UA81499C2 - Pharmaceutical composition containing histone deacetylase inhibitor - Google Patents

Pharmaceutical composition containing histone deacetylase inhibitor

Info

Publication number: UA81499C2
Authority: UA; Ukraine
Prior art keywords: pharmaceutical composition; composition containing; histone deacetylase; deacetylase inhibitor; containing histone
Prior art date: 2003-05-26

Application number

UAA200512454A

Other languages

English (en)

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-05-26

Filing date

2004-05-26

Publication date

2008-01-10

2004-05-26 Application filed by Schering Ag filed Critical Schering Ag

2008-01-10 Publication of UA81499C2 publication Critical patent/UA81499C2/xx

Links

229940121372 histone deacetylase inhibitor Drugs 0.000 title 1
239000003276 histone deacetylase inhibitor Substances 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
INVTYAOGFAGBOE-UHFFFAOYSA-N entinostat Chemical compound NC1=CC=CC=C1NC(=O)C(C=C1)=CC=C1CNC(=O)OCC1=CC=CN=C1 INVTYAOGFAGBOE-UHFFFAOYSA-N 0.000 abstract 2
102000003893 Histone acetyltransferases Human genes 0.000 abstract 1
108090000246 Histone acetyltransferases Proteins 0.000 abstract 1
239000013543 active substance Substances 0.000 abstract 1
230000001093 anti-cancer Effects 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
229940041181 antineoplastic drug Drugs 0.000 abstract 1
230000002195 synergetic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyridine Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

UAA200512454A 2003-05-26 2004-05-26 Pharmaceutical composition containing histone deacetylase inhibitor UA81499C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2003148073		2003-05-26
PCT/JP2004/007562 WO2004103369A1 (en)	2003-05-26	2004-05-26	Pharmaceutical composition containing histone deacetylase inhibitor

Publications (1)

Publication Number	Publication Date
UA81499C2 true UA81499C2 (en)	2008-01-10

Family

ID=33475383

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UAA200512454A UA81499C2 (en)	2003-05-26	2004-05-26	Pharmaceutical composition containing histone deacetylase inhibitor

Country Status (27)

Country	Link
US (1)	US20070098816A1 (xx)
EP (1)	EP1626719A1 (xx)
JP (1)	JP2006526031A (xx)
KR (1)	KR100938712B1 (xx)
CN (2)	CN1794991A (xx)
AR (1)	AR045318A1 (xx)
AU (1)	AU2004241873C1 (xx)
BR (1)	BRPI0410959A (xx)
CA (4)	CA2527191A1 (xx)
CL (1)	CL2004001278A1 (xx)
CO (1)	CO5660262A2 (xx)
CR (1)	CR8163A (xx)
CU (1)	CU23490B7 (xx)
EC (1)	ECSP056253A (xx)
IL (1)	IL171941A0 (xx)
ME (1)	MEP32308A (xx)
MX (1)	MXPA05012345A (xx)
NO (1)	NO20055417L (xx)
NZ (1)	NZ543591A (xx)
PE (1)	PE20050206A1 (xx)
RS (1)	RS20050884A (xx)
RU (1)	RU2322971C2 (xx)
TW (1)	TW200505424A (xx)
UA (1)	UA81499C2 (xx)
UY (1)	UY28330A1 (xx)
WO (1)	WO2004103369A1 (xx)
ZA (1)	ZA200509515B (xx)

