SI2049113T1 - Zdravilo za povečanje kognitivne funkcije in nevroprotekcijo - Google Patents

Zdravilo za povečanje kognitivne funkcije in nevroprotekcijo

Info

Publication number: SI2049113T1
Authority: SI; Slovenia
Prior art keywords: memory; cognitive function; pyridazinone; benz; piperidin
Prior art date: 2006-07-03

Application number

SI200730327T

Other languages

English (en)

Inventor

Istvan Gacsalyi

Gabor Gigler

Marta Agoston

Hajnalka Kompagne

Szabolcs Kertesz

Krisztina Moricz

Gyorgy Levay

Gabor Szenasi

Laszlo Gabor Harsing

Jozsef Barkoczy

Gyula Simig

Original Assignee

Asag Egis Gyogyszergyar Nyilva

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-07-03

Filing date

2007-07-03

Publication date

2010-10-29

2007-07-03 Application filed by Asag Egis Gyogyszergyar Nyilva filed Critical Asag Egis Gyogyszergyar Nyilva

2010-10-29 Publication of SI2049113T1 publication Critical patent/SI2049113T1/sl

Links

239000003814 drug Substances 0.000 title abstract 3
230000003920 cognitive function Effects 0.000 title abstract 2
230000004112 neuroprotection Effects 0.000 title 1
208000000044 Amnesia Diseases 0.000 abstract 2
125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 abstract 2
RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
208000031091 Amnestic disease Diseases 0.000 abstract 1
208000018737 Parkinson disease Diseases 0.000 abstract 1
208000034189 Sclerosis Diseases 0.000 abstract 1
208000006011 Stroke Diseases 0.000 abstract 1
230000006986 amnesia Effects 0.000 abstract 1
206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 1
230000007423 decrease Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000006870 function Effects 0.000 abstract 1
125000004284 isoxazol-3-yl group Chemical group [H]C1=C([H])C(*)=NO1 0.000 abstract 1
231100000863 loss of memory Toxicity 0.000 abstract 1
206010027175 memory impairment Diseases 0.000 abstract 1
230000006993 memory improvement Effects 0.000 abstract 1
230000003340 mental effect Effects 0.000 abstract 1
230000016273 neuron death Effects 0.000 abstract 1
230000000324 neuroprotective effect Effects 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
208000011580 syndromic disease Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Psychology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SI200730327T 2006-07-03 2007-07-03 Zdravilo za povečanje kognitivne funkcije in nevroprotekcijo SI2049113T1 (sl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
HU0600555A HUP0600555A3 (en)	2006-07-03	2006-07-03	Use of 4-chloro-5-{2-[4-(6-fluoro-1,2-benz[d]izoxazol-3-yl)piperidin-1-yl]ethylamino}2-methyl-3(2h)-piridazinon for the production of pharmaceutical compositions for influencing cognitive functions and causing neuroprotective effect
PCT/HU2007/000059 WO2008004013A2 (en)	2006-07-03	2007-07-03	Medicament for the enhancement of cognitive function and neuroprotection
EP07766491A EP2049113B8 (en)	2006-07-03	2007-07-03	Medicament for the enhancement of cognitive function and neuroprotection

Publications (1)

Publication Number	Publication Date
SI2049113T1 true SI2049113T1 (sl)	2010-10-29

Family

ID=89986887

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI200730327T SI2049113T1 (sl)	2006-07-03	2007-07-03	Zdravilo za povečanje kognitivne funkcije in nevroprotekcijo

Country Status (25)

