+

SG11201507429TA - Il-22 polypeptides and il-22 fc fusion proteins and methods of use - Google Patents

Il-22 polypeptides and il-22 fc fusion proteins and methods of use

Info

Publication number
SG11201507429TA
SG11201507429TA SG11201507429TA SG11201507429TA SG11201507429TA SG 11201507429T A SG11201507429T A SG 11201507429TA SG 11201507429T A SG11201507429T A SG 11201507429TA SG 11201507429T A SG11201507429T A SG 11201507429TA SG 11201507429T A SG11201507429T A SG 11201507429TA
Authority
SG
Singapore
Prior art keywords
polypeptides
methods
fusion proteins
fusion
proteins
Prior art date
Application number
SG11201507429TA
Inventor
Justin Scheer
Wenjun Ouyang
Eric Gary Stefanich
Richard Vandlen
Philip E Haas
Ganesh A Kolumam
Xiaoting Wang
Jed Ross
Bruggen Nicholas Van
Wyne P Lee
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of SG11201507429TA publication Critical patent/SG11201507429TA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
SG11201507429TA 2013-03-15 2014-03-14 Il-22 polypeptides and il-22 fc fusion proteins and methods of use SG11201507429TA (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201361800795P 2013-03-15 2013-03-15
US201361801144P 2013-03-15 2013-03-15
US201361800148P 2013-03-15 2013-03-15
US201361821062P 2013-05-08 2013-05-08
US201361860176P 2013-07-30 2013-07-30
PCT/US2014/029652 WO2014145016A2 (en) 2013-03-15 2014-03-14 Il-22 polypeptides and il-22 fc fusion proteins and methods of use

Publications (1)

Publication Number Publication Date
SG11201507429TA true SG11201507429TA (en) 2015-10-29

Family

ID=50942310

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201507429TA SG11201507429TA (en) 2013-03-15 2014-03-14 Il-22 polypeptides and il-22 fc fusion proteins and methods of use
SG10201808523RA SG10201808523RA (en) 2013-03-15 2014-03-14 Il-22 polypeptides and il-22 fc fusion proteins and methods of use

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201808523RA SG10201808523RA (en) 2013-03-15 2014-03-14 Il-22 polypeptides and il-22 fc fusion proteins and methods of use

Country Status (29)

Country Link
US (12) US10160793B2 (en)
EP (2) EP2970422B1 (en)
JP (3) JP6456356B2 (en)
KR (1) KR102426481B1 (en)
CN (1) CN105143252A (en)
AU (3) AU2014233494B2 (en)
BR (1) BR112015023140A8 (en)
CA (1) CA2903587C (en)
CL (1) CL2015002654A1 (en)
DK (1) DK2970422T3 (en)
EA (1) EA035645B1 (en)
ES (1) ES2676023T3 (en)
HK (1) HK1218424A1 (en)
HR (1) HRP20181090T1 (en)
HU (1) HUE039291T2 (en)
LT (1) LT2970422T (en)
MX (2) MX368005B (en)
PE (2) PE20151673A1 (en)
PH (2) PH12015502125B1 (en)
PL (1) PL2970422T3 (en)
PT (1) PT2970422T (en)
RS (1) RS57393B1 (en)
SG (2) SG11201507429TA (en)
SI (1) SI2970422T1 (en)
TR (1) TR201809571T4 (en)
TW (2) TW202214675A (en)
UA (1) UA118843C2 (en)
WO (1) WO2014145016A2 (en)
ZA (1) ZA201506297B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111757751A (en) * 2018-02-21 2020-10-09 豪夫迈·罗氏有限公司 Dosage regimen for treatment with IL-22 Fc fusion protein

