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SG11201906780SA - Bcma-targeting antibody and use thereof - Google Patents

Bcma-targeting antibody and use thereof

Info

Publication number
SG11201906780SA
SG11201906780SA SG11201906780SA SG11201906780SA SG11201906780SA SG 11201906780S A SG11201906780S A SG 11201906780SA SG 11201906780S A SG11201906780S A SG 11201906780SA SG 11201906780S A SG11201906780S A SG 11201906780SA SG 11201906780S A SG11201906780S A SG 11201906780SA
Authority
SG
Singapore
Prior art keywords
bcma
targeting antibody
antibody
modified
cell
Prior art date
Application number
SG11201906780SA
Inventor
Peng Wang
Huamao Wang
Hua Jiang
Original Assignee
Carsgen Therapeutics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carsgen Therapeutics Co Ltd filed Critical Carsgen Therapeutics Co Ltd
Publication of SG11201906780SA publication Critical patent/SG11201906780SA/en

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    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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Abstract

Provided in the present invention are a specific antibody of BCMA and a BCMA-targeting immune effector cell, and also provided are a chimeric antigen receptor-modified T cell prepared using the antibody and the use thereof. 5 No suitable figure.
SG11201906780SA 2017-01-23 2018-01-23 Bcma-targeting antibody and use thereof SG11201906780SA (en)

