SU1421302A1 - Method of determining the rate of absorption of glucose with organism - Google Patents

Description

(21) 4070164 / 28-14

(22) 04/28/86

(46) 09/07/88. Bnsh. Number 33

(71) All-Union Scientific Center of Surgery, Medical Academy of Medical Sciences of the USSR. ;

(72) V.V. Kislukhin and N.M.Krivitsky

(53) 612.015 (088.8)

(56) Ermolenko V.M. Chronic hemodialysis. - M .: Medicine 1982, p. 203204. I

(54) METHOD FOR DETERMINING THE GLUCOSE ABSORPTION RATE BY THE ORGANISM

(57) The invention relates to medicine and medical technology, to methods for determining the parameters of an organism by the method of dilution of indicators. The purpose of the invention is to shorten the research time while simultaneously increasing the selectivity. For this

in the arterial blood sample, the glucose concentration and osmolarity are determined. Electrodes are injected into the arterial bed and the electrical resistance (ES) of the blood is measured, then the isosmoticus solution of glucose is administered intravenously and the value of the increase in the ES level of the blood is measured. Next, the isoosmotic solution of glucose is re-intravenously injected, and the blood ES curve is recorded. The glucose uptake rate (v) is calculated using the formula v-CE-C- (S / 4Z) (g / U), where CB is the measured cardiac output, C is the concentration of glucose in arterial blood, S is the area under the first-pass curve; 4 Z is the increment of blood ES; g is the volumetric rate of channel injection; V is the volume of the input pulsed glucose.

SS

The invention relates to medicine and medical technology, and in particular to methods for determining the parameters of the body by the method of dilution of indicative

ROVO

A: The purpose of the invention is to shorten the time of the study while simultaneously increasing the selectivity.

The method is carried out as follows.

: A blood sample is taken from the artery and the glucose concentration and os-colony are determined. Electrodes are introduced into the arterial bed and the electrical resistance is measured. Carry out intravenous injection of a glucose zoosmotic solution. for 1--3 min, register the steady-state increment of the electrical resistance of the blood, i.e. when the amount of absorbed glucose is compared with the amount injected, and measures the increment of the electrical resistance of the blood d Z. Next, an intravenous pulsed injection of nzoosmotic glucose (10-20 m) is performed and the curve of the electrical resistance of the blood under which the area S is determined is measured. ". The cardiac output is determined by any known method (according to the Cubichek-modeler5 dilution of impedance indicators). Further, according to the formula, the speed v of glucose absorption

RPG2-03, the curves were recorded.

First, a blood sample was taken and the concentration of sugar C ± 1.04 g / l and osmol p- was determined by standard methods. 307 mosmol / l, since the osmolarity is normal, about 300 mosmol / l, then a standard 5% glucose solution was used. For 2 min, 100 ml of glucose was injected, the injection rate was 50 ml / min (2.5 g / min), while the increase in electrical resistance was A Z 15 dm. Then, a pulse of 20 mp of 5% glucose solution was injected intravenously and the area under the first pass curve S 20 m / min was calculated. Cardiac output was determined by dilution of electrical impedance indicators, 5 L / min. Then the rate of absorption of glucose by the body will be

.V CB.C.- | - -S2, 25 g / min.

Thus, the proposed method allows for 5 minutes to determine the rate of glucose absorption by the body, and to determine this parameter repeatedly, and thereby determine the energy status (of the organism in patients with resuscitation, hemodialysis, etc.

V CB-C --- A Z

V

where CB is cardiac output, measured dd

in a known manner; With arterial glucose concentration: blood | S - the area under the curve of the first

prohohodeni; 45

U Z - electric increment

blood resistance, g is the volumetric rate of drip glucose; - the volume of the input pulse.

glucose,

Example. The diagnosis is. chronic renal failure. Investigations, nor performed during a hemodialysis session, used as electrodes. two injection needles, which were 5z, were led; they were led to the artery trunk vest. The electrical resistance of the blood was measured with a reoplethismograph.

Claims (1)

Invention Formula The method for determining the glucose uptake rate by the body by administering glucose, measuring its concentration in the blood before and after administration, and then calculating the absorption rate, characterized in that, in order to reduce the time of the study while increasing the selectivity, the blood, then electrodes are introduced into the arterial bed with which the initial electrical resistance of the blood is measured, then an isosmotic glucose solution is administered intravenously and the prior the stabilization level of the electrical resistance of the blood, then the isosmotic solution of glucose is reintroduced intravenously, the curve of the electrical resistance of the blood is recorded, and the velocity v glucose uptake is determined by the for- S shape of the area under the curve of the first-, mulep passage; V CB C ---, D2 is the increment of the electrical rejection of blood; where CB is the heart emission, measured g is the channel velocity in a known manner; administration; C is the concentration of glucose in arte-V, the volume of injected pulsed rial blood, glucose.