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101361968B (en) 2007-08-06 2011-08-03 健能隆医药技术（上海）有限公司 Use of interleukin-22 in treating fatty liver
JP6254146B2 (en) 2012-03-27 2017-12-27 エヌジーエム バイオファーマシューティカルス，インコーポレーテッド Compositions and methods for treating metabolic disorders
CA2899170C (en) 2013-01-30 2022-08-02 Ngm Biopharmaceuticals, Inc. Compositions and methods of use in treating metabolic disorders
US9161966B2 (en) 2013-01-30 2015-10-20 Ngm Biopharmaceuticals, Inc. GDF15 mutein polypeptides
US9580486B2 (en) 2013-03-14 2017-02-28 Amgen Inc. Interleukin-2 muteins for the expansion of T-regulatory cells
SG11201507429TA (en) 2013-03-15 2015-10-29 Genentech Inc Il-22 polypeptides and il-22 fc fusion proteins and methods of use
CN104623639A (en) 2013-11-07 2015-05-20 健能隆医药技术（上海）有限公司 Application of interleukin-22 dimer in preparation of drugs for treating pancreatitis
CN104623637A (en) 2013-11-07 2015-05-20 健能隆医药技术（上海）有限公司 Application of IL-22 dimer in preparation of intravenous injection drugs
ES2739129T5 (en) * 2013-11-07 2024-04-02 Memorial Sloan Kettering Cancer Center IL-22 for use in the treatment of gastrointestinal graft-versus-host disease
MX370115B (en) 2014-07-30 2019-12-02 Ngm Biopharmaceuticals Inc Compositions and methods of use for treating metabolic disorders.
DK3212226T3 (en) 2014-10-31 2020-06-15 Ngm Biopharmaceuticals Inc COMPOSITIONS AND METHODS OF USE FOR TREATING METABOLIC DISORDERS
US11566082B2 (en) 2014-11-17 2023-01-31 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
WO2016108130A1 (en) * 2014-12-30 2016-07-07 Sun Pharmaceutical Industries Limited Topical pharmaceutical compositions comprising nebivolol for the treatment of diabetic wounds
MY188430A (en) 2015-04-10 2021-12-08 Amgen Inc Interleukin-2 muteins for the expansion of t-regulatory cells
CN106317225A (en) * 2015-06-28 2017-01-11 复旦大学 Long-acting interleukin 22 fusion protein with targeting property, and preparation method and applications thereof
RU2018105687A (en) * 2015-07-16 2019-08-16 Филоджен С.П.А. IMMUNO CONJUGATES BASED ON IL22
NZ739721A (en) * 2015-08-07 2019-09-27 Imaginab Inc Antigen binding constructs to target molecules
EP3167892A1 (en) 2015-11-10 2017-05-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for preventing or treating imflammatory bowel diseases
MY194669A (en) 2016-03-31 2022-12-12 Ngm Biopharmaceuticals Inc Binding Proteins and Methods of use Thereof
CN109328069B (en) * 2016-04-15 2023-09-01 亿一生物医药开发(上海)有限公司 Use of IL-22 in the treatment of necrotizing enterocolitis
WO2017191817A1 (en) * 2016-05-02 2017-11-09 味の素株式会社 Azide group-containing fc protein
EP3455240B1 (en) 2016-05-11 2025-01-01 Cytiva BioProcess R&D AB Method of storing a separation matrix
JP6987424B2 (en) 2016-05-11 2022-01-05 サイティバ・バイオプロセス・アールアンドディ・アクチボラグ How to clean and / or disinfect the isolation matrix
US10889615B2 (en) 2016-05-11 2021-01-12 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
US10730908B2 (en) 2016-05-11 2020-08-04 Ge Healthcare Bioprocess R&D Ab Separation method
US10703774B2 (en) 2016-09-30 2020-07-07 Ge Healthcare Bioprocess R&D Ab Separation method
JP7031934B2 (en) 2016-05-11 2022-03-08 サイティバ・バイオプロセス・アールアンドディ・アクチボラグ Separation matrix
EP3455243B1 (en) 2016-05-11 2021-03-24 Cytiva BioProcess R&D AB Separation matrix
US10654887B2 (en) 2016-05-11 2020-05-19 Ge Healthcare Bio-Process R&D Ab Separation matrix
BR112019002394B1 (en) 2016-08-10 2021-12-21 Ajou University Industry-Academic Cooperation Foundation HETERODIMERIC PROTEIN FLUTED WITH CF AND ITS USE
CN108239151B (en) * 2016-12-23 2020-07-03 海门晟斯生物制药有限公司 Recombinant single-chain human FVIII-Fc fusion protein and its application
WO2018147960A1 (en) 2017-02-08 2018-08-16 Imaginab, Inc. Extension sequences for diabodies
EP3589725A1 (en) * 2017-02-28 2020-01-08 Vib Vzw Means and methods for oral protein delivery