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Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL303905A (en) 2015-05-18 2023-08-01 Tcr2 Therapeutics Inc Compositions and methods for TCR programming using fusion proteins
WO2016187594A1 (en) 2015-05-21 2016-11-24 Harpoon Therapeutics, Inc. Trispecific binding proteins and methods of use
US10100106B2 (en) 2016-05-20 2018-10-16 Harpoon Therapeutics, Inc. Single domain serum albumin binding protein
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
JP7291396B2 (en) 2016-11-22 2023-06-15 ティーシーアール２ セラピューティクス インク． Compositions and methods for TCR reprogramming using fusion proteins
US11535668B2 (en) 2017-02-28 2022-12-27 Harpoon Therapeutics, Inc. Inducible monovalent antigen binding protein
US10543271B2 (en) 2017-05-12 2020-01-28 Harpoon Therapeutics, Inc. Mesothelin binding proteins
IL315737A (en) 2017-10-13 2024-11-01 Harpoon Therapeutics Inc B cell maturation antigen binding proteins
AU2018347582B2 (en) 2017-10-13 2025-08-28 Harpoon Therapeutics, Inc. Trispecific proteins and methods of use
US11492409B2 (en) 2018-06-01 2022-11-08 Novartis Ag Binding molecules against BCMA and uses thereof
TWI838389B (en) 2018-07-19 2024-04-11 美商再生元醫藥公司 BISPECIFIC ANTI-BCMAxANTI-CD3 ANTIBODIES AND USES THEREOF
CN119954969A (en) 2018-07-19 2025-05-09 瑞泽恩制药公司 Chimeric antigen receptors specific for BCMA and uses thereof
CA3107515A1 (en) * 2018-07-24 2020-01-30 Carsgen Therapeutics Co., Ltd. Method for tumor treatment with immune effector cells
US12195544B2 (en) 2018-09-21 2025-01-14 Harpoon Therapeutics, Inc. EGFR binding proteins and methods of use
CA3114038A1 (en) 2018-09-25 2020-04-02 Harpoon Therapeutics, Inc. Dll3 binding proteins and methods of use
CN112125974B (en) * 2018-09-25 2022-04-15 上海邦耀生物科技有限公司 Antibodies, Chimeric Antigen Receptors and Drugs Targeting BCMA Proteins
WO2020072536A1 (en) 2018-10-01 2020-04-09 Adicet Bio, Inc. COMPOSITIONS AND METHODS REGARDING ENGINEERED AND NON- ENGINEERED γδ-Τ CELLS FOR TREATMENT OF HEMATOLOGICAL TUMORS
CN109485733B (en) * 2018-12-28 2020-04-24 广州百暨基因科技有限公司 Fully human anti-BCMA chimeric antigen receptor and application thereof
BR112021023048A2 (en) 2019-05-21 2022-04-19 Novartis Ag cd19 binding molecules and uses thereof
BR112021026416A8 (en) * 2019-06-28 2022-06-28 Cafa Therapeutics Ltd TRANSPLANTATION IMMUNE REJECTION RESISTANT CELL, AND, METHODS TO PREVENT OR REGULATE TRANSPLANTATION IMMUNE REJECTION AND TO PREVENT OR REGULATE NK CELL ATTACK ON EXOGENOUS CELLS
WO2021016091A1 (en) * 2019-07-19 2021-01-28 St. Jude Children's Research Hospital, Inc. Chimeric antigen receptors for direct and indirect targeting of fibronectin-positive tumors
CN112585168B (en) * 2019-07-30 2022-04-15 上海翰森生物医药科技有限公司 anti-BCMA antibodies, antigen binding fragments thereof, and medical uses thereof
NZ784614A (en) * 2019-08-29 2025-08-29 Carsgen Life Sciences Co Ltd Cell for resisting transplant reaction and method
CN111944062B (en) * 2019-12-09 2023-11-07 深圳市体内生物医药科技有限公司 Chimeric antigen receptor for recognizing Fc fragment and application thereof
CN112979807B (en) * 2019-12-17 2022-07-26 深圳市菲鹏生物治疗股份有限公司 BCMA binding antibodies and uses thereof
KR102837521B1 (en) * 2020-01-03 2025-07-22 바이오션, 인코포레이티드 Antibodies binding to BCMA and uses thereof
CN112851814B (en) * 2020-03-17 2023-07-07 西安宇繁生物科技有限责任公司 Fully human single-chain antibody targeting BCMA and preparation method and application thereof
KR102316091B1 (en) * 2020-06-17 2021-10-25 국립암센터 Chimeric antigen receptor targeting BCMA and use thereof
CN113173991B (en) * 2020-12-31 2023-03-28 北京艺妙神州医药科技有限公司 anti-BCMA antibody and application thereof
CN114763383B (en) * 2021-01-13 2024-12-17 博生吉医药科技(苏州)有限公司 Monoclonal antibody targeting human BCMA and application thereof
CN117545771A (en) 2021-04-08 2024-02-09 克莱格医学有限公司 Application of cellular immunotherapy
IL307598A (en) 2021-04-16 2023-12-01 Juno Therapeutics Inc T cell therapy in patients who have had prior stem cell transplant
WO2023284874A1 (en) * 2021-07-16 2023-01-19 克莱格医学有限公司 Composition and method for tumor immunology
WO2023081735A1 (en) 2021-11-03 2023-05-11 Celgene Corporation Chimeric antigen receptors specific for b-cell maturation antigen for use in treating myeloma
CN116284385A (en) * 2021-12-07 2023-06-23 信达细胞制药(苏州)有限公司 P329G antibody targeting BCMA and combination and application of P329G antibody and chimeric antigen receptor cell
JP2025504002A (en) 2022-01-28 2025-02-06 ジュノー セラピューティクス インコーポレイテッド Methods for Producing Cellular Compositions
WO2023220655A1 (en) 2022-05-11 2023-11-16 Celgene Corporation Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy
EP4522183A2 (en) 2022-05-11 2025-03-19 Celgene Corporation Methods and uses related to t cell therapy and production of same
WO2023230581A1 (en) 2022-05-25 2023-11-30 Celgene Corporation Methods of manufacturing t cell therapies
WO2023230548A1 (en) 2022-05-25 2023-11-30 Celgene Corporation Method for predicting response to a t cell therapy
CN114891108B (en) * 2022-05-30 2022-11-15 上海驯鹿生物技术有限公司 BCMA (brain-cell-binding antigen) -targeted fully-humanized antibody and application thereof
CN116102661A (en) * 2022-10-10 2023-05-12 武汉波睿达生物科技有限公司 Fusion chimeric antigen receptor modified T cell of target GPR87 surface antigen cell and application thereof
WO2024097905A1 (en) 2022-11-02 2024-05-10 Celgene Corporation Methods of treatment with t cell therapy and immunomodulatory agent maintenance therapy
WO2024146398A1 (en) * 2023-01-04 2024-07-11 北京艺妙神州医药科技有限公司 Isolated antibody, car comprising same, and use thereof
WO2024168192A1 (en) 2023-02-10 2024-08-15 Celgene Corporation Assessment of bcma in biological samples
US12311033B2 (en) 2023-05-31 2025-05-27 Capstan Therapeutics, Inc. Lipid nanoparticle formulations and compositions
EP4520346A1 (en) * 2023-09-06 2025-03-12 Gyncentrum Sp. z o.o. Cells, methods and systems for use in the treatment of a cancer with dual-car-t
WO2025076113A1 (en) 2023-10-05 2025-04-10 Capstan Therapeutics, Inc. Ionizable cationic lipids with conserved spacing and lipid nanoparticles
US20250127728A1 (en) 2023-10-05 2025-04-24 Capstan Therapeutics, Inc. Constrained Ionizable Cationic Lipids and Lipid Nanoparticles