Country	Link
US (1)	US8318743B2 (sl)
EP (1)	EP2049113B8 (sl)
JP (1)	JP5174018B2 (sl)
KR (1)	KR101465415B1 (sl)
CN (1)	CN101516373B (sl)
AT (1)	ATE468854T1 (sl)
AU (1)	AU2007270910B2 (sl)
BR (1)	BRPI0713395A2 (sl)
CA (1)	CA2656549C (sl)
CY (1)	CY1110741T1 (sl)
DE (1)	DE602007006813D1 (sl)
DK (1)	DK2049113T3 (sl)
EA (1)	EA016142B1 (sl)
HR (1)	HRP20100465T1 (sl)
HU (1)	HUP0600555A3 (sl)
IL (1)	IL196315A (sl)
MA (1)	MA30951B1 (sl)
MX (1)	MX2009000243A (sl)
NZ (1)	NZ574596A (sl)
PL (1)	PL2049113T3 (sl)
PT (1)	PT2049113E (sl)
RS (1)	RS51429B (sl)
SI (1)	SI2049113T1 (sl)
WO (1)	WO2008004013A2 (sl)
ZA (1)	ZA200900507B (sl)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUP9602763A3 (en) *	1996-10-09	1999-05-28	Egyt Gyogyszervegyeszeti Gyar	3-phenyl isoxazole derivatives, process for producing them and pharmaceutical compositions containing the same
AU7547100A (en) *	1999-09-09	2001-04-10	Egis Gyogyszergyar Rt.	Alkylpiperidi nylbenzo [d] isoxazole derivatives having psychotropic activity, pharmaceutical compositions containing the same, and a process for the preparation of the active ingredient
US20030024849A1 (en)	2001-07-26	2003-02-06	Nielsen Jacob Sturich	Package for blister pack strips
HU225955B1 (en) *	2001-07-26	2008-01-28	Egis Gyogyszergyar Nyilvanosan	Novel 2h-pyridazin-3-one derivatives, process for their preparation, their use and pharmaceutical compositions containing them
HU227118B1 (en) *	2001-11-13	2010-07-28	Egis Gyogyszergyar Nyilvanosan	Process for the preparation of 3-{2-[4-(6-fluoro-1,2-benzizoxazol-3-yl)-1-piperidinyl]-ethyl}-6,7,8,9-tetrahydro-2-methyl-4h-pyrido[1,2-a]pyrimidin-4-one
HU227255B1 (en)	2002-04-26	2010-12-28	Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag	Novel piperidine-alkyl-amino-pyridazine derivatives, pharmaceutical compositions containing the same and process for the preparation of the active ingredient

2006
- 2006-07-03 HU HU0600555A patent/HUP0600555A3/hu unknown
2007
- 2007-07-03 KR KR1020097002214A patent/KR101465415B1/ko not_active Expired - Fee Related
- 2007-07-03 CA CA2656549A patent/CA2656549C/en not_active Expired - Fee Related
- 2007-07-03 BR BRPI0713395-2A patent/BRPI0713395A2/pt not_active IP Right Cessation
- 2007-07-03 DE DE602007006813T patent/DE602007006813D1/de active Active
- 2007-07-03 AU AU2007270910A patent/AU2007270910B2/en not_active Ceased
- 2007-07-03 PL PL07766491T patent/PL2049113T3/pl unknown
- 2007-07-03 ZA ZA200900507A patent/ZA200900507B/xx unknown
- 2007-07-03 PT PT07766491T patent/PT2049113E/pt unknown
- 2007-07-03 MX MX2009000243A patent/MX2009000243A/es active IP Right Grant
- 2007-07-03 HR HR20100465T patent/HRP20100465T1/hr unknown
- 2007-07-03 WO PCT/HU2007/000059 patent/WO2008004013A2/en active Application Filing
- 2007-07-03 NZ NZ574596A patent/NZ574596A/xx not_active IP Right Cessation
- 2007-07-03 EA EA200900088A patent/EA016142B1/ru not_active IP Right Cessation
- 2007-07-03 CN CN2007800306551A patent/CN101516373B/zh not_active Expired - Fee Related
- 2007-07-03 DK DK07766491.0T patent/DK2049113T3/da active
- 2007-07-03 AT AT07766491T patent/ATE468854T1/de active
- 2007-07-03 SI SI200730327T patent/SI2049113T1/sl unknown
- 2007-07-03 JP JP2009517450A patent/JP5174018B2/ja not_active Expired - Fee Related
- 2007-07-03 EP EP07766491A patent/EP2049113B8/en active Active
- 2007-07-03 US US12/307,385 patent/US8318743B2/en not_active Expired - Fee Related
- 2007-07-03 RS RSP-2010/0375A patent/RS51429B/en unknown
2009
- 2009-01-01 IL IL196315A patent/IL196315A/en not_active IP Right Cessation
- 2009-01-27 MA MA31589A patent/MA30951B1/fr unknown
2010
- 2010-08-18 CY CY20101100766T patent/CY1110741T1/el unknown