CN112142859A (en) * 2017-05-22 2020-12-29 杭州博虎生物科技有限公司 Human interleukin 10-Fc fusion protein and coding gene and application thereof
JP7345479B2 (en) * 2018-01-26 2023-09-15 ジェネンテック， インコーポレイテッド Composition and method of use
SG11202006259SA (en) * 2018-01-26 2020-08-28 Genentech Inc Il-22 fc fusion proteins and methods of use
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
CA3102391A1 (en) 2018-06-05 2019-12-12 Bioatla, Inc. Anti-il-22 antibodies, antibody fragments, their immunoconjugates and uses thereof
CN108918571B (en) * 2018-06-15 2021-02-02 山西大学 Application of metabolic markers in the preparation of diagnostic reagents for nephrotic syndrome lesion process
AU2019318209B2 (en) * 2018-08-10 2025-09-25 Diapin Therapeutics, Llc Tri-peptides and treatment of metabolic, cardiovascular and inflammatory disorders
AU2019336230B2 (en) 2018-09-06 2023-09-07 Cidara Therapeutics, Inc. Compositions and methods for the treatment of viral infections
WO2020055768A1 (en) 2018-09-10 2020-03-19 Cold Spring Harbor Laboratory Methods for treating pancreatitis
KR20210080460A (en) * 2018-10-23 2021-06-30 드래곤플라이 쎄라퓨틱스, 인크. Heterodimeric Fc-fused protein
ES2911075T3 (en) * 2018-11-07 2022-05-17 Applied Molecular Transport Inc Delivery constructs for transcytosis and related methods
CN113347997A (en) 2018-11-07 2021-09-03 应用分子运输公司 Cholix-derived carriers for oral delivery of heterologous payloads
US20220010019A1 (en) * 2018-11-27 2022-01-13 The General Hospital Corporation Targeting intraepithelial lymphocytes for treatment of metabolic syndrome
WO2021021647A1 (en) * 2019-07-26 2021-02-04 Genentech, Inc. Dosing for prevention or treatment of graft versus host disease (gvhd) with il-22 fc fusion proteins
AU2020331939A1 (en) 2019-08-16 2022-03-24 Applied Molecular Transport Inc. Compositions, formulations, and interleukin production and purification
WO2021046133A1 (en) * 2019-09-03 2021-03-11 Amgen Inc. Il-22 oral, intra-rectal, or other gut-related compositions and methods of use thereof
TWI861205B (en) 2019-09-06 2024-11-11 美商席達拉醫療有限公司 Compositions and methods for the treatment of viral infections
WO2021062012A1 (en) * 2019-09-25 2021-04-01 Emory University Use of klk10 and engineered derivatizations thereof
CN112618698B (en) * 2019-10-08 2021-10-08 北京东方百泰生物科技股份有限公司 Injection preparation of human interleukin 10-Fc fusion protein
EP3819307A1 (en) * 2019-11-07 2021-05-12 CytoKi Pharma ApS Therapeutic derivatives of interleukin-22
EP4107185A1 (en) 2020-03-23 2022-12-28 Genentech, Inc. Biomarkers for predicting response to il-6 antagonist in covid-19 pneumonia
WO2021207662A1 (en) * 2020-04-10 2021-10-14 Genentech, Inc. Use of il-22fc for the treatment or prevention of pneumonia, acute respiratory distress syndrome, or cytokine release syndrome
AU2021257348A1 (en) * 2020-04-17 2022-11-03 The Board Of Trustees Of The Leland Stanford Junior University Engineered interleukin-22 polypeptides and uses thereof
CN116234830A (en) 2020-08-07 2023-06-06 基因泰克公司 FLT3 ligand fusion proteins and methods of use
CN112007146A (en) * 2020-09-03 2020-12-01 上海市儿童医院 Use of IL-22 in a medicament for the treatment and/or prevention of sepsis-induced liver injury
CN116685351A (en) 2020-09-17 2023-09-01 基因泰克公司 Results of EMPACTA: random, double-blind, placebo-controlled, multicenter study for assessing the efficacy and safety of tobrazumab in hospitalized patients with covd-19 pneumonia
CA3200885A1 (en) 2020-11-23 2022-05-27 Genentech, Inc. Methods for modulating host cell surface interactions with sars-cov-2
US20240150453A1 (en) 2021-03-09 2024-05-09 Massachusetts Institute Of Technology Methods of predicting response to anti-tnf blockade in inflammatory bowel disease
WO2024092131A1 (en) * 2022-10-26 2024-05-02 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Engineered bacterium and uses thereof for treating cancer