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU690528B2 (en) 1992-12-04 1998-04-30 Medical Research Council Multivalent and multispecific binding proteins, their manufacture and use
UA112434C2 (en) * 2011-05-27 2016-09-12 Ґлаксо Ґруп Лімітед ANTIGENCY BINDING SPECIFICALLY Binds to ALL
KR101972446B1 (en) 2011-05-27 2019-04-25 글락소 그룹 리미티드 Bcma(cd269/tnfrsf17)-binding proteins
TW201425336A (en) * 2012-12-07 2014-07-01 Amgen Inc BCMA antigen binding proteins
ES2829499T3 (en) * 2013-02-05 2021-06-01 Engmab Sarl Method for the selection of antibodies against BCMA
US9209965B2 (en) 2014-01-14 2015-12-08 Microsemi Semiconductor Ulc Network interface with clock recovery module on line card
JOP20200094A1 (en) * 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc Antibody Molecules of PD-1 and Their Uses
JOP20200096A1 (en) 2014-01-31 2017-06-16 Children’S Medical Center Corp Antibody molecules to tim-3 and uses thereof
ES2703826T3 (en) 2014-02-19 2019-03-12 Merck Patent Gmbh Immunotherapy with IL-12 for cancer
AU2015292744C1 (en) * 2014-07-21 2021-01-21 Novartis Ag Treatment of cancer using humanized anti-BCMA chimeric antigen receptor
BR112017011914A2 (en) * 2014-12-05 2018-02-27 Memorial Sloan-Kettering Cancer Center Antibody targeting b cell maturation antigen and methods of use?
CN107207598B (en) * 2014-12-12 2020-12-08 蓝鸟生物公司 BCMA Chimeric Antigen Receptor
CN105777911B (en) * 2016-04-12 2019-07-02 上海优卡迪生物医药科技有限公司 Anti- BCMA Chimeric antigen receptor, encoding gene, recombinant expression carrier and its construction method and application
WO2019052562A1 (en) 2017-09-15 2019-03-21 科济生物医药（上海）有限公司 FUSION PROTEIN OF IL-4R AND USE THEREOF
CA3107515A1 (en) * 2018-07-24 2020-01-30 Carsgen Therapeutics Co., Ltd. Method for tumor treatment with immune effector cells
CN112805371A (en) * 2018-09-21 2021-05-14 佧珐药业有限公司 Method for carrying out gene editing on cells based on CRISPR/Cas system
BR112021026416A8 (en) * 2019-06-28 2022-06-28 Cafa Therapeutics Ltd TRANSPLANTATION IMMUNE REJECTION RESISTANT CELL, AND, METHODS TO PREVENT OR REGULATE TRANSPLANTATION IMMUNE REJECTION AND TO PREVENT OR REGULATE NK CELL ATTACK ON EXOGENOUS CELLS

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