SG11201505719TA - Low temperature synthesis of rapamycin derivatives - Google Patents
Low temperature synthesis of rapamycin derivativesInfo
- Publication number
- SG11201505719TA SG11201505719TA SG11201505719TA SG11201505719TA SG11201505719TA SG 11201505719T A SG11201505719T A SG 11201505719TA SG 11201505719T A SG11201505719T A SG 11201505719TA SG 11201505719T A SG11201505719T A SG 11201505719TA SG 11201505719T A SG11201505719T A SG 11201505719TA
- Authority
- SG
- Singapore
- Prior art keywords
- low temperature
- temperature synthesis
- rapamycin derivatives
- rapamycin
- derivatives
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical class C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361755388P | 2013-01-22 | 2013-01-22 | |
| PCT/US2014/012398 WO2014116611A1 (en) | 2013-01-22 | 2014-01-21 | Low temperature synthesis of rapamycin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201505719TA true SG11201505719TA (en) | 2015-09-29 |
Family
ID=51227971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201505719TA SG11201505719TA (en) | 2013-01-22 | 2014-01-21 | Low temperature synthesis of rapamycin derivatives |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9434744B2 (en) |
| EP (1) | EP2948460B1 (en) |
| JP (1) | JP6401713B2 (en) |
| CN (1) | CN105102463B (en) |
| CA (1) | CA2898723C (en) |
| ES (1) | ES2645951T3 (en) |
| SG (1) | SG11201505719TA (en) |
| WO (1) | WO2014116611A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106153756B (en) * | 2015-04-25 | 2020-04-28 | 山东新时代药业有限公司 | High performance liquid chromatography for detecting rapamycin in everolimus |
| CN106146535B (en) * | 2015-04-25 | 2019-07-26 | 山东新时代药业有限公司 | A kind of preparation method of everolimus |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7220755B2 (en) * | 2003-11-12 | 2007-05-22 | Biosensors International Group, Ltd. | 42-O-alkoxyalkyl rapamycin derivatives and compositions comprising same |
| JP4716280B2 (en) * | 2004-03-01 | 2011-07-06 | テルモ株式会社 | Process for producing O-alkylated rapamycin derivatives |
| ATE418559T1 (en) * | 2004-03-01 | 2009-01-15 | Terumo Corp | METHOD FOR PRODUCING O-ALKYLATED RAPAMYCIN DERIVATIVES |
| CN101522691B (en) * | 2006-11-27 | 2012-08-22 | 泰尔茂株式会社 | Process for producing o-alkylated rapamycin derivative, and o-alkylated rapamycin derivative |
| WO2009131631A1 (en) | 2008-04-14 | 2009-10-29 | Poniard Pharmaceuticals, Inc. | Rapamycin analogs as anti-cancer agents |
| TW200948361A (en) | 2008-05-26 | 2009-12-01 | Chunghwa Chemical Synthesis & Biotech Co Ltd | Method for synthesizing Biolimus A9 and the like and method for improving stability of the same |
| CN103140494A (en) * | 2010-08-04 | 2013-06-05 | 美利奴生命科学有限公司 | Process for preparation of novel 42-0-(heteroalkoxyalkyl) rapamycin compounds with anti-proliferative properties |
| ES2753529T3 (en) * | 2010-11-19 | 2020-04-13 | Biocon Ltd | Processes for the preparation of everolimus and intermediate products thereof |
-
2014
- 2014-01-21 EP EP14743372.6A patent/EP2948460B1/en active Active
- 2014-01-21 SG SG11201505719TA patent/SG11201505719TA/en unknown
- 2014-01-21 WO PCT/US2014/012398 patent/WO2014116611A1/en active Application Filing
- 2014-01-21 CA CA2898723A patent/CA2898723C/en active Active
- 2014-01-21 CN CN201480005663.0A patent/CN105102463B/en active Active
- 2014-01-21 ES ES14743372.6T patent/ES2645951T3/en active Active
- 2014-01-21 JP JP2015553903A patent/JP6401713B2/en not_active Expired - Fee Related
-
2015
- 2015-07-21 US US14/804,714 patent/US9434744B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2948460A4 (en) | 2016-06-08 |
| JP2016505048A (en) | 2016-02-18 |
| HK1218118A1 (en) | 2017-02-03 |
| CN105102463A (en) | 2015-11-25 |
| EP2948460A1 (en) | 2015-12-02 |
| US9434744B2 (en) | 2016-09-06 |
| CA2898723A1 (en) | 2014-07-31 |
| CA2898723C (en) | 2021-09-14 |
| US20150322086A1 (en) | 2015-11-12 |
| WO2014116611A1 (en) | 2014-07-31 |
| ES2645951T3 (en) | 2017-12-11 |
| CN105102463B (en) | 2017-05-31 |
| JP6401713B2 (en) | 2018-10-10 |
| EP2948460B1 (en) | 2017-07-19 |
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