SG11201804758QA - Aqueous pharmaceutical formulation comprising anti-pd-1 antibody avelumab - Google Patents
Aqueous pharmaceutical formulation comprising anti-pd-1 antibody avelumabInfo
- Publication number
- SG11201804758QA SG11201804758QA SG11201804758QA SG11201804758QA SG11201804758QA SG 11201804758Q A SG11201804758Q A SG 11201804758QA SG 11201804758Q A SG11201804758Q A SG 11201804758QA SG 11201804758Q A SG11201804758Q A SG 11201804758QA SG 11201804758Q A SG11201804758Q A SG 11201804758QA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- pct
- pharmaceutical formulation
- aqueous pharmaceutical
- antibody
- Prior art date
Links
- 229950002916 avelumab Drugs 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau ristspi id (43) International Publication Date .... .....r ,„„01 15 June 2017(15.06.2017) WIPO I PCT ID Hit (10) WO International 2017/097407 111111111111111111IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIMIIIIIIIIIIIIIII Publication Al Number (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, A61K 39/395 (2006.01) C07K 16/28 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (21) International Application Number: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, PCT/EP2016/002040 KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (22) International Filing Date: MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, 5 December 2016 (05.12.2016) OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, (25) Filing Language: English TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (26) Publication Language: English ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 15198233.7 7 December 2015 (07.12.2015) EP kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (71) Applicants: MERCK PATENT GMBH [DE/DE]; Frank- TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, flirter Strasse 250, 64293 Darmstadt (DE). PFIZER, INC. TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, [US/US]; 235 East 42nd Street, New York, New York DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, 10017 (US). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (72) Inventors: RINALDI, Gianluca; Via Gino Silvestrini 9, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, 00015 Monterotondo (IT). DEL RIO, Alessandra; Via GW, KM, ML, MR, NE, SN, TD, TG). lldebrando Vivanti 108, 00144 Roma (IT). FRATAR- Published: CANGELI, Silvia; C.so Risorgimento 3, 03024 Ceprano with international search report (Art 21(3)) FR (IT). — with sequence listing of description (Rule 5.2(a)) part (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, Il .4t IN C:: , i t IN CI P C:: , IN l'I C:: , N (54) Title: AQUEOUS PHARMACEUTICAL FORMULATION COMPRISING ANTI-PD-1 ANTIBODY AVELUMAB 52 (57) : The present invention relates to a novel anti-PD-Ll antibody formulation. In particular, the invention relates to an aqueous pharmaceutical formulation of the anti-PD-L1 antibody Avelumab.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15198233 | 2015-12-07 | ||
| PCT/EP2016/002040 WO2017097407A1 (en) | 2015-12-07 | 2016-12-05 | Aqueous pharmaceutical formulation comprising anti-pd-1 antibody avelumab |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201804758QA true SG11201804758QA (en) | 2018-07-30 |
Family
ID=54838201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201804758QA SG11201804758QA (en) | 2015-12-07 | 2016-12-05 | Aqueous pharmaceutical formulation comprising anti-pd-1 antibody avelumab |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US11058769B2 (en) |
| EP (2) | EP3386541B1 (en) |