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US7244853B2 (en)	2001-05-09	2007-07-17	President And Fellows Of Harvard College	Dioxanes and uses thereof
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PL2263694T3 (pl)	2003-09-25	2013-11-29	Astellas Pharma Inc	Środek przeciwnowotworowy zawierający FK228 jako inhibitor deacetylazy histonowej i doksorubicynę jako inhibitor topoizomerazy II
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JP2008533053A (ja) *	2005-03-11	2008-08-21	ザリージェンツオブザユニバーシティオブコロラド	ヒストン脱アセチル化酵素阻害剤は、がん細胞を上皮増殖因子受容体阻害剤に対して感受性にする
JP5744376B2 (ja)	2005-03-22	2015-07-08	プレジデントアンドフェローズオブハーバードカレッジ	タンパク質分解障害の治療
JP2008540574A (ja)	2005-05-11	2008-11-20	タケダサンディエゴインコーポレイテッド	ヒストンデアセチラーゼ阻害剤
EA200800321A1 (ru)	2005-07-14	2008-06-30	Такеда Сан Диего, Инк.	Ингибиторы гистондеацетилазы
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RU2515611C2 (ru)	2008-07-23	2014-05-20	Президент Энд Феллоуз Оф Гарвард Колледж	Ингибиторы деацетилазы и их применение
CN102137846B (zh) *	2008-08-29	2014-04-23	拜耳知识产权有限责任公司	N-(2-氨基苯基)-4-[n-(吡啶-3-基)甲氧基羰基氨基甲基]苯甲酰胺(ms-275)多晶型物b
GB2462893B (en) *	2008-08-29	2010-10-13	Bayer Schering Pharma Ag	N-(2-aminophenyl)-4-[N-(pyridine-3-yl)-methoxycarbonyl-aminomethyl]-benzamide (MS-275) polymorph B
MX2011006503A (es)	2008-12-19	2011-09-06	Vertex Pharma	Derivados de pirazina utiles como inhibidores de la cinasa de atr.
EP2395972A4 (en) *	2009-02-11	2014-02-12	Liangping Yu	PARTICULATE COMPOSITION AND METHOD FOR PRODUCING THE SAME
US20120128667A1 (en) *	2009-05-01	2012-05-24	Oncozyme Pharma Inc.	Pentamidine combinations for treating cancer
EP2440519A1 (en) *	2009-06-08	2012-04-18	Gilead Sciences, Inc.	Alkanoylamino benzamide aniline hdac inihibitor compounds
US8716344B2 (en)	2009-08-11	2014-05-06	President And Fellows Of Harvard College	Class- and isoform-specific HDAC inhibitors and uses thereof
KR20120053052A (ko) *	2009-08-25	2012-05-24	아브락시스 바이오사이언스, 엘엘씨	헤지호그 억제제 및 탁산의 나노입자 조성물로의 조합 요법
CA2798763A1 (en)	2010-05-12	2011-11-17	Vertex Pharmaceuticals Incorporated	Compounds useful as inhibitors of atr kinase
CN103917231B (zh)	2011-09-13	2016-09-28	药品循环有限责任公司	组蛋白脱乙酰酶抑制剂与苯达莫司汀的联合制剂及其用途
US20130089626A1 (en) *	2011-09-30	2013-04-11	Vertex Pharmaceuticals Incorporated	Treating Cancer with ATR Inhibitors
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WO2013085902A1 (en) *	2011-12-05	2013-06-13	The University Of Texas M.D.	Combination therapy methods for treating an inflammatory breast cancer
PL2833973T3 (pl)	2012-04-05	2018-02-28	Vertex Pharmaceuticals Incorporated	Związki użyteczne jako inhibitory kinazy ATR i ich terapie skojarzone
EP2904406B1 (en)	2012-10-04	2018-03-21	Vertex Pharmaceuticals Incorporated	Method for measuring atr inhibition mediated increases in dna damage
WO2014164708A1 (en) *	2013-03-12	2014-10-09	Quanticel Pharmaceuticals, Inc.	Histone dementhylase inhibitors
US9963452B2 (en) *	2013-03-14	2018-05-08	Augusta Pharmaceuticals Inc.	Methods, compounds, and compositions for inhibition of ROS
EA201592012A8 (ru) *	2014-02-21	2018-10-31	Общество С Ограниченной Ответственностью "Биолаб 612"	Применение флагеллина для улучшенной химиотерапии
KR20170048601A (ko)	2014-09-17	2017-05-08	셀젠 콴티셀 리서치, 인크.	히스톤 탈메틸효소 억제제
US11464774B2 (en)	2015-09-30	2022-10-11	Vertex Pharmaceuticals Incorporated	Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors
TWI808055B (zh)	2016-05-11	2023-07-11	美商滬亞生物國際有限公司	Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh)	2016-05-11	2023-03-01	美商滬亞生物國際有限公司	Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
US11596612B1 (en)	2022-03-08	2023-03-07	PTC Innovations, LLC	Topical anesthetics
WO2025041160A1 (en) *	2023-08-19	2025-02-27	Birla Institute Of Technology And Science (Bits), Pilani	Bifunctional conjugate molecules for cancer treatment and process of making the same