Family Cites Families (150)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS6023084B2 (en) 1979-07-11 1985-06-05 味の素株式会社 blood substitute
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
US4873191A (en) 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
NZ201705A (en) 1981-08-31 1986-03-14 Genentech Inc Recombinant dna method for production of hepatitis b surface antigen in yeast
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
AU2353384A (en) 1983-01-19 1984-07-26 Genentech Inc. Amplification in eukaryotic host cells
US4713339A (en) 1983-01-19 1987-12-15 Genentech, Inc. Polycistronic expression vector construction
WO1984003506A1 (en) 1983-03-08 1984-09-13 Commw Serum Lab Commission Antigenically active amino acid sequences
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
JPS60500673A (en) 1983-03-08 1985-05-09 コモンウエルス　セラム　ラボラトリ−ズ　コミツシヨン Amino acid sequence with antigenic activity
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
US4736866B1 (en) 1984-06-22 1988-04-12 Transgenic non-human mammals
NZ215865A (en) 1985-04-22 1988-10-28 Commw Serum Lab Commission Method of determining the active site of a receptor-binding analogue
US4737456A (en) 1985-05-09 1988-04-12 Syntex (U.S.A.) Inc. Reducing interference in ligand-receptor binding assays
EP0206448B1 (en) 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hemoglobin combined with a poly(alkylene oxide)
EP0272253A4 (en) 1986-03-07 1990-02-05 Massachusetts Inst Technology Method for enhancing glycoprotein stability.
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US4717717A (en) 1986-11-05 1988-01-05 Ethicon, Inc. Stabilized compositions containing epidermal growth factor
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
EP0307434B2 (en) 1987-03-18 1998-07-29 Scotgen Biopharmaceuticals, Inc. Altered antibodies
US5010182A (en) 1987-07-28 1991-04-23 Chiron Corporation DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides
NZ226171A (en) 1987-09-18 1990-06-26 Ethicon Inc Gel formulation containing polypeptide growth factor
US5705485A (en) 1987-09-18 1998-01-06 Ethicon, Inc. Gel formulations containing growth factors
US5457093A (en) 1987-09-18 1995-10-10 Ethicon, Inc. Gel formulations containing growth factors
GB8724885D0 (en) 1987-10-23 1987-11-25 Binns M M Fowlpox virus promotors
JPH04501201A (en) 1987-12-21 1992-03-05 ジ・アップジョン・カンパニー Agrobacterium-mediated transformation of germinated plant seeds
US5571689A (en) 1988-06-16 1996-11-05 Washington University Method of N-acylating peptide and proteins with diheteroatom substituted analogs of myristic acid
AU4005289A (en) 1988-08-25 1990-03-01 Smithkline Beecham Corporation Recombinant saccharomyces
US5663143A (en) 1988-09-02 1997-09-02 Dyax Corp. Engineered human-derived kunitz domains that inhibit human neutrophil elastase
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5116964A (en) 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
FR2646437B1 (en) 1989-04-28 1991-08-30 Transgene Sa NOVEL DNA SEQUENCES, THEIR APPLICATION AS A SEQUENCE ENCODING A SIGNAL PEPTIDE FOR THE SECRETION OF MATURE PROTEINS BY RECOMBINANT YEASTS, EXPRESSION CASSETTES, PROCESSED YEASTS AND PROCESS FOR PREPARING THE SAME
US5130298A (en) 1989-05-16 1992-07-14 Ethicon, Inc. Stabilized compositions containing epidermal growth factor
US5959177A (en) 1989-10-27 1999-09-28 The Scripps Research Institute Transgenic plants expressing assembled secretory antibodies
ATE176239T1 (en) 1990-11-21 1999-02-15 Iterex Pharma Lp SYNTHESIS OF EQUIMOLAR MIXTURES OF VARIOUS OLIGOMERS, SPECIFICALLY OLIGOPEPTIDE MIXTURES
ES2113940T3 (en) 1990-12-03 1998-05-16 Genentech Inc ENRICHMENT METHOD FOR PROTEIN VARIANTS WITH ALTERED UNION PROPERTIES.
US5206161A (en) 1991-02-01 1993-04-27 Genentech, Inc. Human plasma carboxypeptidase B
US6407213B1 (en) 1991-06-14 2002-06-18 Genentech, Inc. Method for making humanized antibodies
EP0604580A1 (en) 1991-09-19 1994-07-06 Genentech, Inc. EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab') 2? ANTIBODIES
JPH08511420A (en) 1993-06-16 1996-12-03 セルテック・セラピューテイクス・リミテッド Body
