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SG162803A1 - Imidazole based lxr modulators - Google Patents

Imidazole based lxr modulators

Info

Publication number
SG162803A1
SG162803A1 SG201004272-9A SG2010042729A SG162803A1 SG 162803 A1 SG162803 A1 SG 162803A1 SG 2010042729 A SG2010042729 A SG 2010042729A SG 162803 A1 SG162803 A1 SG 162803A1
Authority
SG
Singapore
Prior art keywords
compounds
lxr modulators
imidazole based
based lxr
modulators
Prior art date
Application number
SG201004272-9A
Inventor
Brett B Busch
Brenton T Flatt
Xiao-Hui Gu
Shao-Po Lu
Richard Martin
Raju Mohan
Michael Charles Nyman
Edwin Schweiger
William C Stevens Jr
Tie-Lin Wang
Yinong Xie
Original Assignee
Exelixis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc filed Critical Exelixis Inc
Publication of SG162803A1 publication Critical patent/SG162803A1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of the invention, such as compounds of Formulae IIa, IIb, Ile or IId, and pharmaceutically acceptable salts, isomers, and prodrugs thereof, are useful as modulators of the activity of liver X receptors, where R1, R2, R21, R3 and G are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed. (No suitable figure)
SG201004272-9A 2005-06-27 2006-06-26 Imidazole based lxr modulators SG162803A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69437205P 2005-06-27 2005-06-27

Publications (1)

Publication Number Publication Date
SG162803A1 true SG162803A1 (en) 2010-07-29

Family

ID=39947886

Family Applications (1)

Application Number Title Priority Date Filing Date
SG201004272-9A SG162803A1 (en) 2005-06-27 2006-06-26 Imidazole based lxr modulators

Country Status (3)

Country Link
CN (2) CN101248049B (en)
SG (1) SG162803A1 (en)
ZA (1) ZA200710582B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2761934C (en) * 2009-05-28 2018-01-09 Exelixis Patent Company Llc Substituted 1-(biphenyl-4-yl)-2-benzyl-4-hydroxyalkyl-1h-imidazole compounds and their use as lxr modulators
EP2395003A1 (en) * 2010-05-27 2011-12-14 Laboratorios Del. Dr. Esteve, S.A. Pyrazole compounds as sigma receptor inhibitors
TW201242953A (en) * 2011-03-25 2012-11-01 Bristol Myers Squibb Co Imidazole prodrug LXR modulators
KR102112879B1 (en) * 2012-03-02 2020-05-19 랄렉사르 테라퓨틱스 인코퍼레이티드 Liver x receptor (lxr) modulators for the treatment of dermal diseases, disorders and conditions
EP3626712A3 (en) 2013-09-04 2020-04-15 Ellora Therapeutics, Inc. Liver x receptor (lxr) modulators
JP2016532713A (en) 2013-09-04 2016-10-20 アレクサー セラピューティクス， インク． Liver X receptor (LXR) modulator
JP2018507212A (en) * 2015-02-20 2018-03-15 バイエル・ファルマ・アクティエンゲゼルシャフト N-phenyl- (morpholin-4-yl or piperazinyl) acetamide derivatives and their use as inhibitors of the WNT signaling pathway
CN105001210B (en) * 2015-07-06 2017-11-28 南京大学 Pyrazoles nitro imidazole derivatives, its preparation method and the application of a kind of skeleton containing metronidazole
CN106543092B (en) * 2016-10-14 2019-05-17 华东师范大学 Bis- aromatic radical -1,2,4- triazole compound of 1,5- and its pharmaceutical applications
BR112020008157A2 (en) * 2017-11-01 2020-10-06 Bristol-Myers Squibb Company spirocyclic compounds as farnesoid x receptor modulators
CN113527281B (en) * 2020-04-20 2023-12-22 昆山彭济凯丰生物科技有限公司 Heterocyclic compounds, process for their preparation and their use
WO2024179572A1 (en) * 2023-03-01 2024-09-06 成都先导药物开发股份有限公司 Aromatic-ring compound and use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2179254T3 (en) * 1996-11-04 2003-01-16 Bayer Cropscience Sa 1-PESTICIDE POLYARILPIRAZOLES.
WO2004011446A1 (en) * 2002-07-26 2004-02-05 Bayer Pharmaceuticals Corporation Indane, dihydrobenzofuran, and tetrahydronaphthalene carboxylic acid derivatives and their use as antidiabetics
US7109227B2 (en) * 2002-08-26 2006-09-19 National Health Research Institutes Imidazolamino compounds
CN1747936A (en) * 2003-02-12 2006-03-15 特兰斯泰克制药公司 Substituted azole derivatives as therapeutic agents
DE10315573A1 (en) * 2003-04-05 2004-10-14 Merck Patent Gmbh Substituted pyrazoles
WO2004106307A2 (en) * 2003-05-27 2004-12-09 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Novel imidazole derivatives, the production thereof, and the use of the same as a medicament
WO2005012263A1 (en) * 2003-07-24 2005-02-10 Pharmagene Laboratories Limited 5-ht2b receptor antagonists
JP2006528661A (en) * 2003-07-25 2006-12-21 ファイザー・インク Aminopyrazole compounds and use as CHK1 inhibitors
CA2545942C (en) * 2003-11-14 2012-07-10 Lorus Therapeutics Inc. Aryl imidazoles and their use as anti-cancer agents

Also Published As

Publication number Publication date
ZA200710582B (en) 2008-12-31
CN101248049A (en) 2008-08-20
CN101248048A (en) 2008-08-20
CN101248048B (en) 2013-08-28
CN101248049B (en) 2013-08-28

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