| JP (1) | JP6925337B2 (en) |
| KR (1) | KR102697026B1 (en) |
| CN (1) | CN108367072B (en) |
| AR (1) | AR107014A1 (en) |
| AU (1) | AU2016368099C1 (en) |
| BR (1) | BR112018010211A2 (en) |
| CA (1) | CA3007481C (en) |
| CL (1) | CL2018001488A1 (en) |
| CO (1) | CO2018005525A2 (en) |
| CY (1) | CY1123358T1 (en) |
| DK (1) | DK3386541T3 (en) |
| EA (1) | EA201891339A1 (en) |
| ES (1) | ES2823279T3 (en) |
| HR (1) | HRP20201573T1 (en) |
| HU (1) | HUE050811T2 (en) |
| IL (1) | IL259563B (en) |
| LT (1) | LT3386541T (en) |
| MX (1) | MX389289B (en) |
| MY (1) | MY195681A (en) |
| NZ (1) | NZ743964A (en) |
| PE (1) | PE20181400A1 (en) |
| PH (1) | PH12018500894A1 (en) |
| PL (1) | PL3386541T3 (en) |
| PT (1) | PT3386541T (en) |
| RS (1) | RS61029B1 (en) |
| SA (1) | SA518391743B1 (en) |
| SG (1) | SG11201804758QA (en) |
| SI (1) | SI3386541T1 (en) |
| SM (1) | SMT202000497T1 (en) |
| TW (1) | TWI630917B (en) |
| UA (1) | UA123270C2 (en) |
| WO (1) | WO2017097407A1 (en) |
| ZA (1) | ZA201804534B (en) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012344260B2 (en) | 2011-11-28 | 2017-09-07 | Merck Patent Gmbh | Anti-PD-L1 antibodies and uses thereof |
| EP3757130A1 (en) | 2013-09-26 | 2020-12-30 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
| JOP20200094A1 (en) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | Antibody Molecules of PD-1 and Their Uses |
| JOP20200096A1 (en) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | Antibody molecules to tim-3 and uses thereof |
| EA201691765A1 (en) | 2014-03-14 | 2016-12-30 | Новартис Аг | ANTIBODY MOLECULES AGAINST LAG-3 AND THEIR APPLICATIONS |
| RU2718914C2 (en) | 2014-09-13 | 2020-04-15 | Новартис Аг | Combined treatment methods using alk inhibitors |
| KR102513870B1 (en) | 2014-10-14 | 2023-03-23 | 노파르티스 아게 | Antibody molecules to pd-l1 and uses thereof |
| KR20170135860A (en) | 2015-03-13 | 2017-12-08 | 싸이톰스 테라퓨틱스, 인크. | Anti-PD1 antibodies, activatable anti-PD1 antibodies, and methods of using them |
| HRP20201573T1 (en) | 2015-12-07 | 2020-12-11 | Merck Patent Gmbh | Aqueous pharmaceutical formulation comprising anti-pd-1 antibody avelumab |
| JP6730466B2 (en) | 2016-06-13 | 2020-07-29 | アイ−エムエービー バイオファーマ ユーエス リミテッド | Anti-PD-L1 antibody and use thereof |
| BR112019006504A2 (en) | 2016-10-06 | 2019-06-25 | Merck Patent Gmbh | Avelumab Dosage Regimen For Cancer Treatment |
| JP7379159B2 (en) * | 2017-03-06 | 2023-11-14 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | Aqueous anti-PD-L1 antibody preparation |
| JP2020522486A (en) | 2017-06-01 | 2020-07-30 | サイトメックス セラピューティクス インコーポレイテッド | Activatable anti-PDL1 antibody and method of using the same |
| CN114632150B (en) * | 2017-11-02 | 2023-12-19 | 正大天晴药业集团股份有限公司 | Pharmaceutical composition of anti-PD-L1 humanized monoclonal antibody |
| EP3730126B1 (en) * | 2017-12-22 | 2025-05-14 | Samsung Bioepis Co., Ltd. | Liquid composition comprising vegf antagonist |
| US20210079106A1 (en) * | 2017-12-28 | 2021-03-18 | Julius-Maximilians-Universität Würzburg | TUMOR NECROSIS FACTOR (TNF) RECEPTOR SUPERFAMILY (TNFRSF) RECEPTOR-ACTIVATING ANTIBODY FUSION PROTEINS WITH FCgR-INDEPENDENT AGONISTIC ACTIVITY (TNFRSF RECEPTOR-ACTIVATING ANTIBODY FUSION PROTEINS WITH FCgR-INDEPENDENT AGONISTIC ACTIVITY; TRAAFFIAA) |
| CN112041348B (en) | 2018-07-25 | 2023-09-22 | 天境生物科技(上海)有限公司 | Anti-CD73 anti-PD-L1 bispecific antibody |
| WO2020060183A1 (en) * | 2018-09-18 | 2020-03-26 | 삼성바이오에피스 주식회사 | Liquid formation for stabilizing trastuzumab antibody |