US5789199A (en) 1994-11-03 1998-08-04 Genentech, Inc. Process for bacterial production of polypeptides
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5840523A (en) 1995-03-01 1998-11-24 Genetech, Inc. Methods and compositions for secretion of heterologous polypeptides
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
GB9603256D0 (en) 1996-02-16 1996-04-17 Wellcome Found Antibodies
EP0980431A1 (en) 1997-05-14 2000-02-23 Human Genome Sciences, Inc. Antimicrobial peptide
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
WO1998058964A1 (en) 1997-06-24 1998-12-30 Genentech, Inc. Methods and compositions for galactosylated glycoproteins
US6040498A (en) 1998-08-11 2000-03-21 North Caroline State University Genetically engineered duckweed
WO2002016611A2 (en) 2000-08-24 2002-02-28 Genentech, Inc. Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders
ES2236931T3 (en) 1997-10-08 2005-07-16 Theragem, Inc. PEPTIDES DERIVED FROM MAMMALS FOR THE TREATMENT OF MICROBIAL INFECTIONS.
DE69840412D1 (en) 1997-10-31 2009-02-12 Genentech Inc METHODS AND COMPOSITIONS CONTAINING GLYCOPROTEIN GLYCOR FORMS
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
ES2292236T3 (en) 1998-04-02 2008-03-01 Genentech, Inc. VARIATIONS OF ANTIBODIES AND THEIR FRAGMENTS.
WO1999054342A1 (en) 1998-04-20 1999-10-28 Pablo Umana Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
US20010023070A1 (en) 1998-05-29 2001-09-20 Reinhard Ebner Interleukins-21 and 22
US20030003545A1 (en) 1998-05-29 2003-01-02 Reinhard Ebner Interleukins-21 and 22
US6335155B1 (en) 1998-06-26 2002-01-01 Sunesis Pharmaceuticals, Inc. Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules
DK1107791T3 (en) 1998-09-04 2007-09-03 Scios Inc Hydrogel preparations for controlled release administration of growth factors
US6927044B2 (en) 1998-09-25 2005-08-09 Regeneron Pharmaceuticals, Inc. IL-1 receptor based cytokine traps
BR9914777A (en) 1998-10-26 2001-07-03 Ludwig Inst Cancer Res Isolated nucleic acid molecules that encode factors inducible by t cells (tifs), encoded proteins and their uses
EP1141708A1 (en) 1998-12-28 2001-10-10 Sunesis Pharmaceuticals Inc. Identifying small organic molecule ligands for binding
HUP0104865A3 (en) 1999-01-15 2004-07-28 Genentech Inc Polypeptide variants with altered effector function
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
EP3031917A1 (en) 1999-04-09 2016-06-15 Kyowa Hakko Kirin Co., Ltd. Method for controlling the activity of immunologically functional molecule
PT1177312E (en) 1999-04-28 2008-01-22 Genetics Inst Llc Human gil-19/ae289 proteins and polynucleotides encoding same
US6939545B2 (en) 1999-04-28 2005-09-06 Genetics Institute, Llc Composition and method for treating inflammatory disorders
AU5047600A (en) 1999-05-27 2000-12-18 Schering Corporation Mammalian interleukin-10 homologs: il-d110 and il-d210
JP2004522402A (en) 1999-06-02 2004-07-29 ジェネンテック・インコーポレーテッド Secreted and transmembrane polypeptides and nucleic acids encoding the same
KR100797667B1 (en) 1999-10-04 2008-01-23 메디카고 인코포레이티드 How to regulate transcription of foreign genes
US7125978B1 (en) 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
EP1229125A4 (en) 1999-10-19 2005-06-01 Kyowa Hakko Kogyo Kk PROCESS FOR PRODUCING A POLYPEPTIDE
US7226591B2 (en) 2000-05-22 2007-06-05 Genentech, Inc. Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders
JP2003524415A (en) 1999-12-23 2003-08-19 ザイモジェネティクス，インコーポレイティド Cytokine ZCYTO18
US20030170823A1 (en) 1999-12-23 2003-09-11 Presnell Scott R. Novel cytokine ZCYTO18
GB0024442D0 (en) 2000-10-05 2000-11-22 Isis Innovation Genetic factors affecting the outcome of viral infections
EA013563B1 (en) 2000-10-06 2010-06-30 Киова Хакко Кирин Ко., Лтд. A transgenic non-human animal, producing antibodies with modified sugar chains, a process for producing antibodies composition and a medicament comprising the antibodies
US7064191B2 (en) 2000-10-06 2006-06-20 Kyowa Hakko Kogyo Co., Ltd. Process for purifying antibody
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
