule and methods, devices and systems for making same

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2473368A (en) * 1944-02-25 1949-06-14 Flintermann Gerhard Suppository
US2808691A (en) * 1949-05-10 1957-10-08 Moore Howard Nelson Individual packaging machine
US2640623A (en) * 1951-06-07 1953-06-02 Irvin C Ryder Compartmented container
US3186910A (en) * 1962-03-08 1965-06-01 Jacob A Glassman Method for producing peroral capsules
US3236369A (en) * 1962-11-09 1966-02-22 George W Moore Compartmented package
US4936461A (en) * 1986-09-18 1990-06-26 Makiej Jr Walter J Multidose capsules
EP0274345A1 (en) * 1986-11-13 1988-07-13 Warner-Lambert Company Dividable capsule
US5074426A (en) * 1986-11-13 1991-12-24 Warner-Lambert Company Dividable capsule
US5042663A (en) * 1989-05-05 1991-08-27 Richard Heinrich Joinable inflatable bladders for packaging
US6361552B1 (en) 1998-03-25 2002-03-26 Michael J. Badalamenti Teething gel applicator with cutter, and burstable ampule and method of making the same
WO2001022914A1 (en) * 1999-09-27 2001-04-05 Badalamenti Michael J Teething gel applicator with cutter, and burstable ampule and method of making the same
US9340004B2 (en) 2011-10-06 2016-05-17 Bio Capsule Pharmaceutical And Nutritional Products (Pty) Ltd. Method and apparatus for manufacturing a capsule
US10046549B2 (en) * 2011-10-06 2018-08-14 Combocap, Inc. Method and apparatus for manufacturing a capsule
US20180264798A1 (en) * 2011-10-06 2018-09-20 Combocap, Inc. Method and apparatus for manufacturing a capsule
US12043018B2 (en) * 2011-10-06 2024-07-23 Combocap, Inc. Method and apparatus for manufacturing a capsule
US9456987B2 (en) 2013-04-03 2016-10-04 Binutra, Inc. Capsule with internal diaphragm
US11478429B2 (en) 2015-10-09 2022-10-25 Combocap, Inc. Capsule with internal diaphragm and solid ingredients
US11160759B1 (en) 2015-10-09 2021-11-02 Combocap, Inc. Capsule with internal diaphragm for improved bioavailability
US11357732B2 (en) * 2015-10-09 2022-06-14 Combocap, Inc. Capsule with volume-adjustable internal diaphragm
US20180289625A1 (en) * 2015-10-09 2018-10-11 Combocap, Inc. Capsule with volume-adjustable internal diaphragm
US20190307699A1 (en) * 2017-07-10 2019-10-10 Gel Cap Technologies, LLC Dual release dosage form capsule and methods, devices and systems for making same
US11944707B2 (en) * 2017-07-10 2024-04-02 Gel Cap Technologies, LLC Dual release dosage form capsule and methods, devices and systems for making same
US20240307315A1 (en) * 2017-07-10 2024-09-19 Gel Cap Technologies, LLC Dual release dosage form capsule and methods, devices and systems for making same

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