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US6794392B1 (en) *	1996-09-30	2004-09-21	Schering Aktiengesellschaft	Cell differentiation inducer
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JP2003137866A (ja) *	2001-11-01	2003-05-14	Sankyo Co Ltd	フェニレンジアミン誘導体

2004
- 2004-05-25 PE PE2004000533A patent/PE20050206A1/es not_active Application Discontinuation
- 2004-05-26 CA CA002527191A patent/CA2527191A1/en not_active Abandoned
- 2004-05-26 TW TW093114934A patent/TW200505424A/zh unknown
- 2004-05-26 ME MEP-323/08A patent/MEP32308A/xx unknown
- 2004-05-26 RS YUP-2005/0884A patent/RS20050884A/sr unknown
- 2004-05-26 EP EP04734923A patent/EP1626719A1/en not_active Withdrawn
- 2004-05-26 CA CA002634765A patent/CA2634765A1/en not_active Abandoned
- 2004-05-26 US US10/558,208 patent/US20070098816A1/en not_active Abandoned
- 2004-05-26 CL CL200401278A patent/CL2004001278A1/es unknown
- 2004-05-26 AR ARP040101807A patent/AR045318A1/es not_active Application Discontinuation
- 2004-05-26 NZ NZ543591A patent/NZ543591A/en unknown
- 2004-05-26 WO PCT/JP2004/007562 patent/WO2004103369A1/en active Application Filing
- 2004-05-26 UA UAA200512454A patent/UA81499C2/xx unknown
- 2004-05-26 BR BRPI0410959-7A patent/BRPI0410959A/pt not_active IP Right Cessation
- 2004-05-26 RU RU2005140570/15A patent/RU2322971C2/ru active IP Right Revival
- 2004-05-26 CA CA002634709A patent/CA2634709A1/en not_active Abandoned
- 2004-05-26 JP JP2006519178A patent/JP2006526031A/ja active Pending
- 2004-05-26 MX MXPA05012345A patent/MXPA05012345A/es active IP Right Grant
- 2004-05-26 AU AU2004241873A patent/AU2004241873C1/en not_active Ceased
- 2004-05-26 UY UY28330A patent/UY28330A1/es not_active Application Discontinuation
- 2004-05-26 CN CNA2004800146332A patent/CN1794991A/zh active Pending
- 2004-05-26 CA CA002634766A patent/CA2634766A1/en not_active Abandoned
- 2004-05-26 CN CNA2008101007303A patent/CN101322707A/zh active Pending
- 2004-05-26 KR KR1020057022615A patent/KR100938712B1/ko not_active Expired - Fee Related
2005
- 2005-11-14 IL IL171941A patent/IL171941A0/en unknown
- 2005-11-16 NO NO20055417A patent/NO20055417L/no not_active Application Discontinuation
- 2005-11-24 ZA ZA200509515A patent/ZA200509515B/en unknown
- 2005-11-25 CU CU20050237A patent/CU23490B7/es not_active IP Right Cessation
- 2005-12-22 CO CO05129159A patent/CO5660262A2/es unknown
- 2005-12-26 EC EC2005006253A patent/ECSP056253A/es unknown
2006
- 2006-01-02 CR CR8163A patent/CR8163A/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
CL2004001278A1 (es)	2005-05-06
RU2322971C2 (ru)	2008-04-27
MEP32308A (en)	2010-10-10
AU2004241873A1 (en)	2004-12-02
UY28330A1 (es)	2004-12-31
JP2006526031A (ja)	2006-11-16
NO20055417L (no)	2005-12-19
CO5660262A2 (es)	2006-07-31
RS20050884A (xx)	2008-04-04
MXPA05012345A (es)	2006-02-08
US20070098816A1 (en)	2007-05-03
AU2004241873B8 (en)	2008-05-29
PE20050206A1 (es)	2005-03-26
NZ543591A (en)	2009-09-25
AR045318A1 (es)	2005-10-26
CA2634709A1 (en)	2004-12-02
ZA200509515B (en)	2006-07-26
CN1794991A (zh)	2006-06-28
CA2634766A1 (en)	2004-12-02
AU2004241873B2 (en)	2008-05-08
KR20060009371A (ko)	2006-01-31
KR100938712B1 (ko)	2010-01-25
EP1626719A1 (en)	2006-02-22
CN101322707A (zh)	2008-12-17
CR8163A (es)	2006-07-14
CA2527191A1 (en)	2004-12-02
RU2005140570A (ru)	2006-06-10
TW200505424A (en)	2005-02-16
IL171941A0 (en)	2006-04-10
ECSP056253A (es)	2006-10-25
BRPI0410959A (pt)	2006-07-04
WO2004103369A1 (en)	2004-12-02
NO20055417D0 (no)	2005-11-16
CU23490B7 (es)	2010-02-23
AU2004241873C1 (en)	2009-01-22
CA2634765A1 (en)	2004-12-02