US7638604B2 (en) 2001-02-23 2009-12-29 Genetics Institute, Llc Monoclonal antibodies against interleukin-22
BR0207528A (en) 2001-02-23 2006-01-17 Inst Genetics Llc Antibody, pharmaceutical composition, and uses of an effective amount of an agent, a therapeutically effective amount of an il-22 antibody, an immunogenic amount of antigen, and an immunogenicity enhancing amount of il-22 in combination, a effective amount of the antibody or fragment thereof and a sufficient amount of antibody or antigen-linked fragment thereof
AU2002252460A1 (en) 2001-03-27 2002-10-08 Zymogenetics, Inc. Human cytokine receptor
NZ592087A (en) 2001-08-03 2012-11-30 Roche Glycart Ag Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
CA2461665A1 (en) 2001-10-19 2003-05-01 Genentech, Inc. Compositions and methods for the diagnosis and treatment of inflammatory bowel disorders
PL213948B1 (en) 2001-10-25 2013-05-31 Genentech Inc Glycoprotein compositions
FR2833011B1 (en) 2001-12-04 2004-10-29 Univ Claude Bernard Lyon NOVEL PROTEIN WITH IL-6 INHIBITING ACTIVITY
US20040093621A1 (en) 2001-12-25 2004-05-13 Kyowa Hakko Kogyo Co., Ltd Antibody composition which specifically binds to CD20
JP4504023B2 (en) 2002-03-22 2010-07-14 ザイモジェネティクス インコーポレーティッド Anti-IL-TIF antibodies and methods for use in inflammation
JPWO2003085119A1 (en) 2002-04-09 2005-08-11 協和醗酵工業株式会社 Method for enhancing binding activity of antibody composition to Fcγ receptor IIIa
PL373256A1 (en) 2002-04-09 2005-08-22 Kyowa Hakko Kogyo Co, Ltd. Cells with modified genome
AU2003236015A1 (en) 2002-04-09 2003-10-20 Kyowa Hakko Kirin Co., Ltd. Process for producing antibody composition
EP1502603A4 (en) 2002-04-09 2006-12-13 Kyowa Hakko Kogyo Kk MEDICAMENT CONTAINING ANTIBODY COMPOSITION APPROPRIATE TO PATIENT SUFFERING FROM POLYMORPHISM FC gammma RIIIA
CA2481920A1 (en) 2002-04-09 2003-10-16 Kyowa Hakko Kogyo Co., Ltd. Antibody composition-containing medicament
ES2362419T3 (en) 2002-04-09 2011-07-05 Kyowa Hakko Kirin Co., Ltd. CELLS WITH DEPRESSION OR DELETION OF THE ACTIVITY OF THE PROTEIN THAT PARTICIPATES IN THE TRANSPORT OF GDP-FUCOSA.
US20030235561A1 (en) 2002-06-25 2003-12-25 Cell Based Delivery Inc. Vascularized organized tissues and uses thereof
EP1539235A2 (en) 2002-07-01 2005-06-15 Human Genome Sciences, Inc. Antibodies that specifically bind to reg iv
US7361740B2 (en) 2002-10-15 2008-04-22 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
EP2301966A1 (en) 2002-12-16 2011-03-30 Genentech, Inc. Immunoglobulin variants and uses thereof
WO2004058307A1 (en) 2002-12-18 2004-07-15 Wyeth Methods for screening, treating and diagnosing inflammatory bowel disease and compositions thereof
US20060104968A1 (en) 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
US7871607B2 (en) 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
GB2401040A (en) 2003-04-28 2004-11-03 Chugai Pharmaceutical Co Ltd Method for treating interleukin-6 related diseases
KR100973564B1 (en) 2003-05-02 2010-08-03 젠코어 인코포레이티드 Optimized Fc Variants and Methods of Making the Same
CA2530386A1 (en) 2003-06-23 2005-01-06 Jing Li Antibodies against interleukin-22 and uses therefor
PT3100611T (en) 2003-08-01 2018-12-14 Stratatech Corp Human skin equivalents expressing exogenous polypeptides
US20080241884A1 (en) 2003-10-08 2008-10-02 Kenya Shitara Fused Protein Composition
US20070134759A1 (en) 2003-10-09 2007-06-14 Harue Nishiya Process for producing antibody composition by using rna inhibiting the function of alpha1,6-fucosyltransferase
EP1748789B1 (en) 2003-11-05 2010-12-29 Institut de Recherche pour le Développement ( IRD) IL-22 for preventing infectious diseases
DE602004026470D1 (en) 2003-11-05 2010-05-20 Roche Glycart Ag FC RECEPTOR AND EFFECTOR FUNCTION
JPWO2005053742A1 (en) 2003-12-04 2007-06-28 協和醗酵工業株式会社 Medicament containing antibody composition
PT1699822E (en) * 2003-12-30 2008-07-30 Merck Patent Gmbh Il-7 fusion proteins with antibody portions, their preparation and their use
PL1737891T3 (en) 2004-04-13 2013-08-30 Hoffmann La Roche Anti-p-selectin antibodies
US20050277593A1 (en) 2004-05-24 2005-12-15 Washington University Therapeutic uses of Reg protein
TWI309240B (en) 2004-09-17 2009-05-01 Hoffmann La Roche Anti-ox40l antibodies
WO2006034488A2 (en) 2004-09-23 2006-03-30 Genentech, Inc. Cysteine engineered antibodies and conjugates
JO3000B1 (en) 2004-10-20 2016-09-05 Genentech Inc Antibody Formulations.
CN100515491C (en) 2005-01-04 2009-07-22 健能隆医药技术（上海）有限公司 Medical application of interleukin-22
KR20080017362A (en) 2005-06-17 2008-02-26 제넨테크, 인크. Use of vegf for wound healing
RU2302460C1 (en) 2005-11-02 2007-07-10 Институт цитологии и генетики Сибирского отделения Российской академии наук (СО РАН) RECOMBINANT PLASMID DNA pBi101-IL18 ENCODING HUMAN INTERLEUKIN-18 SYNTHESIS IN TRANSGENIC PLANTS
US20090293137A1 (en) 2005-11-21 2009-11-26 Genentech, Inc. Novel Gene Disruptions, Compositions and Methods Relating Thereto
EP3006466B1 (en) 2005-12-02 2018-08-01 Genentech, Inc. Compositions and methods for the treatment of diseases and disorders associated with cytokine signaling involving antibodies that bind to il-22 and il-22r
TWI417301B (en) 2006-02-21 2013-12-01 Wyeth Corp Antibodies against human il-22 and uses therefor
CA2652924A1 (en) 2006-06-19 2007-12-27 Wyeth Methods of modulating il-22 and il-17
WO2008023689A1 (en) * 2006-08-21 2008-02-28 National University Corporation Kobe University Method of producing fused protein
US20080226635A1 (en) 2006-12-22 2008-09-18 Hans Koll Antibodies against insulin-like growth factor I receptor and uses thereof
US20080267910A1 (en) 2007-03-09 2008-10-30 Wu Paul W Rat, rabbit, and cynomolgus monkey IL-21 and IL-22 nucleotide and polypeptide sequences
CN101361968B (en) 2007-08-06 2011-08-03 健能隆医药技术（上海）有限公司 Use of interleukin-22 in treating fatty liver
WO2009026524A1 (en) 2007-08-22 2009-02-26 Baylor College Of Medicine Delipidation of hdl using serum opacity factor to prevent atherosclerosis
CN101225110B (en) 2007-10-23 2010-10-20 中国人民解放军军事医学科学院基础医学研究所 Human interleukins-22 mutant as well as construction method and use thereof
LT2514436T (en) 2007-11-07 2018-04-10 Genentech, Inc. Il-22 for use in treating microbial disorders
CA2718634A1 (en) 2008-03-21 2009-09-24 Wyeth Llc Antibodies against interleukin-10-like cytokines and uses therefor
BRPI0916904A2 (en) * 2008-08-04 2016-10-11 Fiveprime Therapeutics Inc polypeptides, ecd fgfr4 fusion molecules, pharmaceutical compositions, polynucleotide and methods of treating angiogenic disorder, patient cancer and patient macular degeneration and their uses
JP5981141B2 (en) 2009-01-12 2016-08-31 ジェネロン（シャンハイ）コーポレーションＧｅｎｅｒｏｎ （Ｓｈａｎｇｈａｉ） Ｃｏｒｐｏｒａｔｉｏｎ Use of interleukin-22 for prevention and / or treatment of multiple organ dysfunction syndrome (MODS)
MX2011007833A (en) * 2009-01-23 2011-10-06 Biogen Idec Inc Stabilized fc polypeptides with reduced effector function and methods of use.
AU2010239216B2 (en) 2009-04-21 2012-07-12 Amgen Inc. Fragmentation resistant IgG1 Fc-conjugates
JP5523771B2 (en) 2009-09-02 2014-06-18 三菱農機株式会社 Transplanter
GB0916124D0 (en) 2009-09-15 2009-10-28 Univ Cardiff Method and kit for the classification and prognosis of wounds
CA2788096A1 (en) * 2010-01-13 2011-07-21 Amgen Inc. Il-22-fc and hepcidin activity
MX346731B (en) 2010-04-23 2017-03-30 Genentech Inc * Production of heteromultimeric proteins.
CN102380091A (en) 2010-08-31 2012-03-21 健能隆医药技术（上海）有限公司 Application of interleukin-22 in curing virus hepatitis
WO2012102679A1 (en) 2011-01-24 2012-08-02 National University Of Singapore Pathogenic mycobacteria-derived mannose-capped lipoarabinomannan antigen binding proteins
MX359384B (en) 2011-10-11 2018-09-25 Genentech Inc Improved assembly of bispecific antibodies.
CN103182072B (en) 2011-12-27 2017-05-03 健能隆医药技术（上海）有限公司 Application of interleukin-22 in treating and preventing nerve injuries and neurodegeneration diseases
JP5668708B2 (en) 2012-02-14 2015-02-12 住友電気工業株式会社 Optical probe
US9580486B2 (en) * 2013-03-14 2017-02-28 Amgen Inc. Interleukin-2 muteins for the expansion of T-regulatory cells
SG11201507429TA (en) 2013-03-15 2015-10-29 Genentech Inc Il-22 polypeptides and il-22 fc fusion proteins and methods of use