| US20230287122A1 (en) * | 2018-11-29 | 2023-09-14 | Harbour Biomed Therapeutics Limited | Anti-pd-l1 antibody preparation |
| SG11202108627SA (en) | 2019-02-18 | 2021-09-29 | Lilly Co Eli | Therapeutic antibody formulation |
| EP3991745A1 (en) * | 2019-06-25 | 2022-05-04 | Innovent Biologics (Suzhou) Co., Ltd. | Formulations containing anti-cd47/pd-l1 bispecific antibody and preparation method therefor and use thereof |
| CN111420049A (en) | 2019-08-22 | 2020-07-17 | Biocad股份公司 | Aqueous pharmaceutical composition of anti-PD 1 antibody PRO L GO L IMAB and application thereof |
| US12121565B2 (en) | 2019-09-13 | 2024-10-22 | Duke University | Methods of treatment of specific cancers with NLRP3 inhibitors and anti-PD1/PD-L1 antibodies |
| US12380963B2 (en) | 2019-10-14 | 2025-08-05 | The Medical College Of Wisconsin, Inc. | Gene expression signature of hyperprogressive disease (HPD) in patients after anti-PD-1 immunotherapy |
| EP4055153A4 (en) | 2019-11-04 | 2024-02-14 | Duke University | TREATMENT OF PRIMARY AND METASTATIC CANCER |
| WO2021118321A1 (en) * | 2019-12-13 | 2021-06-17 | 삼성바이오에피스 주식회사 | Stable anti-pd-1 antibody pharmaceutical preparation |
| KR102683876B1 (en) * | 2020-11-11 | 2024-07-11 | 가톨릭대학교 산학협력단 | Antibody-Based Conjugate for Enhancing Therapeutic Effect of Targeted Therapeutics |
| EP4362984A1 (en) | 2021-07-02 | 2024-05-08 | Yale University | Compositions and methods for treating cancers |
| WO2023034864A1 (en) | 2021-08-31 | 2023-03-09 | Yale University | Compositions and methods for treating cancers |
| US20240294651A1 (en) | 2023-01-30 | 2024-09-05 | Kymab Limited | Antibodies |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040033228A1 (en) * | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
| JO3000B1 (en) * | 2004-10-20 | 2016-09-05 | Genentech Inc | Antibody Formulations. |
| DK1934236T3 (en) | 2005-09-02 | 2013-02-25 | Glycomimetics Inc | Heterobifunctional pan-selectin inhibitors |
| PL1962886T6 (en) * | 2005-12-20 | 2023-03-13 | Bristol-Myers Squibb Company | Stable protein formulations |
| WO2009126556A1 (en) | 2008-04-08 | 2009-10-15 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
| PT4209510T (en) * | 2008-12-09 | 2024-04-02 | Hoffmann La Roche | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| EP2196476A1 (en) * | 2008-12-10 | 2010-06-16 | Novartis Ag | Antibody formulation |
| JP2013515754A (en) * | 2009-12-29 | 2013-05-09 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Novel antibody formulation |
| WO2012037034A1 (en) | 2010-09-14 | 2012-03-22 | Glycomimetics, Inc. | E-selectin antagonists |
| CA2830806C (en) * | 2011-03-31 | 2020-05-12 | Merck Sharp & Dohme Corp. | Stable formulations of antibodies to human programmed death receptor pd-1 and related treatments |
| AU2012344260B2 (en) | 2011-11-28 | 2017-09-07 | Merck Patent Gmbh | Anti-PD-L1 antibodies and uses thereof |
| WO2013112438A1 (en) * | 2012-01-23 | 2013-08-01 | Regeneron Pharmaceuticals, Inc. | Stabilized formulations containing anti-ang2 antibodies |
| US9216219B2 (en) * | 2012-06-12 | 2015-12-22 | Novartis Ag | Anti-BAFFR antibody formulation |
| JP6942465B2 (en) * | 2013-09-27 | 2021-09-29 | ジェネンテック， インコーポレイテッド | Anti-PDL1 antibody preparation |
| CA2926588C (en) * | 2013-10-16 | 2020-07-21 | Oncobiologics, Inc. | Buffer formulations for enhanced antibody stability |
| KR20170003692A (en) * | 2014-05-15 | 2017-01-09 | 브리스톨-마이어스 스큅 컴퍼니 | Treatment of lung cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent |
| CN105085680A (en) * | 2014-05-23 | 2015-11-25 | 复旦大学 | Humanized anti-PD-1 and c-MET bispecific antibody, and preparation method and application thereof |