Publication	Publication Date	Title
UA81499C2 (en)	2008-01-10	Pharmaceutical composition containing histone deacetylase inhibitor
BRPI0410727A (pt)	2006-06-20	composto, composição farmacêutica, e, uso de um composto
NO20055216D0 (no)	2005-11-04	Nye hydroksamater som terapeutiske midler
BR0308081A (pt)	2004-12-21	Inibidores de histona desacetilase
PL370982A1 (en)	2005-06-13	Carbonylamino-derivatives as novel inhibitors of histone deacetylase
PL371036A1 (en)	2005-06-13	Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase
MXPA06000013A (es)	2006-03-21	Agente terapeutico para sarcoma de tejido suave.
EA200801492A1 (ru)	2008-10-30	Фармацевтическое применение замещенных амидов
MY142177A (en)	2010-10-15	Benzamide derivatives useful as histone deacetylase inhibitors
NO20033732L (no)	2003-10-22	N-substituerte ikke-aryl-heterosykliske NMDA/NR2B-antagonister, og farmasoytiske preparater som omfatter slike forbindelser.
MXPA04007775A (es)	2004-10-15	Derivados de sulfonilo como novedosos inhibidores de la histona desacetilasa.
WO2008101907A3 (en)	2008-10-23	N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
ZA200708749B (en)	2009-08-26	Hydroxamates as histone deacetylase inhibitors and pharmaceutical formulations containing them
TW200638927A (en)	2006-11-16	Bambuterol and integrin inhibitor combination
GB2427405A (en)	2006-12-27	Novel hydroxamates as therapeutic agents
MXPA02010828A (es)	2004-07-16	Composicion farmaceutica en capsulas que comprende un antiinflamatorio no esteroideo y un analgesico opiaceo para el manejo del dolor.
PA8633001A1 (es)	2006-12-07	Composicion farmaceutica antimicobacterial
MX2008008470A (es)	2008-09-26	Nuevos derivados pirrolicos con actividad inhibidora de desacetilasa de histonas.
TW200640464A (en)	2006-12-01	Pharmaceutical composition comprising phenoxazinium compounds as an active ingredient
ATE402703T1 (de)	2008-08-15	Tablette enthaltend efletirizin und pseudoephedrin
TH81162A (th)	2006-11-16	สารผสมทางเภสัชกรรมที่มีตัวยับยั้งฮิสโตนดีอะซีทิลเลส
TH81162B (th)	2006-11-16	สารผสมทางเภสัชกรรมที่มีตัวยับยั้งฮิสโตนดีอะซีทิลเลส
MY140524A (en)	2009-12-31	Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase