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TW200600499A - Novel amido-substituted hydroxy-6-phenylphenanthridines - Google Patents

Novel amido-substituted hydroxy-6-phenylphenanthridines

Info

Publication number
TW200600499A
TW200600499A TW094107344A TW94107344A TW200600499A TW 200600499 A TW200600499 A TW 200600499A TW 094107344 A TW094107344 A TW 094107344A TW 94107344 A TW94107344 A TW 94107344A TW 200600499 A TW200600499 A TW 200600499A
Authority
TW
Taiwan
Prior art keywords
phenylphenanthridines
substituted hydroxy
novel amido
novel
amido
Prior art date
Application number
TW094107344A
Other languages
English (en)
Inventor
Ulrich Kautz
Beate Schmidt
Dieter Flockerzi
Armin Hatzelmann
Christof Zitt
Johannes Barsig
Degenhard Marx
Hans-Peter Kley
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of TW200600499A publication Critical patent/TW200600499A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Emergency Medicine (AREA)
TW094107344A 2004-03-10 2005-03-10 Novel amido-substituted hydroxy-6-phenylphenanthridines TW200600499A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04100990 2004-03-10
EP04106677 2004-12-17

Publications (1)

Publication Number Publication Date
TW200600499A true TW200600499A (en) 2006-01-01

Family

ID=34965034

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094107344A TW200600499A (en) 2004-03-10 2005-03-10 Novel amido-substituted hydroxy-6-phenylphenanthridines

Country Status (15)

Country Link
US (1) US20070185149A1 (zh)
EP (1) EP1725534A1 (zh)
JP (1) JP2007527901A (zh)
KR (1) KR20060130697A (zh)
CN (1) CN1926113B (zh)
AR (1) AR049324A1 (zh)
AU (1) AU2005221832A1 (zh)
BR (1) BRPI0508481A (zh)
CA (1) CA2558391A1 (zh)
IL (1) IL177496A0 (zh)
MX (1) MXPA06009892A (zh)
NO (1) NO20064415L (zh)
NZ (1) NZ549254A (zh)
TW (1) TW200600499A (zh)
WO (1) WO2005087745A1 (zh)

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GB0316915D0 (en) 2003-07-18 2003-08-20 Glaxo Group Ltd Compounds
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RS52916B (en) * 2004-03-03 2014-02-28 Takeda Gmbh NEW HYDROXY-6-HETEROARYLPHENANTRIDINES AND THEIR USE AS PDE4 INHIBITORS
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
JP5009799B2 (ja) 2004-09-08 2012-08-22 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規の３−オキサ−１０−アザ−フェナントレン
EP1791847A2 (en) 2004-09-08 2007-06-06 Altana Pharma AG Novel 3-thia-10-aza-phenanthrene derivatives
BRPI0607645A2 (pt) * 2005-03-02 2009-09-22 Nycomed Gmbh sais de derivados de hexaidrofenantridina substituìdos com 6-heterociclila
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
US20100041662A1 (en) 2006-10-30 2010-02-18 Sandrine Ferrand Heterocyclic compounds as antiinflammatory agents
JP5362729B2 (ja) 2007-10-04 2013-12-11 エフ．ホフマン−ラ ロシュ アーゲー シクロプロピルアリールアミド誘導体及びその使用
EA201001129A1 (ru) 2008-01-11 2011-02-28 Новартис Аг Пиримидины в качестве ингибиторов киназы
US8853455B2 (en) 2009-03-09 2014-10-07 Basf Se Process for preparing substituted 2-nitrobiphenyls
UY33597A (es) 2010-09-09 2012-04-30 Irm Llc Compuestos y composiciones como inhibidores de la trk
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
CN103492384B (zh) 2011-02-25 2016-05-11 诺华股份有限公司 作为trk抑制剂的化合物和组合物

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BRPI0607645A2 (pt) * 2005-03-02 2009-09-22 Nycomed Gmbh sais de derivados de hexaidrofenantridina substituìdos com 6-heterociclila
EP1856092A1 (en) * 2005-03-02 2007-11-21 Nycomed GmbH 6-heteroaryl-1,2,3,4,4a,10b-hexahydro-phenanthridines as pde-4 inhibitors for the treatment of inflammatory disorders
JP2008532980A (ja) * 2005-03-09 2008-08-21 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング アミド置換された６−フェニルフェナントリジン

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WO2005087745A8 (en) 2006-10-26
KR20060130697A (ko) 2006-12-19
CA2558391A1 (en) 2005-09-22
MXPA06009892A (es) 2007-03-01
US20070185149A1 (en) 2007-08-09
BRPI0508481A (pt) 2007-07-31
CN1926113B (zh) 2010-06-23
WO2005087745A1 (en) 2005-09-22
AR049324A1 (es) 2006-07-19
AU2005221832A1 (en) 2005-09-22
NZ549254A (en) 2010-06-25
IL177496A0 (en) 2006-12-10
NO20064415L (no) 2006-10-10
CN1926113A (zh) 2007-03-07
EP1725534A1 (en) 2006-11-29
JP2007527901A (ja) 2007-10-04

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