| EP3262073A1 (en) | 2015-02-26 | 2018-01-03 | Merck Patent GmbH | Pd-1 / pd-l1 inhibitors for the treatment of cancer |
| TW201705955A (en) | 2015-05-14 | 2017-02-16 | 輝瑞大藥廠 | Combination therapies comprising a pyrrolidine-2,5-dione IDO1 inhibitor and an anti-PD1/anti-PD-L1 antibody |
| AU2016274584A1 (en) | 2015-06-08 | 2018-01-04 | Genentech, Inc. | Methods of treating cancer using anti-OX40 antibodies and PD-1 axis binding antagonists |
| AU2016280003B2 (en) | 2015-06-16 | 2021-09-16 | Merck Patent Gmbh | PD-L1 antagonist combination treatments |
| US20180282415A1 (en) | 2015-09-30 | 2018-10-04 | Merck Patent Gmbh | Combination of a PD-1 Axis Binding Antagonist and an ALK Inhibitor for Treating ALK-Negative Cancer |
| HRP20201573T1 (en) | 2015-12-07 | 2020-12-11 | Merck Patent Gmbh | Aqueous pharmaceutical formulation comprising anti-pd-1 antibody avelumab |
| JP7379159B2 (en) | 2017-03-06 | 2023-11-14 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | Aqueous anti-PD-L1 antibody preparation |
-
2016
- 2016-12-05 HR HRP20201573TT patent/HRP20201573T1/en unknown
- 2016-12-05 EP EP16818985.0A patent/EP3386541B1/en active Active
- 2016-12-05 BR BR112018010211A patent/BR112018010211A2/en active Search and Examination
- 2016-12-05 WO PCT/EP2016/002040 patent/WO2017097407A1/en not_active Ceased
- 2016-12-05 EP EP20184113.7A patent/EP3747466A1/en not_active Withdrawn
- 2016-12-05 UA UAA201807363A patent/UA123270C2/en unknown
- 2016-12-05 EA EA201891339A patent/EA201891339A1/en unknown
- 2016-12-05 MY MYPI2018702171A patent/MY195681A/en unknown
- 2016-12-05 CA CA3007481A patent/CA3007481C/en active Active
- 2016-12-05 NZ NZ743964A patent/NZ743964A/en unknown
- 2016-12-05 SI SI201630940T patent/SI3386541T1/en unknown
- 2016-12-05 PL PL16818985T patent/PL3386541T3/en unknown
- 2016-12-05 DK DK16818985.0T patent/DK3386541T3/en active
- 2016-12-05 RS RS20201201A patent/RS61029B1/en unknown
- 2016-12-05 JP JP2018529213A patent/JP6925337B2/en active Active
- 2016-12-05 SG SG11201804758QA patent/SG11201804758QA/en unknown
- 2016-12-05 ES ES16818985T patent/ES2823279T3/en active Active
- 2016-12-05 AU AU2016368099A patent/AU2016368099C1/en active Active
- 2016-12-05 US US16/060,319 patent/US11058769B2/en active Active
- 2016-12-05 CN CN201680071740.1A patent/CN108367072B/en active Active
- 2016-12-05 PE PE2018001077A patent/PE20181400A1/en unknown
- 2016-12-05 SM SM20200497T patent/SMT202000497T1/en unknown
- 2016-12-05 HU HUE16818985A patent/HUE050811T2/en unknown
- 2016-12-05 MX MX2018006875A patent/MX389289B/en unknown
- 2016-12-05 PT PT168189850T patent/PT3386541T/en unknown
- 2016-12-05 KR KR1020187019480A patent/KR102697026B1/en active Active
- 2016-12-05 LT LTEP16818985.0T patent/LT3386541T/en unknown
- 2016-12-06 TW TW105140288A patent/TWI630917B/en active
- 2016-12-07 AR ARP160103760A patent/AR107014A1/en not_active Application Discontinuation
-
2018
- 2018-04-26 PH PH12018500894A patent/PH12018500894A1/en unknown
- 2018-05-23 IL IL259563A patent/IL259563B/en active IP Right Grant
- 2018-05-25 CO CONC2018/0005525A patent/CO2018005525A2/en unknown
- 2018-06-04 CL CL2018001488A patent/CL2018001488A1/en unknown
- 2018-06-06 SA SA518391743A patent/SA518391743B1/en unknown
- 2018-07-06 ZA ZA201804534A patent/ZA201804534B/en unknown
-
2020
- 2020-09-24 CY CY20201100904T patent/CY1123358T1/en unknown
- 2020-12-09 US US17/116,587 patent/US20210100903A1/en not_active Abandoned
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