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111757751A (en) * 2018-02-21 2020-10-09 豪夫迈·罗氏有限公司 Dosage regimen for treatment with IL-22 Fc fusion protein

Also Published As

Publication number Publication date
NZ711095A (en) 2021-06-25
BR112015023140A2 (en) 2017-11-21
US20190177387A1 (en) 2019-06-13
US11155591B2 (en) 2021-10-26
US20170088596A1 (en) 2017-03-30
JP2016522795A (en) 2016-08-04
WO2014145016A3 (en) 2015-03-05
CN105143252A (en) 2015-12-09
UA118843C2 (en) 2019-03-25
KR102426481B1 (en) 2022-07-27
US11130791B2 (en) 2021-09-28
US20190233491A1 (en) 2019-08-01
CL2015002654A1 (en) 2016-07-15
HUE039291T2 (en) 2018-12-28
US11136365B2 (en) 2021-10-05
JP7245021B2 (en) 2023-03-23
PT2970422T (en) 2018-07-06
US9815880B2 (en) 2017-11-14
CA2903587C (en) 2021-09-28
DK2970422T3 (en) 2018-07-16
KR20150128944A (en) 2015-11-18
US20170320926A1 (en) 2017-11-09
HRP20181090T1 (en) 2018-09-07
PE20211272A1 (en) 2021-07-19
TWI772250B (en) 2022-08-01
TW202214675A (en) 2022-04-16
HK1218424A1 (en) 2017-02-17
TW201524995A (en) 2015-07-01
US20190177386A1 (en) 2019-06-13
MX368005B (en) 2019-09-13
PE20151673A1 (en) 2015-11-27
PL2970422T3 (en) 2018-09-28
PH12015502125A1 (en) 2016-01-25
AU2018223004B2 (en) 2020-04-16
US11332507B2 (en) 2022-05-17
AU2018223004A1 (en) 2018-09-20
EA201591515A1 (en) 2016-03-31
US20180362608A1 (en) 2018-12-20
JP6456356B2 (en) 2019-01-23
LT2970422T (en) 2018-06-25
US20170008942A1 (en) 2017-01-12
JP2019030308A (en) 2019-02-28
SG10201808523RA (en) 2018-11-29
PH12020550205A1 (en) 2021-09-01
TR201809571T4 (en) 2018-07-23
MX2015011146A (en) 2016-03-08
EP2970422B1 (en) 2018-04-18
US20190177390A1 (en) 2019-06-13
MX2019010846A (en) 2019-10-30
BR112015023140A8 (en) 2018-01-23
NZ751499A (en) 2021-07-30
US10584155B2 (en) 2020-03-10
EP3385277A1 (en) 2018-10-10
AU2020205284A1 (en) 2020-08-06
US20190177388A1 (en) 2019-06-13
EP2970422A2 (en) 2016-01-20
AU2014233494A1 (en) 2015-09-03
CA2903587A1 (en) 2014-09-18
JP2022046520A (en) 2022-03-23
AU2014233494B2 (en) 2018-10-04
US20140314711A1 (en) 2014-10-23
EA035645B1 (en) 2020-07-21
ES2676023T3 (en) 2018-07-16
ZA201506297B (en) 2018-11-28
SI2970422T1 (en) 2018-07-31
US10160793B2 (en) 2018-12-25
US20190177389A1 (en) 2019-06-13
PH12015502125B1 (en) 2022-02-11
US10544198B2 (en) 2020-01-28
US10087227B2 (en) 2018-10-02
US20230063741A1 (en) 2023-03-02
RS57393B1 (en) 2018-09-28
WO2014145016A2 (en) 2014-09-18

Similar Documents

Publication Publication Date Title
ZA201506297B (en) Il-22 polypeptides and il-22 fc fusion proteins and methods of use
ZA201801640B (en) Gitrl fusion proteins and uses thereof
IL262727A (en) Cd40l-fc fusion polypeptides and methods of use thereof
ZA201700245B (en) Interleukin-2/interleukin-2 receptor alpha fusion proteins and methods of use
IL245484A0 (en) Interleukin-2 fusion proteins and uses thereof
IL240034A0 (en) Pd-l1 and pd-l2-based fusion proteins and uses thereof
IL244149A0 (en) Methods and preparations containing purified recombinant polypeptides
ZA201505927B (en) Apelin fusion proteins and uses thereof
IL236933A0 (en) Interleukin-2 fusion proteins and uses thereof
EP3049445A4 (en) Interleukin-2 fusion proteins and uses thereof
PL2986633T3 (en) Methods for the expression of peptides and proteins
EP2969009A4 (en) Modified fc fusion proteins
DK2983704T3 (en) FUSION POLYPEPTIDES AND VACCINES
EP3092248A4 (en) Fusion polypeptides and methods of use
IL275602B (en) Il-22 polypeptides and il-22 fc fusion proteins and methods of use
EP3029071A4 (en) Saxatilin-fc fusion protein and use thereof
HK40116369A (en) Interleukin-2/interleukin-2 receptor alpha fusion proteins and methods of use
TH1501005499A (en) IL-22 polypeptide and IL-22 Fc fusion protein and how to use them
AU2013901331A0 (en) Fusion Proteins and Use Thereof
IL239671A0 (en) Stable form of signal converting protein fusion proteins, and methods of use and preparation thereof
GB201321911D0 (en) N-Glycosylation of peptides and proteins
GB201318313D0 (en) N-Glycosylation of peptides and proteins
点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载