Also Published As

Publication number	Publication date
HRP20100465T1 (hr)	2010-10-31
CA2656549C (en)	2014-07-22
AU2007270910A1 (en)	2008-01-10
US8318743B2 (en)	2012-11-27
PL2049113T3 (pl)	2011-02-28
KR20090091686A (ko)	2009-08-28
WO2008004013A3 (en)	2008-04-03
ATE468854T1 (de)	2010-06-15
JP5174018B2 (ja)	2013-04-03
KR101465415B1 (ko)	2014-11-26
CA2656549A1 (en)	2008-01-10
ZA200900507B (en)	2010-05-26
CY1110741T1 (el)	2014-02-12
HUP0600555A3 (en)	2008-10-28
CN101516373A (zh)	2009-08-26
IL196315A0 (en)	2009-09-22
WO2008004013A2 (en)	2008-01-10
DK2049113T3 (da)	2010-08-16
JP2009542614A (ja)	2009-12-03
IL196315A (en)	2014-09-30
PT2049113E (pt)	2010-08-26
US20100075975A1 (en)	2010-03-25
NZ574596A (en)	2012-12-21
DE602007006813D1 (de)	2010-07-08
EP2049113B8 (en)	2010-11-03
MX2009000243A (es)	2009-07-22
EP2049113B1 (en)	2010-05-26
HU0600555D0 (en)	2006-09-28
CN101516373B (zh)	2012-09-12
EA016142B1 (ru)	2012-02-28
HK1131032A1 (en)	2010-01-15
EP2049113A2 (en)	2009-04-22
EA200900088A1 (ru)	2009-12-30
WO2008004013A8 (en)	2009-07-02
HUP0600555A2 (en)	2008-09-29
BRPI0713395A2 (pt)	2012-04-17
AU2007270910B2 (en)	2012-08-09
MA30951B1 (fr)	2009-12-01
RS51429B (en)	2011-04-30

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JP2008513516A5 (sl)	2008-10-23
UA112055C2 (uk)	2016-07-25	Солі 4-[2-[[5-метил-1-(2-нафталініл)-1h-піразол-3-іл]оксі]етил]морфоліну
CA2641473A1 (en)	2007-10-18	Condensed imidazole derivatives as aldosterone synthase inhibitors
MX2009011830A (es)	2009-11-13	Compuestos amino-heterociclicos.
MX2008013836A (es)	2008-11-10	Derivados de 2-piridona para el tratamiento de enfermedades o condiciones en las cuales es benefica la inhibicion de la actividad de elastasa de neutrofilos.
NZ592961A (en)	2012-09-28	Aryl methyl benzoquinazolinone m1 receptor positive allosteric modulators
JP2008513504A5 (sl)	2008-10-16
SG170101A1 (en)	2011-04-29	2-pyrazinone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial.
MX2012012952A (es)	2012-12-17	Compuestos de 2, 5, 6, 7,-tetrahidro-[1, 4] oxazepin-3-ilamina o 2, 3, 6, 7-tetrahidro-[1, 4] oxazepin-5-ilamina.
WO2008002621A3 (en)	2008-02-21	Benzyl-substituted quinolone m1 receptor positive allosteric modulators
NZ595571A (en)	2013-04-26	Pyrazole compounds and uses thereof
CA2634676A1 (en)	2007-08-09	Trisubstituted amine compounds as inhibitors of cholesteryl ester transfer protein cetp
NZ600136A (en)	2013-09-27	Pyrazine derivatives and their use in the treatment of neurological disorders
JPWO2007097403A1 (ja)	2009-07-16	消化管潰瘍治療又は予防薬
NO20092286L (no)	2009-08-13	Nitrogenhaldige heterosykliske forbindelser og anvendelse derav
PE20080360A1 (es)	2008-05-22	Derivados 4-bencilftalazinona 2-sustituidos como antagonistas de histaminas h1 y h3
EA201071006A1 (ru)	2011-02-28	Набор, композиция, продукт или лекарственное средство для лечения нарушения познавательной способности
NO20085271L (no)	2009-01-06	Muscarin reseptoragonister som er effektive i behandling av smerte, Alzheimers sykdom og schizofreni
TW200716547A (en)	2007-05-01	Piperidin-4-yl-amide derivatives
NZ596154A (en)	2013-12-20	Cyclic compound having substituted phenyl group
WO2008080988A3 (en)	2011-04-21	Cyclopentanone derivatives, method of synthesis and uses thereof
MX2011010732A (es)	2011-11-18	Pirimidinas sustituidas por imidazol utiles en el tratamiento de trastornos relacionados con glucogeno sintasa cinasa 3 como la enfermedad de alzheimer.
ATE357453T1 (de)	2007-04-15	Comt-inhibitoren
UA85707C2 (ru)	2009-02-25	Бензоксазины для лечения заболеваний дыхательных путей
EP2049113B8 (en)	2010-11-03	Medicament for the enhancement of cognitive function and neuroprotection